24,165 results match your criteria gestational diabetes


Metabolic Syndrome in Obesity: Treatment Success and Adverse Pregnancy Outcomes with Ovulation Induction in Polycystic Ovary Syndrome.

Am J Obstet Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center.

Objective: Obesity is common in women with polycystic ovary syndrome (PCOS). PCOS and obesity are associated with reduced fertility. Metabolic syndrome's (MetS) effect on infertility treatment success and pregnancy outcomes in women with PCOS undergoing ovulation induction (OI) has not been investigated. Read More

View Article and Full-Text PDF

Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus.

Exp Ther Med 2021 Jun 26;21(6):562. Epub 2021 Mar 26.

Department of Obstetrics and Gynecology, Qinghai Red-Cross Hospital, Xining, Qinghai 810000, P.R. China.

A previous study revealed that protein tyrosine phosphatase receptor type D (PTPRD) is highly associated with diabetes mellitus, particularly for type 2 diabetes, through a genome-wide association study. However, the influence of the human polymorphism in the 3'-untranslated region (3'-UTR) of PTPRD on gestational diabetes mellitus (GDM) has remained to be defined. The present study focused on the functional polymorphism located in the 3'-UTR of PTPRD and whether it is associated with the susceptibility to develop GDM. Read More

View Article and Full-Text PDF

Association of maternal body mass index with intellectual disability risk.

Arch Dis Child Fetal Neonatal Ed 2021 Apr 13. Epub 2021 Apr 13.

Department of Clinical Medicine-Department of Clinical Epidemiology, Aarhus Universitet, Aarhus, Midtjylland, Denmark.

Objectives: The study aimed to investigate the association between maternal body mass index (BMI) in early pregnancy and children's intellectual disability (ID) risk in the absence of chromosomal disorders, neurofibromatosis and tuberous sclerosis, taking adverse birth outcomes, maternal hypertension/diabetes and maternal socioeconomic status into consideration.

Methods: We conducted a cohort study of singletons without common genetic defects born in Sweden during 1992-2006, and followed them from birth until 31 December 2014 (n=1 186 836). Cox proportional hazards models were used to analyse the association between maternal BMI in early pregnancy and the risk of offspring's ID. Read More

View Article and Full-Text PDF

Screening for non-invasive risk factors of type 2 diabetes in overweight and obese schoolchildren.

Endocrinol Diabetes Nutr 2021 Apr 10. Epub 2021 Apr 10.

Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences. The Hashemite University, Zarqa, 13133, Jordan.

Introduction: The prevalence of type 2 diabetes mellitus (T2DM) is increasing among young people worldwide. The American Diabetes Association has defined the risk factors that are associated with this increased risk for developing T2DM in youths.

Objective: To explore school children at high-risk for T2DM in Jordan. Read More

View Article and Full-Text PDF

Childbirth and motherhood in women with motor disability due to a rare condition: an exploratory study.

Orphanet J Rare Dis 2021 Apr 13;16(1):176. Epub 2021 Apr 13.

Child Psychiatry, Hopital Pitié Salpêtrière APHP and Sorbonne Université, Paris, France.

Background: Rare diseases may result in motor impairment, which in turn may affect parenthood. Our purpose was to evaluate perinatal outcomes, parenting needs, mother-infant interactions and infant development in a set of volunteer women with motor impairment due to a rare disease. In a parenting support institution, we recruited a consecutive series of 22 volunteer pregnant women or young mothers, recorded perinatal outcomes, and followed mother-infant interaction and relationship and infant development up to 14 months postpartum. Read More

View Article and Full-Text PDF

The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial.

BMC Endocr Disord 2021 Apr 13;21(1):67. Epub 2021 Apr 13.

Department of Obstetrics and Gynecology, School of Medicine, Fertility Infertility and Perinatology Research Center, Imam Khomeini Hospital, Ahvaz, Iran.

Background: Gestational diabetes is the most common medical complication in pregnancy, and it has many side effects for the mother and the fetus. The aim of this study was to evaluate the effect of oat bran consumption on gestational diabetes.

