6,514 results match your criteria geriatric syndromes

Recent advances in Lynch syndrome.

Exp Hematol Oncol 2021 Jun 12;10(1):37. Epub 2021 Jun 12.

Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.

Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal cancer (CRC), endometrial cancer, ovarian cancer, stomach cancer and many other cancers. Lynch syndrome is caused by pathogenic germline variants in one of four DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2) or by an EPCAM deletion. The MLH1 variant is correlated with the highest risk of CRC, while the MSH2 variant is correlated with the highest risk of other cancers. Read More

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Appendicular skeletal muscle mass and quality estimated by bioelectrical impedance analysis in the assessment of frailty syndrome risk in older individuals.

Aging Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Biostructure, University School of Physical Education in Wroclaw, Al. I. J. Paderewskiego 35, 51-612, Wroclaw, Poland.

Background And Aim: The rising aging index of many populations necessitates the continuous evolution of geriatric assessment methods, especially the ones used to identify frailty and the risk of frailty. An appropriately early diagnosis of adverse changes in skeletal muscles can reduce the risk of functional limitations in elderly persons. The aim of this study was to assess the correlation between the appendicular skeletal muscle mass and quality, estimated by the bioelectrical impedance analysis method, and the risk of prevalence of the pre-frailty state in elderly persons. Read More

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National Early Warning Score for predicting intensive care unit admission among elderly patients with influenza infections in the emergency department: an effective disposition tool during the influenza season.

BMJ Open 2021 06 11;11(6):e044496. Epub 2021 Jun 11.

Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan

Objective: During the influenza epidemic season, the fragile elderlies are not only susceptible to influenza infections, but are also more likely to develop severe symptoms and syndromes. Such circumstances may pose a significant burden to the medical resources especially in the emergency department (ED). Disposition of the elderly patients with influenza infections to either the ward or intensive care unit (ICU) accurately is therefore a crucial issue. Read More

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18F-THK5351 PET Can Identify Core Lesions in Different Amyotrophic Lateral Sclerosis Phenotypes.

Clin Nucl Med 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Neurology, Tokyo Metropolitan Geriatric Hospital Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

Abstract: Two patients with different amyotrophic lateral sclerosis (ALS) phenotypes underwent 18F-THK5351 PET to visualize lesions undergoing astrogliosis by measuring monoamine oxidase B activity. Patient 1 was a 57-year-old man with flail leg syndrome. Elevated uptake was observed inside the motor cortex, corresponding to the leg area in a cortical homunculus. Read More

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Longitudinal trajectories of metabolic syndrome on different neurocognitive domains: a cohort study from the Taiwan biobank.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Metabolic syndrome (MetS) brings considerable effects on cognitive function, but trajectories within remain unclear. We investigated the interactions between distinct MetS components and cognitive domains. A total of 5693 participants from the Taiwan biobank during 2008-2018 were enrolled. Read More

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The role of SARC-F scale in predicting progression risk of COVID-19 in elderly patients: a prospective cohort study in Wuhan.

BMC Geriatr 2021 06 10;21(1):355. Epub 2021 Jun 10.

Global Health Research Center, Duke Kunshan University, Suzhou, Jiangsu Province, China.

Background: Since the outbreak of COVID-19, it has been documented that old age and underlying illnesses are associated with poor prognosis among COVID-19 patients. However, it is unknown whether sarcopenia, a common geriatric syndrome, is associated with poor prognosis among older COVID-19 patients. The aim of our prospective cohort study is to investigate the association between sarcopenia risk and severe disease among COVID-19 patients aged ≥60 years. Read More

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Comprehensive geriatric assessment in elderly and senile patients with cardiovascular diseases. Expert opinion of the Russian Association of Gerontologists and Geriatricians.

Kardiologiia 2021 May 31;61(5):71-78. Epub 2021 May 31.

Pirogov Russian National Research Medical University, Russian Gerintology Research and Clinical Centre, Moscow, Russia.

