Dev Biol 2019 08 6;452(1):55-65. Epub 2019 May 6.
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, 80045, USA; Cell Biology, Stem Cells and Development Graduate Program, University of Colorado School of Medicine, Aurora, CO, 80045, USA; Program of Pediatric Stem Cell Biology, Children's Hospital Colorado, Aurora, CO, 80045, USA. Electronic address:
The majority of oligodendrocytes in the neocortex originate from neural progenitors that reside in the dorsal forebrain. We recently showed that Sonic Hedgehog (Shh) signaling in these dorsal progenitors is required to produce normal numbers of neocortical oligodendrocytes during embryonic development. Conditional deletion of the Shh signaling effector, Smo, in dorsal progenitors caused a dramatic reduction in oligodendrocyte numbers in the embryonic neocortex. Read More