143,913 results match your criteria genes common


Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model.

Blood Adv 2021 Oct 14. Epub 2021 Oct 14.

Hannover Medical School, Hannover, Germany.

Primary or secondary immunodeficiencies are characterized by disruption of the cellular and humoral immunity. Respiratory infections are a major cause of morbidity and mortality among immunodeficient or immunocompromised patients with Staphylococcus aureus being a common offending organism. We here propose an adoptive macrophage transfer approach aiming to enhance impaired pulmonary immunity against S. Read More

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October 2021

Expression of the pyrroline-5-carboxylate reductase (P5CR) gene from the wild grapevine Vitis yeshanensis promotes drought resistance in transgenic Arabidopsis.

Plant Physiol Biochem 2021 Oct 6;168:188-201. Epub 2021 Oct 6.

College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture, Yangling, Shaanxi, 712100, China; State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Proline accumulation is one of the most common reactions in plants under drought stress. Pyrroline-5-carboxylate reductase (P5CR) is the final enzyme and plays an important role in proline biosynthesis. The Chinese wild grapevine Vitis yeshanensis J. Read More

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October 2021

Type I interferon production elicits differential CD4 + T-cell responses in mice infected with Plasmodium berghei ANKA and P. chabaudi.

Int Immunol 2021 Oct 14. Epub 2021 Oct 14.

Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.

Plasmodium parasites that infect humans are highly polymorphic, and induce various infections ranging from asymptomatic state to life-threatening diseases. However, how the differences between the parasites affect host immune responses during blood-stage infection remains largely unknown. We investigated the CD4 + T-cell immune responses in mice infected with P. Read More

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October 2021

Identification of candidate genes on the basis of SNP by time-lagged heat stress interactions for milk production traits in German Holstein cattle.

PLoS One 2021 14;16(10):e0258216. Epub 2021 Oct 14.

Institute of Animal Breeding and Genetics, Justus-Liebig-University Gießen, Gießen, Germany.

The aim of this study was to estimate genotype by time-lagged heat stress (HS) variance components as well as main and interaction SNP-marker effects for maternal HS during the last eight weeks of cow pregnancy, considering milk production traits recorded in the offspring generation. The HS indicator was the temperature humidity index (THI) for each week. A dummy variable with the code = 1 for the respective week for THI ≥ 60 indicated HS, otherwise, for no HS, the code = 0 was assigned. Read More

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October 2021

Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.

PLoS One 2021 14;16(10):e0249501. Epub 2021 Oct 14.

Cambridge Centre for Sport & Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom.

The aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype variability, in previously untrained participants. A total of 3,969 potentially relevant papers were identified and processed for inclusion. After eligibility and study selection assessment, 24 studies were selected for meta-analysis, comprising a total of 3,012 participants (male n = 1,512; females n = 1,239; not stated n = 261; age 28 ± 9 years). Read More

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October 2021

Segmentation and genome annotation algorithms for identifying chromatin state and other genomic patterns.

PLoS Comput Biol 2021 Oct 14;17(10):e1009423. Epub 2021 Oct 14.

Department of Computer Science, University of Toronto, Toronto, Canada.

Segmentation and genome annotation (SAGA) algorithms are widely used to understand genome activity and gene regulation. These algorithms take as input epigenomic datasets, such as chromatin immunoprecipitation-sequencing (ChIP-seq) measurements of histone modifications or transcription factor binding. They partition the genome and assign a label to each segment such that positions with the same label exhibit similar patterns of input data. Read More

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October 2021

The evolutionary trajectories of the individual amygdala nuclei in the common shrew, guinea pig, rabbit, fox and pig: A consequence of embryological fate and mosaic-like evolution.

J Anat 2021 Oct 14. Epub 2021 Oct 14.

Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

The amygdala primarily evolved as a danger detector that regulates emotional behaviours and learning. However, it is also engaged in stress responses as well as olfactory/pheromonal and reproductive functions. All of these functions are processed by a set of nuclei which are derived from different telencephalic sources (pallial and subpallial) and have a unique cellular structure and specific connections. Read More

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October 2021

Subacute cadmium exposure modulates Th1 polarization to trigger ER stress-induced porcine hepatocyte apoptosis via regulation of miR-369-TNFα axis.