Methods: This study is a randomized clinical trial that was performed on 112 women with gestational diabetes treated with diet. Read More

View Article and Full-Text PDF

Implementation of a first-trimester prognostic model to improve screening for gestational diabetes mellitus.

BMC Pregnancy Childbirth 2021 Apr 13;21(1):298. Epub 2021 Apr 13.

Department of Obstetrics and Gynaecology, University Medical Centre Utrecht, Utrecht University, Lundlaan 6, Utrecht, 3584 EA, the Netherlands.

Background: Improvement in the accuracy of identifying women who are at risk to develop gestational diabetes mellitus (GDM) is warranted, since timely diagnosis and treatment improves the outcomes of this common pregnancy disorder. Although prognostic models for GDM are externally validated and outperform current risk factor based selective approaches, there is little known about the impact of such models in day-to-day obstetric care.

Methods: A prognostic model was implemented as a directive clinical prediction rule, classifying women as low- or high-risk for GDM, with subsequent distinctive care pathways including selective midpregnancy testing for GDM in high-risk women in a prospective multicenter birth cohort comprising 1073 pregnant women without pre-existing diabetes and 60 obstetric healthcare professionals included in nine independent midwifery practices and three hospitals in the Netherlands (effectiveness-implementation hybrid type 2 study). Read More

View Article and Full-Text PDF

Research progress of metformin in gestational diabetes mellitus: a narrative review.

Ann Palliat Med 2021 Mar;10(3):3423-3437

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang, China.

Gestational diabetes mellitus (GDM) refers to abnormal glucose metabolism that occurs during pregnancy, where blood glucose does not reach the level of overt diabetes during pregnancy. Poor blood glucose control in GDM patients can pose a serious threat to pregnant women and their fetuses by giving rise to adverse pregnancy outcomes for mothers and infants. In 2015, the International Federation of Gynecology and Obstetrics (FIGO) recommended that insulin and metformin be used as the first-line medications for patients with GDM who did not reach the ideal blood glucose level following lifestyle interventions. Read More

View Article and Full-Text PDF

The risks of recurrent small for gestational age infants at term is dependent on the number of previous affected births.

Am J Obstet Gynecol 2021 Apr 10. Epub 2021 Apr 10.

Mater Research Institute-University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Mater Mothers' Hospital, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Faculty of Medicine, The University of Queensland, Australia,. Electronic address:

Background: Small-for-gestational age (SGA) infants are at significantly increased risk of perinatal complications, but the risk of recurrent SGA is not well known, particularly as there are many demographic and obstetric factors that interact and modify this risk. We investigated the relationship between previous SGA births and the risk of recurrence at term in a large Australian cohort.

Objective(s): We aimed to identify key demographic and obstetric variables that influence the risk of recurrence of an SGA infant at term. Read More

View Article and Full-Text PDF

Fetal Heart Rate Decelerations in Women with Sleep-Disordered Breathing.

Reprod Sci 2021 Apr 13. Epub 2021 Apr 13.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Emerging literature has shown that women with sleep-disordered breathing (SDB) have increased risk for gestational hypertension/preeclampsia and gestational diabetes. Case reports suggest an association between maternal apnea and fetal heart rate deceleration but data are lacking on how maternal sleep impacts fetal health. Since decelerations may be associated with adverse outcomes, we sought to determine whether fetal heart rate decelerations were associated with SDB. Read More

View Article and Full-Text PDF

The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women.

Sci Rep 2021 Apr 12;11(1):7993. Epub 2021 Apr 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, 100730, People's Republic of China.

Taurine is a sulfur-containing amino acid that plays an important role in glucose homeostasis. However, it remains unknown whether the plasma concentration of taurine affects the risk of later gestational diabetes mellitus (GDM) development. We recruited 398 singleton-pregnancy women and followed up them during the course of pregnancy. Read More

View Article and Full-Text PDF

Health service use and health system costs associated with diabetes during pregnancy in Australia.

