10,221 results match your criteria glands based

The prevalence of dry eye in a very old population.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a very old population.

Methods: The Ural Very Old Study (UVOS), a population-based cohort study performed in rural and urban Bashkortostan/Russia, included 1526 (81.1%) out of 1882 eligible individuals aged 85+ years. Read More

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Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia.

J Comp Pathol 2021 May 22;185:30-44. Epub 2021 Apr 22.

Department of Equine and Small Animal Medicine, Finland.

American Cocker Spaniels (ACSs) develop aural ceruminous gland hyperplasia and ectasia more often than dogs of other breeds. Data on the cause and development of these breed characteristic histopathological changes are lacking. We performed video-otoscopic examinations and dermatological work-up on 28 ACSs, obtained aural biopsies from each dog and assessed the statistical associations between the presence of ceruminous gland hyperplasia and ectasia and disease history, clinical or microbiological findings and underlying cause of otitis externa (OE). Read More

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18F-Choline PET/CT, MRI, and Software-Based Image Fusion Analysis in Patients With Primary Hyperparathyroidism.

Clin Nucl Med 2021 Jun 10. Epub 2021 Jun 10.

From the Institute of Nuclear Medicine and Endocrinology, Kepler University Hospital Linz GmbH Medical Faculty, Johannes Kepler University Linz Central Radiology Institute Department of General Surgery, Kepler University Hospital Linz GmbH, Linz Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Purpose: The aim of this study was to evaluate the diagnostic performance of 18F-choline PET and MRI in patients with primary hyperparathyroidism. Furthermore, the additional value of software-based PET/MRI scan fusion was analyzed.

Patients And Methods: This retrospective study includes 42 patients (38 women) with an age between 32. Read More

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Evaluation of F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with Ga-DOTATATE PET/CT.

EJNMMI Res 2021 Jun 9;11(1):55. Epub 2021 Jun 9.

Department of Nuclear Medicine, XiangYa Hospital, Central South University, No. 87 XiangYa Road, ChangSha, Hunan Province, People's Republic of China.

Objective: To evaluate the diagnostic efficacy of F-AlF-NOTA-octreotide (F-OC) PET/CT compared with that of Ga-DOTATATE PET/CT.

Materials And Methods: Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. Read More

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Head and neck cancer in Cali, Colombia: Population-based study.

Community Dent Oral Epidemiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pathology, Universidad del Valle, Cali, Colombia.

Introduction: Head and neck cancer (HNC) is the seventh most common type of cancer in the world. In Latin America, data on HCN are limited by the scarcity of population-based cancer registries.

Objective: To describe survival and changes in the time trends of incidence and mortality rates of HCN with data from the Cali Cancer Population Registry (Colombia) during 1962-2018. Read More

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Characterization of nucleic acids from extracellular vesicle-enriched human sweat.

BMC Genomics 2021 Jun 9;22(1):425. Epub 2021 Jun 9.

Faculty of Biochemistry and Molecular Medicine, Disease Networks Research Unit, Laboratory of Developmental Biology, Kvantum Institute, Infotech Oulu, University of Oulu, 90014 University of Oulu, Oulu, Finland.

Background: The human sweat is a mixture of secretions from three types of glands: eccrine, apocrine, and sebaceous. Eccrine glands open directly on the skin surface and produce high amounts of water-based fluid in response to heat, emotion, and physical activity, whereas the other glands produce oily fluids and waxy sebum. While most body fluids have been shown to contain nucleic acids, both as ribonucleoprotein complexes and associated with extracellular vesicles (EVs), these have not been investigated in sweat. Read More

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Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study.

Biomed Phys Eng Express 2021 Jun 16;7(4). Epub 2021 Jun 16.

Institute of Biomedical Engineering, Bogazici University, Kandilli Kampus, Cengelkoy, 34684 Istanbul, Turkey.

. SPECT-CT is a standard procedure conducted before minimally invasive surgery for the treatment of primary hyperthyroidism. In order to improve image quality, it is important to know how defect detectability is influenced by acquisition and processing parameters. Read More

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19-hydroxy Steroids in the Aromatase Reaction: Review on Expression and Potential Functions.