Senile asthenia syndrome (SAS) is a geriatric syndrome characterized by age-associated decline of the physiological reserve and function in multiple systems, which results in higher vulnerability to effects of endo- and exogenous factors and a high risk of unfavorable outcomes, loss of self-sufficiency, and death. Generally, SAS is observed in elderly patients with comorbidities. In cardiovascular diseases, SAS is associated with a poor prognosis, including a higher incidence of exacerbation and death both during acute events and in chronic disease. Read More

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The relationship between primary sarcopenia and SARC-F, serum MMP9, TIMP1 levels, and MMP9/TIMP1 ratio in the geriatric patients.

Eur Geriatr Med 2021 Jun 9. Epub 2021 Jun 9.

Division of Geriatric Medicine, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Cerrahpaşa mahallesi Kocamustafapaşa Caddesi no:34/E Fatih, Istanbul, Turkey.

Purpose: The purpose of this study is to evaluate the relationship between serum MMP9 (Matrix metalloproteinase), TIMP1 (Tissue inhibitor of metalloproteinase) levels and MMP9/TIMP1 ratio and primary sarcopenia in geriatric patients, and compare the diagnostic accuracy of such biomarkers with that of the SARC-F score.

Methods: A total of 88 patients aged 65 years and older were assessed in the study. Comorbidities and geriatric syndromes were determined and patients with secondary sarcopenia were excluded. Read More

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Dasatinib protects against acute respiratory distress syndrome via Nrf2-regulated M2 macrophages polarization.

Drug Dev Res 2021 Jun 9. Epub 2021 Jun 9.

Intensive Care Unit, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Dasatinib, a tyrosine kinase inhibitor, has a protective effect on experimental acute respiratory distress syndrome (ARDS). This study investigated the effect and mechanism of dasatinib in ARDS. C57BL/6 mice were administered with dasatinib (1 and 10 mg/kg) after lipopolysaccharide (LPS) treatment to evaluate the effect of dasatinib on white blood cells (WBC), neutrophils, lymphocytes and macrophages in bronchoalveolar lavage fluid (BALF). Read More

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Can an individualized adherence education program delivered by nurses improve therapeutic adherence in elderly people with acute myocardial infarction?: A randomized controlled study.

Int J Nurs Stud 2021 May 10;120:103975. Epub 2021 May 10.

Department of Heart Disease, Bellvitge University Hospital, IDIBELL, Barcelona, Spain. Electronic address:

Background: The ageing of the population is leading to an increase in the number of elderly patients with acute myocardial infarction. These patients are at higher risk for complications and poor medication adherence, which in turn are associated with higher healthcare resource expenditures. Nursing programmes might help to improve adherence in these complex patients. Read More

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A case of T2DM with edema result in subcutaneous insulin resistance syndrome.

J Diabetes Investig 2021 Jun 8. Epub 2021 Jun 8.

Clinical Pharmacy Center, Zhejiang Provincial People's Hospital, Hangzhou, China.

Subcutaneous insulin resistance syndrome caused by obesity, induration at the injection site, skin temperature and other factors are common clinically, while resistance events caused by edema are relatively rare. This paper introduced a case of female type 2 diabetes mellitus adult with heart failure edema, her blood-glucose control is significantly associated with edema level. Excluded other factors, it can be concluded that edema may lead to subcutaneous insulin resistance syndrome, even if the edema at the injection site is not obvious. Read More

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Geriatric co-management and interdisciplinary transitional care reduced hospital readmissions in frail older patients in Argentina: results from a randomized controlled trial.

Aging Clin Exp Res 2021 Jun 7. Epub 2021 Jun 7.

Internal Medicine Service, Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Perón 4190 (CP 1199ABB), Buenos Aires, Argentina.

Background: Hospitalization is a moment of extreme vulnerability for frail older adults. There is scarce evidence on the effectiveness of geriatric co-management or transitional care interventions in Latin America.

