24,776 results match your criteria glial fibrillary


In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae.

Brain Res Bull 2021 May 11. Epub 2021 May 11.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto, Japan; Department of Applied Pharmacology, Graduate School of Medical and Pharmaceutical Science, University of Toyama, Sugitani, Toyama, Japan. Electronic address:

Cerebral infarct is caused by cerebrovascular occlusion and results in brain damage. Although many rodent models of cerebral infarct exist, there is none based on zebrafish. In this study, we developed a novel ischemia-reperfusion model induced by hypoxic treatment using zebrafish. Read More

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MiR-140-5p targets Prox1 to regulate the proliferation and differentiation of neural stem cells through the ERK/MAPK signaling pathway.

Ann Transl Med 2021 Apr;9(8):671

Department of Neurology and Institute of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: The expression of miR-140-5p increased in the brain tissue of a bilateral common carotid artery ligation model, while the overexpression of miR-140-5p significantly decreased the number of neurons. The luciferase report experiment in the previous study proved that miR-140-5p negatively regulated one of the potential targets of Prospero-related homeobox 1 (Prox1). Therefore, we want to investigate the effect of miR-140-5p on the proliferation and differentiation of neural stem cells (NSCs) and the underlying mechanism. Read More

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CSPGs Promote the Migration of Meningeal Fibroblasts via p38 Mitogen-activated Protein Kinase Signaling Pathway Under OGD Conditions.

Brain Res Bull 2021 May 10. Epub 2021 May 10.

Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Aims: Usually glial scar that occurs after central nervous system injury has significantly affected the local neural microenvironment. Meningeal fibroblasts play an essential role in the formation of the glial scar. However, how and why meningeal fibroblasts migrate to lesion sites is still unclear. Read More

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Neuropsychiatric sequelae of acute carbon monoxide poisoning: The predictive role of neuron specific enolase and glial fibrillary acidic protein.

Neurotoxicology 2021 May 10. Epub 2021 May 10.

Department of neuropsychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Acute carbon monoxide (CO) poisoning is one of the most common poisons worldwide and neuropsychiatric sequelae (NS) are the most frequent form of its morbidity.

Objectives: This study aimed to measure the percentage of patients liable to NS, to evaluate the cognitive profile of patients with NS and to assess the role of neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP) in predicting the development of NS after acute CO poisoning.

Methods: This prospective study included 50 patients with acute CO poisoning presented to the Poison Control Center, Ain Shams University Hospitals during the period from beginning of November 2015 till the end of January 2017. Read More

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Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.

Geroscience 2021 May 13. Epub 2021 May 13.

Unité de Glycobiologie Structurale et Fonctionnelle, University of Lille, CNRS, UMR 8576, UGSF, F-59000, Lille, France.

Brain aging may be programmed by early-life stress. Aging affects males and females differently, but how perinatal stress (PRS) affects brain aging between sexes is unknown. We showed behavioral and neurobiological sex differences in non-stressed control rats that were strongly reduced or inverted in PRS rats. Read More

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Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice.

Pharm Biol 2021 Dec;59(1):557-564

Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, People's Republic of China.

Context: Hepatic encephalopathy (HE) is a complex neuropsychiatric disease caused by liver failure. Dihydromyricetin (DMY) is a traditional medicine used to treat liver injury.

Objective: To investigate the effects of dihydromyricetin (DMY) on hepatic encephalopathy associated with acute hepatic failure mice models established by thioacetamide (TAA) exposure. Read More

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December 2021

Unilateral vagotomy alters astrocyte and microglial morphology in the nucleus tractus solitarii of the rat.

Am J Physiol Regul Integr Comp Physiol 2021 May 12. Epub 2021 May 12.

Area Pathobiology, University of Missouri, Columbia, MO, United Statesgrid.134936.a.

The nucleus tractus solitarii (nTS) is the initial site of integration of sensory information from the cardiorespiratory system and contributes to reflex responses to hypoxia. Afferent fibers of the bilateral vagus nerves carry input from the heart, lungs, and other organs to the nTS where it is processed and modulated. Vagal afferents and nTS neurons are integrally associated with astrocytes and microglia which contribute to neuronal activity and influence cardiorespiratory control. Read More

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Aquaporin 4 differentially modulates osmotic effects on vasopressin neurons in rat supraoptic nucleus.

Acta Physiol (Oxf) 2021 May 12:e13672. Epub 2021 May 12.

