4,661 results match your criteria gip

The Evolving Story of Incretins (GIP and GLP-1) in Metabolic and Cardiovascular Disease: A Pathophysiological Update.

Diabetes Obes Metab 2021 Jul 26. Epub 2021 Jul 26.

Charité - Universitätsmedizin Berlin, Klinik für Endokrinologie, Stoffwechsel- und Ernährungsmedizin, Berlin, Germany.

The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have their main physiological role in augmenting insulin secretion after their nutrient-induced secretion from the gut. A functioning entero-insular (gut-endocrine pancreas) axis is essential for the maintenance of a normal glucose tolerance. This is exemplified by the incretin effect (greater insulin secretory response to oral as compared to "isoglycaemic" intravenous glucose administration due to the secretion and action of incretin hormones). Read More

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Longitudinal Study of Cognitive and Emotional Alterations in Amyotrophic Lateral Sclerosis: Clinical and Imaging Data.

Front Neurol 2021 8;12:620198. Epub 2021 Jul 8.

Normandie Univ, UNICAEN, PSL Université Paris, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France.

Extra-motor manifestations occur in 50% of patients with amyotrophic lateral sclerosis (ALS). These mainly concern cognition, emotional processing and behavior. Depression and anxiety are less frequent. Read More

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Polyphenols and Human Beings: From Epidemiology to Molecular Targets.

Molecules 2021 Jul 12;26(14). Epub 2021 Jul 12.

Grupo de Investigación en Polifenoles (GIP-USAL), Universidad de Salamanca, E-37007 Salamanca, Spain.

Dietary polyphenols have been associated with health benefits in the prevention of a range of degenerative and age-related diseases that constitute the major causes of death and incapacitation in developed countries [... Read More

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Is Zn(d,x)Cu the Best Way to Produce Cu for Medical Applications?

Front Med (Lausanne) 2021 5;8:674617. Epub 2021 Jul 5.

Laboratory SUBATECH, CNRS/IN2P3, IMT Atlantique, Université de Nantes, Nantes, France.

The pair of copper radionuclides Cu/Cu (T = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. Read More

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Longitudinal changes in hippocampal network connectivity in Alzheimer's disease.

Ann Neurol 2021 Jul 19. Epub 2021 Jul 19.

Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000, Caen, France.

Objective: The hippocampus is connected to two distinct cortical brain networks, the posterior-medial and the anterior-temporal networks, involving different medial temporal lobe (MTL) subregions. The aim of this study was to assess the functional alterations of these two networks, their changes over time and links to cognition in Alzheimer's disease.

Methods: We assessed MTL connectivity in 53 amyloid-β positive patients with mild cognitive impairment and Alzheimer dementia and 68 healthy elderly controls, using resting-state functional magnetic resonance imaging, cross-sectionally and longitudinally. Read More

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The effect of melatonin on incretin hormones - results from experimental and randomized clinical studies.

J Clin Endocrinol Metab 2021 Jul 15. Epub 2021 Jul 15.

Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.

Context: Glucose homeostasis is under circadian control through both endocrine and intracellular mechanisms with several lines of evidence suggesting that melatonin affects glucose homeostasis.

Objective: To evaluate the acute in-vivo and in-situ effects of melatonin on secretion of the incretin hormones, GLP-1 and GIP, and their impact on β-cell insulin secretion.

Design: A human randomized, double-blinded, placebo-controlled crossover study combined with a confirmatory in-situ study of perfused rat intestines. Read More

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GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics.

Sci Rep 2021 Jul 14;11(1):14470. Epub 2021 Jul 14.

Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

We recently established a new plasma peptidomic technique and comprehensively identified a large number of low-molecular weight and low-abundance native peptides using a single drop of human plasma. To discover a novel polypeptide that potently modulates the cardiovascular system, we performed a bioinformatics analysis of the large-scale identification results, sequentially synthesized the selected peptide sequences, tested their biological activities, and identified a 30-amino-acid proatherogenic peptide, GIP_HUMAN[22-51], as a potent proatherosclerotic peptide hormone. GIP_HUMAN[22-51] has a common precursor with the glucose-dependent insulinotropic polypeptide (GIP) and is located immediately N-terminal to GIP. Read More

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At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer.

Bioconjug Chem 2021 Jul 14. Epub 2021 Jul 14.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.

Targeted radionuclide therapy (TRT) provides new and safe opportunities for cancer treatment and management with high precision and efficiency. Here we have designed a novel semiconducting polymer nanoparticle (SPN)-based radiopharmaceutical (At-MeATE-SPN-GIP) for TRT against glucose-dependent insulinotropic polypeptide receptor (GIPR)-positive cancers to further explore the applications of nanoengineered TRT. At-MeATE-SPN-GIP was engineered via nanoprecipitation, followed by its functionalization with a glucose-dependent insulinotropic polypeptide (GIP) to target GIPR and deliver At for α therapy. Read More

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Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor.

