11,643 results match your criteria ginseng


Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms.

Phytother Res 2022 Jan 13. Epub 2022 Jan 13.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. Read More

View Article and Full-Text PDF
January 2022

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis the protection of vascular endothelial cells from oxidative stress.

J Adv Res 2021 Dec 6;34:43-63. Epub 2021 Jul 6.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, PR China.

Introduction: Recently, Nrf2/HO-1 has received extensive attention as the main regulatory pathway of intracellular defense against oxidative stress and is considered an ideal target for alleviating endothelial cell (EC) injury.

Objectives: This paper aimed to summarized the natural monomers/extracts that potentially exert protective effects against oxidative stress in ECs.

Methods: A literature search was carried out regarding our topic with the keywords of "atherosclerosis" or "Nrf2/HO-1" or "vascular endothelial cells" or "oxidative stress" or "Herbal medicine" or "natural products" or "natural extracts" or "natural compounds" or "traditional Chinese medicines" based on classic books of herbal medicine and scientific databases including Pubmed, SciFinder, Scopus, the Web of Science, GoogleScholar, BaiduScholar, and others. Read More

View Article and Full-Text PDF
December 2021

Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes.

BMC Complement Med Ther 2022 Jan 12;22(1):13. Epub 2022 Jan 12.

Department of Immunology and Inflammation, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, 310007, Zhejiang, China.

Background: P-glycoprotein (P-gp)-mediated steroid resistance (SR) has been suggested to play a significant role in lupus nephritis (LN) treatment failure. Panax notoginseng saponins (PNS), the main effective components of the traditional Chinese medicine notoginseng, exhibited potent reversal capability of P-gp-mediated SR, but its mechanism remains unknown. This study aimed to investigate the effect of PNS on reversing SR in lupus and its underlying mechanism in vivo and in vitro. Read More

View Article and Full-Text PDF
January 2022

Skin-permissible NIR-actuated hyperthermia using a photothermally responsive hydrogel membrane for the effective treatment of antibiotic-resistant bacterial infection.

Biomater Sci 2022 Jan 11. Epub 2022 Jan 11.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, PR China.

With the long-term widespread overuse of antibiotics, a large number of antibiotic-resistant bacteria have emerged and become a serious threat to healthcare systems. As an alternative strategy, near-infrared light (NIR)-actuated photothermal treatment has been developed for killing antibiotic-resistant bacteria. Although promising, the widespread applications of photothermal antibacterial platforms face great challenges due to the skin-harmful high laser irradiation. Read More

View Article and Full-Text PDF
January 2022

Panos-Fermented Extract-Mediated Nanoemulsion: Preparation, Characterization, and In Vitro Anti-Inflammatory Effects on RAW 264.7 Cells.

Molecules 2021 Dec 30;27(1). Epub 2021 Dec 30.

State Local Joint Engineering Research Center of Ginseng Breeding and Application, Jilin Agricultural University, Changchun 130118, China.

This study focused on developing Panos nanoemulsion (P-NE) and enhancing the anti-inflammatory efficacy for the treatment of inflammation. The effects of P-NE were evaluated in terms of Nitric oxide (NO production) in Lipopolysaccharide (LPS), induced RAW 264.7 cells, Reactive oxygen species (ROS) generation using Human Keratinocyte cells (HaCaT), and quantitative polymerase chain reaction (qPCR) analysis. Read More

View Article and Full-Text PDF
December 2021

Korean Red Ginseng Enhances Immunotherapeutic Effects of NK Cells via Eosinophils in Metastatic Liver Cancer Model.

Nutrients 2021 Dec 28;14(1). Epub 2021 Dec 28.

Department of Pharmacy, College of Pharmacy, Duksung Women's University, Seoul 01369, Korea.

Metastasis decreases the survival rate of patients with liver cancer. Therefore, novel anti-metastatic strategies are needed. Korean Red Ginseng (KRG) is often ingested as a functional food with an immune-boosting effect. Read More

View Article and Full-Text PDF
December 2021

Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model.

Nutrients 2021 Dec 28;14(1). Epub 2021 Dec 28.

Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.

The synergistic effects of Korean Red ginseng (KRG, C.A. Mey. Read More

View Article and Full-Text PDF
December 2021

American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males.

Nutrients 2021 Dec 25;14(1). Epub 2021 Dec 25.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan.

