2,294 results match your criteria glu glucose

The relationship between seeds consumption, lipid profile and body mass index among patients with cardiovascular diseases.

Rocz Panstw Zakl Hig 2021 ;72(2):145-153

Slovak University of Agriculture in Nitra, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Nitra, Slovak Republic.

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide and largely preventable through improving diet quality and other lifestyle factors. In recent years, dietary recommendations have shifted towards diets high in plant-based foods and low in animal-based foods for the prevention of chronic diseases.

Objective: This study aims to evaluate the relationship between seeds consumption, lipid profile and body mass index (BMI) in a group of 889 (313 female and 576 male) randomly selected patients hospitalized in the Nitra Cardio Center, Slovakia. Read More

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January 2021

Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium glutamicum to regulate IRS/PI3K/AKT-mediated glucose metabolism disorder in KK-Ay mice.

Phytomedicine 2021 Jun 3;87:153582. Epub 2021 Jun 3.

College of Pharmaceutical Sciences, Southwest University, No.2 Tiansheng Road, Beibei, Chongqing 400716, PR China. Electronic address:

Background And Purpose: Diosmetin (Dios), a flavonoid compound with multiple pharmacological activities. However, fewer studies have reported its effects on type 2 diabetic mellitus (T2DM). Here, we address the effect of Dios on glucose metabolism and gut microbiota in KK-Ay diabetic mice. Read More

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Sulodexide reduces glucose induced senescence in human retinal endothelial cells.

Sci Rep 2021 Jun 1;11(1):11532. Epub 2021 Jun 1.

Department of Pathophysiology, Poznan University of Medical Sciences, Ul. Rokietnicka 8, 60-806, Poznan, Poland.

Chronic exposure of retinal endothelium cells to hyperglycemia is the leading cause of diabetic retinopathy. We evaluated the effect of high glucose concentration on senescence in human retinal endothelial cells (HREC) and modulation of that effect by Sulodexide. Experiments were performed on HREC undergoing in vitro replicative senescence in standard medium or medium supplemented with glucose 20 mmol/L (GLU) or mannitol 20 mnol/L (MAN). Read More

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Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.

Polymers (Basel) 2021 May 28;13(11). Epub 2021 May 28.

Centro de Biotecnología de los Recursos Naturales (CENBio), Facultad de Ciencias Agrarias y Forestales, Universidad Católica del Maule, Talca 3466706, Chile.

Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer. In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries. The application of the EPSs largely depends upon their thermal stability, as any industrial application is mainly reliant on slow thermal degradation. Read More

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Maternal stevioside supplementation ameliorates intestinal mucosal damage and modulates gut microbiota in chicken offspring challenged with lipopolysaccharide.

Food Funct 2021 May 26. Epub 2021 May 26.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Our previous study showed that dietary stevioside supplementation could alleviate intestinal mucosal damage induced by lipopolysaccharide (LPS) through its anti-inflammatory and antioxidant effects in broiler chickens. However, it remains unknown whether feeding stevioside to breeder hens could exert similar biological functions in their offspring. The present study aimed to investigate whether maternal dietary stevioside supplementation could prevent LPS-induced intestinal mucosal damage and alteration of gut microbiota in chicken offspring. Read More

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Design and preparation of a new multi-targeted drug delivery system using multifunctional nanoparticles for co-delivery of siRNA and paclitaxel.

J Pharm Anal 2021 Apr 23;11(2):163-173. Epub 2020 Apr 23.

Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Drug resistance is a great challenge in cancer therapy using chemotherapeutic agents. Administration of these drugs with siRNA is an efficacious strategy in this battle. Here, the present study tried to incorporate siRNA and paclitaxel (PTX) simultaneously into a novel nanocarrier. Read More

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Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes.

Diabetol Metab Syndr 2021 May 17;13(1):54. Epub 2021 May 17.

Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People's Hospital of Nantong City, No. 6, Haierxiang North Road, Nantong, 226001, China.

