6,135 results match your criteria gilbert's syndrome

Health literacy levels and correlates among refugees in Mount Lebanon.

Public Health 2021 Sep 14;199:25-31. Epub 2021 Sep 14.

Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.

Objectives: The study aimed to assess the levels and correlates of health literacy among refugees.

Study Design: This is a cross-sectional study design.

Methods: Health literacy was assessed through face-to-face interviews in eight primary healthcare centers (PHCs) in Mount Lebanon. Read More

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September 2021

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1.

Elife 2021 Sep 17;10. Epub 2021 Sep 17.

Walter Reed Army Institute of Research, Silver Spring, United States.

A gene signature previously correlated with mosaic adenovirus 26 vaccine protection in simian immunodeficiency virus (SIV) and SHIV challenge models in non-human primates (NHP). In this report we investigated presence of this signature as a correlate of reduced risk in human clinical trials and potential mechanisms of protection. The absence of this gene signature in the DNA/rAd5 human vaccine trial, which did not show efficacy, strengthens our hypothesis that this signature is only enriched in studies that demonstrated protection. Read More

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September 2021

RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection.

Virus Evol 2021 9;7(2):veab057. Epub 2021 Jul 9.

US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.

The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1's high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the effect of vaccination on the evolution of the virus post-breakthrough infection. Read More

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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.

ACS Med Chem Lett 2021 Sep 9;12(9):1389-1395. Epub 2021 Aug 9.

Cognition Therapeutics, 2403 Sidney Street, Suite 261, Pittsburgh, Pennsylvania 15203, United States.

An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented and reversed synaptotoxic effects of Aβ oligomers in neurons were discovered to bind to the sigma-2 receptor complex. Read More

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September 2021

Safety and efficacy of a single intra-articular injection of hyaluronic acid in osteoarthritis of the hip: a case series of 87 patients.

BMC Musculoskelet Disord 2021 Sep 16;22(1):797. Epub 2021 Sep 16.

Centre for Health and Exercise Sports Medicine, Faculty of Medicine, Dentistry and Health Science, University of Melbourne, Level 7, Alan Gilbert Building, 161 Barry Street, Parkville, Victoria, 3010, Australia.

Background: Osteoarthritis (OA) is the most prevalent form of joint disease and commonly affects the hip. Hip OA is associated with a high socioeconomic burden. Intra-articular hyaluronic acid (HA) injection may be of benefit but quality evidence for HA use in hip OA is lacking. Read More

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September 2021

Ultrasound in active surveillance for low-risk papillary thyroid cancer: imaging considerations in case selection and disease surveillance.

Insights Imaging 2021 Sep 16;12(1):130. Epub 2021 Sep 16.

Division of Endocrinology, Department of Medicine, University Health Network and University of Toronto, Toronto, ON, Canada.

Active surveillance (AS) of small, low-risk papillary thyroid cancers (PTCs) is increasingly studied in prospective observational studies. Ultrasound is the primary imaging modality for case selection. While researchers have put forward selection criteria for PTCs based on size, absence of suspicious lymph nodes and tumor location, there are limited reported data highlighting inherent ultrasound limitations and guidelines for case selection and follow-up. Read More

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September 2021

Prioritization of Molecular Targets for Antimalarial Drug Discovery.

ACS Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, DD1 5EH, United Kingdom.

There is a shift in antimalarial drug discovery from phenotypic screening toward target-based approaches, as more potential drug targets are being validated in species. Given the high attrition rate and high cost of drug discovery, it is important to select the targets most likely to deliver progressible drug candidates. In this paper, we describe the criteria that we consider important for selecting targets for antimalarial drug discovery. Read More

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September 2021

On the timing of interventions to preserve hospital capacity: lessons to be learned from the Belgian SARS-CoV-2 pandemic in 2020.

Arch Public Health 2021 Sep 13;79(1):164. Epub 2021 Sep 13.

Spatial Epidemiology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.

Using publicly available data on the number of new hospitalisations we use a newly developed statistical model to produce a phase portrait to monitor the epidemic allowing for assessing whether or not intervention measures are needed to keep hospital capacity under control. The phase portrait is called a cliquets' diagram, referring to the discrete alarm phases it points to. Using this cliquets' diagram we show that intervention measures were associated with an effective mitigation of a Summer resurgence but that too little too late was done to prevent a large autumn wave in Belgium. Read More

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September 2021

Changing Trends in Mortality Among Solid Organ Transplant Recipients Hospitalized for Covid-19 During the Course of the Pandemic.

