131,793 results match your criteria glomerular


Management of acute kidney injury associated with Covid-19: what have we learned?

Curr Opin Nephrol Hypertens 2021 Sep 15. Epub 2021 Sep 15.

Department of Critical Care, Royal Surrey Hospital, Surrey, UK Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA Department of Clinical & Experimental Medicine, Faculty of Health Sciences, University of Surrey, Surrey, UK.

Purpose Of Review: Although initially kidney involvement in COVID-19 infection was felt to occur relatively infrequently, this has proved not to be the case. In critically ill patients with COVID-19, multiorgan failure including acute kidney injury (AKI) is common and is associated with an increased risk of mortality and morbidity. This review focuses briefly on the epidemiology and pathophysiology of COVID-19 associated AKI as well as options for management. Read More

View Article and Full-Text PDF
September 2021

Biomarkers of kidney function and cognitive ability: A Mendelian randomization study.

J Neurol Sci 2021 Sep 14;430:118071. Epub 2021 Sep 14.

Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA.

Background: Estimated glomerular filtration rate (eGFR), albuminuria and serum uric acid (SUA) are markers of kidney function that have been associated with cognitive ability. However, whether these associations are causal is unclear.

Methods: We performed one-sample Mendelian randomization (MR) to estimate the effects of kidney function markers on cognitive performance using data from the UK Biobank. Read More

View Article and Full-Text PDF
September 2021

Clinical Outcomes Following Durable Mitral Valve Repair for Ischemic Mitral Regurgitation.

Ann Thorac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: This study aimed to clarify the incidence and determinants of postoperative adverse events in patients with ischemic cardiomyopathy who achieved long-term durable mitral valve repair.

Methods: Between 1999 and 2015, 166 patients with chronic ischemic mitral regurgitation (MR) and left ventricular (LV) ejection fraction ≤40% underwent restrictive mitral annuloplasty. During follow-up (65±34 months), echocardiographic assessments were performed 809 times (mean, 4. Read More

View Article and Full-Text PDF
September 2021

Vitamin D metabolism in human kidney organoids.

Nephrol Dial Transplant 2021 Sep 17. Epub 2021 Sep 17.

Erasmus MC Transplant Institute, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Human kidney organoids possess early glomerular and tubular function. However, little is known about their hormone producing ability. In this report, we show that kidney organoids take up and metabolize inactive 25(OH) vitamin D (25(OH)D3). Read More

View Article and Full-Text PDF
September 2021

Renal Functional and Perioperative Outcomes of Retroperitoneal Robot-Assisted Versus Laparoscopic Partial Nephrectomy with Segmental Renal Artery Clamping.

J Laparoendosc Adv Surg Tech A 2021 Sep 17. Epub 2021 Sep 17.

Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Retroperitoneal approach and segmental renal artery clamping in partial nephrectomy are techniques that facilitate postoperative recovery and renal function preservation. This study aimed to compare the renal function preservation and perioperative outcomes of robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) with these techniques. Clinical parameters of 43 patients who had undergone retroperitoneal RAPN from March 2017 to December 2019 were retrospectively collected and compared with those of 52 patients who had undergone retroperitoneal LPN at the same period in our institution. Read More

View Article and Full-Text PDF
September 2021

Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study.

J Diabetes Investig 2021 Sep 17. Epub 2021 Sep 17.

Division of Diabetes and Metabolism, The Institute of Medical Science, Asahi Life Foundation, Chuo-ku, Tokyo, 103-0002, Japan.

Aims/introduction: We aimed to study the relationships among the copper (Cu)/zinc (Zn) ratio, inflammatory biomarkers, and the prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes.

Materials And Methods: We performed a cross-sectional study on 651 patients with type 2 diabetes. DKD was defined as a urinary albumin-to-creatinine ratio ≥30 mg/g creatinine and/or an estimated glomerular filtration rate using cystatin C <60 mL/min/1. Read More

View Article and Full-Text PDF
September 2021

High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1.

FASEB J 2021 Oct;35(10):e21912

Clinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

High salt diet (HSD) is a hallmark of blood pressure elevations, weight gain and diabetes onset in the metabolic syndrome. In kidney, compensatory mechanisms are activated to balance salt turnover and maintain homeostasis. Data on the long-term effects of HSD with respect to tubular cell functions and kidney architecture that exclude confounding indirect blood pressure effects are scarce. Read More

View Article and Full-Text PDF
October 2021

Double whammy: anticoagulant-related nephropathy with leukocytoclastic vasculitis due to warfarin.