J Endocr Soc 2021 Jul 23;5(7):bvab050. Epub 2021 Mar 23.

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

Scientific evidence related to the aromatase reaction in various biological processes spanning from mid-1960 to today is abundant; however, as our analytical sensitivity increases, a new look at the old chemical reaction is necessary. Here, we review an irreversible aromatase reaction from the substrate androstenedione. It proceeds in 3 consecutive steps. Read More

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The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders.

Front Psychiatry 2021 21;12:669193. Epub 2021 May 21.

Department of Orthodontics, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School and Hospital of Stomatology, Tongji University, Shanghai, China.

Autism spectrum disorders (ASD) are neurodevelopmental disorders with changes in the gut and oral microbiota. Based on the intimate relationship between the oral microbiota and oral mucosal immunity, this study aimed to investigate changes in salivary immunoglobulin A (IgA) level in ASD and the underlying mechanism for any such changes. We recruited 36 children diagnosed with ASD and 35 normally developing children and measured their salivary IgA content using enzyme-linked immunosorbent assay (ELISA). Read More

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A Single-center Retrospective Trial of a Blink-assisted Eyelid Device in Treating the Signs and Symptoms of Dry Eye.

Thomas Chester

Optom Vis Sci 2021 Jun;98(6):605-612

Significance: The clinical features of meibomian gland disease include altered tear film stability, damage to the ocular surface, symptoms of ocular surface irritation, and visual fluctuations. Finding an adequate treatment to alleviate a patient's signs and symptoms is vital to caring for those with dry eye disease resulting from meibomian gland disease.

Purpose: The purpose of this analysis was to determine whether the controlled heating of meibomian glands with the SmartLid devices (TearCare) combined with evacuation of the liquefied meibum using a handheld clearance assistant would improve a patient's dry eye symptoms (as measured by the Standardized Patient Evaluation of Eye Dryness [SPEED] questionnaire) and signs (as measured by meibomian gland expression [MGE] scores). Read More

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Machine learning-based texture analysis for differentiation of radiologically indeterminate small adrenal tumors on adrenal protocol CT scans.

Abdom Radiol (NY) 2021 Jun 3. Epub 2021 Jun 3.

Department of Body Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Goal: To evaluate the ability of radiomic feature extraction and a machine learning algorithm to differentiate between benign and malignant indeterminate adrenal lesions on contrast-enhanced computed tomography (CT) studies.

Background: Adrenal "incidentalomas" are adrenal lesions that are accidentally discovered during workup not related to the adrenal glands; they have an incidence as high as 5%. Small adrenal incidentalomas (< 4 cm) with high attenuation values on pre-contrast CT(> 10 HU) need further evaluation to calculate the absolute percentage of washout (APW). Read More

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Mucocele of the tongue: A case report and review of literature.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S37-S41. Epub 2021 Mar 19.

Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Aurangabad, Maharashtra, India.

Mucoceles are common cystic lesions in the oral cavity. It may occur in different locations in the oral mucosa due to trauma or obstruction of minor salivary gland ducts with the lower lip as the predominant site. However, mucoceles located on the ventral surface of the tongue originating from the anterior lingual salivary glands are extremely rare and often overlooked during screening procedures because of their asymptomatic nature. Read More

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Dapsone as an Effective Treatment for Arthritis Secondary to Hidradenitis Suppurativa.

Bull Hosp Jt Dis (2013) 2021 Jun;79(2):137-140

Hidradenitis suppurativa (HS) is a disorder of the terminal follicular epithelium in the apocrine sweat glands. Chronic relapsing inflammation, mucopurulent discharge, and progressive scarring frequently involving the axillary and inguinoperineal area characterize HS. Reactive arthritis is associated with chronic infections, such as HS, although joint involvement is uncommon. Read More

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Feasibility evaluation of amide proton transfer-weighted imaging in the parotid glands: a strategy to recognize artifacts and measure APT value.

Quant Imaging Med Surg 2021 Jun;11(6):2279-2291

Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: The feasibility and image quality of three-dimensional (3D) amide proton transfer (APT)-weighted (APTw) in parotid tumor lesions have not been well established in previous studies. This study aimed to evaluate the utility of APT imaging in parotid lesions and glands.