Nutr Metab Cardiovasc Dis 2021 Feb 17. Epub 2021 Feb 17.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address:

Background And Aims: In the context of the rising rate of diabetes in pregnancy in Australia, this study aims to examine the health service and resource use associated with diabetes during pregnancy.

Methods And Results: This project utilised a linked administrative dataset containing health and cost data for all mothers who gave birth in Queensland, Australia between 2012 and 2015 (n = 186,789, plus their babies, n = 189,909). The association between maternal characteristics and diabetes status were compared with chi-square analyses. Read More

View Article and Full-Text PDF
February 2021

Risk factors for pregnancy morbidity in women with antiphospholipid syndrome.

J Reprod Immunol 2021 Mar 29;145:103315. Epub 2021 Mar 29.

Obstetrics and Gynecology Department, Peking University People's Hospital, Beijing, China. Electronic address:

Antiphospholipid syndrome (APS) increases the risk of obstetric complications, but risk factors for pregnancy morbidity in women with APS remain incompletely characterized. This retrospective study included pregnant women with APS and a control group without APS admitted to Peking University People's Hospital between January 2013 and September 2019. Clinical data were extracted from medical records. Read More

View Article and Full-Text PDF

Barriers to a healthy postpartum lifestyle and the possibilities of an information technology-based intervention: A qualitative study.

Midwifery 2021 Apr 3;98:102994. Epub 2021 Apr 3.

Centre for Innovative Medical Technology, Odense University Hospital, Odense, Denmark; Department of Endocrinology, Odense University Hospital, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. Electronic address:

Background: Being overweight or obese is associated with higher risk of adverse maternal and fetal outcomes, including gestational diabetes and childhood obesity. Many women exceed the gestational weight gain recommendations. Thus, it is important to focus on the women's lifestyle between their pregnancies to lower the risk of weight retention before the next pregnancy as well as in a life course perspective. Read More

View Article and Full-Text PDF

Air pollution exposure and risk of adverse obstetric and neonatal outcomes among women with type 1 diabetes.

Environ Res 2021 Apr 9:111152. Epub 2021 Apr 9.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Bethesda, MD 20892, USA; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, 401 Kimball Tower, Buffalo, NY 14214, USA.

Aims/hypothesis: Women with type 1 diabetes have increased risk for poor obstetric outcomes. Prenatal air pollution exposure is also associated with adverse outcomes for women and infants. We examined whether women with type 1 diabetes are more vulnerable than other women to pollution-associated risks during pregnancy. Read More

View Article and Full-Text PDF

Obstructive sleep apnea syndrome is associated with maternal complications in pregnant women.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Bursa Yüksek İhtisas Training and Researh Hospital, Turkey.

Objectives: This study was performed to evaluate the relationship between obstructive sleep apnea syndrome and pregnancy complications.

Material And Methods: A total of 500 women (18-45 years) who had delivered (vaginal delivery or caesarean section) between January 2017 and March 2017 in our clinic were included in the study. Patients at high risk for obstructive sleep apnea syndrome were identified using the Stop Bang questionnaire. Read More

View Article and Full-Text PDF

Exercise and outcomes in macrosomic pregnancies.

J Matern Fetal Neonatal Med 2021 Apr 11:1-5. Epub 2021 Apr 11.

Department of Obstetrics and Gynecology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Objective: Pregnancy is generally known to be a period when physical activity is partially or totally restricted to avoid negative outcomes such as miscarriage or premature birth. The aim of this study was to evaluate the effect on maternal and fetal outcomes of exercise in pregnancies complicated by macrosomia.

Material And Method: In this retrospective study, the data were retrospectively screened of women who gave birth at ≥38 weeks with infant birthweight of ≥4000 gr. Read More

View Article and Full-Text PDF

Pregnancy outcome in women with prior placenta accreta spectrum disorders treated with conservative-reconstructive surgery: analysis of 202 cases.

J Matern Fetal Neonatal Med 2021 Apr 11:1-5. Epub 2021 Apr 11.

