115,213 results match your criteria gland tumors


Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours.

Vet Comp Oncol 2021 Sep 23. Epub 2021 Sep 23.

Institute of Biological Bases of Animal Production, University of Life Sciences in Lublin, Lublin, Poland.

The aim of this study was to determine molecular defects in mitochondrial DNA with the use of large-scale genome analysis in malignant canine mammary gland tumours and indicate whether these changes were linked with the carcinogenesis process. With the use of the NGS technology, we sequenced 27 samples of mtDNA isolated from blood and tumours obtained from 13 dogs with mammary gland tumours. The total number of mutations and polymorphisms in the analysed mitochondrial genomes was 557. Read More

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September 2021

Spontaneous extracapsular parathyroid adenoma hemorrhage: when surgery is required?

Endocrine 2021 Sep 23. Epub 2021 Sep 23.

Department of Otolaryngology-Head and Neck Surgery, Scientific Institute of Hospitalization and Care San Raffaele Hospital, Vita-Salute University, Milan, Italy.

Purpose: Spontaneous bleeding is a rare but serious complication of parathyroid adenomas and few cases were reported in the literature. Clinical manifestations and treatment may vary but sometimes an immediate surgery is required. In other cases a conservative approach can be preferred based on clinical stability and patients' conditions. Read More

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September 2021

Malignant carcinoma and skin melanoma neoplasms concomitantly in the thyroid.

Clin Case Rep 2021 Sep 15;9(9):e04790. Epub 2021 Sep 15.

Medical Research Center Al Rassoul Al Aazam Hospital Beirut Lebanon.

Malignant melanomas metastatic to the thyroid gland are uncommon. Based on microscopy and DNA methylation profile, we report a rare coexistence of neoplasms in the thyroid, presumably in our case, with relapse-free condition on adjuvant therapy. Read More

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September 2021

Surgical Outcomes of Aldosterone-Producing Adenoma on the Basis of the Histopathological Findings.

Front Endocrinol (Lausanne) 2021 6;12:663096. Epub 2021 Sep 6.

Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Introduction: Previous studies on the surgical outcomes of aldosterone-producing adenoma (APA) patients were mainly based on the histopathological diagnosis of HE staining or adrenal venous sampling (AVS) instead of the functional pathology. The aim of the present study was to evaluate the surgical outcomes of APA patients based on the functional pathological diagnosis of APA according to HISTALDO (histopathology of primary aldosteronism) consensus.

Methods: Clinical data of 137 patients with suspected APA were analyzed retrospectively. Read More

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September 2021

Machine learning methods for automated classification of tumors with papillary thyroid carcinoma-like nuclei: A quantitative analysis.

PLoS One 2021 22;16(9):e0257635. Epub 2021 Sep 22.

Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.

When approaching thyroid gland tumor classification, the differentiation between samples with and without "papillary thyroid carcinoma-like" nuclei is a daunting task with high inter-observer variability among pathologists. Thus, there is increasing interest in the use of machine learning approaches to provide pathologists real-time decision support. In this paper, we optimize and quantitatively compare two automated machine learning methods for thyroid gland tumor classification on two datasets to assist pathologists in decision-making regarding these methods and their parameters. Read More

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September 2021

Review and characteristics of 585 salivary gland neoplasms from a tertiary hospital registered in the Polish National Major Salivary Gland Benign Tumors Registry over a period of 5 years: a prospective study.

Otolaryngol Pol 2020 Apr;74(5):1-6

Department of Otolaryngology and Laryngological Oncology, Poznan University of Medical Sciences, Poznan, Poland.

<b>Introduction:</b> A Polish National Major Salivary Gland Benign Tumors Registry (SGR) is a report of benign salivary gland neoplasms (SGNs) from 26 different centres in Poland, introduced in 2014. The aim of this study is to analyze demographic characteristics and clinico-pathological factors of benign SGNs treated in large tertiary institutions and to determine possible correlations between selected variables. <br><b>Material and method:</b> Analysis of 585 patients recorded in SGR and operated on for SGNs in the Department of Otolaryngology and Laryngological Surgery, University of Medical Sciences, Poznań, Poland, over a 5-year period. Read More

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Adult adrenal neuroblastoma: A case report.

Mol Clin Oncol 2021 Nov 1;15(5):225. Epub 2021 Sep 1.

Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

Adrenal neuroblastoma (NB) is very rare in adults. According to the literature, <100 cases have been reported worldwide to date, with >90% of the patients aged <10 years. As the early symptoms of the disease are not obvious, distant metastasis has often already occurred when the patients develop clinical symptoms. Read More

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November 2021

Activating HRAS mutation in a case of inverted ductal papilloma of the salivary gland.

Pathol Int 2021 Sep 21. Epub 2021 Sep 21.

Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Inverted ductal papilloma (IDP) is one of the least common benign papillary/cystic neoplasms of the salivary duct system, being characterized histologically by florid hyperplasia of duct-type epithelial cells into a cystic lumen near the orifice with occasional endophytic growth of the surface squamous epithelium along the terminus of the affected excretory duct. Given its rarity, the exact etiology of IDP remains to be defined. We herein present the first evidence of oncogenic HRAS mutation in a case of oral IDP. Read More

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September 2021

Role of GATA3 in tumor diagnosis: A review.

Pathol Res Pract 2021 Sep 13;226:153611. Epub 2021 Sep 13.

Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

GATA binding protein 3 (GATA3) belongs to a family of transcription factors comprising six members. These proteins identify G-A-T-A containing sequences in the target gene and bind to DNA target via two zinc-finger domains. The aim of this study was to evaluate the role of GATA3 in the diagnosis of tumors and its value as a prognostic marker. Read More

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September 2021

Prognostic factors and outcome of pineoblastoma: 10 years single-center experience.

J Egypt Natl Canc Inst 2021 Sep 20;33(1):26. Epub 2021 Sep 20.

Pediatric Oncology, National Cancer Institute (NCI), Cairo University and Children Cancer Hospital of Egypt (CCHE), Cairo, Egypt.

Background: The survival of pineoblastoma patients is low, particularly in infants and those with metastatic disease. This study aimed to analyze the prognostic factors affecting the outcome of Pineoblastoma in different age groups.

Methods: A retrospective study included 33 patients. Read More

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September 2021

A tale of many tumors and one endocrine site: A case series of pituitary metastases.

Qatar Med J 2021 9;2021(2):38. Epub 2021 Sep 9.

Endocrine Department, Hamad Medical Corporation, Doha, Qatar.

Background: Metastases to the pituitary gland are extremely rare with an incidence rate reported from an autopsy series of 1.8%-12%, and only 20% was diagnosed clinically. Tumors that commonly metastasize are breast and lung tumors. Read More

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September 2021

Paired-Box Gene 8 (PAX8) and Its Association With Epithelial Carcinomas.

Cureus 2021 Aug 16;13(8):e17208. Epub 2021 Aug 16.

Internal Medicine, JC Medical Center, Orlando, USA.

Cancer is the second most common culprit of mortality in the United States and epithelial carcinomas are considered as one of the most predominant types of cancer. The association between epithelial cancers and paired-box gene 8 (PAX8) has been studied significantly before. PAX8 belongs to the paired-box gene family, which plays an important role in the organogenesis of different body organ systems, especially the thyroid gland, the renal system, and the Müllerian system. Read More

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Extracapsular Dissection for Small Benign Tumors of Parotid Gland: A Case Report on Contemporary Technique.

Cureus 2021 Aug 8;13(8):e17007. Epub 2021 Aug 8.

Department of Oral and Maxillofacial Surgery, St. Joseph Dental College, Eluru, IND.

Salivary gland tumor looms as painless enlarging mass which may embrace in both major or minor glands. Pleomorphic adenoma (PA) accord about 40-70% of all salivary gland tumors, where Warthin tumor, basal cell adenoma (BCA), adenoid cystic carcinoma (ACC), and sebaceous tumors have a strong predilection for major salivary gland. However, polymorphous low-grade adenocarcinoma (PLGA) has a marked predilection for the minor salivary gland. Read More

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Management of Non-High-Risk Salivary Gland Carcinomas With Surgery Alone.

Cureus 2021 Aug 7;13(8):e16970. Epub 2021 Aug 7.

Otolaryngology - Head and Neck Surgery, University of South Florida Morsani College of Medicine, Tampa, USA.

Background Risk stratification and appropriate treatment selection are essential for the management of head and neck malignancies, in order to optimize long-term outcomes. Salivary gland carcinomas (SGCs) pose a particular challenge due to their extensive biologic heterogeneity. Primary surgical resection remains the mainstay of treatment; however, outcomes with single modality therapy for 'non-high-risk' lesions are less elucidated in the literature present on the subject. Read More

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Mismatch repair deficiency in canine neoplasms.

