48,461 results match your criteria giant cell

Radiological features of central giant cell granuloma: comparative study of 7 cases and literature review.

Dentomaxillofac Radiol 2021 Apr 21:20200429. Epub 2021 Apr 21.

Department Of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.

Objective: To review and analyze the clinical and imaging features of central giant cell granuloma patients and to review the relevant literatures for the diagnosis and clinical manifestation of central giant cell granuloma.

Methods: Seven cases of central giant cell granuloma were retrospectively selected for the study, all of which were confirmed by pathology and had relevant imaging investigations. All seven cases had undergone CT scan, three cases had undergone MRI scan. Read More

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Multiple Artery Aneurysms: Unusual Presentation of IgG4 Vasculopathy.

J Clin Imaging Sci 2021 26;11:17. Epub 2021 Mar 26.

Department of Computed Tomography and Magnetic Resonance Imaging, Sir Ganga Ram Hospita, New Delhi, India.

Immunoglobulin G4 (IgG4)-related disease is a chronic systemic disease. It is characterized by inflammatory fibrosis and high serum IgG4 levels. IgG4-positive plasma cells infiltrate target organs in this disease. Read More

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Assessment of Extra-Cortical Bone Bridge Interface in Cemented Mega Endoprosthesis for Limb Salvage Surgery.

Malays Orthop J 2021 Mar;15(1):93-99

Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Introduction: Mega endoprosthesis replacement for resection of primary malignant bone tumour requires immediate and long-term stability, particularly in the young and active patient. Extracortical bone bridge interface (EBBI) is a technique whereby autograft is wrapped around the interface junction of bone and porous-coated implant to induce and enhance bone formation for biological incorporation. This procedure increases the mean torsional stiffness and the mean maximum torque, which eventually improves the implant's long-term survival. Read More

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Efficacy and safety of steroid-sparing treatments in giant cell arteritis according to the glucocorticoids tapering regimen: A systematic review and meta-analysis.

Eur J Intern Med 2021 Apr 17. Epub 2021 Apr 17.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, UMR-S 1136, AP-HP.Sorbonne Université, Hôpital Pitié-Salpêtrière, Département de Santé Publique, Paris, France. Electronic address:

Objectives: To assess the efficacy and safety of adjuvant therapies in newly diagnosed or relapsing giant cell arteritis (GCA) in terms of relapse rate at week 52 (primary outcome) and to assess the impact of GC tapering regimen on adjuvant effectiveness.

Methods: For this systematic review and meta-analysis, we searched PubMed, EMBASE, CENTRAL, trial registries, from inception to November 2020. We included all randomized controlled trials (RCTs) and controlled prospective studies evaluating adjuvant treatments in GCA, without date or language restriction. Read More

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The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.

Diagn Pathol 2021 Apr 20;16(1):32. Epub 2021 Apr 20.

Emeritus Professor, Kyung Hee University, School of Medicine Vice President of Asia, International Academy of Pathology, U2Labs, Jangwon Medical Foundation 68 Geoma-ro, Songpa-gu, Seoul, 05755, South Korea.

Background: Solitary Fibrous Tumor (SFT) is a distinct soft tissue neoplasm associated with NAB2-STAT6 gene fusion. It can involve a number of anatomic sites and exhibits a wide spectrum of histological features.

Main Body: Apart from diversity in morphological features seen even in conventional SFT, two histologic variants (fat-forming and giant cell-rich) are also recognized. Read More

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Malignant Transformation of Giant Cell Tumor of Bone 7 years After Initial Surgery: A Case Report and Literature Review.

JBJS Case Connect 2021 04 20;11(2). Epub 2021 Apr 20.

Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Japan.

Case: A 64-year-old man with a history of giant cell tumor of bone (GCTB) in the fibula 7 years earlier developed a recurrence with histologic features of osteosarcoma. Both the primary GCTB and the secondary osteosarcoma were found to have the H3F3A gene mutation. Despite immediate above-the-knee amputation, the patient died of respiratory failure because of lung metastases 3 months later. Read More

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Cell differentiation and the cytoskeleton in Acetabularia.

Diedrik Menzel

New Phytol 1994 Nov;128(3):369-393

Max-Planck-Institut für Zellbiologie, Rosenhof, 68526 Ladenburg, Germany.

In multicellular organisms, differentiation of individual cells is typically linked to the development of the whole organism. As cells acquire tissue-specific morphologies and become functionally specialized they lose in turn a number of other functions. A free living, single celled organism, however, maintains all such functions. Read More

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November 1994

Cardiovascular events and the role of accelerated atherosclerosis in systemic vasculitis.