Aims: To assess whether geriatric co-management combined with an interdisciplinary transitional care intervention could reduce 30-day hospital readmission rate compared to usual care in hospitalized frail older patients in a tertiary hospital in Argentina. Read More

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Therapeutic vaccine for chronic diseases after the COVID-19 Era.

Hypertens Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.

There is currently a respiratory disease outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After rapid development, RNA vaccines and adenoviral vector vaccines were approved within a year, which has demonstrated the strong impact of preventing infectious diseases using gene therapy technology. Furthermore, intensive immunological analysis has been performed to evaluate the efficiency and safety of these vaccines, potentially allowing for rapid progress in vaccine technology. Read More

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Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.

Drugs Aging 2021 Jun 7. Epub 2021 Jun 7.

Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, 1225 Center Dr, Gainesville, FL, 32610, USA.

Background: Dihydropyridine calcium channel blockers (DH CCBs) are commonly used for hypertension in older adults. However, loop diuretics can be inappropriately added to treat DH CCB-induced edema, putting individuals at increased risk for adverse events and potential decreases in quality of life.

Methods: We conducted a cross-sectional analysis using United States Medical Expenditure Panel Survey (MEPS) data from 2003 to 2015. Read More

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Permanent loss of independence in adult FIRES (Febrile Infection-Related Epilepsy Syndrome) survivors: an underestimated and unsolved challenge.

Eur J Neurol 2021 Jun 5. Epub 2021 Jun 5.

University Hospital Bonn, Department of Epileptology, Bonn, Germany.

Background: Febrile Infection-Related Epilepsy Syndrome (FIRES) is an exceedingly rare and devastating subtype of new-onset refractory status epilepticus (NORSE), which causes refractory epilepsy and permanent neurocognitive impairment.

Methods: Long-term follow-up of adult FIRES survivors treated between 2005 and 2018, as part of the EpiCARE initiative, a European Reference Network for rare and complex epilepsies. We describe clinical, EEG, imaging, and functional outcome measures: Scores of Independence for Neurologic and Geriatric Rehabilitation (SINGER), modified Rankin Scale (mRS), Global Assessment of Severity of Epilepsy Scale (GASE). Read More

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Novel compound heterozygous CPLANE1 variants identified in a Chinese family with Joubert syndrome.

Int J Dev Neurosci 2021 Jun 5. Epub 2021 Jun 5.

Medical Genetic Department, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.

Joubert syndrome (JS) and JS-related disorders (JSRD) are a group of neurodevelopmental diseases that share the "molar tooth sign" on axial brain magnetic resonance imaging (MRI), accompanied by cerebellar vermis hypoplasia, ataxia, hypotonia, and developmental delay. To identify variants responsible for the clinical symptoms of a Chinese family with JS and to explore the genotype-phenotype associations, we conducted a series of clinical examinations, including blood tests, brain MRI scans, ultrasound imaging, and ophthalmologic examination. Genomic DNA was extracted from the peripheral blood of the six-person family, and the pathogenic variants were detected by whole-exome sequencing (WES) and verified by Sanger sequencing. Read More

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The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults.

Neurobiol Aging 2021 May 6;105:174-185. Epub 2021 May 6.

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Hospital Department of Veterans Affairs, Madison, WI, USA.

Insulin resistance (IR) has been related to reduced cerebral glucose metabolism in regions identified as hypometabolic in Alzheimer's clinical syndrome. Insulin secretion (IS) has been less studied than IR despite findings that decreased IS is an early indicator of future type 2 diabetes and a potential predictor of Alzheimer's clinical syndrome. We investigated whether higher IR and lower IS would be associated with greater age-related reductions in regional cerebral glucose metabolism and worse cognitive performance. Read More

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Development of a simple screening tool based on the 5-question geriatric locomotive function scale for locomotive syndrome.

J Orthop Sci 2021 Jun 2. Epub 2021 Jun 2.

Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Japan.

