32,184 results match your criteria gleason grade

Current Status and Quality of Machine Learning-Based Radiomics Studies for Glioma Grading: A Systematic Review.

Oncology 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.

Introduction: Radiomics now has significant momentum in the era of precision medicine. Glioma is one of the pathologies that has been extensively evaluated by radiomics. However, this technique has not been incorporated into clinical practice. Read More

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Long Term Outcomes of Dose Escalated Pelvic Lymph Node Intensity Modulated Radiation Therapy (IMRT) with A Simultaneous Hypofractionated Boost to the Prostate For Very High Risk Adenocarcinoma of the Prostate, a Prospective Phase II Clinical Trial.

Pract Radiat Oncol 2021 Apr 10. Epub 2021 Apr 10.

Froedtert and the Medical College of Wisconsin Department of Radiation Oncology.

Purpose/objectives: There remains limited data as to the feasibility, safety and efficacy of higher doses of elective radiation therapy (RT) to the pelvic lymph nodes in men with high risk prostate cancer. We conducted a phase II study to evaluate moderate dose escalation to the pelvic lymph nodes using a simultaneous integrated boost (SIB) to the prostate.

Materials/methods: Patients were eligible with biopsy proven adenocarcinoma of the prostate, a calculated lymph node (LN) risk of at least 25%, Karnofsky Performance Scale ≥ 70, and no evidence of M1 disease. Read More

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Comparative study of neuroendocrine acquisition and biomarker expression between neuroendocrine and usual prostatic carcinoma.

Prostate 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, LAC+USC and Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Background: Neuroendocrine prostatic carcinoma (NEPC) is uncommon. The pathogenesis, clinical association, and clinical implications of this disease are still evolving.

Methods: Clinicopathologic, immunohistochemical and genomic studies were used to investigate the incidence of NEPC in various clinicopathologic settings and the expression of various biomarkers in NEPC and non-NEPC as well as small cell NEPC. Read More

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Cytologic Assessment of Cystic/Intraductal Lesions of the Pancreatobiliary Tract.

Michelle D Reid

Arch Pathol Lab Med 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.

Context.—: Because of new and improved imaging techniques, cystic/intraductal pancreatobiliary tract lesions are increasingly being discovered, and brushings or endoscopic ultrasound/computed tomography/magnetic resonance imaging-guided fine-needle aspiration biopsies from these lesions have become an integral part of pathologists' daily practice. Because patient management has become increasingly conservative, accurate preoperative diagnosis is critical. Read More

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Changing biological behaviour of NETs during the evolution of the disease: progress on progression.

Endocr Relat Cancer 2021 Apr 1. Epub 2021 Apr 1.

A Grossman, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University, Oxford, United Kingdom of Great Britain and Northern Ireland.

Following improvements in the management and outcome of neuroendocrine neoplasms (NENs) in recent years, we see a subset, particularly of pancreatic NENs, which become more aggressive during the course of the disease. This is reflected by an increase in the Ki-67 labelling index, as a marker of proliferation, which may lead on occasion to an increase in grading, but generally does not appear to be correlated with histologically confirmed de-differentiation. A systematic review of the literature was performed in PubMed, Cochrane Library, and Embase until May 2020 to identify cases that have behaved in such a manner. Read More

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Immunohistochemical Expression of Emerin in Renal Cell Carcinomas: Does It Contribute to Histopathological Features and WHO/ISUP Grading in Predicting Prognosis?

J Environ Pathol Toxicol Oncol 2021 ;40(2):89-98

Izmir Katip Çelebi University, Department of Medical Oncology, Izmir, Turkey.

Aim: In our study, a new grading model (e-GM) including nuclear membrane irregularity highlighted by emerin expression was proposed for renal cell carcinomas (RCC). It was aimed to investigate the relationship of this model with WHO/ISUP grading system, histopathological features, and prognosis.

Methods And Results: 86 RCC cases were included in the study. Read More

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Grading of Multifocal Prostate Cancer Cases in which the Largest Volume and the Highest Grade do Not Coincide within One Lesion.

J Urol 2021 Apr 5:101097JU0000000000001765. Epub 2021 Apr 5.

Keio University School of Medicine, Department of Urology.

Purpose: In general, the index lesion of prostate cancer has the largest tumor volume, the highest Grade Group (GG), and the highest stage (concordant cases). However these factors sometimes do not coincide within one lesion (discordant cases). In such discordant cases, the largest tumor may not be of biological significance and the secondary tumor may more greatly impact the prognosis. Read More

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Gleason Grade Group Concordance between Preoperative Targeted Biopsy and Radical Prostatectomy Histopathologic Analysis: A Comparison Between In-Bore MRI-guided and MRI-Transrectal US Fusion Prostate Biopsies.

