87 results match your criteria genotoxicity ethanolic

Regulatory safety pharmacology and toxicity assessments of a standardized stem extract of Cassia occidentalis Linn. in rodents.

Regul Toxicol Pharmacol 2021 May 19;123:104960. Epub 2021 May 19.

Pharmaceutics & Pharmacokinetics, CSIR-CDRI, Lucknow, 226 031, India. Electronic address:

Cassia occidentalis Linn (CO) is an annual/perennial plant having traditional uses in the treatments of ringworm, gastrointestinal ailments and piles, bone fracture, and wound healing. Previously, we confirmed the medicinal use of the stem extract (ethanolic) of CO (henceforth CSE) in fracture healing at 250 mg/kg dose in rats and described an osteogenic mode of action of four phytochemicals present in CSE. Here we studied CSE's preclinical safety and toxicity. Read More

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Genotoxicity of Asiasari Radix et Rhizoma (Aristolochiaceae) ethanolic extract in vitro and in vivo.

J Ethnopharmacol 2021 Aug 5;276:114122. Epub 2021 May 5.

Korea Institute of Oriental Medicine, 1672 Expo-ro, Yuseong-gu, Daejeon 34054, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Traditional herbal medicines have diverse efficacy and are increasingly used worldwide. However, some of these herbal medicines have toxicities or side effects, but the scientific understanding of traditional herbal medicine toxicity has not yet been established. Asiasari Radix et Rhizoma (ARE) is known as a herbal medicine used to relieve pain, and recent studies have shown that ARE has anticancer and antimelanogenesis efficacy. Read More

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Health-promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig, .

Food Sci Nutr 2021 Apr 3;9(4):2269-2279. Epub 2021 Mar 3.

Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand.

species have been used as a typical component in food and folk medicine in Asia for centuries. However, little is known regarding the bioactivity and genotoxicity of the recently identified (FD), an indigenous plant of the tropical evergreen rain forest. FD is unique from other species because of its highly sought-after red-brown latex. Read More

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Wild Italian subsp. (Godr.) Nyman: From Morphological and Phytochemical Evidences to Biological Activities.

Plants (Basel) 2021 Mar 26;10(4). Epub 2021 Mar 26.

Pharmaceutical Biology Lab., Research Unit 7 of Terra&Acqua Tech Technopole Lab., Department of Life Sciences and Biotechnology, University of Ferrara, Piazzale Luciano Chiappini, 3, 44123 Ferrara, Italy.

Three specimens of subsp. were collected in three areas of the Abruzzo region (Italy) and subjected to macroscopic and microscopic observation to support their botanical identification. The essential oils (EOs) obtained from the aerial parts of the samples were characterized with the object to define their phytochemical and pharmaceutical biology profile. Read More

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Protective Effect of Extract against Potassium Bromate Induced Oxidative Stress and Genotoxicity in Mice.

Evid Based Complement Alternat Med 2021 19;2021:8875238. Epub 2021 Jan 19.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Despite the commercial value of potassium bromate (KBrO), it has been linked to many diseases including cancer. possesses exceptional ethnobotanical, pharmaceutical, and economic prominence by virtue of its bioactive components. The present study was designed to explore the protective role and antioxidant potential of ethanolic leaves extract of against the oxidative stress, genotoxicity, and apoptosis induced by KBrO in an experimental animal model. Read More

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January 2021

Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytogenotoxicity activities of Mart. (Combretaceae).

J Toxicol Environ Health A 2021 May 25;84(10):399-417. Epub 2021 Jan 25.

Department of Organic Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil.

Mart. (Combretaceae), a shrub popularly known as mofumbo, is used in folk medicine for treatment of uterine bleeding, pertussis, gastric pain, and as a sedative. The aim of this study was to (1) determine the phytochemical profile,(2) identify chemical constituents and (3) examine antioxidant and cytogenotoxic activity of ethanolic extracts and fractions of stem bark and leaves. Read More

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Evaluation of the cytotoxic and genotoxic effects of Cav extract using human neuroblastoma cell line SH-SY5Y.

J Toxicol Environ Health A 2021 Apr 12;84(8):345-355. Epub 2021 Jan 12.