Department of Physiology, Harbin Medical University, Harbin, 150086, China.

Aim: Glial fibrillary acidic protein (GFAP) has molecular association with aquaporin 4 (AQP4) in astrocytic plasticity. Here, we further examined how AQP4 modulates osmotic effects on vasopressin (VP) neurons in rat supraoptic nucleus (SON) through interactions with GFAP.

Methods: Brain slices from adult male rats were under osmotic stimulation. Read More

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The diagnostic competence of Glial Fibrillary Acidic Protein in mild traumatic brain injury and its prognostic value in patient recovery.

Turk Neurosurg 2020 Jul 6. Epub 2020 Jul 6.

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Aim: Aim: In clinical assessments and literature conducted on TBI, the mild TBI is less studied, because the initial symptoms are non-specific and subjective, and have overlap with psychological disorders. Glial Fibrillary Acidic Protein (GFAP) is a protein expressed by most of the abundant cells of the CNS. Therefore, this paper attempted to show whether the GFAP levels are significantly higher in the serum of patients with mild traumatic brain injury Material and Methods: The level of serum GFP was measured in 176 patients suffering from brain trauma. Read More

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Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients.

J Neurol 2021 May 10. Epub 2021 May 10.

Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.

Background And Aims: Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). Read More

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IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis.

J Neuroinflammation 2021 May 11;18(1):108. Epub 2021 May 11.

Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.

Background: Interleukin 9 (IL-9), produced mainly by T helper 9 (Th9) cells, has been recognized as an important regulator in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Astrocytes respond to IL-9 and reactive astrocytes always associate with blood-brain barrier damage, immune cell infiltration, and spinal injury in MS and EAE. Several long non-coding RNAs (lncRNAs) with aberrant expression have been identified in the pathogenesis of MS. Read More

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Rapid progression of an IDH-wild type histological low-grade glioma harbouring TERT promoter mutation and diffuse CD34 expression: a case report.

Folia Neuropathol 2021 ;59(1):104-111

Department of Pathology, Shanghai Changzheng Hospital, Shanghai, China.

IDH-wild type (WT) histological low-grade gliomas are a rare group with distinct character and prognostic heterogeneity. Studies involving genetic and molecular analyses are warranted to stratify these patients into specific entities for the facilitation of tumour management. In this study, we reported a novel IDH-WT glioma with histological characteristics of a low-grade tumour. Read More

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January 2021

One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury.

Front Neurol 2021 21;12:643743. Epub 2021 Apr 21.

Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

To investigate the longitudinal evolution of three blood biomarkers: neurofilament light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized patients with mild traumatic brain injury (mTBI) compared to controls, along with their associations-in patients-with clinical injury characteristics and demographic variables, and ability to discriminate patients with mTBI from controls. A longitudinal observation study including 207 patients with mTBI, 84 age and sex-matched community controls (CCs) and 52 trauma controls (TCs). Blood samples were collected at 5 timepoints: acute (<24 h), 72 h (24-72 h post-injury), 2 weeks, 3 and 12 months. Read More

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Shock wave and mesenchymal stem cells as treatment in the acute phase of spinal cord injury: A pilot study.

Rehabilitacion (Madr) 2021 May 6. Epub 2021 May 6.

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche - Centro Superior de Investigaciones Científicas, Spain.

Introduction: Spinal cord injury (SCI) is a complex pathology with thousands of patients worldwide. During the acute early phase, neural tissue shows some regenerative properties that disappear at the chronic phase. Shock Waves and Stem Cells have been proposed as a possible therapy. Read More

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Transplantation of Rat Dental Pulp Stem Cells Facilities Post-Lesion Recovery in the Somatosensory Whisker Cortex of Male Wistar Rats.

Brain Res Bull 2021 May 5. Epub 2021 May 5.

Neuroscience Research Center, Institute of Neuropharmachology, Kerman University of Medical Sciences, Kerman, Iran; Cognitive Neuroscience Research Center, Institute of Neuropharmachology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Damage to somatosensory "barrel" cortex reduces the rats' behavioral sensitivity in discrimination of tactile stimuli. Here, we examined how transplantation of stem cells into the lesioned barrel cortex can help in recovery of sensory capacities. We induced mechanical lesions in the right barrel cortex area of male rats. Read More

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Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats.

Front Pharmacol 2021 20;12:653175. Epub 2021 Apr 20.

Institute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile.