Am J Transplant 2021 Sep 12. Epub 2021 Sep 12.

Transplant Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.

Mortality among patients hospitalized for Covid-19 has declined over the course of the pandemic. Mortality trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry of SOTR hospitalized for Covid-19, we compared 28-day mortality between early 2020 (3/1/20-6/19/20) and late 2020 (6/20/20-12/31/20). Read More

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September 2021

First Clinical Results of the Merit WRAPSODY™ Cell-Impermeable Endoprosthesis for Treatment of Access Circuit Stenosis in Haemodialysis Patients.

Cardiovasc Intervent Radiol 2021 Sep 12. Epub 2021 Sep 12.

General Hospital of Athens "G.Gennimatas", Athens, Greece.

Purpose: This prospective, observational first in human study evaluated the safety and effectiveness of WRAPSODY Cell-impermeable Endoprosthesis (Merit Medical Systems, Inc.) in the treatment of arteriovenous fistula and arteriovenous graft access circuit stenosis.

Materials And Methods: Investigators conducted a prospective analysis of 46 patients with access circuit stenosis from three centres. Read More

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September 2021

Effects of Cognitive Reserve on Cognition in Individuals With Central Nervous System Disease.

Cogn Behav Neurol 2021 Sep 10. Epub 2021 Sep 10.

Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland NIH Library/Office of Research Services, National Institutes of Health, Bethesda, Maryland.

Cognitive reserve (CR) has been proposed to account for functional outcome differences in brain pathology and its clinical manifestations. The purpose of our paper is to systematically review the effects of CR on cognitive outcomes in individuals with neurodegenerative and structural CNS diseases. We performed a systematic search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsychInfo using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

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September 2021

Self-rated mental health among sexual health service clients during the first months of the COVID-19 pandemic, British Columbia, Canada.

Prev Med 2021 Sep 8;153:106789. Epub 2021 Sep 8.

BC Centre for Disease Control, Canada; University of British Columbia, Canada. Electronic address:

We investigated self-reported mental health during the first three months of the COVID-19 pandemic (March-May 2020), using a survey of HIV-testing and sexual health service clients from British Columbia, Canada (N = 1198). Over half (55%) reported their mental health as poor at the beginning of the COVID-19 pandemic, more than double that of the general Canadian population in the same time frame (22%). Acknowledging that this burden of poor mental health that is likely to persist in the coming years, we propose that sexual health clinics should facilitate access to mental health supports as a low-barrier point of primary care contact. Read More

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September 2021

Estimation of Vaccine Efficacy for Variants that Emerge After the Placebo Group Is Vaccinated.

medRxiv 2021 Sep 2. Epub 2021 Sep 2.

SARS-CoV-2 continues to evolve and the vaccine efficacy against variants is challenging to estimate. It is now common in phase III vaccine trials to provide vaccine to those randomized to placebo once efficacy has been demonstrated, precluding a direct assessment of placebo controlled vaccine efficacy after placebo vaccination. In this work we extend methods developed for estimating vaccine efficacy post placebo vaccination to allow variant specific time varying vaccine efficacy, where time is measured since vaccination. Read More

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September 2021

Machine Learning Approach Identified Multi-Platform Factors for Caries Prediction in Child-Mother Dyads.

Front Cell Infect Microbiol 2021 19;11:727630. Epub 2021 Aug 19.

Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.

Untreated tooth decays affect nearly one third of the world and is the most prevalent disease burden among children. The disease progression of tooth decay is multifactorial and involves a prolonged decrease in pH, resulting in the demineralization of tooth surfaces. Bacterial species that are capable of fermenting carbohydrates contribute to the demineralization process by the production of organic acids. Read More

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Lethal giant basal cell carcinoma.

Med Sci Law 2021 Sep 3:258024211041792. Epub 2021 Sep 3.

Forensic Science SA, The University of Adelaide, Australia.

Basal cell carcinomas are the most common malignancy in Caucasian populations with a very low predisposition to metastatic disease and an excellent prognosis if appropriately treated. Given the rarity of a lethal outcome two cases are reported. : A 61-year-old reclusive man who had an untreated facial basal cell carcinoma for 10 years died of hypothermia and sepsis complicating the extensively ulcerated and infected tumour. Read More

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September 2021

Building an advocacy model to improve the dementia-capability of health plans in California.