Elife 2021 Jul 13;10. Epub 2021 Jul 13.

School of Pharmacy, Fudan University, Shanghai, China.

Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that exerts crucial metabolic functions by binding and activating its cognate receptor, GIPR. As an important therapeutic target, GIPR has been subjected to intensive structural studies without success. Here, we report the cryo-EM structure of the human GIPR in complex with GIP and a G heterotrimer at a global resolution of 2. Read More

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Evaluation of the early-phase [F]AV45 PET as an optimal surrogate of [F]FDG PET in ageing and Alzheimer's clinical syndrome.

Neuroimage Clin 2021 Jul 1;31:102750. Epub 2021 Jul 1.

Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France; Inserm U1077, Caen-Normandie University, École Pratique des Hautes Études, Caen, France. Electronic address:

Dual-phase [F]AV45 positron emission tomography (PET) is highly promising in the assessment of neurodegenerative diseases, allowing to obtain information on both neurodegeneration (early-phase; eAV45) and amyloid deposition (late-phase; lAV45) which are highly complementary; yet eAV45 needs further evaluation. This study aims at validating eAV45 as an optimal proxy of [F]FDG PET in a large mixed-population of healthy ageing and Alzheimer's clinical syndrome participants (n = 191) who had [F]FDG PET, eAV45 and lAV45 scans. We found early time frame 0-4 min to give maximal correlation with [F]FDG PET and minimal correlation with lAV45. Read More

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What is the role of neurosurgeons in the current management of intracranial aneurysm in France? An analysis of professional practices.

Neurochirurgie 2021 Jul 8. Epub 2021 Jul 8.

Department of Neurosurgery, CHRU de la Cavale Blanche, Boulevard Tanguy-Prigent, 29609 Brest cedex, FRANCE; Université de Bretagne Occidentale, INSERM, UMR 1101, LaTIM, Laboratoire de Traitement de l'Information Médicale, 29200, Brest, France.

Study Design: Retrospective observational survey-based study.

Introduction: In France, intracranial aneurysm (IA) patients are managed by neurosurgeons and by interventional neuroradiologists. The growth of endovascular treatment led us to reflect on the role of neurosurgeons in the management of patients with IA. Read More

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The enteroendocrine-osseous axis in patients with long-term type 1 diabetes mellitus.

Bone 2021 Jul 8;153:116105. Epub 2021 Jul 8.

Department of Pediatric and Adolescent Endocrinology, Pediatric Institute, Jagiellonian University Medical College, Kraków, Poland. Electronic address:

Introduction: The relationship between the gut and skeleton is increasingly recognized as a component of the regulation of carbohydrate metabolism. The aim of our study was to assess the relationship between bone mineral density (BMD), incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), intestinotrophic peptide glucagon-like peptide-2 (GLP-2) and osteocalcin isoforms in patients with long-term type 1 diabetes (T1D) when compared to healthy controls.

Methods: Eighty two patients with long term T1D, treated in the Department of Metabolic Diseases and 53 healthy controls were recruited to the study. Read More

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History of Magnetic Resonance Imaging: A Trip Down Memory Lane.

Neuroscience 2021 Jul 6. Epub 2021 Jul 6.

Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, GIP Cyceron, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France.

The history of magnetic resonance imaging (MRI) is closely linked to our improved understanding of memory systems, be it in normal functioning or altered due to pathologies. Over the years, brain imaging using MRI has moved from simple volumetric imaging to complex analysis using multiple sequences, allowing the measurement of microstructural integrity and brain activation through a dedicated task or at rest. This review aims at showing how the advent and evolution of magnetic resonance imaging has shaped a better understanding of memory and brain function in humans. Read More

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Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes.

Oncoimmunology 2021 27;10(1):1940676. Epub 2021 Jun 27.

Université De Nantes, CNRS, INSERM, CRCINA, Nantes, France.

The optimization of adoptive transfer approaches of anti-tumor T cells requires both the functional improvement of the injected T cells and the modulation of the tumor microenvironment, favoring the recruitment of these T cells and their activation. We have recently shown the therapeutic benefit of two approaches tested individually in a melanoma model wich were on one hand the adoptive transfer of specific T cells deficient for the expression of the inhibitory receptor PD-1, and on the other hand PD-L1 targeted alpha therapy (TAT). In this study, we sought to investigate the efficacy of these two therapies combined, compared to each monotherapy, in order to evaluate the synergy between these two approaches, in the same melanoma model. Read More

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Using Network Distance Analysis to Predict lncRNA-miRNA Interactions.