Laboratory of Genetic Toxicology, PPGBioSaúde (Postgraduate Program in Cellular and Molecular Biology Applied to Health), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil.

is a weed thought to have originated in Brazil, where it is present in abundant quantities, but also this plant is also found in south-central Florida, Indian Ocean Islands, and the Pacific Islands. produces neurotoxicity that adversely affects livestock breeding with heavy animal losses and consequent negative impact on Brazil's economy. The aim of this study was to determine the chemical profile, cytotoxic and genotoxic effects of ethanolic extracts of collected in winter (leaf extract) and summer (leaf extract and leaf + flower extract) using an model of human neuroblastoma cell line SH-SY5Y. Read More

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L. (Mustard) NanoParticles and Knocking off Oxidative Stress, ProInflammatory Cytokine and Reverse DNA Genotoxicity.

Biomolecules 2020 12 9;10(12). Epub 2020 Dec 9.

Therapeutic Chemistry Department, Pharmaceutical Industries Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.

is one of the main vital tasks performed by the liver. The purpose of this study was to investigate whether mustard in its normal or nanoparticles could confer a protective/therapeutic effect against TAA-induced acute liver failure in experimental animal models. Mustard ethanolic extract was analyzed by HPLC/MS. Read More

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December 2020

Evaluation of cellular safety and the chemical composition of the peanut ( L.) ethanolic extracts.

Heliyon 2020 Oct 8;6(10):e05119. Epub 2020 Oct 8.

Universidad Nacional de Río Cuarto, Departamento de Microbiología e Inmunología, Área Virología, Ruta 36 Km 601, Río Cuarto, Córdoba, Argentina.

L. (Leguminosae) is distributed in tropical and subtropical areas. Peanut has high nutritional and commercial value. Read More

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October 2020

Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents.

Chem Biodivers 2020 Dec 17;17(12):e2000683. Epub 2020 Nov 17.

Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 2, 21000, Novi Sad, Serbia.

Medicinal mushrooms have tremendous potential in production of bioactive compounds with diverse bioactivities while the biochemical potential of some specific mushroom strains (autochthonous for the region) in production of specific bioactive agents may be of the main importance in a continuous search for novel strains with supreme activities all over the world. In this study, the ethanolic (EtOH) and water (H O) extracts of wild-growing polypore mushroom species were investigated: Trametes versicolor (L.) Lloyd and Stereum subtomentosum Pouzar. Read More

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December 2020

Phytochemical composition and in vitro safety evaluation of Ziziphora clinopodioides Lam. ethanolic extract: Cytotoxicity, genotoxicity and mutagenicity assessment.

J Ethnopharmacol 2021 Feb 1;266:113428. Epub 2020 Oct 1.

Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address:

Ethnopharmacological Relevance: The application of the herb Ziziphora clinopodioides Lam. in folk medicine and as a food additive has been recommended due to its many claimed bioactivities. Regardless of the plant benefits, its safety considerations are largely unknown. Read More

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February 2021

Evaluation of genetic toxicity, acute and sub-chronic oral toxicity and systemic safety of and 50% ethanolic extract mixture (APRG64) in vitro and in vivo (rodent and non-rodent animal models).

Toxicol Res 2020 Oct 14;36(4):367-406. Epub 2020 Apr 14.

Department of Oriental Medicine Biotechnology, Kyung Hee University, 1732, Deogyong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104 Republic of Korea.

(AP) and (RG) are traditional medicinal plants. The bioflavonoid composition standardized by HPLC analysis was named APRG64. Despite many studies reported to beneficial bioactivities of AP and RG, very limited range of toxicity tests have documented. Read More

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October 2020

Bioactive extracts from brewer's spent grain.

Food Funct 2020 Oct;11(10):8963-8977

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

In this study, antioxidant-rich extracts from brewer's spent grain (BSG) extracted by solid-to-liquid extraction using different solvents water and ethanol and their mixtures at two ratios (80% ethanol : water (v/v) and 60% ethanol : water (v/v)) were characterized. Nutritional composition was evaluated for the extracts and for the solid residues obtained after extraction. Additionally, the extracts were analyzed for the total phenolic content and individual phenolic compounds and related biological properties including antioxidant capacity (ABTS; ORAC and DNA protection), antihypertensive capacity, antibacterial activity and antibiofilm capacity. Read More

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October 2020

Genotoxicity studies with an ethanolic extract of Kalanchoe pinnata leaves.