CYMSA Clínica y Maternidad Suizo Argentina, Buenos Aires, Argentina.

Aim: To report the outcome of pregnant women with a prior pregnancy complicated by placenta accreta spectrum (PAS) disorders treated with resective-conservative surgery at the time of cesarean section.

Materials And Methods: Retrospective analysis of pregnant women treated with conservative surgery in the prior pregnancy complicated by PAS disorders. The primary outcome was spontaneous preterm birth with intact membranes or following a preterm labor rupture of the membranes before 37 weeks of gestation. Read More

View Article and Full-Text PDF

Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.

J Zhejiang Univ Sci B 2020 Dec.;21(12):990-998

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a molecular chaperone involved in the multimerization of adiponectin. Recent studies have found that DsbA-L is related to metabolic diseases including gestational diabetes mellitus (GDM), and can be regulated by peroxisome proliferator-activated receptor γ (PPARγ) agonists; the specific mechanism, however, is uncertain. Furthermore, the relationship between DsbA-L and the novel adipokine chemerin is also unclear. Read More

View Article and Full-Text PDF

Screening of postpartum diabetes in women with gestational diabetes: high-risk subgroups and areas for improvements-the STRONG observational study.

Acta Diabetol 2021 Apr 12. Epub 2021 Apr 12.

AMD-SID Diabetes and Pregnancy Study Group, Rome, Italy.

Aims: To assess the proportion of women with gestational diabetes (GDM) by performing postpartum Oral Glucose Tolerance Test (OGTT) and to identify GDM phenotypes at high-risk of postpartum dysglycemia (PPD).

Methods: Observational, retrospective, multicenter study involving consecutive GDM women. Recursive partitioning (RECPAM) analysis was used to identify distinct and homogeneous subgroups of women at different PPD risk. Read More

View Article and Full-Text PDF

Pregnancy outcomes in women with a hemoglobinopathy trait: a multicenter, retrospective study.

Arch Gynecol Obstet 2021 Apr 11. Epub 2021 Apr 11.

Department of Obstetrics and Antenatal Care, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.

Purpose: To determine the risk of adverse maternal and neonatal outcomes in pregnant women with a hemoglobinopathy trait.

Materials And Methods: Retrospective cohort study was conducted to compare adverse maternal and neonatal outcomes between pregnant women with a hemoglobinopathy trait (study group; n = 172), and without a hemoglobinopathy trait (control group; n = 360). The medical data were extracted from clinical records of pregnant women attending antenatal care and delivering at the University Hospital Basel or University Hospital Zurich between 2015 and 2018. Read More

View Article and Full-Text PDF

Association between maternal folate status and gestational diabetes mellitus.

Food Sci Nutr 2021 Apr 17;9(4):2042-2052. Epub 2021 Feb 17.

Department of Metabolism and Endocrinology Metabolic Syndrome Research Center Key Laboratory of Diabetes Immunology Ministry of Education National Clinical Research Center for Metabolic Diseases The Second Xiangya Hospital of Central South University Changsha China.

Studies on the association between maternal folate status and gestational diabetes mellitus (GDM) have yielded inconsistent results. This meta-analysis was performed to determine whether there may exist some association between maternal folate status and GDM. Unrestricted searches of PubMed, Web of Science, Cochrane, and Embase were conducted. Read More

View Article and Full-Text PDF

Specific amino acids but not total protein attenuate postpartum weight gain among Hispanic women from Southern California.

Food Sci Nutr 2021 Apr 13;9(4):1842-1850. Epub 2021 Feb 13.

Department of Pediatrics The Saban Research Institute Children's Hospital Los Angeles University of Southern California Los Angeles CA USA.

There is a high prevalence of obesity and type 2 diabetes in the United States, particularly among Hispanic women, which may be partly explained by failure to lose gestational weight during the postpartum period. Previous work indicates that protein and amino acids may protect against weight gain; therefore, this study examined the impact of dietary protein and amino acid intake on changes in postpartum weight and the percent of women meeting the Estimated Average Requirement (EAR) for these dietary variables among Hispanic women from the Southern California Mother's Milk Study ( = 99). Multivariable linear regression analysis was used to examine the associations between protein and amino acid intake with change in weight after adjusting for maternal age, height, and energy intake. Read More

View Article and Full-Text PDF

The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2021 26;12:640004. Epub 2021 Mar 26.

Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.

Objectives: It is uncertain whether the treatment of mild gestational diabetes mellitus (GDM) improves pregnancy outcomes. The aim of this systemic review and meta-analysis was to investigate the effect of mild GDM treatment on adverse pregnancy outcomes.

Methods: A comprehensive literature search was conducted on the databases of PubMed, Scopus, and Google Scholar to retrieve studies that compared interventions for the treatment of mild GDM with usual antenatal care. Read More

View Article and Full-Text PDF

Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland.

Food Nutr Res 2021 23;65. Epub 2021 Mar 23.

Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland.

Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland.

Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Read More

View Article and Full-Text PDF

[Risk factors for endotracheal intubation during resuscitation in the delivery room among very preterm infants].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):369-374

Department of Neonatology, Health Center for Children and Women, Chongqing 401147, China.

Objective: To explore the risk factors for endotracheal intubation during resuscitation in the delivery room among very preterm infants.

Methods: A retrospective analysis was performed for 455 very preterm infants who were admitted to the neonatal intensive care unit from January 2017 to December 2019. They were divided into an intubation group (=79) and a non-intubation group (=376) according to whether endotracheal intubation was performed during resuscitation. Read More

View Article and Full-Text PDF

Maternal medicine in the COVID era.

Best Pract Res Clin Obstet Gynaecol 2021 Mar 18. Epub 2021 Mar 18.

WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, UK. Electronic address:

The coronavirus disease-19 (COVID-19) pandemic has directly and indirectly impacted pregnant women with co-morbidities or antenatal medical complications, through vulnerability to the severe effects of COVID-19 and service reconfiguration. Women with diabetes or hypertension in pregnancy are at higher risk of admission to intensive care, need for invasive ventilation and death from COVID-19. Suggested service modifications specific to maternal medicine services include home measurement of blood glucose or blood pressure, the use of risk calculators, adaptations to screening criteria for gestational diabetes and monitoring of obstetric cholestasis. Read More

View Article and Full-Text PDF

Diabetes in Pregnancy 100 Years after the Discovery of Insulin: Hot Topics and Open Questions to be Addressed in the Coming Years.

Authors:
Ravi Retnakaran

Metabolism 2021 Apr 7:154772. Epub 2021 Apr 7.

Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada; Division of Endocrinology, University of Toronto, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Electronic address:

By making it possible for women with diabetes to achieve their family planning goals, the discovery of insulin ushered in the field of diabetes in pregnancy. The ensuing century has witnessed tremendous advances, with clinical focus on preconception planning and maternal glycemic control making successful pregnancy an achievable goal. Currently, the global epidemic of overweight/obesity has led to maternal hyperglycemia now affecting one in every six pregnancies worldwide, prompting intense research interest. Read More

View Article and Full-Text PDF

Circadian rhythm and gestational diabetes: working conditions, sleeping habits and lifestyle influence insulin dependency during pregnancy.

Acta Diabetol 2021 Apr 10. Epub 2021 Apr 10.

Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.

Objective: Management of gestational diabetes (GDM) is currently changing toward a more personalized approach. There  is a growing number of GDM patients requiring only a single dose of basal insulin at night to achieve glucose control. Well-known risk factors like obesity, parity and family history have been associated with GDM treatment requirements. Read More

View Article and Full-Text PDF

Risk of Recurrent Stillbirth: A Cohort Study.

BJOG 2021 Apr 9. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology Foothills Medical Center, Alberta Health Services, Canada.

Objectives: To evaluate the recurrence risk of stillbirth.

Design: Retrospective cohort study.

Setting And Population: All births 1992-2017, Alberta, Canada METHODS: Retrospective cohort study. Read More

View Article and Full-Text PDF