Atherosclerosis 2021 Mar 28;325:8-15. Epub 2021 Mar 28.

Division of Rheumatology, Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada. Electronic address:

The spectrum of inflammatory blood vessel diseases includes both atherosclerosis and the primary systemic vasculitides. Although the inciting triggers differ, significant overlap exists in the mechanisms that contribute to sustained inflammation and vascular damage in both entities. With improvement in therapeutics to control acute vasculitis leading to longer survival, cardiovascular morbidity and mortality has emerged as the leading cause of death for vasculitis patients. Read More

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Vasculitis therapy refines vasculitis mechanistic classification.

Autoimmun Rev 2021 Apr 16:102829. Epub 2021 Apr 16.

Department of Biomedicine, Aarhus University, Aarhus, Denmark; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Rheumatology, Silkeborg Regional Hospital, Silkeborg, Denmark. Electronic address:

The primary vasculitides constitute a heterogeneous group of immune mediated diseases of incompletely understood pathogenesis currently classified by the size of blood vessels affected (Chapel Hill classification). In recent years, several drugs with well-characterized immunological targets have been tested in clinical trials in large vessel vasculitis and small vessel vasculitis. Such trials provide "reverse translational" or bedside to bench information about underlying pathogenic mechanisms. Read More

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Extended single-dose toxicity study of [At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer.

Ann Nucl Med 2021 Apr 19. Epub 2021 Apr 19.

Institute for Radiation Sciences, Osaka University, Suita, Japan.

Objective: Astatine (At) is a promising alpha emitter as an alternative to iodine (I). We are preparing the first-in-human (FIH) clinical trial of targeted alpha therapy for differentiated thyroid cancer in consultation with Pharmaceuticals and Medical Devices Agency. Here, we performed an extended single-dose toxicity examination under a reliability standard, as a preclinical safety assessment of [At]NaAt to determine the FIH dose. Read More

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Evaluation of revised classification criteria for giant cell arteritis and its clinical phenotypes.

Rheumatology (Oxford) 2021 Apr 19. Epub 2021 Apr 19.

Rheumatology, Department of Clinical Sciences, Malmö,Lund University.

Background: Giant cell arteritis (GCA) is a systemic vasculitis of the elderly, viewed by many as a disease with multiple and overlapping clinical phenotypes. Retrospective studies have shown differences in clinical presentation between these phenotypes. To reflect the heterogeneity of GCA, and novel diagnostic methods, new classification criteria have been proposed. Read More

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Unusual Location of a Giant Cell Tumour.

Eur J Case Rep Intern Med 2021 1;8(3):002329. Epub 2021 Mar 1.

Hôpital 20 Août, Casablanca, Morocco.

Giant cell tumours (GCT) are rare aggressive non-cancerous tumours which usually affect the long bones. We describe a case of GCT of the first rib in a young woman without a relevant history. The patient presented a left cervico-thoracic mass which was biopsied in our department (CT-guided biopsy). Read More

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Peripheral Giant Cell Granuloma of Posterior Maxilla in a 9-Year Child.

J Coll Physicians Surg Pak 2021 Apr;30(4):475-477

Department of Oral and Maxillofacial Surgery, Khyber College of Dentistry, Peshawar, Pakistan.

Peripheral giant cell granuloma is a relatively uncommon benign reactive gingival lesion of the oral cavity. A 9-year boy presented with a painless, slow-growing, reddish-blue, soft tissue lesion on attached gingiva adjacent to maxillary right first and second premolars, which was interfering with eating. A periapical radiograph demonstrated focal alveolar bone loss and slight teeth displacement adjacent to the lesion. Read More

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Quantitative bone SPECT/CT applications for primary bone neoplasms.

Hell J Nucl Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 Japan.

Objective: To evaluate the clinical utility of quantitative values obtained with bone single photon emission computed tomography/computed tomography (SPECT/CT) for primary bone neoplasms.

Subjects And Methods: Bone SPECT/CT scans of 23 patients with 19 benign bone neoplasms (5 osteoid osteomas, 4 bone giant cell tumor, 4 osteofibrous dysplasia, 3 intraosseous ganglion, 2 aneurysmal bone cyst, 1 intraosseous hemangioma) and 5 malignant bone neoplasms (2 osteosarcoma, 1 periosteal osteosarcoma, 1 malignancy in bone giant cell tumor, 1 Ewing sarcoma) were retrospectively analyzed with maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), mean SUV (SUVmean), metabolic bone volume (MBV), and total bone uptake (TBU) of primary lesions.

