46,543 results match your criteria geneva university

Multi-level multi-modality (PET and CT) fusion radiomics: Prognostic modeling for non-small cell lung carcinoma.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Division of Nuclear Medicine, University Hospital of Geneva, 24 Rue Micheli-du-Crest, 1211 Geneva 4, Geneva, SWITZERLAND.

We developed multi-modality radiomic models by integrating information extracted from 18F-FDG PET and CT images using feature- and image-level fusions, toward improved prognosis for non-small cell lung carcinoma (NSCLC) patients. Two independent cohorts of NSCLC patients from two institutions (87 and 95 patients) were cycled as training and testing datasets. Fusion approaches were applied at two levels, namely feature- and image-levels. Read More

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September 2021

Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis.

Neuroimage Clin 2021 Sep 16;32:102825. Epub 2021 Sep 16.

University of Basel, Department of Psychiatry (UPK), Basel, Switzerland. Electronic address:

Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric diagnoses. T1-weighted images from 313 participants including 89 healthy controls (HC), 22 patients with opioid use disorder (OUD), 50 patients with major depressive disorder (MDD), 45 patients with borderline personality disorder (BPD), 49 patients with first-episode psychosis (FEP), 43 patients with cocaine use disorder (CUD) and 15 patients with schizophrenia (SZ) were included. Read More

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September 2021

In vitro and in vivo accuracy of full-arch digital implant impressions.

Clin Oral Implants Res 2021 Sep 20. Epub 2021 Sep 20.

Biomedical Engineering Institute, Kaunas University of Technology, Lithuania, Department of Electronics Engineering, Kaunas University of Technology, Lithuania.

Objectives: The main objective of the study was to compare the accuracy of full-arch digital implant impressions for fixed dental prosthesis under in vitro and in vivo conditions.

Material And Methods: Eight patients (5 women and 3 men) with at least one edentulous arch and with 4-6 osseointegrated implants participated in this study. For each edentulous arch (n=10) experimental screw-retained titanium bar with attached 4 scan bodies was fabricated. Read More

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September 2021

Hapln1b, a central organizer of the extracellular matrix, modulates kit signalling to control developmental haematopoiesis.

Blood Adv 2021 Sep 20. Epub 2021 Sep 20.

University of Geneva, faculty of Medicine, Geneva 4, Switzerland.

During early vertebrate development, hematopoietic stem and progenitor cells (HSPCs) are produced from hemogenic endothelium located in the dorsal aorta, before they migrate to a transient niche where they expand, the fetal liver and the caudal hematopoietic tissue (CHT), in mammals and zebrafish, respectively. In zebrafish, previous studies have shown that the extracellular matrix (ECM) around the aorta needs to be degraded to allow HSPCs to leave the aortic floor and reach blood circulation. However, the role of the ECM components in HSPC specification has never been addressed. Read More

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September 2021

Antifungal Susceptibility of 182 spp Isolates from 20 European Centers Comparison between EUCAST and Gradient Concentration Strips Methods.

Antimicrob Agents Chemother 2021 Sep 20:AAC0149521. Epub 2021 Sep 20.

AP-HP, Groupe Hospitalier La Pitié-Salpêtrière, Service de Parasitologie Mycologie, F-75013, Paris, France.

We determined the susceptibility of 182 Fusarium spp. isolates to 5 antifungal drugs (amphotericin B, voriconazole, posaconazole, isavuconazole, terbinafine) by EUCAST method. Based on the latest taxonomic insights, isolates collected from 20 European centers were distributed into 7 complexes and 27 species. Read More

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September 2021

Ventilation Parameters Before Extracorporeal Membrane Oxygenator and In-Hospital Mortality in Children: A Review of the ELSO Registry.

ASAIO J 2021 May 10. Epub 2021 May 10.

Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

The aim of this study was to evaluate the impact of pre-extracorporeal membrane oxygenation (ECMO) ventilatory parameters with in-hospital mortality in children with pediatric acute respiratory distress syndrome undergoing ECMO for respiratory indication. In this retrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry, all pediatric patients (>=29 days to <=18 years) who required ECMO for respiratory indications were screened. The primary outcome was in-hospital mortality. Read More

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Localised Versus Systemic Granulomatosis with Polyangiitis: Data from the French Vasculitis Study Group Registry.

Rheumatology (Oxford) 2021 Sep 20. Epub 2021 Sep 20.

National Referral Center for Rare Systemic Autoimmune Diseases, Université de Paris, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Objective: To describe the main features at diagnosis and evolution over time of patients with localised granulomatosis with polyangiitis (L-GPA) compared to those of systemic GPA (S-GPA).

Methods: EULAR definitions of L-GPA, i.e. Read More

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September 2021

High-Fluence Accelerated Epithelium-Off Corneal Cross-Linking Protocol Provides Dresden Protocol-Like Corneal Strengthening.