Exercise-induced muscle damage (EIMD) is characterized by a reduction in functional performance, disruption of muscle structure, production of reactive oxygen species, and inflammatory reactions. Ginseng, along with its major bioactive component ginsenosides, has been widely employed in traditional Chinese medicine. The protective potential of American ginseng (AG) for eccentric EIMD remains unclear. Read More

View Article and Full-Text PDF
December 2021

Nucleotide Sequence Variation in Long-Term Tissue Cultures of Chinese Ginseng ( C. A. Mey.).

Plants (Basel) 2021 Dec 27;11(1). Epub 2021 Dec 27.

Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.

Plants have the salient biological property of totipotency, i.e., the capacity to regenerate a whole plant from virtually any kind of fully differentiated somatic cells after a process of dedifferentiation. Read More

View Article and Full-Text PDF
December 2021

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (, , and ).

Plants (Basel) 2021 Dec 26;11(1). Epub 2021 Dec 26.

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.

Background: In the 1960s, research into plant adaptogens began. Plants with adaptogenic properties have rich phytochemical compositions and have been used by humanity since ancient times. However, it is not still clear whether the adaptogenic properties are because of specific compounds or because of the whole plant extracts. Read More

View Article and Full-Text PDF
December 2021

Steamed Panax notoginseng attenuates renal anemia in an adenine-induced mouse model of chronic kidney disease.

J Ethnopharmacol 2022 Jan 7:114941. Epub 2022 Jan 7.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Yunnan Key Laboratory of Panax notoginseng, Kunming University of Science and Technology, Kunming, 650500, China; Leiden University-European Center for Chinese Medicine and Natural Compounds, Institute of Biology Leiden, Leiden University, Leiden, 2333BE, the Netherlands. Electronic address:

Ethnopharmacological Relevance: Panax notoginseng (PN) (Burk.) F. H. Read More

View Article and Full-Text PDF
January 2022

Endothelial injury by circulating IgA1 complex through the activation of mesangial cells in IgA nephropathy.

Clin Nephrol 2022 Jan 10. Epub 2022 Jan 10.

Background: IgA nephropathy (IgAN) commonly entails arteriolar microangiopathic (MA) lesions of the kidneys. The most significant reason for MA lesions is endothelial injury, although the mechanism of injury to the vascular endothelium is not clear.

Materials And Methods: 59 patients with IgAN and 19 healthy controls were included for measuring the blood von Willebrand factor (vWF), soluble vascular cell adhesion molecule-1 (sVCAM1), and heparin-binding EGF-like growth factor (HB-EGF) by ELISA. Read More

View Article and Full-Text PDF
January 2022

Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice.

JOR Spine 2021 Dec 30;4(4):e1182. Epub 2021 Nov 30.

Department of Spine Surgery and Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Sun Yat-sen University First Affiliated Hospital Guangzhou China.

Although painkillers could alleviate some of the symptoms, there are no drugs that really cope with the intervertebral disc degeneration (IDD) at present, so it is urgent to find a cure that could prevent or reverse the progression of IDD. During the development of IDD, the cartilaginous end plates (EPs) become hypertrophic and porous by the increase of osteoclast activities, which hinder the penetration of nutrition. The compositional and structural degeneration of the EP may cause both nutritional as well as mechanical impairment to the nucleus pulposus (NP) so that developing drugs that target the degenerating EP may be another option in addition to targeting the NP. Read More

View Article and Full-Text PDF
December 2021

Lysozyme Improves the Inhibitory Effects of Saponins on Phenotype Transformation of Vascular Smooth Muscle Cells by Binding to Ginsenoside Re.

Front Nutr 2021 23;8:795888. Epub 2021 Dec 23.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China.

saponins (PNS) have been used to treat cardiovascular diseases for hundreds of years in China. Lysozyme can bind to exogenous compounds and promote their activity. Nevertheless, knowledge of whether there is a synergistic role between lysozyme and PNS is far from sufficient. Read More

View Article and Full-Text PDF
December 2021

Predicting the suitable habitats of parasitic desert species based on a niche model with and as examples.

Ecol Evol 2021 Dec 12;11(24):17817-17834. Epub 2021 Dec 12.

Beijing Key lab of Traditional Chinese Medicine Protection and Utilization Faculty of Geographical Science Beijing Normal University Beijing China.

, an excellent tree species for sand fixation and afforestation in the desert areas of western China, is threatened by climate change and anthropogenic activities. The suitable habitat of this species is shrinking at a remarkable rate, although conservation measures have been implemented. is an entirely parasitic herb that occurs in deserts, is a source of "desert ginseng" worldwide, and has extremely high medicinal value. Read More

View Article and Full-Text PDF
December 2021

Exploring the Mechanism of Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation.

