127,235 results match your criteria glands function


Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism.

Exp Eye Res 2021 Jul 30:108710. Epub 2021 Jul 30.

Qingdao Eye Hospital of Shandong First Medical University, Qingdao, 266071, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China. Electronic address:

Diabetes is a significant risk factor for meibomian gland dysfunction (MGD), but its mechanism is poorly understood. The main function of the meibomian glands (MGs) is to synthesize, store, and secrete lipids. In this study, we found that the amount of lipids in the meibomian acini in STZ-induced type 1 diabetic mice decreased, and the lipid droplets became larger and irregular. Read More

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SPM Receptor Expression and Localization in Irradiated Salivary Glands.

J Histochem Cytochem 2021 Aug;69(8):523-534

Department of Otolaryngology-Head and Neck Surgery, University of Missouri, Columbia, Missouri.

Radiation therapy-mediated salivary gland destruction is characterized by increased inflammatory cell infiltration and fibrosis, both of which ultimately lead to salivary gland hypofunction. However, current treatments (e.g. Read More

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Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation.

Front Med (Lausanne) 2021 15;8:707104. Epub 2021 Jul 15.

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, United Kingdom.

Primary Sjögren's syndrome (pSS) is a chronic, systemic autoimmune disease. It is the second most common rheumatic autoimmune disorder, affecting 0.7% of European Americans and up to 1% of people globally. Read More

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Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto's Thyroiditis Patients.

Mediators Inflamm 2021 11;2021:3192409. Epub 2021 Jul 11.

Department of Restorative Dentistry and Independent Laboratory of Experimental Dentistry, Medical University of Bialystok, 24A M. Sklodowskiej-Curie Street, 15-276 Bialystok, Poland.

Hashimoto's thyroiditis (HT) is one of the most common autoimmune diseases. It is suggested that, in addition to thyroid gland dysfunction, HT is responsible for impaired secretion from the salivary glands. The aim of this study was to evaluate the extent of symptoms of salivary gland dysfunction. Read More

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Morphological and histochemical features of the digestive tract of Leiarius marmoratus (Gill, 1870).

J Fish Biol 2021 Jul 31. Epub 2021 Jul 31.

Faculty of Sciences, Department of Biological Sciences, São Paulo State University (UNESP), Bauru, SP, Brazil.

Leiarius marmoratus, a freshwater catfish from Pimelodidae family, shows great biological and commercial relevance, due its geographic distribution and adaptation to fish-farm. The knowledge of the morphological characteristics of the digestive tract is fundamental to the understanding of fish physiology and nutrition, helping in the planning of diets to provide better management and success in fish farming. Thus, this work described the morphology and histochemistry of the digestive tract of Leiarius marmoratus adults. Read More

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Seminal plasma metabolomics profiles following long (4-7 days) and short (2 h) sexual abstinence periods.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 15;264:178-183. Epub 2021 Jul 15.

Department of Medical Biosciences, University of the Western Cape, Cape Town, South Africa.

Objective: Metabolomic profiling of seminal plasma has been suggested as a possible approach for a fast and non-invasive male infertility evaluation diagnosis. However, metabolomics profiles in normozoospermic men have not been thoroughly investigated, and the influence of ejaculation-abstinence has not been described. To provide interim reference values and find associations between the metabolomics profiles of human seminal plasma and length of ejaculation-abstinence period in normozoospermic men. Read More

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Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

J Dent Res 2021 Jul 29:220345211029270. Epub 2021 Jul 29.

Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Sciences, East China Normal University, Shanghai, China.

Chronic sclerosing sialadenitis of the submandibular gland (also known as Küttner tumor) is characterized by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis. The pathogenesis of this disease has been unclear, but it is associated with immune disorders. ADAMTS18 is a member of the ADAMTS superfamily of extracellular proteinases. Read More

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Identification of novel yolk ferritins unique to planarians: planarians supply aluminum rather than iron to vitellaria in egg capsules.

Cell Tissue Res 2021 Jul 28. Epub 2021 Jul 28.

Department of Biology, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori, 036-8561, Japan.

All animals, other than Platyhelminthes, produce eggs containing yolk, referred to as "entolecithal" eggs. However, only Neoophora, in the phylum Platyhelminthes, produce "ectolecithal" eggs (egg capsules), in which yolk is stored in the vitelline cells surrounding oocytes. Vitelline cells are derived from vitellaria (yolk glands). Read More

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TSH, Hyperthyroidism, and Bone Mass.