Methods: Patients with parotid lesions received 3D turbo spin echo (TSE) APTw on a 3. Read More

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Standardization of terminology, imaging features, and interpretation of CBCT sialography of major salivary glands: a clinical review.

Quintessence Int 2021 Jun 2;0(0). Epub 2021 Jun 2.

Sialography combined with cone beam computerized tomography (sialo-CBCT) is an imaging technique that demonstrates the ductal system of the major salivary glands and allows evaluation of gland function. This review describes the sialo-CBCT technique, terminology, common pitfalls and limitations, as well as radiographic features and suggested pathogenicity of various salivary gland disorders, based on 1,758 sialo-CBCT examinations conducted over the last decade in one institution, and the current literature. The adoption of standardized terminology is proposed to prevent miscommunication, facilitate formulation of differential diagnoses, and thereby promote patient management: (1) Sialo-CBCT requires specific training, and operator experience is required for adequate glandular filling with minimal extravasation; (2) Limit injection-to-scan time to avoid premature emptying; (3) The sialo-CBCT report should include a description of the morphology of the primary duct as well as the secondary, tertiary, and descending branches, the maximal branching level, the presence of sialectasis, overall glandular size, and parenchymal findings; (4) Functional evaluation is based on assessment of iodine clearance in the post evacuation image; (5) Sialectasis and ductopenia are the main findings in Sjogren syndrome and recurrent juvenile parotitis; (6) Sialodochitis with or without fillings defects or hyperdense calcifications characterize obstructive sialadenitis and sialolithiasis; (7) The findings following radioactive-iodine-induced damage are similar to obstructive sialadenitis, with atrophy in late stages; (8) In chronic graft-versus-host disease (cGVHD), variable presentations of ductopenia, sialectasis, and sialodochitis may be evident; (9) The red flags indicating a space-occupying lesion include areas of no filling, splaying of ducts, and primary duct deviation. Read More

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Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review.

Medicina (Kaunas) 2021 May 23;57(6). Epub 2021 May 23.

Maestría en Estomatología con Opción Terminal en Ortodoncia, Facultad de Estomatología, Benemérita Universidad Autónoma de Puebla, Puebla C.P. 72410, Mexico.

: The aim of this systematic review is to summarize the current data about the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its entry factors in oral tissues and cells. : This systematic review was carried out based on the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA). Three databases were analyzed (Pubmed, Web of science and Scopus) by three independent researchers. Read More

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Prevalence of Oral and Maxillofacial Disorders in Patients with Systemic Scleroderma-A Systematic Review.

Int J Environ Res Public Health 2021 May 14;18(10). Epub 2021 May 14.

Department of Oral Surgery and Policlinical Ambulance, Faculty of Health, Witten/Herdecke University, Alfred-Herrhausen-Str. 45, 58448 Witten, Germany.

Background: Systematic scleroderma is a rare chronic autoimmune disease of unknown aetiology. The aim of this study was to identify the prevalence of orofacial pathognomonic conditions in patients with systemic scleroderma using only randomised prospective studies that investigated the treatment of oral and maxillofacial changes, highlighted associations between the disease and Sjogren's syndrome, and/or analysed the effect of oral hygiene.

Methods: The literature was systematically reviewed based on Cochrane Library, EMBASE, PubMed, Scopus, and Web of Science articles published up to March 2020. Read More

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Mining the Royal Jelly Proteins: Combinatorial Hexapeptide Ligand Library Significantly Improves the MS-Based Proteomic Identification in Complex Biological Samples.

Molecules 2021 May 7;26(9). Epub 2021 May 7.

Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznań, Poland.

Royal jelly (RJ) is a complex, creamy secretion produced by the glands of worker bees. Due to its health-promoting properties, it is used by humans as a dietary supplement. However, RJ compounds are not fully characterized yet. Read More

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Competition ('Steal' Phenomenon) between [Ga]Ga-PSMA-11 Uptake in Prostate Tumor Tissue Versus Healthy Tissue.