Objective: Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease, which characterized by islet beta cell dysfunction. Serum adenosine deaminase (ADA) is an important enzyme that regulates the biological activity of insulin, and its levels are greatly increased in inflammatory diseases with insulin resistance. The present study was designed to explore the relationship between serum ADA levels and islet beta cell function in patients with T2D. Read More

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[Effect of Dendrobii officinalis superfine powder on overeating greasy-induced metabolic hypertension in rats].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1658-1666

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobii officinalis, with a definite effect of nourishing Yin and clearing heat, has been a folk habit for drinking after being mixed with water. Because its superfine powder has the advantages of high dissolution and convenient drinking, we observed the effect of D. officinalis superfine powder on metabolic hypertension model rats and its possible mechanism in this experiment, which can be used as a reference for its clinical application for hypertension. Read More

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Protein Conjugated with Glucose via Maillard Reaction: Antioxidant and Techno-Functional Properties.

Int J Food Sci 2021 23;2021:5572554. Epub 2021 Apr 23.

Department of Food Science and Technology, Cape Peninsula University of Technology, Bellville 7535, South Africa.

The food industry is considering novel sources of proteins with enhanced functionalities to meet the increasing demand and population growth. Edible insect proteins have emerged as an alternative that is environmentally friendly and economically viable and thus could make a significant contribution to global food security. This study was aimed to establish the effect of conjugation via the Maillard reaction on the antioxidant and techno-functional properties of black soldier fly larvae protein concentrate. Read More

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Effect of the silkworm pupa protein-glucose conjugate on the thermal stability and antioxidant activity of anthocyanins.

Food Funct 2021 May;12(9):4132-4141

School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212018, China. and Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu 212018, China.

Anthocyanin (cyanidin-3-O-glucose) is a natural water-soluble pigment with a robust antioxidant capacity. However, its poor stability and bioavailability limits its application as a functional food ingredient. This study explored the ability of the silkworm pupa protein-glucose (Spp-Glu) conjugate, developed under wet-heating conditions, to improve the thermal stability and antioxidant activity of cyanidin-3-O-glucose (C3G) at pH 3. Read More

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Surface Selenylation Engineering for Construction of a Hierarchical NiSe/Carbon Nanorod: A High-Performance Nonenzymatic Glucose Sensor.

ACS Appl Mater Interfaces 2021 May 10;13(19):22866-22873. Epub 2021 May 10.

College of Food Science and Engineering, Northwest A&F University, Yangling, 712100 Xianyang, Shaanxi, China.

As glucose (Glu) is an essential substance for metabolism as well as a symbol to diagnose diabetes, the demand of Glu sensors has increased significantly in recent decades. In this work, a hierarchical Ni-based electrochemical enzyme-free Glu sensor, namely, NiSe/CNR (carbon nanorod), was engineered through a facile thermal treatment using dimethylglyoxime dinickel salt with selenium (Se) powder. The prepared NiSe/CNR not only subtly introduces a hierarchical structure with rod-like carbon nanorods and rock-like NiSe nanoparticles, which are extremely helpful in offering a greater catalytic activity area and more catalytic active sites, but also incorporates the Se element to increase the inherent activity. Read More

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Intravenous infusion of glucose improved farrowing performance of hyperprolific crossbred sows.

J Anim Sci 2021 May;99(5)

Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark.

The sow at parturition is challenged with respect to energy status due to increases in energetic expenses associated with 1) nest building 2) uterine contractions, and 3) colostrum production. A previous study indicated that sows were depleted of glucogenic energy around farrowing. The aim was to investigate whether intravenous infusion of glucose from observed nest-building behavior to 24 h postpartum affected the farrowing kinetics and colostrum production in sows. Read More

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A hexokinase from the oyster Crassostrea gigas is involved in immune recognition as a pattern recognition receptor.

Dev Comp Immunol 2021 Sep 28;122:104083. Epub 2021 Apr 28.

Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, 116023, China; Functional Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China; Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University, Dalian, 116023, China; Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control, Dalian Ocean University, Dalian, 116023, China. Electronic address:

Hexokinase (HK) is generally recognized as a crucial enzyme participating in glycolysis. In the present study, a HK (named CgHK) was identified as a potential pattern recognition receptor (PRR) from the Pacific oyster Crassostrea gigas. The open reading frame (ORF) of CgHK was of 1395 bp, encoding a peptide of 464 amino acids with one Hexokinase_1 domain and one Hexokinase_2 domain. Read More

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September 2021

The Effect of a New Glucose-Methotrexate Conjugate on Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma Cell Lines.

Molecules 2021 Apr 27;26(9). Epub 2021 Apr 27.

Department of Pathology, Wroclaw Medical University, 50-367 Wroclaw, Poland.

Patients with hematologic malignancies require intensive therapies, including high-dose chemotherapy. Antimetabolite-methotrexate (MTX) has been used for many years in the treatment of leukemia and in lymphoma patients. However, the lack of MTX specificity causes a significant risk of morbidity, mortality, and severe side effects that impairs the quality of patients' life. Read More

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Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study.

Diabetes Metab Syndr Obes 2021 22;14:1773-1781. Epub 2021 Apr 22.

Department of Endocrinology, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People's Republic of China.

Purpose: In this study, we explored the correlation between diabetic retinopathy (DR) and metabolic syndrome (MetS) among diabetes mellitus (DM) patients.

Methods: Logistic regression analysis was utilized to test the effects of MetS and its indicators on the incidence of DR and vision-related functional burden. The spline smoothing functions of continuous indicators of MetS were used to establish the logistic generalized additive model (GAM). Read More

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Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii.

Int J Med Microbiol 2021 May 19;311(4):151504. Epub 2021 Apr 19.

Bavarian NMR Center - Structural Membrane Biochemistry, Department of Chemistry, Technische Universität München, Garching, Germany. Electronic address:

The metabolism of Legionella pneumophila strain Paris was elucidated during different time intervals of growth within its natural host Acanthamoeba castellanii. For this purpose, the amoebae were supplied after bacterial infection (t =0 h) with 11 mM [U-C]glucose or 3 mM [U-C]serine, respectively, during 0-17 h, 17-25 h, or 25-27 h of incubation. At the end of these time intervals, bacterial and amoebal fractions were separated. Read More

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1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection.

Front Pharmacol 2021 4;12:634176. Epub 2021 Mar 4.

Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.

The outbreak of SARS-CoV-2 virus caused more than 80,155,187 confirmed COVID-19 cases worldwide, which has posed a serious threat to global public health and the economy. The development of vaccines and discovery of novel drugs for COVID-19 are urgently needed. Although the FDA-approved SARS-CoV-2 vaccines has been launched in many countries recently, the strength of safety, stringent storage condition and the possibly short-term immunized efficacy remain as the major challenges in the popularity and recognition of using vaccines against SARS-CoV-2. Read More

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Using the Major Components (Cellulose, Hemicellulose, and Lignin) of Bamboo Shoot as Dietary Fiber.

Front Bioeng Biotechnol 2021 31;9:669136. Epub 2021 Mar 31.

China National Bamboo Research Center, Hangzhou, China.

Bamboo shoots are a renewable and abundant biomass containing cellulose, hemicellulose, and lignin. Although many studies have explored the applications of each of these components in the preparation of biochemicals and biopolymers, few studies have evaluated the utility of these components as a dietary fiber supplement. In this study, a powder consisting of the main components of bamboo shoots (cellulose, hemicellulose, and lignin) was prepared from fresh shoots and characterized by scanning electron microscopy, infrared spectroscopy, and X-ray diffraction. Read More

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Pyometra-associated insulin resistance assessment by insulin binding assay and tyrosine kinase activity evaluation in canine muscle tissue.