Background: The optimal cut-off values of the 5-question Geriatric Locomotive Function Scale (GLFS-5) as a screening tool to identify Locomotive Syndrome (LS) diagnosed with the 25-question Geriatric Locomotive Function Scale (GLFS-25) has yet to be fully investigated. This study aimed to construct a simple screening tool, based on the GLFS-5, for the detection of LS-1, LS-2, and LS-3 diagnosed with the GLFS-25.

Methods: This research was approved by the institutional review board of Fukushima Medical University School of Medicine (No. Read More

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The impact of nutritional support on malnourished inpatients with aging-related vulnerability.

Nutrition 2021 Apr 22;89:111279. Epub 2021 Apr 22.

Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland. Electronic address:

Objectives: Malnutrition is highly prevalent in patients with aging-related vulnerability defined by very old age (≥80 y), physical frailty or cognitive impairment, and increases the risks for morbidity and mortality. The effects of individualized nutritional support for patients with aging-related vulnerability in the acute hospital setting on mortality and other clinical outcomes remains understudied.

Methods: For this secondary analysis of the randomized-controlled Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), we analyzed data of patients at a nutritional risk (Nutritional Risk Screening 2002 score ≥3 points) with aging-related vulnerability, randomized to receive protocol-guided individualized nutritional support to reach specific protein and energy goals (intervention group) or routine hospital food (control group). Read More

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Characterizing the Spectrum of Bladder Health and Lower Urinary Tract Symptoms (LUTS) among Women: Results from the CARDIA Study.

Urology 2021 Jun 1. Epub 2021 Jun 1.

School of Public Health, Birmingham, AL. Electronic address:

Objectives: To operationalize a new definition for bladder health, we examined the distribution of lower urinary tract symptoms (LUTS) and impact, along with associated factors, among women in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Methods: We performed cluster analyses using validated LUTS symptom burden and impact scales collected between 2005-06 and 2010-11. We performed multinomial logistic regression analyses to evaluate cardiovascular factors (metabolic syndrome, cardiovascular health behaviors, and inflammation) between clusters after adjusting for covariates (demographic, obstetric/gynecologic, co-morbidities). Read More

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Anemia in older adults as a geriatric syndrome: A review.

Geriatr Gerontol Int 2021 Jun 3. Epub 2021 Jun 3.

Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.

Anemia, a frequently occurring condition in older patients, has no standard definition; however, in most studies, it is defined as hemoglobin level <12 and <13 g/dL in women and men, respectively. Approximately 10% of older adults living in the community have anemia. The prevalence of anemia is significantly correlated with advanced age and male sex. Read More

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Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study.

Sci Rep 2021 Jun 3;11(1):11732. Epub 2021 Jun 3.

Department of Behavioral Neurology and Neuropsychiatry, Osaka University United Graduate School of Child Development, Toyonaka, Osaka, Japan.

Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable syndrome commonly observed in older adults. However, it is unclear whether clinical improvements after surgery can effectively reduce the long-term care burden (LTCB). In this study, we determined whether shunt surgery was effective in decreasing LTCB. Read More

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Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan.

The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Read More

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Geriatric Assessment and In-Hospital Economic Cost of Elderly Patients With Acute Coronary Syndromes.

Heart Lung Circ 2021 May 31. Epub 2021 May 31.

Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Background: Elderly patients with acute coronary syndromes (ACS) are at higher risk for complications and health care resources expenditure. No previous study has assessed the specific contribution of frailty and other geriatric syndromes to the in-hospital economic cost in this setting.

Method: Unselected patients with ACS aged ≥75 years were prospectively included. Read More

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Genomic instability as a main driving factor of unsuccessful ageing: Potential for translating the use of micronuclei into clinical practice.

Mutat Res 2021 Jan-Jun;787:108359. Epub 2020 Nov 27.

Instituto de Investigación Biomédica de A Coruña (INIBIC), AE CICA-INIBIC, Oza, 15071 A, Coruña, Spain; Universidade da Coruña, Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A, Coruña, Spain.