Evid Based Complement Alternat Med 2021 30;2021:5730812. Epub 2021 Dec 30.

School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China.

Background: saponins (PNS) have been used for neurodegenerative disorders such as cerebral ischemia and Alzheimer's disease (AD). Although increasing evidences show the neuron protective effects of PNS, the vital compounds and their functional targets remain elusive. To explore the potential functional ingredients of PNS for the AD treatment and their molecular mechanisms, an neuron injured model induced by A was investigated, and the potential mechanism was predicted by network pharmacology approach and validated by molecular biology methods. Read More

View Article and Full-Text PDF
December 2021

Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells.

Stem Cells Int 2021 31;2021:4633270. Epub 2021 Dec 31.

Department of Reproductive Medicine Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Ginsenoside Rg1 (Rg1), a purified, active component of the root or stem of ginseng, exerts positive effects on mesenchymal stem cells (MSCs). Many recent studies have found that hematopoietic stem cells (HSCs), which can develop into hematopoietic progenitor cells (HPCs) and mature blood cells, are another class of heterogeneous adult stem cells that can be regulated by Rg1. Rg1 can affect HSC proliferation and migration, regulate HSC/HPC differentiation, and alleviate HSC aging, and these findings potentially provide new strategies to improve the HSC homing rate in HSC transplantation and for the treatment of graft-versus-host disease (GVHD) or other HSC/HPC dysplasia-induced diseases. Read More

View Article and Full-Text PDF
December 2021

Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants.

Front Pharmacol 2021 23;12:809994. Epub 2021 Dec 23.

Laboratorio de Etnofarmacología, Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Liver plays a pivotal role in maintaining blood glucose levels through complex processes which involve the disposal, storage, and endogenous production of this carbohydrate. Insulin is the hormone responsible for regulating hepatic glucose production and glucose storage as glycogen, thus abnormalities in its function lead to hyperglycemia in obese or diabetic patients because of higher production rates and lower capacity to store glucose. In this context, two different but complementary therapeutic approaches can be highlighted to avoid the hyperglycemia generated by the hepatic insulin resistance: 1) enhancing insulin function by inhibiting the protein tyrosine phosphatase 1B, one of the main enzymes that disrupt the insulin signal, and 2) direct regulation of key enzymes involved in hepatic glucose production and glycogen synthesis/breakdown. Read More

View Article and Full-Text PDF
December 2021

Strategies for Remodeling the Tumor Microenvironment Using Active Ingredients of Ginseng-A Promising Approach for Cancer Therapy.

Front Pharmacol 2021 22;12:797634. Epub 2021 Dec 22.

Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.

The tumor microenvironment (TME) plays a key role in promoting the initiation and progression of tumors, leading to chemoradiotherapy resistance and immunotherapy failure. Targeting of the TME is a novel anti-tumor therapeutic approach and is currently a focus of anti-tumor research. C. Read More

View Article and Full-Text PDF
December 2021

Saringosterol acetate isolated from Sargassum fusiformis induces mitochondrial-mediated apoptosis in MCF-7 breast cancer cells.

Chem Biodivers 2022 Jan 7. Epub 2022 Jan 7.

Jeju National University, Department of Marine Life Science, 102 Daehak-ro, Jeju, Jeju, KOREA, REPUBLIC OF.

Sargassum fusiformis is among the most important edible brown seaweeds in Eastern Asia that contains various bioactive compounds and strong activities. Saringosterol acetate (SA) was successfully isolated from S. fusiformis in our previous research. Read More

View Article and Full-Text PDF
January 2022

The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Inflammopharmacology 2022 Jan 8. Epub 2022 Jan 8.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases the levels of IL-6 and acute phase reactants such as C-reactive protein. Read More

View Article and Full-Text PDF
January 2022

Rhizosphere analysis of field-grown Panax ginseng with different degrees of red skin provides the basis for preventing red skin syndrome.

BMC Microbiol 2022 Jan 6;22(1):12. Epub 2022 Jan 6.

National& Local Joint Engineering Research Center for Ginseng Breeding and Development, Jilin Agricultural University, Changchun, China.