J Am Geriatr Soc 2021 Sep 2. Epub 2021 Sep 2.

Alzheimer's Los Angeles, Los Angeles, California, USA.

Background: Given the high and growing prevalence of Alzheimer's disease and related dementias, and the intensity of this population's care needs, it is imperative that healthcare systems increase their capacity to effectively serve people living with dementia (PLwD). The Dementia Cal MediConnect (Dementia CMC) project proposes an advocacy model that may foster dementia-capable systems change.

Methods: The Dementia CMC project was a 5-year partnership (2013-2018) between local Alzheimer's organizations and 10 managed care health plans (HPs) in California's duals demonstration. Read More

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September 2021

Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults.

Sci Rep 2021 Sep 2;11(1):17575. Epub 2021 Sep 2.

Clinical Trial Service Unit and Epidemiological Studies, Nuffield Department of Population Health, University of Oxford, Big Data Institute, Old Road Campus, Oxford, OX 7LF, UK.

Absolute risks of stroke are typically estimated using measurements of cardiovascular disease risk factors recorded at a single visit. However, the comparative utility of single versus sequential risk factor measurements for stroke prediction is unclear. Risk factors were recorded on three separate visits on 13,753 individuals in the prospective China Kadoorie Biobank. Read More

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September 2021

Use of a Digital Chronic Obstructive Pulmonary Disease Respiratory Tracker in a Primary Care Setting: A Feasibility Study.

Pulm Ther 2021 Aug 31. Epub 2021 Aug 31.

AstraZeneca, Wilmington, DE, USA.

Introduction: Telemonitoring is a promising self-management strategy to improve health care outcomes. This study evaluated real-world adoption of the chronic obstructive pulmonary disease (COPD) Co-Pilot daily symptom monitoring tool by patients and primary care providers (PCPs).

Methods: An open-label, 6-month, single-arm, multicenter, noninterventional feasibility study enrolled 97 patients aged ≥ 40 years with symptomatic or poorly controlled COPD and ≥ 10 pack-year smoking history. Read More

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Differences in rituximab use between pediatric rheumatologists and nephrologists for the treatment of refractory lupus nephritis and renal flare in childhood-onset SLE.

Pediatr Rheumatol Online J 2021 Aug 30;19(1):137. Epub 2021 Aug 30.

Medical University of South Carolina, 135 Rutledge Ave, MSC 561, Charleston, SC, 29425, USA.

Background: Consensus treatment plans have been developed for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in childhood-onset systemic lupus erythematosus. However, patients who do not respond to initial therapy, or who develop renal flare after remission, warrant escalation of treatment. Our objective was to assess current practices of pediatric nephrologists and rheumatologists in North America in treatment of refractory proliferative LN and flare. Read More

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National Landscape of HIV+ Deceased Organ Donors in the United States.

Clin Infect Dis 2021 Aug 28. Epub 2021 Aug 28.

New York University Langone Transplant Institute, New York University Grossman School of Medicine, New York, NY, USA.

Background: Organ transplantation from donors with HIV to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV+ donors is critical for safety.

Methods: We performed a prospective study of donors with HIV-positive and HIV false-positive (FP) testing within the HOPE in Action studies of HIV D+/R+ transplantation (ClinicalTrials. Read More

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Historical Benchmarks for Quality Tolerance Limits Parameters in Clinical Trials.

Ther Innov Regul Sci 2021 Aug 27. Epub 2021 Aug 27.

Global Development Operations, Trial Management, Novartis Pharma S.A.S., 92506, Pueil-Malmaison Cedex, France.

Background: In 2016, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use updated its efficacy guideline for good clinical practice and introduced quality tolerance limits (QTLs) as a quality control in clinical trials. Previously, TransCelerate proposed a framework for QTL implementation and parameters. Historical data can be important in helping to determine QTL thresholds in new clinical trials. Read More

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Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK.

Br J Cancer 2021 Aug 27. Epub 2021 Aug 27.

PRIME Centre Wales, Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.

Background: Cancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation.

Methods: This is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Read More

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Occurrence of tick-borne pathogens in questing Ixodes ricinus ticks from Wester Ross, Northwest Scotland.

Parasit Vectors 2021 Aug 26;14(1):430. Epub 2021 Aug 26.

Institute of Terrestrial Ecosystems, Department of Environmental Systems Science, ETH Zürich, Universitätstrasse 16, 8092, Zürich, Switzerland.

