Search Our Scientific Publications & Authors

JAMA Netw Open 2022 May 2;5(5):e2214273. Epub 2022 May 2.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Importance: There is conflicting evidence on the association between intrapartum epidural analgesia and risk of autism spectrum disorder (ASD) in offspring.

Objective: To evaluate the association between intrapartum epidural analgesia and the risk of ASD in offspring.

Design, Setting, And Participants: This population-based cohort study was conducted in Ontario, Canada, using the health and administrative records of singleton live births by vaginal delivery between April 1, 2006, and March 31, 2014. Read More

J Ultrasound 2022 May 26. Epub 2022 May 26.

Department of Neonatology, Bharati Vidyapeeth University Medical College, Hospital and Research Center, Pune, Maharashtra, India.

Purpose: SGA infants with fetal growth restriction have reduced ability to adapt themselves to the postnatal life because of certain epigenetic changes in cardiac function. The aim of the present study is to assess and compare the cardiac functions of fetal growth restricted SGA newborns to the term stable AGA newborns, and evaluate any differences in the cardiac functions during the postnatal transitional circulation.

Method: This observational study was conducted at a multispecialty tertiary care hospital in Western India from June to November 2021. Read More

Pediatr Int 2022 Feb 1;64(1):e15155. Epub 2022 Feb 1.

Department of Neonatology, Gaziantep University Medical Faculty, Gaziantep, Turkey.

Background: This study aimed to evaluate the indications, complications, and outcomes of peritoneal dialysis (PD) in term neonates from a state hospital.

Methods: The demographic, clinical, and laboratory data of 67 newborn term infants who underwent PD within the first 4 weeks of life between June 2014 and June 2019 were retrospectively analyzed.

Results: Twenty-five patients (37. Read More

Pediatrics 2022 May 26. Epub 2022 May 26.

Université Paris Cité, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, F-75004 Paris, France.

Background And Objectives: Children born extremely preterm (EPT), <28 weeks' gestational age, face higher risks of movement difficulties than their term-born peers. Studies report varying prevalence estimates and prognostic factors identifying children who could benefit from early intervention are inconsistent. This study investigated the prevalence of movement difficulties in children born EPT and associated risk factors. Read More

Acta Paediatr 2022 May 26. Epub 2022 May 26.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Aim: To investigate the associations between sodium supply, fluid volume, sodium imbalances, and severe intraventricular haemorrhage (IVH) in extremely preterm infants.

Methods: We used data from the EXtremely PREterm infants in Sweden Study (EXPRESS) cohort consisting of all infants born at 22 to 26 gestational weeks during 2004 to 2007 and conducted a nested case-control study. For every infant with severe IVH (grade 3 or peri-ventricular haemorrhagic infarction) one IVH-free control infant with the birthday closest to the case infant and matched for hospital, sex, gestational age, and birth weight was selected (n = 70 case-control pairs). Read More

J Nepal Health Res Counc 2022 Mar 13;19(4):767-771. Epub 2022 Mar 13.

Patan Academy of Health Sciences, School of Nursing and Midwifery, (Lalitpur Nursing Campus), Lalitpur.

Background: Low birth weight is the most serious challenge for infant survival, healthy growth and development. It is the major determinant of the infant morbidity, mortality and disability in childhood. Different maternal and newborn factors contribute to Low birth weight. Read More

Front Physiol 2022 9;13:874684. Epub 2022 May 9.

Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.

Changes in the maternal autonomic nervous system are essential in facilitating the physiological changes that pregnancy necessitates. Insufficient autonomic adaptation is linked to complications such as hypertensive diseases of pregnancy. Consequently, tracking autonomic modulation during progressing pregnancy could allow for the early detection of emerging deteriorations in maternal health. Read More

J Pak Med Assoc 2022 Apr;72(4):658-663

Pakistan Health Research Council, Islamabad, Pakistan.

Objective: To investigate the maternal and peri-natal outcomes of dengue infection and frequency of dengue immunoglobulin G positivity in pregnant women along with pregnancy outcomes.

Method: The observational two-phase study was conducted from 2012 to 2015 in Lahore, Pakistan. In phase 1, pregnant women who had acute dengue fever were prospectively and retrospectively enrolled from 4 tertiary care hospitals. Read More

Reprod Biomed Online 2022 Mar 4. Epub 2022 Mar 4.

Department of Reproductive Medicine, Instituto Bernabeu, Alicante, Spain.

Research Question: Is embryo cryopreservation a cause of high birth weight and large for gestational age (LGA) in singletons resulting from vitrified-warmed embryo transfer?

Design: Retrospective cohort study evaluating 670 oocyte recipients who underwent fresh (367 cycles) or vitrified-warmed embryo transfer (303 cycles) at Instituto Bernabeu between July 2017 and March 2019. All single blastocyst transfers carried out in an artificial cycle that resulted in a singleton live birth were included.

Results: Maternal age (42. Read More

Am J Perinatol 2022 May 25. Epub 2022 May 25.

Department of Pediatrics, Ohta General Hospital Foundation Ohta Nishinouchi Hospital, Koriyama City, Fukushima, Japan.