Background: Ginseng red skin root syndrome (GRS) is one of the most common ginseng (Panax ginseng Meyer) diseases. It leads to a severe decline in P. ginseng quality and seriously affects the P. Read More

View Article and Full-Text PDF
January 2022

Ginsenoside Rd Attenuates Tau Phosphorylation in Olfactory Bulb, Spinal Cord, and Telencephalon by Regulating Glycogen Synthase Kinase 3 and Cyclin-Dependent Kinase 5.

Evid Based Complement Alternat Med 2021 26;2021:4485957. Epub 2021 Dec 26.

Department of Neurology, Xinchang Hospital Affiliated to Wenzhou Medical University, 117 Gushan Middle Rd, Xinchang 312500, China.

Objective: Ginseng is a plant of the family Acanthopanaceae. It has been used for thousands of years in China. It is known as the king of hundred herbs. Read More

View Article and Full-Text PDF
December 2021

Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis.

Chin Med 2022 Jan 4;17(1). Epub 2022 Jan 4.

Changchun University of Chinese Medicine, Changchun, Jilin, China.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied with itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) consists of a mixture of extracts from five plants, which had been used in AD treatment due to good anti-inflammatory and anti-allergic effects.

Materials And Methods: In this study, high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometer (LC/MS) were performed to analyze the active ingredients of CTCMDO in detail and to establish its HPLC fingerprint. Read More

View Article and Full-Text PDF
January 2022

Comprehensive phytochemicals analysis and anti-myocardial ischemia activity of total saponins of American ginseng berry.

J Food Biochem 2022 Jan 3:e14042. Epub 2022 Jan 3.

School of Pharmaceutical Sciences, Jilin Uni, Changchun, China.

American ginseng berry (AGB) is a new medicinal source. Total saponins of American ginseng berry (TSAGB) are the main active ingredients. The effects and active saponins of TSAGB on myocardial ischemia (MI) rats were evaluated for the first time. Read More

View Article and Full-Text PDF
January 2022

The Effects of Ginsenosides on the Nrf2 Signaling Pathway.

Adv Exp Med Biol 2021 ;1328:307-322

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism. Conversely, the Nrf2 signaling pathway is impaired in several pathological conditions including cancer. Read More

View Article and Full-Text PDF
January 2022

Effect of Ginsenoside Rb2 on a Myocardial Cell Model of Coronary Heart Disease through Nrf2/HO-1 Signaling Pathway.

Biol Pharm Bull 2022 ;45(1):71-76

Department of Pediatrics, The 3rd Hospital of Changsha.

The ginsenoside Rbs are the primary active compounds of Panax ginseng and ginsenoside Rb2 is a renowned component among the Rbs. This study aimed to investigate the potential effects of ginsenoside Rb2 on coronary heart disease (CHD). H9c2 cells were exposed to HO to establish CHD model in vitro. Read More

View Article and Full-Text PDF
January 2022

Diversity and structure of the rhizosphere microbial communities of wild and cultivated ginseng.

BMC Microbiol 2022 Jan 3;22(1). Epub 2022 Jan 3.

Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, 130024, Changchun, China.

Background: The resources of wild ginseng have been reducing sharply, and it is mainly dependent on artificial cultivation in China, Korea and Japan. Based on cultivation modes, cultivated ginseng include understory wild ginseng (the seeds or seedlings of cultivated ginseng were planted under the theropencedrymion without human intervention) and farmland cultivated ginseng (grown in farmland with human intervention). Cultivated ginseng, can only be planted on the same plot of land consecutively for several years owing to soilborne diseases, which is mainly because of the variation in the soil microbial community. Read More

View Article and Full-Text PDF
January 2022

Genomic and Transcriptomic Analysis Provide Insights Into Root Rot Resistance in .

Front Plant Sci 2021 15;12:775019. Epub 2021 Dec 15.

Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

( (Burk.) F.H. Read More

View Article and Full-Text PDF
December 2021

Different Responses of Soil Environmental Factors, Soil Bacterial Community, and Root Performance to Reductive Soil Disinfestation and Soil Fumigant Chloropicrin.

Front Microbiol 2021 15;12:796191. Epub 2021 Dec 15.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.

Reductive soil disinfestation (RSD) and soil fumigant chloropicrin (SFC) are two common agricultural strategies for the elimination of soil-borne pathogens. However, the differences in soil environmental factors, soil bacterial microbiome, and root performance between SFC and RSD are poorly understood. In this study, three soil treatments, untreated control (CK), SFC with 0. Read More

View Article and Full-Text PDF
December 2021