1,685 results match your criteria ginseng active


Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms.

Phytother Res 2022 Jan 13. Epub 2022 Jan 13.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. Read More

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January 2022

American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males.

Nutrients 2021 Dec 25;14(1). Epub 2021 Dec 25.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan.

Exercise-induced muscle damage (EIMD) is characterized by a reduction in functional performance, disruption of muscle structure, production of reactive oxygen species, and inflammatory reactions. Ginseng, along with its major bioactive component ginsenosides, has been widely employed in traditional Chinese medicine. The protective potential of American ginseng (AG) for eccentric EIMD remains unclear. Read More

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December 2021

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (, , and ).

Plants (Basel) 2021 Dec 26;11(1). Epub 2021 Dec 26.

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.

Background: In the 1960s, research into plant adaptogens began. Plants with adaptogenic properties have rich phytochemical compositions and have been used by humanity since ancient times. However, it is not still clear whether the adaptogenic properties are because of specific compounds or because of the whole plant extracts. Read More

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December 2021

Exploring the Mechanism of Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation.

Evid Based Complement Alternat Med 2021 30;2021:5730812. Epub 2021 Dec 30.

School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China.

Background: saponins (PNS) have been used for neurodegenerative disorders such as cerebral ischemia and Alzheimer's disease (AD). Although increasing evidences show the neuron protective effects of PNS, the vital compounds and their functional targets remain elusive. To explore the potential functional ingredients of PNS for the AD treatment and their molecular mechanisms, an neuron injured model induced by A was investigated, and the potential mechanism was predicted by network pharmacology approach and validated by molecular biology methods. Read More

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December 2021

Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells.

Stem Cells Int 2021 31;2021:4633270. Epub 2021 Dec 31.

Department of Reproductive Medicine Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Ginsenoside Rg1 (Rg1), a purified, active component of the root or stem of ginseng, exerts positive effects on mesenchymal stem cells (MSCs). Many recent studies have found that hematopoietic stem cells (HSCs), which can develop into hematopoietic progenitor cells (HPCs) and mature blood cells, are another class of heterogeneous adult stem cells that can be regulated by Rg1. Rg1 can affect HSC proliferation and migration, regulate HSC/HPC differentiation, and alleviate HSC aging, and these findings potentially provide new strategies to improve the HSC homing rate in HSC transplantation and for the treatment of graft-versus-host disease (GVHD) or other HSC/HPC dysplasia-induced diseases. Read More

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December 2021

Strategies for Remodeling the Tumor Microenvironment Using Active Ingredients of Ginseng-A Promising Approach for Cancer Therapy.

Front Pharmacol 2021 22;12:797634. Epub 2021 Dec 22.

Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.

The tumor microenvironment (TME) plays a key role in promoting the initiation and progression of tumors, leading to chemoradiotherapy resistance and immunotherapy failure. Targeting of the TME is a novel anti-tumor therapeutic approach and is currently a focus of anti-tumor research. C. Read More

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December 2021

The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Inflammopharmacology 2022 Jan 8. Epub 2022 Jan 8.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases the levels of IL-6 and acute phase reactants such as C-reactive protein. Read More

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January 2022

Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis.

Chin Med 2022 Jan 4;17(1). Epub 2022 Jan 4.

Changchun University of Chinese Medicine, Changchun, Jilin, China.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied with itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) consists of a mixture of extracts from five plants, which had been used in AD treatment due to good anti-inflammatory and anti-allergic effects.

Materials And Methods: In this study, high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometer (LC/MS) were performed to analyze the active ingredients of CTCMDO in detail and to establish its HPLC fingerprint. Read More

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January 2022

Comprehensive phytochemicals analysis and anti-myocardial ischemia activity of total saponins of American ginseng berry.

J Food Biochem 2022 Jan 3:e14042. Epub 2022 Jan 3.

School of Pharmaceutical Sciences, Jilin Uni, Changchun, China.

American ginseng berry (AGB) is a new medicinal source. Total saponins of American ginseng berry (TSAGB) are the main active ingredients. The effects and active saponins of TSAGB on myocardial ischemia (MI) rats were evaluated for the first time. Read More

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January 2022

The Effects of Ginsenosides on the Nrf2 Signaling Pathway.