Environ Sci Pollut Res Int 2021 Oct 14. Epub 2021 Oct 14.

College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.

Cadmium (Cd), as a common environmental pollutant, has been reported to cause T lymphocyte dysfunction and cell apoptosis in multiple organs. However, whether subacute Cd exposure can induce apoptosis of hepatocytes and the relationship with Th1/Th2 imbalance were still unclear. In this study, ten 6-week-old piglets were selected and randomly assigned into two groups, the control group and the Cd group. Read More

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October 2021

Carbapenem-resistant bacteria on hand-held and hands-free electronic devices of healthcare workers and non-healthcare workers in Delhi, India.

Infect Prev Pract 2021 Sep 21;3(3):100162. Epub 2021 Jul 21.

Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, Delhi, India.

Background: Monitoring sensitivity profiles of circulating hospital strains is a key activity of a hospital infection control policy. The hospital environment and equipment may be reservoirs for carbapenem-resistant bacteria. Mobile phones have been shown to be a potential source for the transmission of bacteria in the healthcare environment. Read More

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September 2021

Genome features of common vetch () in natural habitats.

Plant Direct 2021 Oct 7;5(10):e352. Epub 2021 Oct 7.

Kazusa DNA Research Institute Kisarazu Japan.

Wild plants are often tolerant to biotic and abiotic stresses in their natural environments, whereas domesticated plants such as crops frequently lack such resilience. This difference is thought to be due to the high levels of genome heterozygosity in wild plant populations and the low levels of heterozygosity in domesticated crop species. In this study, common vetch () was used as a model to examine this hypothesis. Read More

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October 2021

Investigation of Key Signaling Pathways Associating miR-204 and Common Retinopathies.

Biomed Res Int 2021 4;2021:5568113. Epub 2021 Oct 4.

Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

MicroRNAs are a large group of small noncoding RNAs that work in multiple cellular pathways. miR-204, as one of the key axes in the development, maintenance, and pathogenesis of the retina, plays several roles by modulating its target genes. This study was aimed at evaluating the target genes of miR-204 involved in the development and progression of common retinopathies such as glaucoma, retinoblastoma, and age-related macular degeneration. Read More

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October 2021

Identification of Mast Cell-Based Molecular Subtypes and a Predictive Signature in Clear Cell Renal Cell Carcinoma.

Front Mol Biosci 2021 27;8:719982. Epub 2021 Sep 27.

Pediatric Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Kidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. Surgery is the preferred treatment option; however, the rate of distant metastasis is high. Mast cells in the tumor microenvironment promote or inhibit tumorigenesis depending on the cancer type; however, their role in KIRC is not well-established. Read More

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September 2021

Case Report: Systemic Treatment and Serial Genomic Sequencing of Metastatic Prostate Adenocarcinoma Progressing to Small Cell Carcinoma.

Front Oncol 2021 27;11:732071. Epub 2021 Sep 27.

Department of Bioinformatics, Center for Translational Medicine, Second Military Medical University, Shanghai, China.

Small cell carcinoma (SCC)/neuroendocrine prostate cancer (NEPC) is a rare and highly aggressive subtype of prostate cancer associated with an AR(androgen receptor)-null phenotype and visceral metastases. This study presents a 44-year-old man originally diagnosed with metastatic hormone-sensitive prostatic adenocarcinoma. After 6-month androgen deprivation therapy (ADT) combined with docetaxel, the patient developed paraplegia. Read More

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September 2021

Metagenomic profiling reveals dominance of gram-positive bacteria in the gut microbiome shifts associated with immunoglobulin A vasculitis (Henoch-Schönlein Purpura).

Clin Transl Immunology 2021 8;10(10):e1342. Epub 2021 Oct 8.

Department of Pediatrics The First Affiliated Hospital of Kunming Medical University Kunming China.

Objectives: Immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schönlein purpura, is the most common vasculitis that has a classical skin manifestation of palpable purpuric rash. Factors pertinent to IgAV remain inadequately understood. Here, we aimed to examine the gut microbiome shifts associated with IgAV and its recovery. Read More

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October 2021

Network-based pharmacology to predict the mechanism of and combined treatment of viral pneumonia.