J Clin Endocrinol Metab 2021 Jul 28. Epub 2021 Jul 28.

The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, USA.

Thyrotropin, traditionally seen as a pituitary hormone that regulates thyroid glands, has additional roles in physiology including skeletal remodeling. Population-based observations in subjects with euthyroidism or subclinical hyperthyroidism indicated a negative association between bone mass and low-normalTSH. The findings of correlative studies were supported by small intervention trials using recombinant human TSH (rhTSH) injection, and genetic and case-based evidence. Read More

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Posthatching ultrastructural development of the oropharyngeal cavity roof in five age-stages of Coturnix coturnix (Linnaeus, 1758).

Microsc Res Tech 2021 Jul 27. Epub 2021 Jul 27.

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.

Recent literature has demonstrated only adult avian palate, albeit there has been only limited focus on the postnatal development of the avian oropharyngeal cavity roof. Hence, the current investigation was designed to obtain the full ultrastructure postnatal description of the oropharyngeal roof during the five developmental age-stages of Coturnix coturnix by employing assessments using gross morphometric analysis and stero and scanning electron microscopy. The elongated triangular oropharyngeal roof has a spoonful rounded beak tip. Read More

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Substratum stiffness tunes membrane voltage in mammary epithelial cells.

J Cell Sci 2021 07 12;134(13). Epub 2021 Jul 12.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Membrane voltage (Vm) plays a critical role in the regulation of several cellular behaviors, including proliferation, apoptosis and phenotypic plasticity. Many of these behaviors are affected by the stiffness of the underlying extracellular matrix, but the connections between Vm and the mechanical properties of the microenvironment are unclear. Here, we investigated the relationship between matrix stiffness and Vm by culturing mammary epithelial cells on synthetic substrata, the stiffnesses of which mimicked those of the normal mammary gland and breast tumors. Read More

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Feminising Wolbachia disrupt Armadillidium vulgare Insulin-like signalling pathway.

Cell Microbiol 2021 Jul 27:e13381. Epub 2021 Jul 27.

Université de Poitiers, UMR CNRS 7267 Écologie et Biologie des Interactions, Poitiers, France.

The endosymbiont Wolbachia feminizes male isopods by making them refractory to the insulin-like masculinising hormone, which shunts the autocrine development of the androgenic glands. It was therefore proposed that Wolbachia silences the IR receptors, either by preventing their expression or by inactivating them. We describe here the two IR paralogs of Armadillidium vulgare. Read More

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The evaluatıon of lung ınvolvement and functıonal capacıtıes ın patients diagnosed wıth prımary sjogren's syndrome.

Int J Clin Pract 2021 Jul 26:e14635. Epub 2021 Jul 26.

Department of Pulmonology, University of Health Sciences, Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Introduction: Sjögren syndrome is a chronic, systemic, inflammatory disease characterized with lymphocytic infiltration of the exocrine glands, frequently manifested by dryness in the region affected. Although the most common extraglandular involvement in SS is pulmonary involvement. Early diagnosis and treatment is considered to be important. Read More

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The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle programme.

J Exp Bot 2021 Jul 26. Epub 2021 Jul 26.

Centre for Plant Sciences, University of Leeds, Leeds.

The potato cyst nematode Globodera pallida acquires all of its nutrients from an elaborate feeding site that it establishes in a host plant root. Normal development of the root cells is re-programmed in a process coordinated by secreted nematode effector proteins. The biological function of the G. Read More

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Interferon (IFN)-stimulated gene 15: A novel biomarker for lymphoma development in Sjögren's syndrome.

J Autoimmun 2021 Jul 20;123:102704. Epub 2021 Jul 20.

Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Supported by a competitive scholarship from the Academy of Athens, Greece; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Objective: We investigated whether interferon (IFN) induced genes could serve as biomarkers for the detection of lymphoma development among patients with Sjögren's syndrome (SS).

Methods: Total RNA was extracted from 98 labial minor salivary glands (LMSG) biopsies of SS patients [61 not complicated by lymphoma (SS-nL) and 37 complicated by Non-Hodgkin Lymphoma (NHL) (SS-L)] and 67 matched peripheral blood (PB) samples, as well as from 30 LMSG biopsies and 17 matched PB derived from sicca controls (SC). RNA sequencing was performed in LMSG biopsies of high and low risk SS patients for lymphoma development and SC. Read More

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[Clinical and molecular genetic features of 3 family cases of the central precocious puberty, due to gene defects].