CEN Case Rep 2021 Sep 17. Epub 2021 Sep 17.

Department of Nephrology, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi, 110060, India.

Anticoagulation-related nephropathy (ARN) is a rare form of acute kidney injury where the use of anticoagulation causes hemorrhage in various compartments of nephron including glomerulus, renal tubules, and interstitial compartment. Also, warfarin-induced vasculitis is an extremely rare condition characterized by the appearance of purpuric lesions on the skin which on biopsy are suggestive of leukocytoclastic vasculitis (LV). We hereby report a case presenting with coexistent warfarin-induced nephropathy and cutaneous vasculitis. Read More

View Article and Full-Text PDF
September 2021

Histopathologic findings on indication renal allograft biopsies after recovery from acute COVID-19.

Clin Transplant 2021 Sep 16:e14486. Epub 2021 Sep 16.

Current knowledge on histopathological changes occurring after COVID-19 in transplanted kidneys is limited. Herein, we present renal allograft pathology findings in patients recovered from COVID-19. Six patients underwent indication biopsy, and one required allograft nephrectomy after acute COVID-19. Read More

View Article and Full-Text PDF
September 2021

Long non-cording RNA XIST promoted cell proliferation and suppressed apoptosis by miR-423-5p/HMGA2 axis in diabetic nephropathy.

Mol Cell Biochem 2021 Sep 16. Epub 2021 Sep 16.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, 215006, Jiangsu, China.

This research studied the effect of long non-coding RNA X-inactive-specific transcript (XIST) on DN. The effect of high glucose (HG) on the expression of XIST and miR-423-5p was detected by quantitative real-time PCR (qRT-PCR) in human kidney (HK) cells (human glomerular mesangial cells (HMCs) and human kidney-2 (HK-2) cells). The effect of XIST depletion and miR-423-5p inhibition or overexpression on high mobility group protein A2 (HMGA2) protein level was examined by western blot in HG-induced HK cells. Read More

View Article and Full-Text PDF
September 2021

A prognostic staging system for light-chain amyloidosis using hepatic and renal indicator data from 1,064 Chinese patients.

Ann Transl Med 2021 Aug;9(16):1347

Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Light-chain (AL) amyloidosis frequently involves severe multiple end-organ damage, thus affecting prognosis. As the current disease staging system is based only on cardiac indicators, we propose a new staging system based on multiple organ indicators to supplement the existing system.

Methods: Patients with AL amyloidosis (n=1,064) from 18 Chinese hospitals were enrolled and divided into test and validation cohorts (4:1). Read More

View Article and Full-Text PDF

The RNA binding protein hnRNPK protects against adriamycin-induced podocyte injury.

Ann Transl Med 2021 Aug;9(16):1303

Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Background: Podocytes maintain the integrity of the glomerular filtration barrier and serve as the final barrier to protein loss. Podocyte injury may induce severe apoptosis, which can result in serious kidney damage and disease. Therefore, it is necessary to explore how podocyte injury can be prevented and to thereby discover a feasible therapy for kidney disease. Read More

View Article and Full-Text PDF

Association of Adult-Onset Bartter Syndrome With Undifferentiated Connective Tissue Disorder.

Cureus 2021 Aug 13;13(8):e17140. Epub 2021 Aug 13.

internal Medicine/Nephrology, Shifa International Hospital, Islamabad, PAK.

Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. We are reporting a case of 21 years old patient, who presented with lower limb weakness, marked hypokalemia, proteinuria, and renal impairment detected on laboratory evaluation. The diagnosis of Bartter syndrome was suspected by marked hypokalemia and was supported by renal biopsy which showed evidence of Juxtaglomerular (JG) hyperplasia. Read More

View Article and Full-Text PDF

FOXA1 Suppresses SATB1 Transcription and Inactivates the Wnt/β-Catenin Pathway to Alleviate Diabetic Nephropathy in a Mouse Model.

Diabetes Metab Syndr Obes 2021 10;14:3975-3987. Epub 2021 Sep 10.

Department of Endocrinology, The Third People's Hospital of Yunnan Province, Kunming, 650011, Yunnan, People's Republic of China.

Objective: Diabetic nephropathy (DN) represents the most common diabetic complication that may lead to end-stage renal disease. This work focused on the effect of FOXA1 on the DN development and the molecular mechanism.

Methods: A mouse model of DN was induced by high-fat diets and streptozotocin. Read More

View Article and Full-Text PDF
September 2021

Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria.