Results: Mean SUVmax of 19 benign and 5 malignant primary bone neoplasms were 6. Read More

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Role of diffusion-weighted MRI in differentiating between benign and malignant bone lesions: a prospective study.

Clin Radiol 2021 Apr 14. Epub 2021 Apr 14.

Radio-diagnosis Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Aim: To evaluate the ability of diffusion-weighted magnetic resonance imaging (DW-MRI) to differentiate between benign and malignant bony tumours.

Materials And Methods: This prospective study was conducted from October, 2018 to December, 2019. The study included 62 patients (37 male and 25 female) with clinically suspected bony lesions referred to the Radiology Department. Read More

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Acute leg compartment syndrome after CT-guided core needle biopsy of a giant cell tumor of the proximal fibula.

Acta Orthop Belg 2020 Dec;86(4):624-627

Imaging-guided percutaneous core needle biopsy (CNB) is the preferred diagnostic method for bone and soft tissue tumors. In less than 1% of cases, complications are clinically significant and include mainly haema-toma and bleeding. We present a case of acute compartment syndrome (ACS) following CNB of the proximal fibula. Read More

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December 2020

Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane-Membrane Interfaces.

Biochemistry 2021 Apr 16. Epub 2021 Apr 16.

Department of Physics, Chemistry and Pharmacy (FKF), University of Southern Denmark (SDU), Campusvej 55, 5230 Odense M, Denmark.

Rapid membrane repair is required to ensure cell survival after rupture of the plasma membrane. The annexin family of proteins is involved in plasma membrane repair (PMR) and is activated by the influx of Ca from the extracellular medium at the site of injury. Annexins A1 and A2 (ANXA1 and ANXA2, respectively) are structurally similar and bind to negatively charged phosphatidylserine (PS) to induce membrane cross-linking and to promote fusion, which are both essential processes that occur during membrane repair. Read More

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Hemorrhagic Giant Cell Tumor of the Occipital Skull Base: A Case Report and Literature Review.

Cureus 2021 Mar 11;13(3):e13832. Epub 2021 Mar 11.

Department of Pediatric Surgery, Division of Pediatric Neurosurgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, USA.

Giant cell tumor of bone is a benign but locally aggressive osteolytic neoplasm that represents 3% to 5% of all primary bone tumors, primarily found at the epiphyses of long bones. Less than 1% are of calvarial origin. Herein, we report a rare case of a nine-year-old girl with a hemorrhagic giant cell tumor of the left occipital skull base. Read More

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Reconstitution of contractile actomyosin rings in vesicles.

Nat Commun 2021 04 15;12(1):2254. Epub 2021 Apr 15.

Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Martinsried, Germany.

One of the grand challenges of bottom-up synthetic biology is the development of minimal machineries for cell division. The mechanical transformation of large-scale compartments, such as Giant Unilamellar Vesicles (GUVs), requires the geometry-specific coordination of active elements, several orders of magnitude larger than the molecular scale. Of all cytoskeletal structures, large-scale actomyosin rings appear to be the most promising cellular elements to accomplish this task. Read More

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Towards better understanding of giant cell granulomas of the oral cavity.

J Clin Pathol 2021 Apr 15. Epub 2021 Apr 15.

Oral Pathology, University of Missouri Kansas City, Kansas City, Missouri, USA.

Giant cell granulomas are enigmatic lesions of the oral cavity characterised by a peculiar combined proliferation of mononuclear and multinucleated giant cells in a mesenchymal stromal background. Central and peripheral giant cell granulomas may have similar pathogenesis and histology but differ in their location and biological behaviour. It is important to differentiate them from other giant cell lesions that can occur in the oral cavity, such as giant cell tumour of the bone, aneurysmal bone cyst, brown tumour of hyperparathyroidism, and giant cell lesions of Ramon syndrome, Noonan syndrome, neurofibromatosis and Jaffe-Campanacci syndrome. Read More

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Aggressive progression of a facial super giant basal cell carcinoma.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA

Super giant basal cell carcinoma (BCC) is a rare oncological entity. A 52-year-old man with a history of a left upper facial lesion for 11 years was transferred to our facility seeking an evaluation. He frequented multiple hospitals where he was treated with antibiotics for this condition. Read More

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Placentation and embryo death in the plains viscacha (Lagostomus maximus).

Placenta 2021 Apr 1;108:97-102. Epub 2021 Apr 1.

Laboratory of Descriptive, Experimental and Comparative, Histology and Embryology, Argentina.

Caviomorpha are an exceptional group among rodents due to their extended gestational period and the delivery of precocial offspring. Among them, Lagostomus maximus is characterized by its polyovulation, polyembryony, and the highest embryonic death known in mammals. Its chorioallantoic placenta is hemomonochorial, an ancestral character among rodents. Read More

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Multiprofessional management of giant cell tumors in the cervical spine: a systematic review.

World Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

St. Barbara Hospital Hamm-Heesen, Department of Neurosurgery, Hamm, Germany.

Background: Giant cell tumors of the bone (GCTB) are rare bone tumors, especially in the cervical spine. Generally considered benign, local aggressiveness and metastatic growth have been described. Surgical concepts for GCTB are challenged by complex neurovascular anatomy. Read More

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Contribution of Janus-Kinase/Signal Transduction Activator of Transcription Pathway in the Pathogenesis of Vasculitis: A Possible Treatment Target in the Upcoming Future.

Front Pharmacol 2021 29;12:635663. Epub 2021 Mar 29.

Rheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Janus-kinase (JAK) and signal transduction activator of transcription (STAT) signal transduction pathway is involved in a wide range of physiological and pathological processes, including in the pathogenesis of several autoimmune diseases. Data supporting the role of JAK/STAT in the development of vasculitis are limited and mostly focused on large vessel vasculitis and Behçet's disease. In this review, we provide a thorough picture of currently available evidence on the topic, gathered from experiments, animal models and human real-life data, analyzing the rationale for the use of JAK inhibitors for the management of vasculitis. Read More

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Diamond formation from methane hydrate under the internal conditions of giant icy planets.

Sci Rep 2021 Apr 14;11(1):8165. Epub 2021 Apr 14.

Faculty of Geo-Environmental Science, Rissho University, Kumagaya, Saitama, 360-0194, Japan.

Hydrocarbon chemistry in the C-O-H system at high pressure and high temperature is important for modelling the internal structure and evolution of giant icy planets, such as Uranus and Neptune, as their interiors are thought to be mainly composed of water and methane. In particular, the formation of diamond from the simplest hydrocarbon, i.e. Read More

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Optical vector field rotation and switching with near-unity transmission by fully developed chiral photonic crystals.

Proc Natl Acad Sci U S A 2021 Apr;118(16)

Department of Electrical Engineering, School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA 16802

State-of-the-art nanostructured chiral photonic crystals (CPCs), metamaterials, and metasurfaces have shown giant optical rotatory power but are generally passive and beset with large optical losses and with inadequate performance due to limited size/interaction length and narrow operation bandwidth. In this work, we demonstrate by detailed theoretical modeling and experiments that a fully developed CPC, one for which the number of unit cells is high enough that it acquires the full potentials of an ideal ( → ∞) crystal, will overcome the aforementioned limitations, leading to a new generation of versatile high-performance polarization manipulation optics. Such high- CPCs are realized by field-assisted self-assembly of cholesteric liquid crystals to unprecedented thicknesses not possible with any other means. Read More

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Use of three-dimensional planning and guidance technology in surgical correction of central giant cell granuloma-induced facial deformity.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Department of Oral and Maxillofacial Surgery, North Manchester General Hospital, UK.

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Primer malignant giant cell tumour of kidney: a case report.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Sitki Kocman University, Mugla, Turkey.

Osteoclast-like giant cell tumours of the kidney are extremely rare and usually accompanied by a conventional urothelial neoplasm such as papillary, transitional renal cell, or sarcomatoid carcinoma. Although they have morphological features similar to those of the giant cell tumours in the skeletal system, their counterparts in the urinary system show highly malignant features. Our case is the third primer malignant giant cell tumour of the kidney in the literature. Read More

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mutant melanoma arising in a giant congenital melanocytic nevus in an infant.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):402-405

Department of Molecular Genetics, Tata Medical Center, Kolkata, West Bengal, India.

Pediatric melanomas are uncommon and sometimes arise in the background of giant congenital melanocytic nevus (GCMN). A 1-year-old girl was born with GCMN affecting her left half of the face and smaller nodules affecting trunk, hands, and feet. She developed an ulcerated lesion on the left temporoparietal scalp. Read More

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Prediction of the early recurrence in spinal giant cell tumor of bone using radiomics of preoperative CT: Long-term outcome of 62 consecutive patients.

J Bone Oncol 2021 Apr 16;27:100354. Epub 2021 Mar 16.

Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China.

Objectives: To determine if radiomics analysis based on preoperative computed tomography (CT) can predict early postoperative recurrence of giant cell tumor of bone (GCTB) in the spine.

Methods: In a retrospective review, 62 patients with pathologically confirmed spinal GCTB from March 2008 to February 2018, with a minimum follow-up of 24 months, were identified. The mean follow-up was 73. Read More

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