Probl Endokrinol (Mosk) 2021 May 11;67(3):55-61. Epub 2021 May 11.

Endocrinology Research Centre; Research Centre for Medical Genetics.

Gonadotropin-dependent precocious puberty (central) is a condition resulting from the early (up to 8 years in girls and 9 years in boys) reactivation of the hypothalamic-pituitary-gonadal axis. An increase in the secretion of sex steroids by the gonads in this form is a consequence of the stimulation of the sex glands by gonadotropic hormones of the pituitary gland. In the absence of central nervous system abnormalities, CPP is classified as idiopathic and as familial in some cases, emphasizing the genetic origin of this disorder. Read More

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Sex differences in adaptation to intermittent post-exercise sauna bathing in trained middle-distance runners.

Sports Med Open 2021 Jul 23;7(1):51. Epub 2021 Jul 23.

School of Sport Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Background: The purpose of this study was to investigate the effect of sex on the efficacy of intermittent post-exercise sauna bathing to induce heat acclimation and improve markers of temperate exercise performance in trained athletes.

Methods: Twenty-six trained runners (16 female; mean ± SD, age 19 ± 1 years, V̇O F: 52.6 ± 6. Read More

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Floral development and vasculature in Eriocaulon (Eriocaulaceae) provide insights into the evolution of Poales.

Ann Bot 2021 Jul 23. Epub 2021 Jul 23.

Departamento de Biodiversidade, Instituto de Biociências de Rio Claro, Universidade Estadual Paulista "Júlio de Mesquita Filho", Av. 24A 1515, Bela Vista, 13506-900, Rio Claro, SP, Brazil.

Background And Aims: Floral developmental studies are crucial for understanding the evolution of floral structures and sexual systems in angiosperms. Within the monocot order Poales, both subfamilies of Eriocaulaceae have unisexual flowers bearing unusual nectaries. Few previous studies have investigated floral development in subfamily Eriocauloideae, which includes the large, diverse and widespread genus Eriocaulon. Read More

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Effects of a High-Grain Diet With a Buffering Agent on Milk Protein Synthesis in Lactating Goats.

Front Vet Sci 2021 6;8:696703. Epub 2021 Jul 6.

The Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China.

Chinese dairy industries have developed rapidly, providing consumers with high-quality sources of nutrition. However, many problems have also appeared during the development process, especially the low quality of milk. To improve milk quality, a large amount of concentrated feed is usually added to the diet within a certain period of time, which increases the milk production to a certain extent. Read More

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Histologic Aspect of the Curved Vomerine Mucosa in Cleft Lip and Palate.

Cleft Palate Craniofac J 2021 Jul 22:10556656211031419. Epub 2021 Jul 22.

Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel and University of Basel, Switzerland.

Background: Common surgical techniques aim to turn the entire vomerine mucosa with vomer flaps either to the oral side or to the nasal side. The latter approach is widely performed due to the similarity in color to the nasal mucosa. However, we lack a histologic description of the curved vomerine mucosa in cleft lip and palate malformations. Read More

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Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.

Front Cell Neurosci 2021 5;15:674123. Epub 2021 Jul 5.

L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Previous studies suggested that the SARS-CoV-2 virus may gain access to the brain by using a route along the olfactory nerve. However, there is a general consensus that the obligatory virus entry receptor, angiotensin converting enzyme 2 (ACE2), is not expressed in olfactory receptor neurons, and the timing of arrival of the virus in brain targets is inconsistent with a neuronal transfer along olfactory projections. We determined whether nervus terminalis neurons and their peripheral and central projections should be considered as a potential alternative route from the nose to the brain. Read More

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Membrane association of importin α facilitates viral entry into salivary gland cells of vector insects.

Proc Natl Acad Sci U S A 2021 Jul;118(30)

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;

The importin α family belongs to the conserved nuclear transport pathway in eukaryotes. However, the biological functions of importin α in the plasma membrane are still elusive. Here, we report that importin α, as a plasma membrane-associated protein, is exploited by the rice stripe virus (RSV) to enter vector insect cells, especially salivary gland cells. Read More

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Gross and histological morphology of the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps).