Pharmaceutics 2021 May 11;13(5). Epub 2021 May 11.

Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

We aimed to clarify whether a steal 'phenomenon' exists by investigating if uptake of 'prostate specific membrane antigen' (PSMA) in prostate tumor tissue correlates with the uptake in healthy tissue. Patients with prostate cancer referred for a [Ga]Ga-PSMA-11 PET/CT were identified retrospectively. Semi-automated quantitative image analysis was performed; fractional healthy tissue [Ga]Ga-PSMA-11 uptake volume (HT-PSMA (SUV*cm)) in the lacrimal, submandibular, and parotid glands, and kidneys, and the fractional total lesion [Ga]Ga-PSMA-11 uptake volume (TL-PSMA (SUV*cm)) of prostate cancer were used. Read More

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A Rho Kinase (ROCK) Inhibitor, Y-27632, Inhibits the Dissociation-Induced Cell Death of Salivary Gland Stem Cells.

Molecules 2021 May 1;26(9). Epub 2021 May 1.

Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul 08826, Korea.

Salivary gland stem cells (SGSCs) are potential cell sources for the treatment of salivary gland diseases. The control of cell survival is an essential factor for applying stem cells to regenerative medicine or stem cell-based research. The purpose of this study was to investigate the effects of the ROCK inhibitor Y-27632 on the survival of SGSCs and its underlying mechanisms. Read More

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Salivary and imaging-based biomarkers of radiation therapy-induced xerostomia.

J Pak Med Assoc 2021 Mar;71(3):938-942

School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, Malaysia.

Biomarkers are anatomical characteristics or naturally occurring measurable molecules indicating physiological or pathological state of an individual. These biomarkers have the potential to detect or predict diseases at an early stage, which is particularly beneficial in timely management of common complications of radiation therapy done in head and neck cancer treatment regime. Xerostomia is one of the most common oral complaints of radiation therapy. Read More

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Incidental Adrenal Nodules.

Radiol Clin North Am 2021 Jul;59(4):591-601

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Incidentally detected adrenal nodules are common, and prevalence increases with patient age. Although most are benign, it is important for the radiologist to be able to accurately determine which nodules require further testing and which are safely left alone. The American College of Radiology incidental adrenal White Paper provides a structured algorithm based on expert consensus for management of incidental adrenal nodules. Read More

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Immunoglobulin G4-related periodontitis: case report and review of the literature.

BMC Oral Health 2021 05 28;21(1):279. Epub 2021 May 28.

National Clinical Research Center for Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Background: Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory systemic disease of unknown etiology that can affect one or multiple organs. The disease can mimic many infectious and inflammatory diseases, mainly causing organ enlargement or hyperplasia. Its diagnosis primarily relies on clinical, serologic, and histological features (lymphoplasmacytic infiltrates, storiform fibrosis, and obliterative phlebitis of IgG4 + plasma cells). Read More

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A Tool to Locate Parathyroid Glands Using Dynamic Optical Contrast Imaging.

Laryngoscope 2021 May 27. Epub 2021 May 27.

Department of Head and Neck Surgery, University of California Los Angeles (UCLA), Los Angeles, California, U.S.A.

Objectives/hypothesis: Identification of parathyroid glands and adjacent tissues intraoperatively can be quite challenging because of their small size, variable locations, and indistinct external features. The objective of this study is to test the efficacy of the dynamic optical contrast imaging (DOCI) technique as a tool in specifically differentiating parathyroid tissue and adjacent structures, facilitating efficient and reliable tissue differentiation.

Study Design: Prospective study. Read More

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Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult?

Histopathology 2021 May 27. Epub 2021 May 27.

Dental School, Ludwig-Maximilians-University, Munich, Germany.

Aims: There is widespread perception in clinic and pathology, that the histomorphological assessment of minor salivary gland tumours (MinSG) is more difficult and hampared by more misdiagnoses than that of major salivary glands. This is based on a vague, subjective clinical impression, while scientific proof of the difference and of potentional reasons that would explain this are lacking.