Mutat Res 2020 Aug - Sep;856-857:503229. Epub 2020 Jul 10.

GLR Laboratories Pvt Ltd, Mathur, Chennai, 600 068, India; GLR Laboratories (Europe) Pvt Ltd, Sharnbrook, MK44 1LZ, United Kingdom. Electronic address:

Kalanchoe pinnata is a medicinal plant, used mainly in African, Brazilian, and Indian traditional medicine for the treatment of several human disorders. Whole leaf extracts, crude juice of the leaves, and aqueous and organic extracts of the leaves are used. Over the last decade, ethanolic extracts have become the most popular form of Kalanchoe medicinal preparation. Read More

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November 2020

Moringa oleifera leaves ethanolic extract influences DNA damage signaling pathways to protect liver tissue from cobalt -triggered apoptosis in rats.

Ecotoxicol Environ Saf 2020 Sep 22;200:110716. Epub 2020 May 22.

Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt.

This study assessed the potential of Moringa oleifera leaves ethanol extract (MLEE) in attenuating the detrimental effects of cobalt dichloride (CoCl) on rat liver. Forty rats were assigned to five equal groups: control group, MLEE-treated group, CoCl-treated group, prophylaxis co-treated group, and therapeutic co-treated group. The levels of Co, hepatic injury markers, total antioxidant capacity (TAC), and oxidative stress biomarkers (reactive oxygen species [ROS] and protein carbonyl [PC]) were evaluated. Read More

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September 2020

Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide.

Genet Mol Biol 2019 Jul-Sep;42(3):643-654. Epub 2019 Nov 14.

Faculdade de Artes, Ciências, Letras e Educação, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil.

This study evaluated the genotoxicity, mutagenicity, antigenotoxicity, and antimutagenicity effects on biochemical parameters of oxidative stress of the Spondias dulcis bark ethanolic extract on mice. The extract was evaluated in the doses of 500, 1000, and 1500 mg/kg bw via gavage. To evaluate the protective effects of the extract, benzo[a]pyrene (B[a]P) and cyclophosphamide (CP) were chosen as DNA damage inducers. Read More

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November 2019

A comprehensive toxicological safety assessment of an extract of Ageratum conyzoides.

Regul Toxicol Pharmacol 2019 Apr 23;103:140-149. Epub 2019 Jan 23.

Toxi-Coop Zrt., Magyar Jakobinusok tere 4/B, H-1122, Budapest, Hungary. Electronic address:

A battery of toxicological studies was conducted to aid in the safety assessment of an ethanolic extract of Ageratum conyzoides for use as an ingredient in food. In accordance with internationally accepted standards, a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test, an in vivo mammalian micronucleus test, and a 90-day repeated-dose oral toxicity study in rats were performed. In the first three applied test systems, no evidence of mutagenicity, clastogenicity or genotoxicity was revealed. Read More

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Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis.

Chem Biodivers 2019 Mar 20;16(3):e1800558. Epub 2019 Feb 20.

Biochemistry Laboratory, Department of Chemistry, Universidade Federal de Lavras (UFLA), Campus Universitario, CEP: 3037, Lavras, 37200-000, Brazil.

The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. Read More

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Genotoxicity and pharmacokinetic characterization of ethanolic extract in rats.

Biosci Rep 2019 01 18;39(1). Epub 2019 Jan 18.

Post Graduation Program in Pharmaceutical Science, Federal University of Rio Grande do Norte, Natal, Brazil

The effect of ethanolic extract in rats was analyzed using genotoxicity assays and liver and gene expression. The lyophilized extract of cladodes was analyzed with LC-MS/MS. Male Wistar rats (=36) were equally distributed into six groups that did (+) or did not (-) receive cyclophosphamide treatments: Control (-); Control (+); EXP 1 (-), and EXP 1 (+), both treated with 210 mg/kg of ethanolic extract; and EXP 2 (-) and EXP 2 (+), both treated with 420 mg/kg of ethanolic extract. Read More

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January 2019

African Nightshade ( Mill.): Impact of Cultivation and Plant Processing on Its Health Promoting Potential as Determined in a Human Liver Cell Model.