Anat Rec (Hoboken) 2021 Jul 20. Epub 2021 Jul 20.

Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, North Carolina.

Odontocete cetaceans have undergone profound modifications to their integument and sensory systems and are generally thought to lack specialized exocrine glands that in terrestrial mammals function to produce chemical signals (Thewissen & Nummela, 2008). Keenan-Bateman et al. (2016, 2018), though, introduced an enigmatic exocrine gland, associated with the false gill slit pigmentation pattern in Kogia breviceps. Read More

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The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study.

Curr Oncol 2021 Jul 17;28(4):2720-2730. Epub 2021 Jul 17.

Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer risk. Read More

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Metformin as a Treatment Strategy for Sjögren's Syndrome.

Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.

Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Sjögren's syndrome (SS), a chronic inflammatory disease involving the salivary and lacrimal glands, presents symptoms of sicca as well as systemic manifestations such as fatigue and musculoskeletal pain. Only a few treatments have been successful in management of SS; thus treatment of the disease is challenging. Metformin is the first-line agent for type 2 diabetes and has anti-inflammatory potential. Read More

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Morphology and ultrastructure of the epithelial femoral gland in cicadas (Hemiptera: Cicadidae).

Arthropod Struct Dev 2021 Jul 16;64:101086. Epub 2021 Jul 16.

Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China. Electronic address:

Exocrine glands in the legs of social insects are found throughout all leg segments, but studies of exocrine glands in legs of solitary insects are very limited. We discovered a novel gland at the apex of the fore, mid and hind femurs from six representative species of Cicadidae, which we propose to name as the epithelial femoral gland. The epithelial femoral gland is located between the paired apodemes and the articulation membrane within the apex of the femur, which faces the proximal articulation region of the tibia. Read More

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Detrimental or beneficial: Role of endothelial ENaC in vascular function.

J Cell Physiol 2021 Jul 19. Epub 2021 Jul 19.

Departments of Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Heilongjiang Key Laboratory for Metabolic Disorder & Cancer Related Cardiovascular Diseases, NHC Key Laboratory of Cell Transplantation, Harbin Medical University & Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin, China.

In the past, it was believed that the expression of the epithelial sodium channel (ENaC) was restricted to epithelial tissues, such as the distal nephron, airway, sweat glands, and colon, where it is critical for sodium homeostasis. Over the past two decades, this paradigm has shifted due to the finding that ENaC is also expressed in various nonepithelial tissues, notably in vascular endothelial cells. In this review, the recent findings of the expression, regulation, and function of the endothelial ENaC (EnNaC) are discussed. Read More

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Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus.

Front Endocrinol (Lausanne) 2021 2;12:681647. Epub 2021 Jul 2.

School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong.

Spexin (SPX) is a pleiotropic peptide with highly conserved protein sequence from fish to mammals and its biological actions are mediated by GalR2/GalR3 receptors expressed in target tissues. Recently, SPX has been confirmed to be a novel satiety factor in fish species but whether the peptide has a similar function in mammals is still unclear. Using the mouse as a model, the functional role of SPX in feeding control and the mechanisms involved were investigated. Read More

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Atypical Antipsychotic Lumateperone Effects on the Adrenal Gland With Possible Beneficial Effect of Quercetin Co-administration.

Front Physiol 2021 29;12:674550. Epub 2021 Jun 29.

Department of Anatomy Faculty of Medicine, Menoufia University, Shebin El-kom, Egypt.

Schizophrenia remains one of the most chronic and highly disabling mental disorders. Lumateperone is a recent FDA-approved atypical antipsychotic drug for the treatment of schizophrenia. However, the internal FDA pathologist raised concerns regarding pigment deposition associated with degeneration in different tissue in animal studies with lumateperone treatment. Read More

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Exosomes and their cargo are important regulators of cell function in endometriosis.

Reprod Biomed Online 2021 Jun 3. Epub 2021 Jun 3.

Department of Obstetrics and Gynecology, McMaster University, Hamilton Ontario L8N 3Z5, Canada. Electronic address:

Endometriosis is a chronic oestrogen-dependent gynaecological disorder characterized by non-menstrual pelvic pain, infertility and the extrauterine growth of endometrial-like glands and stroma. It has been noted that the eutopic endometrium of women with endometriosis is functionally distinct from that of women without endometriosis. Moreover, ectopic endometrial implants are functionally different from the eutopic endometrium of women with endometriosis. Read More

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