Adv Exp Med Biol 2021 ;1328:307-322

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism. Conversely, the Nrf2 signaling pathway is impaired in several pathological conditions including cancer. Read More

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January 2022

Effect of Ginsenoside Rb2 on a Myocardial Cell Model of Coronary Heart Disease through Nrf2/HO-1 Signaling Pathway.

Biol Pharm Bull 2022 ;45(1):71-76

Department of Pediatrics, The 3rd Hospital of Changsha.

The ginsenoside Rbs are the primary active compounds of Panax ginseng and ginsenoside Rb2 is a renowned component among the Rbs. This study aimed to investigate the potential effects of ginsenoside Rb2 on coronary heart disease (CHD). H9c2 cells were exposed to HO to establish CHD model in vitro. Read More

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January 2022

The efficacy and tolerability of pharmacologically active interventions for alcohol-induced hangover symptomatology: A systematic review of the evidence from randomised placebo-controlled trials.

Addiction 2021 Dec 31. Epub 2021 Dec 31.

National Addiction Centre and the Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Kings College London and the South London and the Maudsley NHS Foundation Trust.

Aims: To compare quantitatively the efficacy and tolerability of pharmacologically active interventions in the treatment and prevention of alcohol-induced hangover.

Methods: Systematic review of placebo-controlled randomised trials in healthy adults that evaluated any pharmacologically active intervention in the treatment or prevention of hangover. We searched Medline, Embase, PsycINFO and CENTRAL from database inception until 1 August 2021. Read More

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December 2021

Preliminary screening of the potential active ingredients in traditional Chinese medicines using the Ussing chamber model combined with HPLC-PDA-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Dec 22;1189:123090. Epub 2021 Dec 22.

School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China; School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China. Electronic address:

An in vitro intestinal absorption model combined with high-performance liquid chromatography-photo diode array-tandem mass spectrometry (HPLC-PDA-MS) was used for preliminary screening of potential active ingredients from complex multi-component traditional Chinese medicine (TCM) system. Oral administration is one of the main administration methods for TCMs. Only the ingredients that could be absorbed have the opportunity to play a role. Read More

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December 2021

Protective Effect of NGR1 against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells by Upregulating the SIRT1/Wnt/-Catenin Pathway.

Evid Based Complement Alternat Med 2021 15;2021:4358163. Epub 2021 Dec 15.

Department of Neurological Diseases, Ziyang People's Hospital of Sichuan Province, Ziyang, Sichuan 641300, China.

Notoginsenoside R1 (NGR1) is an active compound isolated from . Despite the NGR1 having been used as a traditional medicine, little is known about the neuroprotective effects. In this study, we investigate the protective effects of NGR1 against glutamate-induced cytotoxicity in HT22 cells and its possible molecular mechanism. Read More

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December 2021

Impact of Qi-Invigorating Traditional Chinese Medicines on Diffuse Large B Cell Lymphoma Based on Network Pharmacology and Experimental Validation.

Front Pharmacol 2021 9;12:787816. Epub 2021 Dec 9.

Fujian Institute of Hematology, Fujian Medical Center of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.

It has been verified that deficiency of Qi, a fundamental substance supporting daily activities according to the Traditional Chinese Medicine theory, is an important symptom of cancer. Qi-invigorating herbs can inhibit cancer development through promoting apoptosis and improving cancer microenvironment. In this study, we explored the potential mechanisms of Qi-invigorating herbs in diffuse large B cell lymphoma (DLBCL) through network pharmacology and experiment. Read More

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December 2021

Effect of steam-processing of the Panax ginseng root on its inducible activity on granulocyte-colony stimulating factor secretion in intestinal epithelial cells in vitro.

J Ethnopharmacol 2021 Dec 23;287:114927. Epub 2021 Dec 23.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, 467-8603, Japan. Electronic address:

Ethnopharmacological Relevance: Panax ginseng root has been used as tonic in traditional Chinese medicine (TCM) and traditional Japanese Kampo medicine. Steam processing of Panax ginseng root is carried out to enhance its nourishing effects on qi.

Aim Of The Study: In order to explore the mechanism of these beneficial effects behind the steam processing of the P. Read More

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December 2021

Ginsenoside Rd: A promising natural neuroprotective agent.

Phytomedicine 2022 Jan 8;95:153883. Epub 2021 Dec 8.

Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Background: Neurological diseases seriously affect human health, which are arousing wider attention, and it is a great challenge to discover neuroprotective drugs with minimal side-effects and better efficacies. Natural agents derived from herbs or plants have become unparalleled resources for the discovery of novel drug candidates. Panax ginseng C. Read More

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January 2022

[Scr eening of key genes and pathways of brain aging and prediction of potential effective Chinese medicinals: based on bioinformatics].

Zhongguo Zhong Yao Za Zhi 2021 Nov;46(21):5701-5709

Beijing Key Laboratory of Taditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease,Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.

Microarray data of hippocampal tissue(HC) of the cognitively intact elderly(60-99 years old) were compared with those of the middle-aged and the young(20-59 years old) by bioinformatics techniques to initially screen out differentially expressed genes(DEGs) and then predict potential effective Chinese medicinals for the treatment of brain aging. The gene expression profile(accession: GSE11882) was downloaded from the Gene Expression Omnibus(GEO) and DEGs were screened based on R package. The key DEGs were identified by STRING, Cytoscape and the plug-in, followed by Gene Ontology(GO) term and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis. Read More

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November 2021

Network Pharmacology and Experimental Assessment to Explore the Pharmacological Mechanism of Qimai Feiluoping Decoction Against Pulmonary Fibrosis.

Front Pharmacol 2021 3;12:770197. Epub 2021 Dec 3.

Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Pulmonary fibrosis (PF) is one of the pathologic changes in COVID-19 patients in convalescence, and it is also a potential long-term sequela in severe COVID-19 patients. Qimai Feiluoping decoction (QM) is a traditional Chinese medicine formula recommended in the Chinese national medical program for COVID-19 convalescent patients, and PF is one of its indications. Through clinical observation, QM was found to improve the clinical symptoms and pulmonary function and reduce the degree of PF of COVID-19 convalescent patients. Read More

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December 2021

Extraction, Structural Characterization, and Anti-Hepatocellular Carcinoma Activity of Polysaccharides From Meyer.

Front Oncol 2021 29;11:785455. Epub 2021 Nov 29.

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

Polysaccharides are the main active ingredients of ginseng. To extract the most effective polysaccharides against hepatocellular carcinoma (HCC), we isolated and characterized the polysaccharides from the mountain cultivated ginseng (MCG) and compared their composition and cytotoxic effect with cultivated ginseng (CG) polysaccharide against HepG2 cell lines for the first time. MCG polysaccharides and CG polysaccharides were fractionated into two fractions such as MTPS-1, MTPS-2 and CTPS-1, CTPS-2 by salting out, respectively. Read More

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November 2021

A Herbal Mixture Formula of OCD20015-V009 Prophylactic Administration to Enhance Interferon-Mediated Antiviral Activity Against Influenza A Virus.

Front Pharmacol 2021 24;12:764297. Epub 2021 Nov 24.

Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, South Korea.

OCD20015-V009 is an herbal mix of water-extracted Ginseng Radix, Poria (Hoelen), Rehmanniae Radix, Adenophorae Radix, Platycodi Radix, Crataegii Fructus, and Astragali Radix. In this study, its and antiviral activity and mechanisms against the influenza A virus were evaluated using a GFP-tagged influenza A virus (A/PR/8/34-GFP) to infect murine macrophages. We found that OCD20015-V009 pre-treatment substantially reduced A/PR/8/34-GFP replication. Read More

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November 2021

Ginsenoside Rb1 ameliorates Glycemic Disorder in Mice With High Fat Diet-Induced Obesity Regulating Gut Microbiota and Amino Acid Metabolism.

Front Pharmacol 2021 24;12:756491. Epub 2021 Nov 24.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.

Accumulating evidences suggested an association between gut microbiome dysbiosis and impaired glycemic control. Ginsenoside Rb1 (Rb1) is a biologically active substance of ginseng, which serves anti-diabetic effects. However, its working mechanism especially interaction with gut microbes remains elusive in detail. Read More

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November 2021

Biomarkers of Mycoplasma pneumoniae pneumonia in children by urine metabolomics based on Q Exactive liquid chromatography tandem mass spectrometry.

Rapid Commun Mass Spectrom 2021 Dec 12:e9234. Epub 2021 Dec 12.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Changchun University of Chinese Medicine, Changchun, China.

Rationale: Mycoplasma pneumoniae has become one of the common pathogens causing pediatric respiratory infections. In clinical diagnosis, throat swabs are very difficult to obtain from children, and there is a possibility of false positive results; hence, there are few clinically available diagnostic methods.