Vet Pathol 2021 Sep 19:3009858211022704. Epub 2021 Sep 19.

Yamaguchi University, Yamaguchi, Japan.

The DNA mismatch repair (MMR) system preserves genomic stability by identifying and repairing mismatched nucleotides in the DNA replication process. The dysfunction of the MMR system, also known as mismatch repair deficiency (dMMR), is implicated as a predictive biomarker for the efficacy of immune checkpoint blockade therapy regardless of the tumor type in humans. This study aimed to evaluate the immunolabeling of MMR proteins in canine tumors and to identify the types of tumors having dMMR. Read More

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September 2021

INSULIN-LIKE GROWTH FACTORS IN THE SERUM OF PATIENTS WITH PAPILLARY THYROID CANCER.

Wiad Lek 2021 ;74(8):1925-1930

KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.

Objective: The aim is to study the level of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2) in the blood serum of patients with papillary thyroid cancer, depending on the main clinical and morphological features of the disease.

Patients And Methods: Materials and methods: The material was the information about 60 patients with papillary thyroid cancer (group 1). In group 2 there were 10 patients without oncopathology. Read More

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September 2021

EXPRESSION FEATURES OF HUMAN PAPILLOMA VIRUS TYPE 16 AND ANTI-EPSTEIN-BARR VIRUS IN PLEOMORPHIC ADENOMA, SURROUNDING AND INTACT SALIVARY GLAND.

Wiad Lek 2021 ;74(8):1789-1793

KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.

Objective: The aim is to reveal the expression features of MCA to human papilloma virus type 16 and anti-Epstein-Barr virus in the pleomorphic adenoma, surrounding and intact salivary gland.

Patients And Methods: Materials and methods: It was used surgical and biopsy material from 30 patients, represented by pleomorphic adenomas with surrounding to tumor tissue of the salivary gland and intact tissue of the salivary gland (the distance between the tumor and the intact salivary gland - 10 mm). Immunohistochemical study was performed using mouse monoclonal antibody (MCA) to human papilloma virus type 16 (clone CAMVIR-1, «Diagnostic BioSystems», USA) and anti-Epstein-Barr virus (LMP, clone CS. Read More

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September 2021

Lymphoepithelial carcinoma in the sublingual gland.

Int J Oral Maxillofac Surg 2021 Sep 14. Epub 2021 Sep 14.

Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Lymphoepithelial carcinoma is rare in the salivary glands, with an incidence of 0.4%. The most commonly affected site is the parotid gland, followed by the submandibular gland. Read More

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September 2021

Targeted Mutational Analysis of Cortisol-Producing Adenomas.

J Clin Endocrinol Metab 2021 Sep 17. Epub 2021 Sep 17.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

Background: Somatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPA). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1.

Objective: To expand our understanding of the prevalence of somatic mutations in CPA from patients with overt Cushing syndrome (OCS) and "subclinical" mild autonomous cortisol excess (MACE), with an immunohistochemistry (IHC)‒guided targeted amplicon sequencing approach using formalin-fixed paraffin-embedded (FFPE) tissue. Read More

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September 2021

The anti-tumour effect of induced pluripotent stem cells against submandibular gland carcinoma in rats is achieved via modulation of the apoptotic response and the expression of Sirt-1, TGF-β, and MALAT-1 in cancer cells.

Mol Cell Biochem 2021 Sep 17. Epub 2021 Sep 17.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.

The era of induced pluripotent stem cells (iPSCs) was used as novel biotechnology to replace embryonic stem cells bypassing the ethical concerns and problems of stem cell transplant rejection. The anti-tumour potential of iPSCs against many tumours including salivary cancer was proven in previous studies. The current study aimed to investigate the contribution of the Bax, Sirt-1, TGF-β, and MALAT genes and/or their protein expression to the pathogenesis of submandibular carcinogenesis before and after iPSCs treatment. Read More

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September 2021

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.

Authors:
Giulio Cantù

Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307

Former Director of Otorhinolaryngology and Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milano, Italy.

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A Novel Scoring System for Predicting the Metastases of Posterior Right Recurrent Laryngeal Nerve Lymph Node Involvement in Patients With Papillary Thyroid Carcinoma by Preoperative Ultrasound.

Front Endocrinol (Lausanne) 2021 31;12:738138. Epub 2021 Aug 31.

