95,519 results match your criteria genetic interaction

Polymorphisms in plants to restrict losses to pathogens: From gene family expansions to complex network evolution.

Curr Opin Plant Biol 2021 Apr 18;62:102040. Epub 2021 Apr 18.

TUM School of Life Sciences, Technical University of Munich, Emil-Ramann-Str. 2, 85354, Freising, Germany. Electronic address:

Genetic polymorphisms are the basis of the natural diversity seen in all life on earth, also in plant-pathogen interactions. Initially, studies on plant-pathogen interaction focused on reporting phenotypic variation in resistance properties and on the identification of underlying major genes. Nowadays, the field of plant-pathogen interactions is moving from focusing on families of single dominant genes involved in gene-for-gene interactions to an understanding of the plant immune system in the context of a much more complex signaling network and quantitative resistance. Read More

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Metabolic patterns in Septoria canker resistant and susceptible Populus trichocarpa genotypes 24 hours post-inoculation.

Phytopathology 2021 Apr 21. Epub 2021 Apr 21.

2062 Cordely HallCorvallis, Oregon, United States, 97331;

Sphaerulina musiva is an economically and ecologically important fungal pathogen that causes Septoria stem canker and leaf spot disease of Populus species. To bridge the gap between genetic markers and structural barriers previously found to be linked to Septoria (Sphaerulina musiva) canker disease resistance in poplar, we employed hydrophilic interaction liquid chromatography (HILIC) and tandem mass spectrometry (MS/MS) to identify and quantify metabolites involved with signaling and cell wall re-modelling. Fluctuations in signaling molecules, organic acids, amino acids, sterols, phenolics, and saccharides in resistant and susceptible Populus trichocarpa inoculated with Sphaerulina musiva, were observed. Read More

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CDC20 and PTTG1 are Important Biomarkers and Potential Therapeutic Targets for Metastatic Prostate Cancer.

Adv Ther 2021 Apr 21. Epub 2021 Apr 21.

Department of Urology, The First Hospital of Qinhuangdao, No. 258 of Cultural North Road, Haigang District, Qinhuangdao, 066000, China.

Introduction: Metastatic prostate cancer (mPCa) is responsible for most prostate cancer (PCa) deaths worldwide. The present study aims to explore the molecular differences between mPCa and PCa.

Methods: The authors downloaded GSE6752, GSE6919, and GSE32269 from the Gene Expression Omnibus and employed integrated analysis to identify differentially expressed genes (DEGs) between mPCa and PCa. Read More

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Body mass index and polygenic risk for Alzheimer's disease predict conversion to Alzheimer's disease.

J Gerontol A Biol Sci Med Sci 2021 Apr 21. Epub 2021 Apr 21.

Department of Psychology, The Ohio State University, Columbus, OH, USA.

Body mass index (BMI) is a risk factor for Alzheimer's disease (AD) although the relationship is complex. Obesity in midlife is associated with increased risk for AD, whereas evidence supports both higher and lower BMI increasing risk for AD in late life. This study examined the influence of individual differences in genetic risk for AD to further clarify the relationship between late-life BMI and conversion to AD. Read More

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Seasonal dynamics of diet-gut microbiota interaction in adaptation of yaks to life at high altitude.

NPJ Biofilms Microbiomes 2021 Apr 20;7(1):38. Epub 2021 Apr 20.

School of Life Science, State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou, Gansu, China.

Dietary selection and intake affect the survival and health of mammals under extreme environmental conditions. It has been suggested that dietary composition is a key driver of gut microbiota variation; however, how gut microbiota respond to seasonal dietary changes under extreme natural conditions remains poorly understood. Sequencing plant trnL (UAA) region and 16S rRNA gene analysis were employed to determine dietary composition and gut microbiota in freely grazing yaks on the Tibetan plateau. Read More

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Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, VIC, 3800, Melbourne, Australia;

Mitochondrial disease is a debilitating condition with a diverse genetic etiology. Here, we report that TMEM126A, a protein that is mutated in patients with autosomal-recessive optic atrophy, participates directly in the assembly of mitochondrial complex I. Using a combination of genome editing, interaction studies, and quantitative proteomics, we find that loss of TMEM126A results in an isolated complex I deficiency and that TMEM126A interacts with a number of complex I subunits and assembly factors. Read More

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Multifunctional hierarchical nanohybrids perform triple antitumor theranostics in a cascaded manner for effective tumor treatment.

Acta Biomater 2021 Apr 17. Epub 2021 Apr 17.