Domest Anim Endocrinol 2021 Jul 23;76:106626. Epub 2021 Mar 23.

Laboratório de Metabolismo e Endocrinologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite 500, Porto Alegre - RS, Brazil. CEP: 90050-170.

Diestrus is associated with insulin resistance in bitches and pyometra can further impair insulin sensitivity. This study aimed to compare insulin sensitivity, insulin binding, and tyrosine kinase activity in bitches in anestrus, diestrus, or with pyometra. Patients submitted to elective ovariohysterectomy were divided into anestrus (n = 11) or diestrus (n = 13) according to reproductive history, vaginal cytology, and uterine histology. Read More

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The Structural Characterization of a Novel Water-Soluble Polysaccharide from Edible Mushroom Leucopaxillus giganteus and Its Antitumor Activity on H22 Tumor-Bearing Mice.

Chem Biodivers 2021 Apr 16. Epub 2021 Apr 16.

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, P. R. China.

In the present study, a novel cold water-soluble polysaccharide fraction (LGP) with the average molecular weight of 1.78×10  Da was extracted and purified from Leucopaxillus giganteus and its primary structure as well as in vivo antitumor activity was evaluated. The monosaccharide composition of LGP was determined by ion chromatography to be galactose, xylose, glucose and fucose in a molar ratio of 2. Read More

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Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men.

Diabetes Obes Metab 2021 Apr 14. Epub 2021 Apr 14.

Department of Internal Medicine, Clinic for Diabetes and Endocrinology, Viborg Regional Hospital, Viborg, Denmark.

Aim: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration.

Methods: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Read More

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Effects of polyethylene microplastics on the microbiome and metabolism in larval zebrafish.

Environ Pollut 2021 Aug 31;282:117039. Epub 2021 Mar 31.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address:

Various microplastics (MPs) are found in the environment and organisms. MP residues in organisms can affect health; however, their impacts on metabolism in aquatic organisms remain unclear. In this study, zebrafish embryos were exposed to polyethylene MPs with sizes ranging from 1 to 4 μm at concentrations of 0, 10, 100, and 1000 μg/L for 7 days. Read More

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Characterization of simultaneous uptake of xylose and glucose in Caldicellulosiruptor kronotskyensis for optimal hydrogen production.

Biotechnol Biofuels 2021 Apr 8;14(1):91. Epub 2021 Apr 8.

Division of Applied Microbiology, Lund University, P.O. Box 124, 221 00, Lund, Sweden.

Background: Caldicellulosiruptor kronotskyensis has gained interest for its ability to grow on various lignocellulosic biomass. The aim of this study was to investigate the growth profiles of C. kronotskyensis in the presence of mixtures of glucose-xylose. Read More

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J Zoo Wildl Med 2021 Apr;52(1):241-252

Global Health Program, Smithsonian's National Zoological Park and Conservation Biology Institute, Washington, DC 20008, USA.

Native to Southeast Asia, the Sunda pangolin () is critically endangered largely because of poorly regulated wildlife trade, consumptive practices, and use in traditional Chinese medicine. Efforts to rescue and rehabilitate animals confiscated from the illegal trade are complicated by a general lack of knowledge surrounding the normal health and disease processes unique to the species. To provide clinical reference intervals for normal health states of Sunda pangolins, biochemical parameters were determined from rescued individuals in Vietnam that had undergone a 14-day observation period and met a set of criteria for release back into the wild. Read More

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Hypoglycemic Effect of Hydrophobic BCAA Peptides Is Associated with Altered PI3K/Akt Protein Expression.

J Agric Food Chem 2021 Apr 6;69(15):4446-4452. Epub 2021 Apr 6.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.

The hypoglycemic activities of the hydrophobic branched-chain amino acid (BCAA) peptides from seabuckthorn seed protein were preliminarily characterized in type 2 diabetic db/db mice. Four novel BCAA peptides (18.27 ± 0. Read More

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Electrochemiluminescence sensor based on cyclic peptides-recognition and Au nanoparticles assisted graphitic carbon nitride for glucose determination.