Int J Clin Exp Pathol 2021 15;14(9):964-971. Epub 2021 Sep 15.

Department of Medicine, Zhejiang Chinese Medical University Hangzhou 310053, Zhejiang, China.

Background: Viral pneumonia (VP) is a common inflammatory disease caused by a virus in the upper respiratory tract. However, current treatment options for pneumonia are limited because of the strong infectivity and lack of research.

Method: Based on various databases, the mechanisms of and were predicted by network pharmacology. Read More

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September 2021

Bioinformatics Analysis Identified miR-584-5p and Key miRNA-mRNA Networks Involved in the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.

Front Genet 2021 27;12:750827. Epub 2021 Sep 27.

Key Laboratory of Oral Biomedical Research of Zhejiang Province, The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China.

Human periodontal ligament cells (PDLCs) play an important role in periodontal tissue stabilization and function. In the process of osteogenic differentiation of PDLSCs, the regulation of molecular signal pathways are complicated. In this study, the sequencing results of three datasets on GEO were used to comprehensively analyze the miRNA-mRNA network during the osteogenic differentiation of PDLSCs. Read More

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September 2021

SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and Experiments.

Front Genet 2021 27;12:743786. Epub 2021 Sep 27.

Department of Biomedical Informatics, School of Medicine, Pusan National University, Busan, South Korea.

Glioma is the most common primary malignant tumor that occurs in the central nervous system. Gliomas are subdivided according to a combination of microscopic morphological, molecular, and genetic factors. Glioblastoma (GBM) is the most aggressive malignant tumor; however, efficient therapies or specific target molecules for GBM have not been developed. Read More

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September 2021

Construction and Validation of an Immune Cell Signature Score to Evaluate Prognosis and Therapeutic Efficacy in Hepatocellular Carcinoma.

Front Genet 2021 27;12:741226. Epub 2021 Sep 27.

Shanghai Center for Bioinformation Technology, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China.

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with high morbidity and mortality worldwide. Tumor immune microenvironment (TIME) plays a pivotal role in the outcome and treatment of HCC. However, the effect of immune cell signatures (ICSs) representing the characteristics of TIME on the prognosis and therapeutic benefit of HCC patients remains to be further studied. Read More

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September 2021

Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers.

Front Genet 2021 27;12:714491. Epub 2021 Sep 27.

Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Barcelona, Spain.

The ability of detecting adaptive (positive) selection in the genome has opened the possibility of understanding the genetic basis of population-specific adaptations genome-wide. Here, we present the analysis of recent selective sweeps, specifically in the X chromosome, in human populations from the third phase of the 1,000 Genomes Project using three different haplotype-based statistics. We describe instances of recent positive selection that fit the criteria of hard or soft sweeps, and detect a higher number of events among sub-Saharan Africans than non-Africans (Europe and East Asia). Read More

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September 2021

Advances in Research on the Mechanism of Heterosis in Plants.

Front Plant Sci 2021 27;12:745726. Epub 2021 Sep 27.

Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Northeast Region), Ministry of Agriculture and Rural Affairs, Harbin, China.

Heterosis is a common biological phenomenon in nature. It substantially contributes to the biomass yield and grain yield of plants. Moreover, this phenomenon results in high economic returns in agricultural production. Read More

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September 2021

Transcriptome-Guided Insights Into Plastic Degradation by the Marine Bacterium.

Front Microbiol 2021 27;12:751571. Epub 2021 Sep 27.

Plant Omics Division, CSIR-Central Salt and Marine Chemical Research Institute, Bhavnagar, India.

Polyethylene terephthalate (PET) is a common single-use plastic that accumulated in the environment because of its non-degradable characteristics. In recent years, microbes from different environments were found to degrade plastics and suggested their capability to degrade plastics under varying environmental conditions. However, complete degradation of plastics is still a void for large-scale implications using microbes because of the lack of knowledge about genes and pathways intricate in the biodegradation process. Read More

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September 2021

Transforming Trauma With Lifestyle Medicine.

Am J Lifestyle Med 2021 Sep-Oct;15(5):538-540. Epub 2021 Apr 15.

Loma Linda University, Loma Linda, California.