Interdiscip Sci 2021 Jul 7. Epub 2021 Jul 7.

Research Center for Computer Simulating and Information Processing of Bio-Macromolecules of Shenyang, Liaoning University, Shenyang, 110036, China.

LncRNA-miRNA interactions contribute to the regulation of therapeutic targets and diagnostic biomarkers in multifarious human diseases. However, it remains difficult to experimentally identify lncRNA-miRNA associations at large scale, and computational prediction methods are limited. In this study, we developed a network distance analysis model for lncRNA-miRNA association prediction (NDALMA). Read More

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The contribution of mamillary body damage to Wernicke's encephalopathy and Korsakoff's syndrome.

Handb Clin Neurol 2021 ;180:455-475

Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands. Electronic address:

Histopathological alterations of the mamillary bodies are the most conspicuous and the most consistent neuropathological features of several disorders that occur after severe thiamine deficiency, such as Wernicke's encephalopathy and Korsakoff's syndrome. Moreover, they are among the few abnormalities that are visible to the naked eye in these disorders. With a lifetime prevalence of approximately 1. Read More

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January 2021

identification of antidiabetic target for phytochemicals of and mechanistic insights by molecular dynamics simulations.

J Biomol Struct Dyn 2021 Jul 6:1-18. Epub 2021 Jul 6.

Department of Botany, D.S.B. Campus, Kumaun University, Nainital, Uttarakhand, India.

The leaves and fruits of (L.) have antidiabetic activity. However, the mode of action and molecules having antidiabetic activity are not known. Read More

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The Postprandial Glycaemic and Hormonal Responses Following the Ingestion of a Novel, Ready-to-Drink Shot Containing a Low Dose of Whey Protein in Centrally Obese and Lean Adult Males: A Randomised Controlled Trial.

Front Endocrinol (Lausanne) 2021 18;12:696977. Epub 2021 Jun 18.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Purpose: Elevated postprandial glycaemia [PPG] increases the risk of cardiometabolic complications in insulin-resistant, centrally obese individuals. Therefore, strategies that improve PPG are of importance for this population. Consuming large doses of whey protein [WP] before meals reduces PPG by delaying gastric emptying and stimulating the secretion of the incretin peptides, glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide 1 [GLP-1]. Read More

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Anti-diabetic drugs and NASH: from current options to promising perspectives.

Expert Opin Investig Drugs 2021 Jul 12:1-13. Epub 2021 Jul 12.

Department of Endocrinology, Université De Nantes, CHU Nantes, CNRS, INSERM, L'institut Du Thorax, Nantes, France.

: Accumulating evidence supports a bidirectional association between nonalcoholic steatohepatitis (NASH) and type 2 diabetes (T2D). There is a clinical challenge to consider pharmaceutical strategies targeting the metabolic dysfunction common to NASH and T2D pathogenesis.: By using PubMed, we performed a literature search to review the potential beneficial effect of anti-diabetic and metabolic investigational drugs on NASH. Read More

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GPCRs: The most promiscuous druggable receptor of the mankind.

Saudi Pharm J 2021 Jun 22;29(6):539-551. Epub 2021 Apr 22.

Molecular BioMedicine Program, Research Centre, King Faisal Specialist Hospital and Research Centre, P.O.Box: 3354, MBC:03, Riyadh 11211, Saudi Arabia.

All physiological events in living organisms originated as specific chemical/biochemical signals on the cell surface and transmitted into the cytoplasm. This signal is translated within milliseconds-hours to a specific and unique order required to maintain optimum performance and homeostasis of living organisms. Examples of daily biological functions include neuronal communication and neurotransmission in the process of learning and memory, secretion (hormones, sweat, and saliva), muscle contraction, cellular growth, differentiation and migration during wound healing, and immunity to fight infections. Read More

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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial.

Lancet 2021 Jul 27;398(10295):143-155. Epub 2021 Jun 27.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Despite advancements in care, many people with type 2 diabetes do not meet treatment goals; thus, development of new therapies is needed. We aimed to assess efficacy, safety, and tolerability of novel dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist tirzepatide monotherapy versus placebo in people with type 2 diabetes inadequately controlled by diet and exercise alone.

Methods: We did a 40-week, double-blind, randomised, placebo-controlled, phase 3 trial (SURPASS-1), at 52 medical research centres and hospitals in India, Japan, Mexico, and the USA. Read More

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GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders.

Diabetes 2021 Jun 27. Epub 2021 Jun 27.

Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.

During the past decade, pharmaceutical engineering of unimolecular agents has revealed the therapeutic potential of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism. From this work, one of the most intriguing findings is that engagement of GIPR enhances the weight loss profile of glucagon-like peptide 1 (GLP-1)-based therapeutics. Consequently, this pharmacological approach, in combination with novel mouse models, has provided evidence indicating that activation of GIPR in certain areas of the brain that regulate energy balance is required for the synergistic weight loss of dual GIPR and GLP-1 receptor (GLP-1R) agonism. Read More

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Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex.