Radiol Imaging Cancer 2021 Mar 5;3(2):e200123. Epub 2021 Mar 5.

Departments of Radiology (D.N.C., Y.X., D.Z.R., N.S., N.M.R., A.D.d.L., I.P.), Pathology (Q.C., R.B.S.), and Urology (A.B., C.G.R., B.H., K.G.), University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas TX 75390.

Purpose: To determine and compare rates of grade group (GG) discrepancies between different targeted biopsy techniques (in-bore vs fusion) after propensity score weighting using whole-mount radical prostatectomy (RP) histopathologic analysis as the reference standard.

Materials And Methods: This retrospective study evaluated men who underwent targeted (fusion or in-bore) biopsy between April 2017 and January 2019 followed by prostatectomy. The primary endpoint of the study was a change in GG from biopsy to RP at a patient level. Read More

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Advanced Imaging Analysis in Prostate MRI: Building a Radiomic Signature to Predict Tumor Aggressiveness.

Diagnostics (Basel) 2021 Mar 26;11(4). Epub 2021 Mar 26.

Department of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Radiomics allows the extraction quantitative features from imaging, as imaging biomarkers of disease. The objective of this exploratory study is to implement a reproducible radiomic-pipeline for the extraction of a magnetic resonance imaging (MRI) signature for prostate cancer (PCa) aggressiveness. One hundred and two consecutive patients performing preoperative prostate multiparametric magnetic resonance imaging (mpMRI) and radical prostatectomy were enrolled. Read More

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The Utility of Combined Target and Systematic Prostate Biopsies in the Diagnosis of Clinically Significant Prostate Cancer Using Prostate Imaging Reporting and Data System Version 2 Based on Biparametric Magnetic Resonance Imaging.

Curr Oncol 2021 Mar 22;28(2):1294-1301. Epub 2021 Mar 22.

Department of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.

This study aimed to determine the predictive value of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) based on biparametric magnetic resonance imaging (bpMRI) with combined target biopsy (TBx) and systematic biopsy (SBx) in patients with suspicion of having clinically significant prostate cancer (csPCa). In this retrospective study, we reviewed the clinical and pathological records of 184 consecutive patients who underwent bpMRI before prostate biopsy. We focused on patients with PI-RADS v2 scores ≥ 3. Read More

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Prospective Validation of Pentraxin-3 as a Novel Serum Biomarker to Predict the Risk of Prostate Cancer in Patients Scheduled for Prostate Biopsy.

Cancers (Basel) 2021 Mar 31;13(7). Epub 2021 Mar 31.

Department of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.

Purpose: To test and internally validate serum Pentraxin-3 (PTX3) levels as a potential PCa biomarker to predict prostate biopsy (PBx) results.

Materials And Methods: Serum PSA and serum PTX3 were prospectively assessed in patients scheduled for PBx at our Institution due to increased serum PSA levels or abnormal digital rectal examination. Uni- and multivariable logistic regression analysis, area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA), were used to test the accuracy of serum PTX3 in predicting anyPCa and clinically significant PCa (csPCa) defined as Gleason Grade (GG) ≥ 2. Read More

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Outcomes of prostate cancer screening among men using antidiabetic medication.

Sci Rep 2021 Apr 1;11(1):7363. Epub 2021 Apr 1.

Faculty of Social Sciences, University of Tampere, Tampere, Finland.

Diabetic men have decreased risk for prostate cancer (PCa) overall and lower PSA compared to non-diabetics. This may affect the outcomes of PSA-based screening. We investigated the effect of PSA-based screening at 4-year intervals on PCa incidence and mortality separately among users and non-users of antidiabetic medication with the hypothesis that screening would detect less low-grade cancer and more high-grade cancer in diabetic men. Read More

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Tumor detection of F-PSMA-1007 in the prostate gland in patients with prostate cancer using prostatectomy specimens as reference method.

J Nucl Med 2021 Mar 31. Epub 2021 Mar 31.

Lund university and Skåne University Hospital, Lund, Sweden.

Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used with positron emission tomography/computed tomography (PET-CT) are a promising tool for managing patients with prostate cancer. This study aimed to determine the accuracy of F-PSMA-1007 PET-CT for detecting tumors in the prostate gland using radical prostatectomy (RP) specimens as a reference method and to determine whether a correlation exists between F-PSMA-1007 uptake and the International Society of Urological Pathology (ISUP) grade and prostate specific antigen (PSA) levels at diagnosis. Thirty-nine patients referred for F-PSMA-1007 PET-CT for initial staging and who underwent RP within four months were retrospectively included. Read More

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Neutrophil-to-lymphocyte Ratio as a Predictor of Malignancy of Intraductal Papillary Mucinous Neoplasms.