High-ethanol intake induces a neuroinflammatory response, which has been proposed as responsible for the maintenance of chronic ethanol consumption. Neuroinflammation decreases glutamate transporter (GLT-1) expression, increasing levels of glutamate that trigger dopamine release at the corticolimbic reward areas, driving long-term drinking behavior. The activation of peroxisome proliferator-activated receptor alpha (PPARα) by fibrates inhibits neuroinflammation, in models other than ethanol consumption. Read More

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miR-125a-5p in astrocytes attenuates peripheral neuropathy in type 2 diabetic mice through targeting TRAF6.

Endocrinol Diabetes Nutr 2021 May 3. Epub 2021 May 3.

Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan City, Hubei Province 430081, China. Electronic address:

Introduction: Elimination or blocking of astrocytes could ameliorate neuropathic pain in animal models. MiR-125a-5p, expressed in astrocyte derived extracellular vesicles, could mediate astrocyte function to regulate neuron communication. However, the role of miR-125a-5p in DPN (diabetic peripheral neuropathy) remains elusive. Read More

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GSK-3β S9A overexpression leads murine hippocampal neural precursors to acquire an astroglial phenotype in vivo.

Dev Neurobiol 2021 May 6. Epub 2021 May 6.

Department of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, Madrid, Spain.

The addition of new neurons to the existing hippocampal circuitry persists in the adult dentate gyrus (DG). During this process, named adult hippocampal neurogenesis (AHN), adult hippocampal progenitor cells (AHPs) give rise to newborn dentate granule cells (DGCs). The acquisition of a neuronal lineage by AHPs is tightly regulated by numerous signaling molecules and transcription factors. Read More

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Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.

Neurotrauma Rep 2021 7;2(1):193-199. Epub 2021 Apr 7.

Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) may aid in the evaluation of traumatic brain injury (TBI). The objective of this analysis was to compare GFAP and UCH-L1 values measured using a handheld device compared with a core laboratory platform. We analyzed plasma samples from patients with TBI and healthy controls enrolled in the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) cohort study. Read More

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CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy.

Front Neurol 2021 16;12:647428. Epub 2021 Apr 16.

Department of Epileptology, University Hospital Bonn, Bonn, Germany.

Our goal was to investigate whether biomarkers of cerebral damage are found in autoimmune-mediated epilepsy (AIE) and whether these can differentiate AIE from other seizure disorders. We retrospectively searched our cerebrospinal fluid (CSF) database for patients with definite AIE, hippocampal sclerosis due to other causes (HS), genetic generalized epilepsy (GGE), and psychogenic, non-epileptic seizures (PNES). We measured serum and CSF tau, neurofilament 1 (NFL), glial fibrillary acid protein (GFAP), and ubiquitin-carboxy-terminal hydrolase L1 with a single-molecule array. Read More

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Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice.

Front Neurosci 2021 15;15:632216. Epub 2021 Apr 15.

Laboratório de Investigações em Neurodegeneração e Infecção, Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, Brazil.

To explore the impact of reduced mastication and a sedentary lifestyle on spatial learning and memory in the aged mice, as well as on the morphology of astrocytes in the molecular layer of dentate gyrus (MolDG), different masticatory regimens were imposed. Control mice received a pellet-type hard diet, while the reduced masticatory activity group received a pellet diet followed by a powdered diet, and the masticatory rehabilitation group received a pellet diet, followed by powder diet and then a pellet again. To mimic sedentary or active lifestyles, mice were housed in an impoverished environment of standard cages or in an enriched environment. Read More

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Poly (L-lactic acid) nanofibrous scaffolds support the proliferation and neural differentiation of mouse neural stem and progenitor cells.

Int J Dev Neurosci 2021 May 2. Epub 2021 May 2.

Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: The distribution and growth of cells on nanofibrous scaffolds seem to be an indispensable precondition in cell tissue engineering. The potential use of biomaterial scaffolds in neural stem cell therapy is increasingly attracting attention.

Aim: In this study, we produced porous nanofibrous scaffolds fabricated from random poly-L-lactic acid (PLLA) to support neurogenic differentiation of neural stem and progenitor cells (NSPCs), isolated from the subventricular zone (SVZ) of the adult mouse brain. Read More

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Boswellia serrata suppress fipronil-induced neuronal necrosis and neurobehavioral alterations via promoted inhibition of oxidative/inflammatory/apoptotic pathways.

Sci Total Environ 2021 Apr 27;785:147384. Epub 2021 Apr 27.