Introduction:  Early-onset hyperbilirubinemia (EOH) is a clinical issue for premature infants. We predicted that EOH management would be improved by fast results from common laboratory tests. Total serum bilirubin (TSB) level and the albumin/globulin ratio may contribute to improving the management of EOH. Read More

BMJ Open 2022 May 25;12(5):e060868. Epub 2022 May 25.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China

Purpose: The Taicang and Wuqiang cohort study (TAWS) was established to examine the association between early-life nutrition and children's health, and to explore the potential roles of maternal health, metabolites and microbiota in children's health in two different regions of China.

Participants: A total of 7041 mother-child pairs were recruited during early pregnancy (n=4035, 57.3%) or delivery phase (n=3006, 42. Read More

BMJ 2022 May 25;377:e067946. Epub 2022 May 25.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China

Objective: To investigate the association between gestational diabetes mellitus and adverse outcomes of pregnancy after adjustment for at least minimal confounding factors.

Design: Systematic review and meta-analysis.

Data Sources: Web of Science, PubMed, Medline, and Cochrane Database of Systematic Reviews, from 1 January 1990 to 1 November 2021. Read More

Breastfeed Med 2022 May 25. Epub 2022 May 25.

Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

The etiology of necrotizing enterocolitis (NEC) is controversially discussed. One of the most recently proposed causes of NEC is an allergy to cow's milk protein. This study was designed to evaluate the effect of a maternal diet without bovine protein on the incidence of any NEC in very low birth weight (VLBW) infants. Read More

Rev Paul Pediatr 2022 6;40:e2021177. Epub 2022 May 6.

Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective: To identify the dietary patterns and associated factors of children aged between 6 and 23 months, born prematurely and assisted at a University Hospital in Curitiba, state of Paraná, Brazil.

Methods: The parents or guardians of the 135 children were asked about their children's eating habits and the family's socioeconomic and demographic conditions. Information regarding birth and health history were obtained from medical records. Read More

Int J Epidemiol 2022 May 25. Epub 2022 May 25.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Severe iodine deficiency adversely affects neurodevelopment; however, evidence regarding the association of non-severe deficiency and child cognitive functioning is inconclusive.

Methods: This prospective mother-child cohort study was nested in a population-based nutritional supplementation trial in Bangladesh (Maternal and Infant Nutrition Interventions in Matlab [MINIMat]). Participants with data on cognitive abilities at 5 and 10 years of age (n = 1530) and at least one measurement of urinary iodine concentration (UIC) (gestational week 8, 5, and 10 years) were selected. Read More

Int J Epidemiol 2022 May 25. Epub 2022 May 25.

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.

Background: Earlier onset of breast development (thelarche) is associated with increased breast cancer risk. Identifying modifiable factors associated with earlier thelarche may provide an opportunity for breast cancer risk reduction starting early in life, which could especially benefit girls with a greater absolute risk of breast cancer due to family history.

Methods: We assessed associations of maternal pre-pregnancy body mass index (BMI), physical activity during pregnancy, gestational weight gain and daughters' weight and length at birth with age at thelarche using longitudinal Weibull models in 1031 girls in the Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study-a prospective cohort of girls, half of whom have a breast cancer family history (BCFH). Read More

Int J Colorectal Dis 2022 May 25. Epub 2022 May 25.

Division of Gastroenterology & Hepatology, School of Medicine at Columbia, University of Missouri, Columbia, MO, USA.

Background And Aims: The incidence of inflammatory bowel disease (IBD) among women is highest during their reproductive years and current estimates suggest that the rate of conception is low in female IBD patients. The aim of our study was to assess the burden of adverse maternal and perinatal outcomes among female IBD patients.

Methods: Using the national inpatient sample database from 2016 to 2018, we recruited all female patients above the age of 15 years admitted with a primary diagnosis of pregnancy and a secondary diagnosis of IBD. Read More

Clin Ter 2022 May;173(3):265-273

Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

Background: Twin-twin transfusion syndrome (TTTS) is a severe prenatal complication of monochorionic diamniotic twins (MCDA). If left untreated, TTTS is associated with a high risk of neonatal death and neurological complications. Various treatment methods for TTTS have been proposed, but fetoscopic laser surgery (FLS) is currently the primary treatment for TTTS in global fetal medicine centers. Read More

Cardiol Young 2022 May 25:1-6. Epub 2022 May 25.

Department of Pediatric Cardiology, Dr. Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Objective: Patent ductus arteriosus is an important cause of morbidity and mortality, especially in very low birth weight infants. The aim of the study is to report our single-centre short-term results of preterm patients who underwent ligation through left anterior mini-thoracotomy .

Methods: Data of 27 preterm infants operated by the same surgeon who underwent Patent ductus arteriosus (PDA) closure with left anterior mini-thoracotomy technique between November 2020 and January 2022 at a single institution were reviewed. Read More

BJOG 2022 May 24. Epub 2022 May 24.

Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: Test the hypothesis potential missed opportunities for antenatal corticosteroids increase as gestational age decreases and are associated with adverse outcomes.