Diabetes 2021 Jun 27. Epub 2021 Jun 27.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

The dorsal vagal complex (DVC) in the hindbrain, composed of the area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus, plays a critical role in modulating satiety. The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) act directly in the brain to modulate feeding, and receptors for both are expressed in the DVC. Given the impressive clinical responses to pharmacologic manipulation of incretin signaling, understanding the central mechanisms by which incretins alter metabolism and energy balance is of critical importance. Read More

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The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity.

Makoto Fukuda

Diabetes 2021 Jun 27. Epub 2021 Jun 27.

Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX

Glucose-dependent insulinotropic polypeptide (GIP) (also known as gastric inhibitory polypeptide) is a hormone produced in the upper gut and secreted to the circulation in response to the ingestion of foods, especially fatty foods. Growing evidence supports the physiological and pharmacological relevance of GIP in obesity. In an obesity setting, inhibition of endogenous GIP or its receptor leads to decreased energy intake, increased energy expenditure, or both, eventually causing weight loss. Read More

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The Role of GIP in the Regulation of GLP-1 Satiety and Nausea.

Diabetes 2021 Jun 27. Epub 2021 Jun 27.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA.

Gastric inhibitory peptide (GIP) is best known for its role as an incretin hormone in control of blood glucose concentrations. As a classic satiation signal, however, the literature illustrates a mixed picture of GIP involvement with an at best weak anorectic response profile being reported for GIP receptor (GIPR) signaling. Not surprisingly, the pursuit of exploiting the GIP system as a therapeutic target for diabetes and obesity has fallen behind that of the other gastrointestinal-derived incretin, glucagon-like peptide 1 (GLP-1). Read More

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Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice.

Front Endocrinol (Lausanne) 2021 8;12:680153. Epub 2021 Jun 8.

Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

A large contribution to glucose elimination from the circulation is achieved by insulin-independent processes. We have previously shown that the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) increase this process and, therefore, seem to contribute to glucose disposal both through this effect and through the classical incretin effect resulting in enhanced insulin levels. We have now explored in more detail the potential contribution by incretin hormone receptors to insulin-independent processes for glucose elimination. Read More

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Negative surgical exploration in suspected gastrointestinal perforation: trend, preoperative predictors, and etiologies.

Ann Transl Med 2021 May;9(10):832

Department of General Surgery, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, China.

Background: Despite the rapid improvement of clinical science and imaging technology including computed tomography, the entity of negative surgical exploration in suspected gastrointestinal perforation (N-GIP) still exist. However, few studies have focused on this issue and most studies are case reports. We undertook this study to investigate the rates of N-GIP, and explore a set of possible preoperative predictors associated with N-GIP. Read More

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Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and astatination of antibodies.

Chem Sci 2020 Nov 23;12(4):1458-1468. Epub 2020 Nov 23.

Université de Nantes, CNRS, Inserm, CRCINA F-44000 Nantes France

Easy access to radioiodinated and At-labelled bio(macro)molecules is essential to develop new strategies in nuclear imaging and targeted radionuclide therapy of cancers. Yet, the labelling of complex molecules with heavy radiohalogens is often poorly effective due to the multiple steps and intermediate purifications needed. Herein, we investigate the potential of arylboron chemistry as an alternative approach for the late stage labelling of antibodies. Read More

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November 2020

["Early detection of schizophrenia, why and who to contact?"]

Rev Prat 2021 Jan;71(1):36-41

"Service de psychiatrie, CHU de Caen, France" - Normandie Univ, UNICAEN, UFR de médecine, Caen, France.

"Early detection Of schizophrenia, why and who to contact? Schizophrenia usually occurs in late adolescence or early adulthood but is generally preceded by a prodromal phase or by a "high risk mental state" which corresponds to the onset of the disease. Early detection of symptoms and rapid specialized intervention begin at this stage. Medical intervention at this stage aims to influence the course of the disease and to limit the transition to a first-episode psychosis (FEP). Read More

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January 2021

Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis.

Ann Palliat Med 2021 Jun 11;10(6):6786-6792. Epub 2021 Jun 11.

Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China; RICU & MICU, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Background: To explore the relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and the disease condition and prognosis in patients with severe acute pancreatitis (SAP).

Methods: A total of 52 patients with SAP (SAP group) and 50 patients with mild acute pancreatitis (MAP group) admitted to Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China between April 2017 and December 2019 were included in the present study. A further 50 people who had received a healthy physical examination during the same period constituted the healthy control group. Read More

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