Department of Histology and Cytology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22516, Egypt. Electronic address:

Boswellic acid (BA) is a pentacyclic terpenoid derived from the gum-resin of Boswellia serrate. It is known for its strong antioxidant, anti-inflammatory, and anticancer properties. It has improved spatial learning and provides neuroprotection against trimethyltin-induced memory impairment. Read More

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Down-regulated long non-coding RNA RMST ameliorates dopaminergic neuron damage in Parkinson's disease rats via regulation of TLR/NF-κB signaling pathway.

Brain Res Bull 2021 Apr 29. Epub 2021 Apr 29.

Neurology Department, The 960th Hospital of the PLA, Zibo 255300, Shandong, China; Neurology Department, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan, China. Electronic address:

Objective: Current treatment and prognosis of Parkinson's disease (PD) are not ideal. This study explored the mechanism of long non-coding RNA (lncRNA) rhabdomyosarcoma 2-associated transcript (RMST) in dopaminergic (DA) neuron damage in PD rats.

Methods: PD rats were modeled and injected with RMST silence or overexpression vectors to figure out its roles in oxidative stress, the apoptosis of DA neurons in brain substantia nigra (SN), and neurobehavioral activities of PD rats. Read More

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The effect of caspase-9 in the differentiation of SH-SY5Y cells.

Eur J Pharmacol 2021 Apr 29:174138. Epub 2021 Apr 29.

Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran; Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Neuroblastoma is the most common solid malignant tumor in infants and young children. Its origin is the incompletely committed precursor cells from the autonomic nervous system. Neuroblastoma cells are multipotent cells with a high potency of differentiation into the neural cell types. Read More

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Serum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.

J Neuroinflammation 2021 May 1;18(1):105. Epub 2021 May 1.

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with a relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are a yet unmet clinical need. Here, we evaluated serum glial fibrillary acidic protein (sGFAP) and neurofilament light (sNfL) as disease severity and prognostic biomarkers in patients with aquaporin-4 immunoglobulin (Ig)G positive (AQP4-IgG) NMOSD. Read More

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Possible antiapoptotic and neuroprotective effects of magnesium sulfate on retina in a preterm hypoxic-ischemic rat model.

Turk J Med Sci 2021 May 2. Epub 2021 May 2.

Background: The effects of systemic magnesium sulfate (MgSO4) on retina in preterm hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2) and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model.

Materials And Methods: Fifteen postnatal day (PND) 7 rat pups were divided into 3 groups: 1. Read More

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Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage.

J Ethnopharmacol 2021 Apr 28;275:114164. Epub 2021 Apr 28.

School of Pharmacy, Anhui University of Chinese Medicine, Anhui Province Key Laboratory of Chinese Medical Formula, Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, China. Electronic address:

Ethnopharmacological Relevance: According to traditional Chinese medicine (TCM) theory (Yi Xue Zheng Zhuan), the main factors associated with the pathogenesis of depression are deficiencies relating to five zang organs, Qi, and blood. Polygonatum sibiricum F. Delaroche (PS), which may avert these pathological changes, has been used in a variety of formulas to treat depression. Read More

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Neuroprotective response and efficacy of intravenous administration of mesenchymal stem cells in traumatic brain injury mice.

Eur J Neurosci 2021 May 1. Epub 2021 May 1.

Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Delhi, India.

Cellular transplantation of stem cells can be a beneficial treatment approach for neurodegenerative diseases such as traumatic brain injury (TBI). In this study, we investigated the proliferation and differentiation potential of infused mesenchymal stem cells (MSCs) after localisation at the injury site. We evaluated the appropriate homing of infused MSCs through immunohistochemistry, followed by Y-chromosome-specific polymerase chain reaction and fluorescent in situ hybridisation analyses. Read More

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Elevated chemokines and cytokines for eosinophils in neuromyelitis optica spectrum disorders.

Mult Scler Relat Disord 2021 Apr 9;52:102940. Epub 2021 Apr 9.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address:

Background: Eosinophil infiltration is one of the distinctive features in neuromyelitis optica spectrum disorders (NMOSD) but not in other demyelinating diseases including multiple sclerosis (MS). Eosinophils express the chemokine receptor CCR3, which is activated by eotaxins (eotaxin-1, -2, and -3) and monocyte chemoattractant protein (MCP)-4. We aimed to investigate the role of MCPs (MCP-1, -2, -3, and -4) and eotaxins in the acute phase of NMOSD. Read More

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