Anticancer Res 2021 Mar;41(3):1663-1669

Department of Gastroenterological Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Background: Intraductal papillary mucinous neoplasm (IPMN) can lead, via the adenoma-carcinoma sequence, to invasive adenocarcinoma, which has a poor prognosis. Most IPMNs do not meet the indications for surgery and instead are monitored regularly, but no biomarkers of malignant transformation during surveillance have been established.

Patients And Methods: A total of 50 patients with IPMN who underwent pancreatectomy were evaluated retrospectively. Read More

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Cribriform prostate cancer: Morphologic criteria enabling a diagnosis, based on survey of experts.

Ann Diagn Pathol 2021 Mar 22;52:151733. Epub 2021 Mar 22.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Among four sub-patterns of Gleason grade 4 prostate cancer, voluminous evidence supports that the cribriform pattern holds an unfavorable prognostic impact, as compared with poorly-formed, fused, or glomeruloid. The International Society of Urological Pathology (ISUP) recommends specifying whether invasive grade 4 cancer is cribriform. Recently, ISUP experts published a consensus definition of cribriform pattern highlighting criteria that distinguish it from mimickers. Read More

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Decoding the heterogeneous landscape in the development prostate cancer.

Oncol Lett 2021 May 15;21(5):376. Epub 2021 Mar 15.

Cancer Biology Research Group, National Institute of Cancerology, Bogota 110411, Colombia.

Prostate cancer (PCa) is characterized as being histologically and molecularly heterogeneous; however, this is not only incorrect among individuals, but also at the multiple foci level, which originates in the prostate gland itself. The reasons for such heterogeneity have not been fully elucidated; however, understanding these may be crucial in determining the course of the disease. PCa is characterized by a complex network of chromosomal rearrangements, which simultaneously deregulate multiple genes; this could explain the appearance of exclusive events associated with molecular subtypes, which have been extensively investigated to establish clinical management and the development of therapies targeted to this type of cancer. Read More

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Magnetic resonance imaging-ultrasound fusion-targeted biopsy combined with systematic 12-core ultrasound-guided biopsy improves the detection of clinically significant prostate cancer: Are we ready to abandon the systematic approach?

Urol Ann 2020 Oct-Dec;12(4):366-372. Epub 2020 Oct 15.

Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Florida, USA.

Background: Multiparametric (mp) magnetic resonance imaging (MRI)-ultrasound fusion-targeted biopsy (TB) has improved the detection of clinically significant prostate cancer (csCaP) using the Prostate Imaging Reporting and Data System (PI-RADS) reporting system, leading some authors to conclude that TB can replace the 12-core systematic biopsy (SB). We compared the diagnostic performance of TB with SB at our institution.

Methods: Eighty-three men with elevated prostate-specific antigen levels (6. Read More

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October 2020

Artificial Intelligence in Magnetic Resonance Imaging-based Prostate Cancer Diagnosis: Where Do We Stand in 2021?

Eur Urol Focus 2021 Mar 24. Epub 2021 Mar 24.

Department of Urology, Faculty of Medicine, University of Freiburg Medical Centre, Freiburg, Germany.

Context: Men suspected of harboring prostate cancer (PCa) increasingly undergo multiparametric magnetic resonance imaging (mpMRI) and mpMRI-guided biopsy. The potential of mpMRI coupled to artificial intelligence (AI) methods to detect and classify PCa before decision-making requires investigation.

Objective: To review the literature for studies addressing the diagnostic performance of combined mpMRI and AI approaches to detect and classify PCa, and to provide selection criteria for relevant articles having clinical significance. Read More

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Estrogen receptor β and treatment with a phytoestrogen are associated with inhibition of nuclear translocation of EGFR in the prostate.

Proc Natl Acad Sci U S A 2021 Mar;118(13)

Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;

Knockout of ERβ in the mouse leads to nuclear expression of epidermal growth factor receptor (EGFR) in the prostate. To examine whether ERβ plays a similar role in the human prostate, we used four cohorts of men: 1) a Swedish cohort of normal prostates and PCa (prostate cancer) of different Gleason grades; 2) men with benign prostatic hyperplasia (BPH) treated with the 5α-reductase inhibitor, finasteride, and finasteride together with the ERβ agonists, soy isoflavones; 3) men with PCa above Gleason grade 4 (GG4), treated with ADT (androgen deprivation therapy) and abiraterone (AA), the blocker of androgen synthesis for different durations; and 4) men with GG4 PCa on ADT or ADT with the AR (androgen receptor) blocker, enzalutamide, for 4 mo to 6 mo. In men with BPH, finasteride treatment induced EGFR nuclear expression, but, when finasteride was combined with isoflavones, EGFR remained on the cell membrane. Read More

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Review of Histological Grading Systems in Veterinary Medicine.