School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, Shenzhen Research Institute, Xi'an Jiao Tong University, Xi'an, China, 714049. Electronic address:

Gene therapy based on transfection of RNAs/DNAs offers tremendous promise for tumor treatment. However, the relatively weak therapeutic efficiency of current genetic nanohybrids in vivo has limited the application of this strategy. Herein, we fabricated multifunctional core-shell-corona nanohybrids by combining cascaded theranostics for enhanced gene therapy. Read More

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Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

Cardiovasc Res 2021 Apr 20. Epub 2021 Apr 20.

Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, 80636, Munich, Germany.

Aims: Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic-effects might be responsible for part of the unaccounted genetic variance. Read More

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Selection maintains protein interactome resilience in the long-term evolution experiment with Escherichia coli.

Genome Biol Evol 2021 Apr 20. Epub 2021 Apr 20.

Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Most cellular functions are carried out by a dynamic network of interacting proteins. An open question is whether the network properties of protein interactomes represent phenotypes under natural selection. One proposal is that protein interactomes have evolved to be resilient, such that they tend to maintain connectivity when proteins are removed from the network. Read More

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Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster.

G3 (Bethesda) 2019 Jul;9(7):2225-2234

Faculty of Medicine and Health Technology, FI-331014, University of Tampere, Finland.

Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). Here we tested whether any of four natural mtDNA variants was able to modify the effect of the phenotypically mild, nuclear tko25t mutation, affecting mitochondrial protein synthesis. When combined with tko25t, the mtDNA from wild strain KSA2 produced pupal lethality, accompanied by the presence of melanotic nodules in L3 larvae. Read More

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Asymmetric Redundancy of ZERZAUST and ZERZAUST HOMOLOG in Different Accessions of Arabidopsis thaliana.

G3 (Bethesda) 2019 Jul;9(7):2245-2252

Entwicklungsbiologie der Pflanzen, Wissenschaftszentrum Weihenstephan, Technische Universität München, Freising, Germany.

Divergence among duplicate genes is one of the important sources of evolutionary innovation. But, the contribution of duplicate divergence to variation in Arabidopsis accessions is sparsely known. Recently, we studied the role of a cell wall localized protein, ZERZAUST (ZET), in Landsberg erecta (Ler) accession, lack of which results in aberrant plant morphology. Read More

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Sequencing of a Wild Apple (Malus baccata) Genome Unravels the Differences Between Cultivated and Wild Apple Species Regarding Disease Resistance and Cold Tolerance.

G3 (Bethesda) 2019 Jul;9(7):2051-2060

College of Life Sciences, Northwest A&F University, Yangling 712100, Shannxi, China.

Malus baccata is one of four wild apple species that can hybridize with the cultivated apple species (Malus domestica). It is widely used in high-latitude apple-producing areas as a rootstock and breeding resource because of its disease resistance, and cold tolerance. A lack of a reference genome has limited the application of M. Read More

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Sex effects for the interaction of dopamine related genetic variants for COMT and BDNF on declarative memory performance.

Genes Brain Behav 2021 Apr 19:e12737. Epub 2021 Apr 19.

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.

Genetic factors are assumed to contribute to memory performance, especially genes affecting the dopaminergic neurotransmission. We aimed to evaluate leading functional genetic variants of the dopamine system, Catechol-O-methyltransferase (COMT) SNP rs4680 and Brain-derived neurotropic factor (BDNF) SNP rs6265, previously found to be associated with memory performance. In two independent general population cohorts (total N=5,937) we investigated direct and interaction effects between COMT and BDNF SNPs on declarative memory performance. Read More

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Declining Levels of Specialized Synaptic Surface Proteins in nNOS-Expressing Interneurons in Mice Treated Prenatally with Valproic Acid.

Neurochem Res 2021 Apr 19. Epub 2021 Apr 19.

Center for Genetic Medicine, Xuzhou Maternity and Child Health Care Hospital, Xuzhou, China.

Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorder characterized by impaired social interaction, and repetitive or restricted interests and behaviors. Membrane proteins are a significant part of the proteins in cell and play key functions in synaptic transmission. We have recently shown that neuronal nitric oxide synthase (nNOS) expression was reduced in the basolateral amygdala (BLA) of mice following postnatal valproic acid (VPA) exposure. Read More

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Genome-wide identification of the GATA transcription factor family and their expression patterns under temperature and salt stress in Aspergillus oryzae.

AMB Express 2021 Apr 19;11(1):56. Epub 2021 Apr 19.

Jiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In-Vitro Diagnostic Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, 330013, China.

GATA transcription factors (TFs) are involved in the regulation of growth processes and various environmental stresses. Although GATA TFs involved in abiotic stress in plants and some fungi have been analyzed, information regarding GATA TFs in Aspergillus oryzae is extremely poor. In this study, we identified and functionally characterized seven GATA proteins from A. Read More

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Transcriptomic analysis to infer key molecular players involved during host response to NDV challenge in Gallus gallus (Leghorn & Fayoumi).

Sci Rep 2021 Apr 19;11(1):8486. Epub 2021 Apr 19.

National Institute of Animal Biotechnology (NIAB), Opposite Journalist Colony, Near Gowlidoddi Extended Q City Road, Gachibowli, Hyderabad, Telangana, 500032, India.

Long non-coding RNAs (lncRNAs) are the transcripts of length longer than 200 nucleotides. They are involved in the regulation of various biological activities. Leghorn and Fayoumi breeds of Gallus gallus were known to be having differential resistance against Newcastle Disease Virus (NDV) infection. Read More

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Antifreeze protein from Ammopiptanthus nanus functions in temperature-stress through domain A.

Sci Rep 2021 Apr 19;11(1):8458. Epub 2021 Apr 19.

Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region, Ministry of Agriculture; Maize Research Institute, Sichuan Agricultural University, Chengdu, 611130, China.

Temperature stress restricts plant growth and development. Antifreeze protein (AFP) can improve plants antifreeze ability. In our previous study, the AnAFP gene cloned from Ammopiptanthus nanus was confirmed to be an excellent candidate enhancing plant cold resistance. Read More

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Recommendations for neonatologists and pediatricians working in first level birthing centers on the first communication of genetic disease and malformation syndrome diagnosis: consensus issued by 6 Italian scientific societies and 4 parents' associations.

Ital J Pediatr 2021 Apr 19;47(1):94. Epub 2021 Apr 19.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.

Background: Genetic diseases are chronic conditions with relevant impact on the lives of patients and their families. In USA and Europe it is estimated a prevalence of 60 million affected subjects, 75% of whom are in developmental age. A significant number of newborns are admitted in the Neonatal Intensive Care Units (NICU) for reasons different from prematurity, although the prevalence of those with genetic diseases is unknown. Read More

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Complete genome sequence analysis of the peanut pathogen Ralstonia solanacearum strain Rs-P.362200.

BMC Microbiol 2021 Apr 19;21(1):118. Epub 2021 Apr 19.

College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.

Background: Bacterial wilt caused by Ralstonia solanacearum species complex is an important soil-borne disease worldwide that affects more than 450 plant species, including peanut, leading to great yield and quality losses. However, there are no effective measures to control bacterial wilt. The reason is the lack of research on the pathogenic mechanism of bacterial wilt. Read More

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Flowering characteristics and fertility of interploidy progeny from normal and 2n gametes in Dactylis glomerata L.

New Phytol 1993 Jun;124(2):309-319

Department of Population Biology, Centre d'Ecologie Fonctionelle et Evolutive, CNRS, Route de Mende, BP 5051, 34033 Montpellier cedex, France.

We performed an extensive experiment to compare male fertility, flowering period, seed set and germination rate between triploid and tetraploid cross-progeny of Dactylis glomerata L. originating from reciprocal diploid (2x) × tetraploid (4x) crosses. Four hundred and forty-five triploid and tetraploid individuals, constituting the cross progeny of 2x-4x reciprocal crosses between diploids from nine distinct subspecies, and tetraploids from five subspecies, were tested for male fertility and phenology under homogeneous conditions. Read More

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Hebeloma cylindrosporum- a model species to study ectomycorrhizal symbiosis from gene to ecosystem.

New Phytol 2004 Sep;163(3):481-498

Université Claude Bernard Lyon 1, Ecologie Microbienne (UMR CNRS 5557), Bât. A. Lwoff, 43 Bd. du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France.

The basidiomycete Hebeloma cylindrosporum has been extensively studied with respect to mycorrhiza differentiation and metabolism and also to population dynamics. Its life cycle can be reproduced in vitro and it can be genetically transformed. Combined biochemical, cytological, genetical and molecular approaches led to the characterisation of mutant strains affected in mycorrhiza formation. Read More

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September 2004

Differential expression of a malate synthase gene during the preinfection stage of symbiosis in the ectomycorrhizal fungus Laccaria bicolor.

New Phytol 2002 May;154(2):517-527

Department of Biological Sciences, Michigan Technological University, Houghton, MI 49931, USA.

•  The ectomycorrhiza is a symbiotic organ formed between a filamentous fungus and a plant root, mainly tree roots. Root colonization involves significant shifts in gene expression resulting in metabolic and structural changes in the fungus, including growth toward the plant root, penetration and establishment of the symbiotic organ. •  The preinfection stage of the association is crucial as changes that occur throughout mycorrhiza formation are set in motion. Read More

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Exploratory analysis of the genetics of impulse control disorders in Parkinson's disease using genetic risk scores.

Parkinsonism Relat Disord 2021 Apr 11;86:74-77. Epub 2021 Apr 11.

Paris Brain Institute, F-75013, Paris, France; Inserm, U 1127, F-75013, Paris, France; CNRS, UMR 7225, F-75013, Paris, France; Sorbonne Université, F-75013, Paris, France; Assistance Publique Hôpitaux de Paris, Department of Neurology, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière, F-75013, Paris, France. Electronic address:

Objective: To study the association between impulse control disorders (ICDs) in Parkinson's disease (PD) and genetic risk scores (GRS) for 40 known or putative risk factors (e.g. depression, personality traits). Read More

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NLK suppresses MAVS-mediated signaling in black carp antiviral innate immunity.

Dev Comp Immunol 2021 Apr 16:104105. Epub 2021 Apr 16.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, China. Electronic address:

Mammalian Nemo-like kinase (NLK) plays important roles in multiple biological processes including immune response; however, the roles of teleost NLK remain largely unknown. In the present study, the NLK homologue (bcNLK) of black carp (Mylopharyngodon piceus) has been cloned and characterized. The coding region of bcNLK consists of 1427 nucleotides and encodes 476 amino acid, including two low complexity region (LCR) domains at the N-terminus and a serine/threonine protein kinase catalytic (S-TKc) domain in the middle region. Read More

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SPRED proteins and their roles in signal transduction, development, and malignancy.

Genes Dev 2020 Nov;34(21-22):1410-1421

Helen Diller Family Comprehensive Cancer, University of California at San Francisco, San Francisco, California 94158, USA.

The roles of SPRED proteins in signaling, development, and cancer are becoming increasingly recognized. SPRED proteins comprise an N-terminal EVH-1 domain, a central c-Kit-binding domain, and C-terminal SROUTY domain. They negatively regulate signaling from tyrosine kinases to the Ras-MAPK pathway. Read More

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November 2020

Transforming Growth Factor Beta (Tgfβ) Signaling: The Master Sculptor Of Fingers.

Dev Dyn 2021 Apr 19. Epub 2021 Apr 19.

Departamento de Anatomía y Biología Celular and IDIVAL., Universidad de Cantabria, Spain.

Transforming growth factor beta (TGFβ) constitutes a large and evolutionarily conserved superfamily of secreted factors that play essential roles in embryonic development, cancer, tissue regeneration and human degenerative pathology. Studies of this signaling cascade in the regulation of cellular and tissue changes in the three-dimensional context of a developing embryo have notably advanced in the understanding of the action mechanism of these growth factors. In this review, we address the role of TGFβ signaling in the developing limb, focusing on its essential function in the morphogenesis of the autopod. Read More

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A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, France.

Background: Blood lipid concentrations display high interindividual variability in response to dietary interventions, partly due to genetic factors. Existing studies have focused on single nucleotide polymorphisms (SNPs) analyzed individually, which only explain a limited fraction of the variability of these complex phenotypes.

Objective: We aimed to identify combinations of SNPs associated with the variability in LDL cholesterol and triglyceride (TG) concentration changes following 5 dietary interventions. Read More

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[MutL Protein from the Neisseria gonorrhoeae Mismatch Repair System: Interaction with ATP and DNA].

Mol Biol (Mosk) 2021 Mar-Apr;55(2):289-304

Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991 Russia.

The mismatch repair system (MMR) ensures the stability of genetic information during DNA replication in almost all organisms. Mismatch repair is initiated after recognition of a non-canonical nucleotide pair by the MutS protein and the formation of a complex between MutS and MutL. Eukaryotic and most bacterial MutL homologs function as endonucleases that introduce a single-strand break in the daughter strand of the DNA, thus activating the repair process. Read More

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Identification of the gene as a potential target for epilepsy therapy and the association between rs10496964 and expression.

J Int Med Res 2020 Dec;48(12):300060520980527

Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Objective: An association between the rs10496964 polymorphism and the gene has not yet been reported, and the role of in epilepsy therapy is also unclear. The aims of this research were to evaluate the role of in the therapy of epilepsy and to explore the association between rs10496964 and expression.

Methods: We used the expression quantitative trait loci (eQTL) dataset resource from the Brain eQTL Almanac to evaluate the association between rs10496964 and expression in human brain tissue. Read More

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December 2020