Design: Observational cohort study.

Setting: 24 US centers in the Neonatal Research Network. Read More

Turk J Pediatr 2022 ;64(2):239-245

Departments of Pediatric Endocrinology, İzmir Katip Çelebi University Faculty of Medicine, İzmir.

Background: Current studies claim that peptides such as leptin, adiponectin, ghrelin, and nesfatin-1 found in breast milk may be responsible for the growth of infants. Therefore, we aimed to determine the association between breast milk total ghrelin and nesfatin-1 levels and anthropometric measurements of infants who were small for gestational age (SGA).

Methods: 20 SGA and 20 appropriate for gestational age (AGA) infants were enrolled in the study. Read More

Turk J Pediatr 2022 ;64(2):221-227

Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Background: To determine the applicability of current international and national retinopathy of prematurity (ROP) screening guidelines and to identify a suitable community-based screening criterion.

Methods: A retrospective study on premature neonates (≤37 weeks gestation) referred to a tertiary eye hospital ROP clinic in the north of Iran was conducted over a 10-year period. Neonates were classified as no ROP, with ROP and type 1 ROP. Read More

Pediatr Gastroenterol Hepatol Nutr 2022 May 9;25(3):276-282. Epub 2022 May 9.

Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand.

Purpose: Infantile colic, a common functional gastrointestinal condition, causes distress and frustration in families. Its prevalence and incidence vary from community to community. The purpose of our study was to demonstrate the incidence of and factors associated with infantile colic in Thai infants. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;57(5):607-611

Department of Otorhinolaryngology, Shenzhen Children's Hospital, Shenzhen 518038, China.

To explore the characteristics of neonatal adenoid development and to study the relationship between neonatal adenoid development and disease. A retrospective analysis of neonates who received an electronic rhinopharyngolaryngoscope at Shenzhen Children's Hospital from January 2019 to December 2020 was conducted to track the children's medical history and to analyze the adenoid development status. All 131 neonates successfully completed the electronic laryngoscopy. Read More

BMC Pregnancy Childbirth 2022 May 24;22(1):433. Epub 2022 May 24.

Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.

Background: Physiologic changes during pregnancy affect the development of postpartum cerebrovascular disease (CVD) in women with Moyamoya disease. Due to the rare prevalence of Moyamoya disease and its large regional variations, large-scale based studies on the risk of CVD after delivery have not been conducted. This study aimed to evaluate whether women with Moyamoya disease have an increased risk of CVD after delivery. Read More

Environ Res 2022 May 21:113503. Epub 2022 May 21.

German Center for Diabetes Research (DZD), Munich, Germany; Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, Munich, Germany; Forschergruppe Diabetes, Chair of Diabetes and Gestational Diabetes, Faculty of Medicine, Technical University Munich at Klinikum Rechts der Isar, Munich, Germany.

Objective: Incidence of early-onset type 1 diabetes (T1D) has been increasing worldwide. Only few studies examined the relationship between geographical environmental variation and T1D incidence or its presymptomatic stage of islet autoimmunity. Our study aimed to investigate the effect of long-term environmental exposures during pregnancy and early life on childhood islet autoimmunity. Read More

Am J Obstet Gynecol 2022 May 21. Epub 2022 May 21.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.

Background: Fetuses with congenital heart disease are at increased risk of perinatal morbidity and mortality, which is highly influenced by their prenatal health. Placental function is vital for the health of the fetus but increased rates of pathologic lesions of the placenta have been observed in pregnancies complicated by fetal congenital heart disease.

Objective: To determine the prevalence of both gross and histologic placental pathologies in a cohort of pregnancies complicated by congenital heart disease compared to healthy Controls using the Amsterdam Placental Workshop Group Consensus Statement sampling and definitions of placental lesions. Read More

Am J Obstet Gynecol 2022 May 21. Epub 2022 May 21.

Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia; Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria Australia.

Background: Congenital cytomegalovirus (cCMV) is the most common perinatal infection and a significant cause of sensorineural hearing loss, cerebral palsy and neurodevelopmental disability. There is a paucity of human gene expression studies examining the pathophysiology of CMV infection.

Objectives: The aim of this study was to perform a whole transcriptomic assessment of amniotic fluid from pregnancies with live fetuses to identify differentially-expressed genes and enriched Gene Ontology categories associated with cCMV infection. Read More

PLoS Biol 2022 May 24;20(5):e3001506. Epub 2022 May 24.

Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.

The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7. Read More

PLoS One 2022 24;17(5):e0268949. Epub 2022 May 24.

"Grupo de investigación César Uribe Piedrahíta", Faculty of Medicine, University of Antioquia, Medellín, Colombia.

Knowledge about placental malaria (PM) is insufficient in the world, and incipient in Colombia where studies are few and recent. In this country, PM has been reported by Plasmodium vivax, Plasmodium falciparum, and mixed infection. The objective was to determine the frequency of PM and its associated clinical-epidemiological factors in mothers and neonates in northwestern Colombia, 2009-2020. Read More