Vet Pathol 2021 Mar 26:300985821999831. Epub 2021 Mar 26.

Department of Veterinary Medicine (DIMEVET), University of Milano, Lodi (LO), Italy.

Tumor grading is a method to quantify the putative clinical aggressiveness of a neoplasm based on specific histological features. A good grading system should be simple, easy to use, reproducible, and accurately segregate tumors into those with low versus high risk. The aim of this review is to summarize the histological and, when available, cytological grading systems applied in veterinary pathology, providing information regarding their prognostic impact, reproducibility, usefulness, and shortcomings. Read More

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Prognostic factors in postoperative radiotherapy for prostate cancer - tertiary center experience.

Radiol Oncol 2021 Mar 25;55(2):203-211. Epub 2021 Mar 25.

Radiotherapy Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.

Background: The aim of the study was to analyse the prognostic factors in postoperative prostate cancer irradiation and develop a nomogram for disease-free survival (DFS).

Patients And Methods: This retrospective study included 236 consecutive prostate cancer patients who had radical prostatectomy followed by radiotherapy (RT) at a single tertiary institution between 2009 and 2014. The main outcome was DFS analysed through uni- and multivariable analysis, Kaplan-Meier curves, log-rank testing, recursive partitioning analysis, and nomogram development. Read More

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Remarkable response to anti-PD1 immunotherapy in refractory metastatic high-grade myxofibrosarcoma patient: A case report.

Medicine (Baltimore) 2021 Mar;100(12):e25262

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

Introduction: Myxofibrosarcoma (MFS) is a locally aggressive tumor and has the potential to be fatal because of distant metastasis. Immunotherapy targeting either programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1) has recently shown a curative effect on multiple cancers including melanoma, non-small cell lung cancer, and renal cell carcinoma. Although the immunotherapy has been applied in sarcoma, there is little information about the efficiency to treat metastatic MFS. Read More

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MRGBP is a potential novel prognostic biomarker and is correlated with immune infiltrates in hepatocellular carcinoma.

Medicine (Baltimore) 2021 Mar;100(12):e25234

Central Laboratory, the Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi, PR China.

Abstract: This study investigated the expression change, prognostic values, and potential regulatory mechanisms of mortality factor on chromosome 4 (MORF4)-related gene-binding protein (MRGBP) in hepatocellular carcinoma (HCC).MRGBP expression and clinical data from The Cancer Genome Atlas were used to evaluate the associations between MRGBP expression and clinicopathological characteristics. Kaplan-Meier and Cox regression analyses were performed to assess the factors contributing to prognosis. Read More

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Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high-risk localized prostate cancer.

Prostate 2021 May 23;81(7):418-426. Epub 2021 Mar 23.

Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Background: Localized prostate cancers (PCs) may resist neoadjuvant androgen receptor (AR)-targeted therapies as a result of persistent intraprostatic androgens arising through upregulation of steroidogenic enzymes. Therefore, we sought to evaluate clinical effects of neoadjuvant indomethacin (Indo), which inhibits the steroidogenic enzyme AKR1C3, in addition to combinatorial anti-androgen blockade, in men with high-risk PC undergoing radical prostatectomy (RP).

Methods: This was an open label, single-site, Phase II neoadjuvant trial in men with high to very-high-risk PC, as defined by NCCN criteria. Read More

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Prostate cancer: a presentation of clinicopathologic prognosticators among Filipino and American men at radical prostatectomy.

Asian J Androl 2021 Mar 19. Epub 2021 Mar 19.

Institute of Pathology, St. Luke's Medical Center-Global City, Taguig, Metro Manila 1634, Philippines.

Lower incidence and mortality rates from prostate cancer (PCa) have been shown in Asian men in general compared to Westerners. This is the first study detailing the clinicopathologic features of resected prostate cancer in Filipino men living in the Philippines (PH). This study investigated the supposed "lower risk" Filipino and "higher risk" American PCa patients from the PH and the United States of America (USA), respectively. Read More

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Hypoxia-Inducible Factor 2a Expression Is Positively Correlated With Gleason Score in Prostate Cancer.

Technol Cancer Res Treat 2021 Jan-Dec;20:1533033821990010

1st Urologic Department, Gennimatas General Hospital, 37782Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: One of the main factors in response to hypoxia in the tumor microenvironment is the hypoxia-inducible factor (HIF) pathway. Although its role in other solid tumors, particularly renal cell carcinoma, has been sufficiently elucidated, it remains elusive in prostate cancer. The aim of the present study was to investigate the expression of main proteins involved in this pathway and determine the correlation of the results with clinicopathological outcomes of patients with prostate cancer. Read More

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