Methods And Results: We identified fourteen putative clinical, pathological, and combined clinico-pathological reasons, which altogether could explain the phenomenon of perceived greater diagnostic difficulty of tumours of MinSG. Read More

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New clinical and pathophysiological perspectives defining the trajectory of cirrhosis.

J Hepatol 2021 Jul;75 Suppl 1:S14-S26

European Foundation for Study of Chronic Liver Failure, EF-Clif, Barcelona, Spain.

Traditionally, the complications of cirrhosis, namely variceal bleeding, ascites and hepatic encephalopathy, were thought to result predominantly from circulatory dysfunction and altered organ perfusion arising as a result of portal hypertension. Over the past 20 years, large, international prospective studies have indicated the importance of systemic inflammation and organ immunopathology as additional determinants of organ dysfunction in cirrhosis, which not only manifests in the liver, brain, circulation and the kidneys, but also the immune system, gut, muscles, adrenal glands, reproductive organs, heart and lungs. This review provides an overview of the traditional and emerging concepts around the initiation and maintenance of organ dysfunction in cirrhosis and proposes a new paradigm based upon a better understanding of acute decompensation of cirrhosis. Read More

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Pathological Changes in Axillary Hyperhidrosis and Axillary Osmidrosis Induced by Microwave Treatment: Comparison of Single- and Double-Pass Irradiation.

Lasers Surg Med 2021 May 26. Epub 2021 May 26.

Department of Plastic and Reconstructive Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato City, Tokyo, 105-8461, Japan.

Background And Objectives: To analyze histopathological changes and degree of damage to the axillary tissue due to single- and double-pass irradiation therapy using a microwave energy-based device. STUDY DESIGN/MATERIALS AND METHODS: We included 15 axillary hyperhidrosis and axillary osmidrosis patients who received microwave irradiation therapy between March 2017 and March 2019. Ten patients underwent single-pass irradiation and five underwent double-pass irradiation, after which skin samples were collected from the right and left axillae for pathological analysis. Read More

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Comparison of a Handheld Device vs Endotracheal Tube-Based Neuromonitoring for Recurrent Laryngeal Nerve Stimulation.

Otolaryngol Head Neck Surg 2021 May 25:1945998211013753. Epub 2021 May 25.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objective: To measure the effect of thyroidectomy difficulty on intraoperative neuromonitoring false loss of signal (LOS) and to compare intraoperative endotracheal tube-based neuromonitoring (ETNM) and Checkpoint palpation-based direct stimulation (pDS) signals with postoperative laryngoscopy. We hypothesized that pDS has higher a positive predictive value for postdissection confirmation of recurrent laryngeal nerve function than ETNM and that this difference is accentuated with increasing thyroidectomy difficulty.

Study Design: Prospective single-arm cross-sectional study comparing ETNM and pDS for patients undergoing hemi-, total, or completion thyroidectomy from July 2018 to March 2020. Read More

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Hyperthyroidism Incidentally Noted on Lymphoscintigraphy.

Clin Nucl Med 2021 May 12. Epub 2021 May 12.

From the Departments of Ultrasonography Nuclear Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Abstract: A 43-year-old woman with edema in both left upper limb and lower limb underwent lymphoscintigraphy to evaluate possible lymphedema. Two separate lymphoscintigraphies, one for the lower and the other for the upper limbs, were performed with interval of 3 days. Incidentally, an activity in the region of the thyroid glands was noted in the delayed images of both studies. Read More

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A Preliminary Experience of Implementing Deep-Learning Based Auto-Segmentation in Head and Neck Cancer: A Study on Real-World Clinical Cases.

Front Oncol 2021 5;11:638197. Epub 2021 May 5.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: While artificial intelligence has shown great promise in organs-at-risk (OARs) auto segmentation for head and neck cancer (HNC) radiotherapy, to reach the level of clinical acceptance of this technology in real-world routine practice is still a challenge. The purpose of this study was to validate a U-net-based full convolutional neural network (CNN) for the automatic delineation of OARs of HNC, focusing on clinical implementation and evaluation.

Methods: In the first phase, the CNN was trained on 364 clinical HNC patients' CT images with annotated contouring from routine clinical cases by different oncologists. Read More

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