Transl Vis Sci Technol 2021 Apr;10(5):10

Laboratory for Ocular Cell Biology, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland.

Purpose: To assess whether optimized technical settings for accelerated epithelium-off corneal cross-linking may lead to increases in biomechanical stiffness similar to the benchmark 30-minute epithelium-off Dresden protocol.

Methods: Three-hundred porcine eyes were divided equally into six groups for analysis. All samples underwent epithelial debridement and soaking with 0. Read More

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I'm not alone,' said the boy. 'I've got a puppy.

Nadia Micali

Eur Child Adolesc Psychiatry 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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September 2021

Conservative Treatment of Upper Urinary Tract Urothelial Carcinoma: Referee.

Eur Urol Open Sci 2021 Oct 9;32:40-42. Epub 2021 Sep 9.

GRC 5 Predictive Onco-Urology, Sorbonne University, APHP, Pitié-Salpêtrière Hôpital, Paris, France.

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October 2021

Blinded study: prospectively defined high-frequency oscillations predict seizure outcome in individual patients.

Brain Commun 2021 2;3(3):fcab209. Epub 2021 Sep 2.

Klinik für Neurochirurgie, UniversitätsSpital Zürich, Universität Zürich, Zürich, Switzerland.

Interictal high-frequency oscillations are discussed as biomarkers for epileptogenic brain tissue that should be resected in epilepsy surgery to achieve seizure freedom. The prospective classification of tissue sampled by individual electrode contacts remains a challenge. We have developed an automated, prospective definition of clinically relevant high-frequency oscillations in intracranial EEG from Montreal and tested it in recordings from Zurich. Read More

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September 2021

The clinical features and management of pulmonary embolism at Chris Hani Baragwanath Academic Hospital.

Afr J Thorac Crit Care Med 2018 10;24(3). Epub 2018 Sep 10.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa.

Background: Pulmonary embolism (PE) is the most common cause of preventable deaths in hospitalised patients.

Objectives: To determine the prevalence and associated features of PE at Chris Hani Baragwanath Academic Hospital (CHBAH) over a period of one year.

Methods: A retrospective study was performed of patients with acute PE, as confirmed by computed tomography of the pulmonary arteries (CTPA). Read More

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September 2018

TOF-PET Image Reconstruction With Multiple Timing Kernels Applied on Cherenkov Radiation in BGO.

IEEE Trans Radiat Plasma Med Sci 2020 Sep 31;5(5):703-711. Epub 2020 Dec 31.

Physics Department, University of Milano-Bicocca, 20126 Milan, Italy.

Today Time-of-Flight (TOF), in PET scanners, assumes a single, well-defined timing resolution for all events. However, recent BGO-Cherenkov detectors, combining prompt Cherenkov emission and the typical BGO scintillation, can sort events into multiple timing kernels, best described by the Gaussian mixture models. The number of Cherenkov photons detected per event impacts directly the detector time resolution and signal rise time, which can later be used to improve the coincidence timing resolution. Read More

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September 2020

Scoping Review on the Impact of Outbreaks on Sexual and Reproductive Health Services: Proposed Frameworks for Pre-, Intra-, and Postoutbreak Situations.

Biomed Res Int 2021 8;2021:9989478. Epub 2021 Sep 8.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland.

Introduction: Recent experiences from global outbreaks have highlighted the severe disruptions in sexual and reproductive health services that expose women and girls to preventable health risks. Yet, to date, there is no review studying the possible impact of outbreaks on sexual and reproductive health (SRH). . Read More

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September 2021

The RAI-6 Questionnaire: A New Screening Questionnaire to Monitor Complications of Radioiodine Treatment.

Front Surg 2021 1;8:641945. Epub 2021 Sep 1.

Department of Otolaryngology-Head and Neck Surgery, University Hospitals of Geneva, Geneva, Switzerland.

The aim of this study is to develop a simple and efficient screening questionnaire to be able to routinely monitor potential radioiodine therapy-induced complications. A new radioiodine 6 (RAI-6) questionnaire containing six questions adressing salivary, ocular, and nasal symptoms as well as quality of life was developed. Validation of the RAI-6 questionnaire was assessed with a group of fifty-four patients diagnosed with differentiated thyroid carcinoma treated post-operatively with radioiodine therapy, and in a group of fifty healthy volunteers. Read More

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September 2021

Discovery of the Locus From for Stable Resistance to Grapevine Powdery Mildew in a Family Segregating for Several Unstable and Tissue-Specific Quantitative Resistance Loci.

Front Plant Sci 2021 3;12:733899. Epub 2021 Sep 3.

School of Integrative Plant Science, Cornell AgriTech, Cornell University, Geneva, NY, United States.