Mikrochim Acta 2021 Apr 4;188(5):151. Epub 2021 Apr 4.

Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, China.

A glucose (Glu) sensor was designed by introducing synthetic cyclic peptides (CPs) as recognition receptors and Au nanoparticles assisted graphitic carbon nitride (AuNPs/g-CN) for electrochemiluminescence (ECL) enhancement. The synthetic CP receptor (cyclo-[-CNDNHCRDNDC-]) with natural active center of Glu binding protein can mimic the interactions between Glu and Glu binding protein to specifically capture Glu. The AuNPs were reduced on g-CN and formed a new nanohybrid that can be applied as an ECL emitter. Read More

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Different Doses of Carbohydrate Mouth Rinse Have No Effect on Exercise Performance in Resistance Trained Women.

Int J Environ Res Public Health 2021 03 26;18(7). Epub 2021 Mar 26.

School of Nutrition and Dietetics, Faculty of Pure & Applied Science, Acadia University, Wolfville, NS B4P 2R6, Canada.

Carbohydrate (CHO) mouth rinse has been shown to enhance aerobic endurance performance. However, the effects of CHO mouth rinse on muscular strength and endurance are mixed and may be dependent on dosage of CHO. The primary purpose was to examine the effects of different dosages of CHO rinse on strength (bench press 1 repetition maximum [1-RM]) and muscular endurance (40% of 1-RM repetitions to failure) in female athletes. Read More

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Umbilical Cord Blood Gas Parameters and Apgar Scoring in Assessment of New-Born Dogs Delivered by Cesarean Section.

Animals (Basel) 2021 Mar 4;11(3). Epub 2021 Mar 4.

Wrocław University of Environmental and Life Sciences, Department of Reproduction and Clinic of Farm Animals, 50-366 Wrocław, Poland.

The article presents the results of the clinical evaluation (Apgar scores, AS) and umbilical cord blood gas analysis (UCBGA) obtained from clamped umbilical cords of newborn pups delivered by the elective Caesarean section. The study was planned as a controlled clinical study, the newborns were allocated into one of the groups, I-critical neonates (severe distress, AS ≤ 3), II-weak neonates (moderate distress, AS 4-6) and III-healthy neonates (no distress, AS ≥ 7). The following parameters were evaluated: pH (pH units), carbon dioxide partial pressure (pCO; mmHg), oxygen partial pressure (pO; mmHg), actual bicarbonate (cHCO; mmol/L), total carbon dioxide (cTCO; mmol/L), base excess of extracellular fluid (BE(ecf); mmol/L), base excess of blood (BE(b); mmol/L), oxygen saturation (csO; %), lactate (Lac; mg/dL), hematocrit (Hct; %PCV), hemoglobin (cHgb; g/dL), glucose (Glu; mg/dL), ions (Na, K, Ca, Cl). Read More

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PCSK9 Levels and Metabolic Profiles in Elderly Subjects with Different Glucose Tolerance under Statin Therapy.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) degrades low-density lipoprotein cholesterol (LDL-C) receptors, and thus regulates the LDL-C levels in the circulation. Type 2 diabetics often have elevated LDL-C levels. However, the functions of PCSK9 in patients with alterations of glu-cose metabolism and statin therapy are still unclear. Read More

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SOX9 Knockdown-Mediated FOXO3 Downregulation Confers Neuroprotection Against Ischemic Brain Injury.

Front Cell Dev Biol 2020 12;8:555175. Epub 2021 Mar 12.

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Evidence exists uncovering that SRY-box transcription factor 9 (SOX9) plays a role in ischemic brain injury (IBI). Thus, the current study was conducted to elucidate the specific role of SOX9 and the mechanism by which SOX9 influenced IBI.

Methods: The IBI-associated regulatory factors were searched by bioinformatics analysis. Read More

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