Nutrients 2018 Oct 17;10(10). Epub 2018 Oct 17.

Molecular Preventive Medicine, Institute for Infection Prevention and Hospital Epidemiology, University Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Strasse 115b, 79106 Freiburg, Germany.

Plant cultivation and processing may impact nutrient and phytochemical content of vegetables. The present study aimed at determining the influence of cultivation and processing on the health promoting capacity of African nightshade ( Mill.) leaves, an indigenous vegetable, rich in nutrients and phytochemicals. Read More

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October 2018

Genotoxic and Chemopreventive Effects of Leaves (Pantanal, Brazil).

Evid Based Complement Alternat Med 2018 19;2018:6596142. Epub 2018 Sep 19.

Universidade de Franca, Avenida Dr. Armando Salles de Oliveira, 201 Parque Universitário, 14404-600 Franca, SP, Brazil.

The medicinal plant is a colonizing tree species of the Pantanal, a unique and little explored wetland region in Brazil. This species is used in folk medicine as syrups and teas to treat respiratory infections, digestive disorders, asthma, scarring, and skin diseases. The objectives of this study were to evaluate the antioxidant, cytotoxic, and genotoxic potential of the ethanolic extract of leaves (VdE), as well as the influence of VdE and its major component (the flavone 3',5-dimethoxy luteolin-7---glucopyranoside; 3'5 DL) on MMS-induced genotoxicity. Read More

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September 2018

Assessment of the phenolic content, mutagenicity and genotoxicity of ethanolic extracts of stem bark and leaves from A. St.-hil.

Drug Chem Toxicol 2020 Sep 13;43(5):539-545. Epub 2018 Sep 13.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, MG, Brazil.

is a plant species whose stem bark is used as bitter tonic beverage. The phytochemical analysis, as well as quantification of phenolic constituents and antioxidant activity of ethanolic extracts from stem bark, and leaves were conducted. The extracts were tested for mutagenicity (Ames test) and DNA-damaging activity (Plasmid Cleavage test). Read More

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September 2020

Preclinical safety evaluation of the ethanolic extract from Campomanesia pubescens (Mart. ex DC.) O.BERG (guavira) fruits: analysis of genotoxicity and clastogenic effects.

Food Funct 2018 Jul;9(7):3707-3717

Center of Biological Sciences and Health, Federal University of the West of Bahia, Barreiras, Bahia, Brazil.

Genotoxicity studies of plants with medicinal and nutritional properties are recommended by international regulatory agencies as part of the risk assessment. Due to their consumption as food, nutraceutical use and ethnopharmacological relevance, Campomanesia pubescens represents one of these plants to be studied. The aim of the present study was to evaluate the genotoxic, cytotoxic potential and clathogenic effects of the ethanolic extract obtained from the pulp of C. Read More

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Cytotoxicity, Genotoxicity, Antioxidant Potential and Chemical Composition of Leaves of Campomanesia pubescens (Mart. ex DC.) O.Berg.

Curr Pharm Biotechnol 2018 ;19(5):416-421

Programa de Pos-Graduacao em Recursos Naturais, Centro de Estudos de Recursos Naturais (CERNA), UEMS, Codigo Postal: 79804-970 Dourados-MS, Brazil.

Background: Plants of the genus Campomanesia belong to the family Myrtaceae and are very abundant in Cerrado areas. Teas from leaves of species of this genus are used for intestinal infections, combating obesity, stomach pathology, fever and among others.

Objective: The present study evaluated the chemical composition and antioxidant potential, cytotoxicity and genotoxicity of ethanolic extract from leaves of Campomanesia pubescens (Mart. Read More

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November 2018

Chemical characterization, pharmacological effects, and toxicity of an ethanol extract of Celtis pallida Torr. (Cannabaceae) aerial parts.

J Ethnopharmacol 2018 Jun 12;219:126-132. Epub 2018 Mar 12.

Department of Pharmacy, Division of Natural and Exact Sciences, University Guanajuato, Noria Alta sin número, C.P. 36040 Guanajuato, Gto., Mexico. Electronic address:

Ethnopharmacological Relevance: Celtis pallida Torr (Cannabaceae) is employed as a folk medicine for the treatment of inflammation, pain, skin infections, and diarrhea, among other diseases.