Race-specific resistance loci, whether having qualitative or quantitative effects, present plant-breeding challenges for phenotypic selection and deciding which loci to select or stack with other resistance loci for improved durability. Previously, resistance to grapevine powdery mildew (GPM, caused by ) was predicted to be conferred by at least three race-specific loci in the mapping family B37-28 × C56-11 segregating for GPM resistance from . In this study, 9 years of vineyard GPM disease severity ratings plus a greenhouse and laboratory assays were genetically mapped, using a rhAmpSeq core genome marker platform with 2,000 local haplotype markers. Read More

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September 2021

Preterm and term prelabour rupture of membranes: A review of timing and methods of labour induction.

Best Pract Res Clin Obstet Gynaecol 2021 Sep 3. Epub 2021 Sep 3.

Sorbonne Université, AP-HP, Department of Gynaecology and Obstetrics, Trousseau Hospital, Paris, France; INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), FHU PREMA, Paris Descartes University, Paris, France. Electronic address:

Prelabour rupture of membranes (PROM) exposes both foetuses and mothers to the risk of infection. Induction of labour has been proposed to reduce this risk, but its neonatal and maternal risks and benefits must be balanced against those of expectant management (EM). Recent randomized studies of preterm PROM show that EM until 37 weeks of gestation is associated with lower overall neonatal morbidity. Read More

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September 2021

Clinical data for paediatric research: the Swiss approach : Proceedings of the National Symposium in Bern, Switzerland, Dec 5-6, 2019.

BMC Proc 2021 Sep 20;15(Suppl 13):19. Epub 2021 Sep 20.

Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.

Background And Purpose: Continuous improvement of health and healthcare system is hampered by inefficient processes of generating new evidence, particularly in the case of rare diseases and paediatrics. Currently, most evidence is generated through specific research projects, which typically require extra encounters with patients, are costly and entail long delays between the recognition of specific needs in healthcare and the generation of necessary evidence to address those needs. The Swiss Personalised Health Network (SPHN) aims to improve the use of data obtained during routine healthcare encounters by harmonizing data across Switzerland and facilitating accessibility for research. Read More

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September 2021

Bacterial colonisation during regular daily use of a power-driven water flosser and risk for cross-contamination. Can it be prevented?

Clin Oral Investig 2021 Sep 18. Epub 2021 Sep 18.

Department of Periodontology, Faculty of Odontology, University of Malmö, Malmö, Sweden.

Objective: To assess whether bacterial colonisation in a power-driven water flosser can be prevented.

Materials And Methods: Twenty-four patients undergoing supportive periodontal treatment used 2 power-driven water flossers [Sonicare AirFloss (SAF), AirFloss Ultra (SAFU)] for 12 weeks each as follows: (a) with bottled water (BW); (b) with BW and cleaning the device extra-orally twice per week with chlorhexidine gluconate or (c) essential-oil-based (EO) mouth-rinse; (d) with EO only. Water-jet samples were taken after 6 and 12 weeks with the used nozzle and after exchanging to a brand-new nozzle. Read More

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September 2021

Smoking bans in prisons.

Lancet Public Health 2021 Sep 16. Epub 2021 Sep 16.

Health Unit International Committee of the Red Cross, Geneva, Switzerland.

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September 2021

Population screening for liver fibrosis: towards early diagnosis and intervention for chronic liver diseases.

Hepatology 2021 Sep 19. Epub 2021 Sep 19.

Centre for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, and Institute for Clinical Research, University of Southern Denmark Odense, Denmark.

Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), although chronic hepatitis B and C infections are still major etiological factors in some areas of the world. Recent studies have shown that liver fibrosis can be assessed with relatively high accuracy non-invasively by serological tests, transient elastography, and radiological methods. Read More

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September 2021

Superior Capsular Reconstruction for irreparable rotator cuff tears: Autografts versus Allografts.

Orthop Traumatol Surg Res 2021 Sep 16:103059. Epub 2021 Sep 16.

Maussins Clinic, Paris, France.

Aims: Superior capsular reconstruction (SCR) is a treatment option for patients with massive irreparable rotator cuff tears. Different types of grafts from various donor sites have been described. There are no clinical studies comparing the different grafts available. Read More

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September 2021

Kaempferol-3-O-α-(3,4-di-E-p-coumaroyl)-rhamnopyranoside from Nectandra oppositifolia releases Ca from intracellular pools of Trypanosoma cruzi affecting the bioenergetics system.

Chem Biol Interact 2021 Sep 16:109661. Epub 2021 Sep 16.

Center of Natural Sciences and Humanities, Federal University of ABC, Santo Andre, SP, 09210-180, Brazil. Electronic address:

Phytochemical analysis of EtOH extract from leaves of Nectandra oppositifolia afforded three flavonoids: kaempferol (1), kaempferol-3-O-α-rhamnopyranoside (2) and kaempferol-3-O-α-(3,4-di-E-p-coumaroyl)-rhamnopyranoside (3), which were characterized by NMR and ESI-HRMS. When tested against the protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, flavonoids 1 and 3 were effective to kill the trypomastigotes with IC values of 32.0 and 6. Read More

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September 2021

Patient-reported outcomes for monitoring symptomatic toxicities in cancer patients treated with immune-checkpoint inhibitors: A Delphi study.