A common misconception is that trauma-"injury" to the mind, body, and spirit-comes only to those individuals who have experienced threats of death, sexual violence, or serious injury. The SARS-CoV-2 (COVID-19) and the widespread disruption, anxiety, and stress it has left in its wake have shown us that this is not the case; trauma is universal. Left unaddressed, trauma can have long-term physical and psychological consequences. Read More

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Analysis of parental abnormal chromosomal karyotype and subsequent live births in Chinese couples with recurrent pregnancy loss.

Sci Rep 2021 Oct 13;11(1):20298. Epub 2021 Oct 13.

Department of Reproductive Medicine, The First Affiliated Hospital of the Medical College, Xi'an Jiaotong University, 76 West Yanta Road, Xi'an, 710061, Shaanxi Province, People's Republic of China.

The frequency and distribution of chromosomal abnormalities and the impact of parental chromosomal aberration on the pregnancy outcomes of couples with recurrent pregnancy loss remains controversial. 3235 RPL couples who experienced two or more miscarriages before 20 weeks were diagnosed in our tertiary referral hospital during 2008-2018 and included in the single-center retrospective cohort study covering a 10-year period. Chromosome aberration was detected in 121 (3. Read More

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October 2021

DNA methylation-based profiling reveals distinct clusters with survival heterogeneity in high-grade serous ovarian cancer.

Clin Epigenetics 2021 Oct 13;13(1):190. Epub 2021 Oct 13.

Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, No. 128, Shenyang Road, Yangpu District, Shanghai, 200090, China.

High-grade serous ovarian cancer (HGSOC) is the most common type of epigenetically heterogeneous ovarian cancer. Methylation typing has previously been used in many tumour types but not in HGSOC. Methylation typing in HGSOC may promote the development of personalized care. Read More

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October 2021

Approximation algorithm for rearrangement distances considering repeated genes and intergenic regions.

Algorithms Mol Biol 2021 Oct 13;16(1):21. Epub 2021 Oct 13.

Institute of Computing, University of Campinas, Campinas, Brazil.

The rearrangement distance is a method to compare genomes of different species. Such distance is the number of rearrangement events necessary to transform one genome into another. Two commonly studied events are the transposition, which exchanges two consecutive blocks of the genome, and the reversal, which reverts a block of the genome. Read More

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October 2021

Intestinal microbiota has important effect on severity of hand foot and mouth disease in children.

BMC Infect Dis 2021 Oct 13;21(1):1062. Epub 2021 Oct 13.

Graduate Collaborative Training Base of the Third People's Hospital of Shenzhen, Hengyang Medical School, University of South China, Hunan, 421001, China.

Background: The incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The relationship between different enterovirus genotypes and disease severity is not clearly understood. Given that enteroviruses are transmitted through the gastrointestinal tract, we hypothesized that variation in intestinal microorganisms of the host might play a role in the prognosis of HFMD. Read More

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October 2021

PPARγ activation by pioglitazone enhances the anti-proliferative effects of doxorubicin on pro-monocytic THP-1 leukemia cells via inducing apoptosis and G2/M cell cycle arrest.

J Recept Signal Transduct Res 2021 Oct 13:1-10. Epub 2021 Oct 13.

Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Purpose: Doxorubicin (DOX) is a common chemotherapeutic agent, with toxic side effects, and chemoresistance. Combination chemotherapy is a successful approach to overcome these limitations. Here, we investigated the effects of pioglitazone (PGZ), a PPARγ agonist, and/or DOX on the viability, cell cycle, apoptosis on THP-1 cells and normal human monocytes (NHMs). Read More

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October 2021

First Report of causing potato soft rot and blackleg in Serbia.

Plant Dis 2021 Oct 13. Epub 2021 Oct 13.

University of Novi Sad Faculty of Agriculture, 229813, Department of Plant and Environmental Protection , Novi Sad, Serbia;

Soft rot and blackleg are common diseases affecting potato () production in Serbia. Pectinolytic plant pathogens belonging to the genera cause soft rot and wilt diseases by plant cell wall degradation. These opportunistic phytopathogens lead to considerable economic losses in many potato-growing regions worldwide and are listed among top 10 plant pathogenic bacteria (Mansfield et al. