J Invest Dermatol 2021 Jun 2. Epub 2021 Jun 2.
Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, and Centre for Genomics and Personalised Health, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove QLD 4059, Australia.
Solid organ transplant recipients (SOTRs) have elevated risks for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), especially in high ultraviolet (UV) radiation environments. We assessed whether polygenic risk scores (PRSs) can improve prediction of BCC and SCC risks and multiplicity over and above traditional risk factors in SOTRs in a high UV setting. We built PRSs for BCC (N=594,881) and SCC (N=581,431) using UK Biobank and 23andMe datasets, validated them in the Australian QSkin Cohort (N>6,300) and applied them in SOTRs in the STAR Cohort from Queensland, Australia, a high UV environment. Read More