Methods: In this study, Q Exactive liquid chromatography tandem mass spectrometry was used to analyze the metabolites in the urine of healthy children (HC) and Mycoplasma pneumoniae pneumonia in children (MPPC) patients. Read More

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December 2021

Notoginseng Triterpenes Inhibited Autophagy in Random Flaps the Beclin-1/VPS34/LC3 Signaling Pathway to Improve Tissue Survival.

Front Bioeng Biotechnol 2021 19;9:771066. Epub 2021 Nov 19.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Random flaps are widely used in tissue reconstruction, attributed to the lack of vascular axial limitation. Nevertheless, the distal end of the flap is prone to necrosis due to the lack of blood supply. Notoginseng triterpenes (NTs) are the active components extracted from , reducing oxygen consumption and improving the body's tolerance to hypoxia. Read More

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November 2021

Transcriptomics and Metabolomics Changes Triggered by Inflorescence Removal in (Burk.).

Front Plant Sci 2021 12;12:761821. Epub 2021 Nov 12.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

The root of (Burk.), in which saponins are the major active components, is a famous traditional Chinese medicine used to stop bleeding and to decrease inflammation and heart disease. Inflorescence removal increases the yield and quality of , but the underlying molecular mechanisms are unknown. Read More

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November 2021

Dihydromyricetin Reverses Thioacetamide-Induced Liver Fibrosis Through Inhibiting NF-κB-Mediated Inflammation and TGF-β1-Regulated of PI3K/Akt Signaling Pathway.

Front Pharmacol 2021 15;12:783886. Epub 2021 Nov 15.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.

As a natural active substance, dihydromyricetin (DHM) has been proven to have good hepatoprotective activity. However, the therapeutic effect of DHM on liver fibrosis, which has become a liver disease threatening the health of people around the world, has not been studied to date. The purpose of this study was to investigate the effect of DHM as a new nutritional supplement on thioacetamide (TAA)-induced liver fibrosis. Read More

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November 2021

Determination of Dammar-20(22)E,24-Diene-3β,6α,12β-Triol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Nov 23:123039. Epub 2021 Nov 23.

North China University of Science and Technology, Hebei, Tangshan 063210, PR China. Electronic address:

Dammar-20(22)E,24-Diene-3β,6α,12β-Triol (YNPT2), as one of the main pharmacological and active components of Panax ginseng, promotes ubiquitination and degradation of hypoxia inducible factor Ia through proteasome, which reduces the content of hypoxia inducible factor Ia in tumor cells. Therefore, it is widely used in tumor inhibition. A sensitive and specific bioanalytical method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of YNPT2 rat plasma has been developed. Read More

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November 2021

The Protective Effect of Mixture on Hepatic Ischemia/Reperfusion Injury in Mice Regulating NR3C2, SRC, and GAPDH.

Front Pharmacol 2021 11;12:756259. Epub 2021 Nov 11.

NHC Key Laboratory of Critical Care Medicine, Tianjin First Central Hospital, Tianjin, China.

mixture (PNM) has the characteristics of multicomponent, multitarget, and multieffect, which can cope with the multidirectional and multidimensional complex pathological process caused by hepatic ischemia/reperfusion injury (HIRI). Our animal experiments showed that PNM composed of notoginseng, dogwood, and white peony root could significantly reduce the level of aspartate transaminase and alanine aminotransferase in the blood of mice with HIRI, indicating that this preparation had a protective effect on HIRI in mice. Therefore, on this basis, the molecular mechanism of PNM intervention in HIRI was further explored by network pharmacology. Read More

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November 2021

The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition.

Heliyon 2021 Nov 12;7(11):e08354. Epub 2021 Nov 12.

Biochemistry Laboratory, Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt.

The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology. Therefore, great therapeutic benefits can be attained from p38 MAPK inhibitors. Read More

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November 2021

Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy.

J Ethnopharmacol 2022 Mar 21;285:114859. Epub 2021 Nov 21.

School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Key Laboratory of Pharmacology of Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Key Laboratory of Guangxi Zhuang and Yao Medicine; Nanning 530200, PR China. Electronic address:

Ethnopharmacological Relevance: Panax notoginseng (Burk) F. H. Chen is a well-known traditional Chinese medicine with a long history and is widely used in the treatment of cerebrovascular disease. Read More

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