Department of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: Our goal was to investigate the correlation between papillary thyroid carcinoma (PTC) characteristics on ultrasonography and metastases of lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN). There is still no good method for clinicians to judge whether a patient needs LN-prRLN resection before surgery, and we also wanted to establish a new scoring system to determine whether patients with papillary thyroid carcinoma require LN-prRLN resection before surgery.

Patients And Methods: There were 482 patients with right or bilateral PTC who underwent thyroid gland resection from December 2015 to December 2017 recruited as study subjects. Read More

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Thyroid diagnostic modalities (fine needle aspiration and core needle biopsy) with histology correlation: a tertiary centre experience.

J Clin Pathol 2021 Sep 16. Epub 2021 Sep 16.

Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Aims: To determine the proportion of thyroid fine needle aspiration (FNA) and core needle biopsy (CNB) cases reported at a single institute into each UK Royal College of Pathologists (RCPath) Thy1-5 and local T category, respectively. Where subsequent histology was available, malignancy rates, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were compared for both procedures.

Methods: 1591 FNAs (2010-2018) and 514 CNBs (2013-2018) cases were identified, together with paired histology excision specimens. Read More

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September 2021

Canalicular adenoma: palatal presentation of an uncommon lesion.

BMJ Case Rep 2021 Sep 16;14(9). Epub 2021 Sep 16.

Department of Oral Medicine and Radiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences, Cochin, India.

Canalicular adenoma is a unique, rare, benign salivary gland neoplasm whose reported prevalence varies in different studies. According to literature, this neoplasm has a marked predilection to occur in the upper lip of elderly women. Histological features are usually distinctive and diagnostic. Read More

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September 2021

Pilot study on the value of Raman spectroscopy in the entity assignment of salivary gland tumors.

PLoS One 2021 16;16(9):e0257470. Epub 2021 Sep 16.

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic & Reconstructive Head and Neck Surgery, University Hospital Würzburg, Würzburg, Germany.

Background: The entity assignment of salivary gland tumors (SGT) based on histomorphology can be challenging. Raman spectroscopy has been applied to analyze differences in the molecular composition of tissues. The aim of this study was to evaluate the suitability of RS for entity assignment in SGT. Read More

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September 2021

Neuroimaging of paediatric pineal, sellar and suprasellar tumours: a guide to differential diagnosis.

Childs Nerv Syst 2021 Sep 16. Epub 2021 Sep 16.

Great Ormond Street Hospital for Children NHS Trust, Department of Radiology, London, UK.

Introduction: Pineal, sellar and suprasellar tumours in children comprise a wide range of diseases with different biological behaviours and clinical management. Neuroimaging plays a critical role in the diagnosis, treatment planning and follow up of these patients, but imaging interpretation can prove challenging due to the significant overlap in radiological features.

Materials And Method: A review of the literature was performed by undertaking a search of the MEDLINE and EMBASE databases for appropriate MeSH terminology. Read More

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September 2021

Hypervascular mucoepidermoid caricinoma of the palate.

Stomatologija 2021 ;23(1):22-25

Department of Radiology, Mayo 200 First St SW, Rochester, MN 55905, USA.

Salivary mucoepidermoid carcinoma is the most common malignant salivary gland tumor. Low or intermediate grade tumors are slow-growing and can be mistaken for benign lesions on both physical exam and imaging studies. We present a case of hypervascular mucoepidermoid carcinoma of the hard palate that was initially thought to represent a benign vascular lesion. Read More

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September 2021

Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.

J Clin Endocrinol Metab 2021 Sep 16. Epub 2021 Sep 16.

Department of Medicine (Division of Endocrinology, Diabetes and Clinical Nutrition) and Neurological Surgery, and Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA.

Hypophysitis is defined as inflammation of the pituitary gland that is primary or secondary to a local or systemic process. Differential diagnosis is broad (including primary tumors, metastases, and lympho-proliferative diseases) and multifaceted. Patients with hypophysitis typically present with headaches, some degree of anterior and/or posterior pituitary dysfunction, and enlargement of pituitary gland and/or stalk, as determined by imaging. Read More

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September 2021

Peripheral pulmonary mucous gland adenoma with a cavity mimicking lung cancer.

Gen Thorac Cardiovasc Surg 2021 Sep 15. Epub 2021 Sep 15.

Department of Thoracic Surgery, Osaka City University Hospital, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

A 71-year-old woman presented to our hospital because of a 10 mm nodule with a cavity in right lower lobe on chest computed tomography. Fluorodeoxyglucose-positron emission tomography showed slight accumulation in the nodule (maximum standard uptake value 2.08). Read More

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September 2021