Background: Lyme borreliosis and other tick-borne diseases emerge from increased interactions between humans, other animals, and infected ticks. The risk of acquiring a tick-borne infection varies across space and time, so knowledge of the occurrence and prevalence of pathogens in ticks can facilitate disease diagnosis in a specific area and the implementation of mitigation measures and awareness campaigns. Here we identify the occurrence and prevalence of several pathogens in Ixodes ricinus ticks in Wester Ross, Northwest Scotland, a region of high tourism and tick exposure, yet data-poor in terms of tick-borne pathogens. Read More

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Transcriptomic Profiling of Dromedary Camels Immunised with a MERS Vaccine Candidate.

Vet Sci 2021 Aug 3;8(8). Epub 2021 Aug 3.

Vaccine Development Unit, Department of Infectious Disease Research, King Abdullah International Medical Research Center (KAIMRC), Riyadh 11481, Saudi Arabia.

Middle East Respiratory Syndrome coronavirus (MERS-CoV) infects dromedary camels and zoonotically infects humans, causing a respiratory disease with severe pneumonia and death. With no approved antiviral or vaccine interventions for MERS, vaccines are being developed for camels to prevent virus transmission into humans. We have previously developed a chimpanzee adenoviral vector-based vaccine for MERS-CoV (ChAdOx1 MERS) and reported its strong humoral immunogenicity in dromedary camels. Read More

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Alopecias in humans: biology, pathomechanisms and emerging therapies.

Vet Dermatol 2021 Aug 25. Epub 2021 Aug 25.

Sinclair Dermatology, 2 Wellington Parade, East Melbourne, VIC, 3002, Australia.

Background: The hair follicle is a complete mini-organ with a complex biology. Recent discoveries have shed light on the pathogenesis and genetic basis of a number of hair loss conditions, offering novel treatment alternatives.

Objective: To explore the biology and physiology of hair growth, the pathomechanism behind alopecias and emerging therapies. Read More

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Evaluation of commercial SARS-CoV-2 serological assays in Canadian public health laboratories.

Diagn Microbiol Infect Dis 2021 Apr 24;101(3):115412. Epub 2021 Apr 24.

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

The COVID-19 pandemic has led to the influx of immunoassays for the detection of antibodies towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the global market. The Canadian Public Health Laboratory Network Serology Task Force undertook a nationwide evaluation of twelve laboratory and 6 point-of-care based commercial serological assays for the detection of SARS-CoV-2 antibodies. We determined that there was considerable variability in the performance of individual tests and that an orthogonal testing algorithm should be prioritized to maximize the accuracy and comparability of results across the country. Read More

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The IRAK4 kinase inhibitor PF-06650833 blocks inflammation in preclinical models of rheumatologic disease and in humans enrolled in a randomized clinical trial.

Arthritis Rheumatol 2021 Aug 23. Epub 2021 Aug 23.

Inflammation and Immunology Research Unit, Pfizer, Inc, 1 Portland St, Cambridge, MA, 02139, USA.

Objective: Use a highly potent and selective small molecule inhibitor of interleukin-1 associated kinase (IRAK) 4, PF-06650833, to demonstrate its role in autoimmune pathophysiology in vitro, in vivo and in the clinic.

Methods: Rheumatoid arthritis (RA) inflammatory pathophysiology was modeled in vitro through stimulation of primary human macrophages (MΦ) with anti-citrullinated protein antibody (ACPA) immune complexes (IC), RA fibroblast-like synoviocyte (-FLS) cultures stimulated with toll-like receptor (TLR) ligands, as well as additional human primary cell co-cultures. Systemic lupus erythematosus (SLE) pathophysiology was simulated in human neutrophils, dendritic cells (DC), B cells and PBMC stimulated with TLR ligands and SLE patient IC. Read More

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PSA: Declining utilization of prostate brachytherapy.

Brachytherapy 2021 Aug 19. Epub 2021 Aug 19.

Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX; Department of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ.

Purpose: To analyze rates of brachytherapy use for prostate cancer over time and evaluate patient characteristics, demographics and factors predictive for its utilization.

Methods: Data was retrospectively analyzed from the National Cancer Database (NCDB) for patients with localized prostate cancer treated between 2010 and 2015. Patients were included if they had biopsy confirmed localized adenocarcinoma of the prostate, were treated with radiation as definitive local therapy, and were at least 18 years old. Read More

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