Sci Rep 2021 Sep 16;11(1):18472. Epub 2021 Sep 16.

Division of Nephrology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang, Gyeonggi-do, 14068, Republic of Korea.

Most epidemiologic studies assessing the relationship between chronic kidney disease (CKD) and sarcopenia have been performed in dialysis patients. This study aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR), proteinuria, and sarcopenia in patients with non-dialysis-dependent CKD. A total of 892 outpatients who did not show any rapid changes in renal function were enrolled in this observational cohort study. Read More

View Article and Full-Text PDF
September 2021

Effects of Metabolic Factors, Race-Ethnicity, and Sex on the Development of Nephropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study.

Authors:

Diabetes Care 2021 Sep 16. Epub 2021 Sep 16.

Objective: To describe the longitudinal effects of sex, race-ethnicity, and metabolic factors on the risk of developing diabetic kidney disease (DKD) in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort.

Research Design And Methods: Urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were assessed annually for up to 15 years after study entry. Markers of DKD included micro- and macroalbuminuria (UACR ≥30 mg/g and ≥300 mg/g, respectively), hyperfiltration (eGFR ≥135 mL/min/1. Read More

View Article and Full-Text PDF
September 2021

Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients.

BMC Nephrol 2021 Sep 16;22(1):311. Epub 2021 Sep 16.

School of Medicine, Federal University of Uberlândia, Minas Gerais, 1720, Pará Avenue, Block 2U, Campus Umuarama, Code postal: 38400-902, Uberlândia, Brazil.

Background: Recent studies have shown that the serum uric acid/creatinine ratio (SUA/SCr) is a better predictor of chronic kidney disease (CKD) than serum uric acid (SUA) isolated. The aim of the present study was to evaluate the association of isolated SUA and the SUA/SCr with CKD in hypertensive patients.

Methods: Cross-sectional study conducted with hypertensive patients followed-up by the Primary Health Care Service (PHC). Read More

View Article and Full-Text PDF
September 2021

Prognostic value of glomerular function estimated by Cockcroft-Gault creatinine clearance, MDRD-4, CKD-EPI and European Kidney Function Consortium equations in patients with acute coronary syndromes.

Clin Chim Acta 2021 Sep 13. Epub 2021 Sep 13.

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Germany.

Background: It remains unknown which equation used to assess the glomerular function is better for risk stratification in patients with acute coronary syndrome (ACS).

Methods: This study included 3985 patients with ACS. Glomerular function was assessed using 4 equations: the Cockcroft-Gault creatinine clearance (C-G), Modification of Diet in Renal Disease-4 (MDRD-4), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and European Kidney Function Consortium (EKFC) equations. Read More

View Article and Full-Text PDF
September 2021

Renal Dysfunction is an Independent Risk Factor for Rebleeding After Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding.

Turk J Gastroenterol 2021 Aug;32(8):622-630

Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan.

Background: Despite the progress in endoscopic hemostasis and pharmacological treatment, the mortality rate of peptic ulcer bleeding remains at 5-10%. Rebleeding after peptic ulcer bleeding is believed to be a risk factor for mortality. This study aimed to evaluate whether renal dysfunction is a predictor of rebleeding after endoscopic hemostasis in patients with peptic ulcer bleeding. Read More

View Article and Full-Text PDF

Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction.

ESC Heart Fail 2021 Sep 16. Epub 2021 Sep 16.

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Cardiology Section, VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, Boston, MA, 02132, USA.

Aims: This study aims to develop the first race-specific and sex-specific risk prediction models for heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF).

Methods And Results: We created a cohort of 1.8 million individuals who had an outpatient clinic visit between 2002 and 2007 within the Veterans Affairs (VA) Healthcare System and obtained information on HFpEF, HFrEF, and several risk factors from electronic health records (EHR). Read More

View Article and Full-Text PDF
September 2021

Low CD4 T cell count predicts radiological progression in severe and critically ill COVID-19 patients: a case control study.

J Thorac Dis 2021 Aug;13(8):4723-4730

Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Novel coronavirus disease (COVID-19) has spread globally and caused over 3 million deaths, posing great challenge on public health and medical systems. Limited data are available predictive factors for disease progression. We aim to assess clinical and radiological predictors for pulmonary aggravation in severe and critically ill COVID-19 patients. Read More

View Article and Full-Text PDF

Jianpi Qushi Heluo Formula alleviates renal damages in Passive Hemann nephritis in rats by upregulating Parkin-mediated mitochondrial autophagy.