Eur J Cancer 2021 Sep 15;157:225-237. Epub 2021 Sep 15.

Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne and Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Background: Immune-related adverse events (IrAEs) associated with the use of immune checkpoint inhibitors (ICIs) may not be fully covered by existing measures like the PRO-CTCAE™. Selecting PRO-CTCAE™ items for monitoring symptomatic adverse events is hindered by the heterogeneity and complexity of IrAEs, and no standardised selection process exists. We aimed to reach expert consensus on the PRO-CTCAE™ symptom terms relevant for cancer patients receiving ICIs and to gather preliminary expert opinions about additional symptom terms reflecting ICI symptomatic toxicities. Read More

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September 2021

Pharmacodynamic biomarkers of long-term interferon beta-1a therapy in REFLEX and REFLEXION.

J Neuroimmunol 2021 Sep 9;360:577715. Epub 2021 Sep 9.

EMD Serono Research & Development Institute, Inc., Billerica, MA, USA.

This post-hoc analysis evaluated candidate biomarkers of long-term efficacy of subcutaneous interferon beta-1a (sc IFN β-1a) in REFLEX/REFLEXION studies of clinically isolated syndrome. Samples from 507 REFLEX and 287 REFLEXION study participants were analyzed. All investigated biomarkers were significantly upregulated 1. Read More

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September 2021

Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients.

J Cachexia Sarcopenia Muscle 2021 Sep 18. Epub 2021 Sep 18.

Genomic Research Lab and Service of Infectious Diseases, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Background: We have previously shown that glycine increases fat-free mass in chronic haemodialysis patients with features of malnutrition as compared with branched-chain amino acids (BCAAs). This multicentre randomized double-blind crossover study evaluates the impact of these amino acids on the gut barrier and microbiota.

Methods: Haemodialysis patients were included if they had plasma albumin <38 g/L or weight loss >5% of dry body weight, and daily dietary intakes <30 kcal/kg and <1 g protein/kg. Read More

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September 2021

Stroke impairs the control of isometric forces and muscle activations in the ipsilesional arm.

Sci Rep 2021 Sep 17;11(1):18533. Epub 2021 Sep 17.

Dept. Informatics, Bioengineering, Robotics and Systems Engineering, University of Genoa, Via Opera Pia 13, 16145, Genoa, Italy.

Stroke often impairs the control of the contralesional arm, thus most survivors rely on the ipsilesional arm to perform daily living activities that require an efficient control of movements and forces. Whereas the ipsilesional arm is often called 'unaffected' or 'unimpaired', several studies suggested that during dynamic tasks its kinematics and joint torques are altered. Is stroke also affecting the ability of the ipsilesional arm to produce isometric force, as when pushing or pulling a handle? Here, we address this question by analyzing behavioral performance and muscles' activity when subjects applied an isometric force of 10 N in eight coplanar directions. Read More

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September 2021

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.

Nat Commun 2021 Sep 17;12(1):5525. Epub 2021 Sep 17.

Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple and robust human liver cell-based system modeling a clinical prognostic liver signature (PLS) predicting long-term liver disease progression toward HCC. Read More

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September 2021

Transverse barrier formation by electrical triggering of a metal-to-insulator transition.

Nat Commun 2021 Sep 17;12(1):5499. Epub 2021 Sep 17.

Department of Physics and Center for Advanced Nanoscience, University of California San Diego, La Jolla, CA, USA.

Application of an electric stimulus to a material with a metal-insulator transition can trigger a large resistance change. Resistive switching from an insulating into a metallic phase, which typically occurs by the formation of a conducting filament parallel to the current flow, is a highly active research topic. Using the magneto-optical Kerr imaging, we found that the opposite type of resistive switching, from a metal into an insulator, occurs in a reciprocal characteristic spatial pattern: the formation of an insulating barrier perpendicular to the driving current. Read More

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September 2021

Sanctioned countries in the global COVID-19 vaccination campaign: the forgotten 70.

Confl Health 2021 Sep 17;15(1):69. Epub 2021 Sep 17.

Graduate Institute of International and Development Studies, Geneva, Switzerland.

COVAX, the global initiative on COVID-19 vaccines, has set the target of achieving a COVID-19 vaccination coverage of up to 30% of the population of 135 countries in 2 years. Here, we argue that COVAX should anticipate important and unforeseen challenges with regard to sanctioned countries. For those, COVAX needs to provide a higher percentage of the vaccines. Read More

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September 2021