Genome instability denotes an increased tendency to alterations in the genome during cell life cycle, driven by a large variety of endogenous and exogenous insults. Ageing is characterized by the presence of damage to various cellular constituents, but genome alterations, randomly accumulating with age in different tissues, constitute the key target in this process, and are believed to be the main factor of ageing. Age-related failure of DNA repair pathways allows DNA lesions to occur more frequently, and their accumulation over time contributes to the age-associated decrease in genome integrity in somatic cells. Read More

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November 2020

Development of a Conceptual Framework for Severe Self-Neglect (SN) by Modifying the CREST Model for Self-Neglect.

Front Med (Lausanne) 2021 17;8:654627. Epub 2021 May 17.

Biology Academic Department, Fort Valley State University, Fort Valley, GA, United States.

Self-neglect is an inability or refusal to meet one's own basic needs as accepted by societal norms and is the most common report received by state agencies charged with investigating abuse, neglect and exploitation of vulnerable adults. Self-neglect is often seen in addition to one or multiple conditions of frailty, mild to severe dementia, poor sleep and depression. While awareness of elder self-neglect as a public health condition and intervention has significantly risen in the past decade as evidenced by the increasing amount of literature available, research on self-neglect still lacks comprehensiveness and clarity since its inception to the medical literature in the late 1960s. Read More

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Adverse Health Effects of Frailty: Systematic Review and Meta-Analysis of Middle-Aged and Older Adults With Implications for Evidence-Based Practice.

Worldviews Evid Based Nurs 2021 Jun 2. Epub 2021 Jun 2.

Graduate Institute of Technological and Vocational Education, National Taipei University of Technology, Taipei, Taiwan, ROC.

Background: Scholars have noted that frailty easily leads to functional deterioration and proneness to complications. Little literature addresses the stages of frailty in middle-aged and older adults and the effects of frailty on overall health.

Aims: This study explores the effect of different stages of frailty on the prospective health (falls, bone fractures, disability, dementia, hospitalization, and death) of middle-aged and older adults. Read More

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A tale of two extremities: A dynamic case of Covid-19 induced hypokalemia and bradycardia leading into Torsade's de pointes.

Ann Med Surg (Lond) 2021 Jun 27;66:102416. Epub 2021 May 27.

William Harvey Hospital, UK.

Introduction: As researchers and academics around the world scramble ahead to dissect and analyse every aspect of the SARS-CoV2 virus, one such study explored the various underlying electrolyte abnormalities that were precipitated in patients suffering from a confirmed COVID-19 infection. A significant proportion of such patients were noted to be hypokalemic. Hypokalemia can be life threatening as it is known to cause cardiac arrhythmia. Read More

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Utilisation of a Suite of Screening Tools to Determine Adverse Healthcare Outcomes in an Older Frail Population Admitted to a Community Virtual Ward.

Int J Environ Res Public Health 2021 May 24;18(11). Epub 2021 May 24.

School of Nursing and Midwifery, Royal College of Surgeons Ireland, 123 St Stephen's Green, Saint Peter's, D02 YN77 Dublin, Ireland.

Risk stratification to assess healthcare outcomes among older people is challenging due to the interplay of multiple syndromes and conditions. Different short risk-screening tools can assist but the most useful instruments to predict responses and outcomes following interventions are unknown. We examined the relationship between a suite of screening tools and risk of adverse outcomes (pre-determined clinical 'decline' i. Read More

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Impact of Selected Geriatric Syndromes on the Quality of Life in the Population Aged 60 and Older.

Healthcare (Basel) 2021 May 31;9(6). Epub 2021 May 31.

Medical Information Centre, 11000 Prague, Czech Republic.

Background: Geriatric syndromes represent a critical domain in the population more than 60 years old. Basic syndromes include frailty, sarcopenia, loss of body mass, and a mild cognitive disorder. These are significant problems which can affect the quality of life. Read More

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