Sci Rep 2021 Sep 15;11(1):18338. Epub 2021 Sep 15.

China Department of Nephrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Jianpi Qushi Heluo Formula (JQHF) is an empirical traditional Chinese medicine prescription for treating Membranous Nephropathy (MN) clinically in China. The therapeutic effect of JQHF has been reported in our previous studies. However, the exact mechanism is still unknown. Read More

View Article and Full-Text PDF
September 2021

Long-term Benefits of Treatment with Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease.

J Nippon Med Sch 2021 Sep 14. Epub 2021 Sep 14.

Department of Nephrology, Graduate School of Medicine, Nippon Medical School.

Background: Tolvaptan is the first effective drug treatment for autosomal dominant polycystic kidney disease (ADPKD) patients, but few long-term observations of the effects of tolvaptan have been reported.

Methods: In this single center, retrospective cohort study, we investigated nine patients who participated in a phase 3 trial of tolvaptan for ADPKD patients at our hospital between 2008 and 2014. Six of the patients discontinued tolvaptan at the end of the clinical trial and were defined as the discontinuation group, and three continued to take it; these were defined as the continuation group. Read More

View Article and Full-Text PDF
September 2021

Novel Chalcone BDD-39 Mitigated Diabetic Nephropathy through the Activation of Nrf2/ARE Signaling.

Curr Mol Pharmacol 2021 Sep 15. Epub 2021 Sep 15.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu. China.

Background: In this study, we investigated the Nrf2/ARE signaling pathway activating capacity of Biphenyl Diester Derivative-39 (BDD-39) in diabetic nephropathy in order to elucidate the mechanism surrounding its antidiabetic potential.

Objectives: Protein expressions of Nrf2, HO-1, NQO-1 and biomarkers of kidney fibrosis were executed after which mRNA levels of Nrf2, HO-1 and NQO-1 were estimated after creating the models following BBD-39 treatment.

Methods: Type 2 diabetes model was established in mice with high-fat diet feeding combined with streptozocin intraperitoneal administration. Read More

View Article and Full-Text PDF
September 2021

Early everolimus-facilitated reduced tacrolimus in liver transplantation: Results from the randomized HEPHAISTOS trial.

Liver Transpl 2021 Sep 15. Epub 2021 Sep 15.

Novartis Pharma GmbH, Nürnberg, Germany.

Background: Everolimus-facilitated reduced tacrolimus exposure (EVR+rTAC) at 30 days post-liver transplantation (LT) has shown advantages in renal preservation. This study evaluated the effects of early initiation of EVR+rTAC in de novo liver transplant recipients (LTR).

Methods: In HEPHAISTOS (NCT01551212, EudraCT 2011-003118-17), a 12-month (M), multicenter, controlled study, LTR were randomized at 7-21 days post-LT to receive EVR+rTAC or standard tacrolimus (sTAC), with steroids. Read More

View Article and Full-Text PDF
September 2021

Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study.

AIDS Patient Care STDS 2021 Sep;35(9):342-353

Unit of Infectious and Tropical Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan-Meier survival curve. Read More

View Article and Full-Text PDF
September 2021

A case of anti-GBM nephritis following centipede bites and COVID-19 vaccination.

CEN Case Rep 2021 Sep 15. Epub 2021 Sep 15.

Department of Nephrology, Hitachi General Hospital, 2-1-1 Jonan-cho, Hitachi, Ibaraki, 317-0077, Japan.

A case of newly developed anti-glomerular basement membrane (GBM) glomerulonephritis (GN) following centipede bites and COVID-19 vaccination is presented. A 70-year-old woman presented for investigation of mild fever, generalized fatigue, and macroscopic hematuria with no past history of renal disease. One year earlier, she had been bitten by a centipede. Read More

View Article and Full-Text PDF
September 2021

Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.

JAMA Netw Open 2021 Sep 1;4(9):e2123365. Epub 2021 Sep 1.

Ottawa Hospital Research Institute, Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.

Importance: Thiazide diuretics are commonly prescribed for the treatment of hypertension, a disease highly prevalent among older individuals and in those with chronic kidney disease. How specific thiazide diuretics compare in regard to safety and clinical outcomes in these populations remains unknown.

Objective: To compare safety and clinical outcomes associated with chlorthalidone or hydrochlorothiazide use among older adults with varying levels of kidney function. Read More

View Article and Full-Text PDF
September 2021