Aim Of The Study: The purpose of this work was to assess the chemical composition, the in vitro and in vivo toxicity, the antimicrobial, anti-inflammatory, antidiarrheal, antinociceptive, locomotor, and sedative effects of an ethanolic extract obtained from Celtis pallida aerial parts (CPE).

Materials And Methods: The composition of CPE was carried out by GC-MS. Read More

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Genotoxicity of Turnera subulata and Spondias mombin × Spondias tuberosa Extracts from Brazilian Caatinga Biome.

J Med Food 2018 Apr 13;21(4):372-379. Epub 2018 Feb 13.

1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .

Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. Read More

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Genetic toxicological assessment and anti-arthritic effects of an ethanolic extract obtained from Salvia lachnostachys Benth leaves in mice.

Regul Toxicol Pharmacol 2018 Feb 9;92:239-244. Epub 2017 Dec 9.

Federal University of Grande Dourados, College of Health Science, Dourados, MS, Brazil.

In the present study, mice were subjected to prolonged treatment with ethanolic extract of Salvia lachnostachys Benth leaves (SLEE), and the inflammatory and arthritic parameters were evaluated using the Complete Freund's Adjuvant (CFA) model. The genotoxicity of SLEE were also assayed using genetic toxicological tests. For the CFA model, 28 male C57BL/6 mice were distributed randomly into four groups (control, 50 mg/kg of SLEE, 100 mg/kg of SLEE and dexamethasone) for the evaluation of hyperalgesia and paw edema for 21 days after injection of CFA into the paw. Read More

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February 2018

Evaluation of genotoxic and modulatory effects of Nyctanthes arbor-tristis calyx extract and the isolated crocin in Ames' assay.

Nat Prod Res 2019 Mar 11;33(6):884-888. Epub 2017 Dec 11.

b Advanced Centre for Treatment Research and Education in Cancer (ACTREC) , Tata Memorial Centre (TMC) , Kharghar , India.

Flowers of the plant Nyctanthes arbor-tristis (NAT) are widely used in the traditional medicinal systems of several Asian countries. In the present study, potential genotoxicity and modulatory effects of ethanolic extract of NAT flower calyx (NAT FCE) and crocin, a carotenoid principle were evaluated employing standard Salmonella assay. Experiments evaluating the genotoxic potential of NAT FCE and crocin, with and without the S9-activation in TA 98, TA 100 and TA 102 showed a lack of increase in revertant mutants. Read More

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[Mutagenicity, genotoxicity and gene expression of Rad51C, Xiap, P53 and Nrf2 induced by antimalarial extracts of plants collected from the middle Vaupés region, Colombia].

Biomedica 2017 Sep 1;37(3):378-389. Epub 2017 Sep 1.

Grupo de Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia Facultad de Ciencias de la Salud, Fundación Universitaria María Cano, Medellín, Colombia.

Introduction: Due to Plasmodium resistance to antimalarial drugs, it is important to find new therapeutic alternatives for malaria treatment and control. Based on the knowledge of Colombian indigenous communities, we collected extracts of plants with potential antimalarial effects from the middle Vaupés region.

Objective: To evaluate the mutagenic and genotoxic effects, as well as the gene expression of Rad51C, Xiap, P53 and Nrf2 induced by four ethanolic extracts with antimalarial activity (R001, T002, T015 and T028). Read More

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September 2017

Safety assessment and antioxidant activity of Lantana montevidensis leaves: Contribution to its phytochemical and pharmacological activity.

EXCLI J 2017 21;16:566-582. Epub 2017 Apr 21.

Universidade Regional do Cariri-URCA, Centro de Ciências Biológicas e da Saúde-CCBS, Departamento de Ciências Biológicas, CEP: 63105-000, Pimenta, Crato-Ceará, Brazil.

the widely studied species, and the less studied species of the genus are both used in traditional medicine for the same purpose (anti-asthma, anti-ulcer, anti-tumor, etc). However, little is known about the toxicity of and there is limited information on its chemical constituents. Here, we investigated for the first time the genotoxicity and cytotoxicity of the ethanolic (EtOH) and aqueous extracts from the leaves of in human leukocytes, as well as their possible interaction with human erythrocyte membranes . Read More

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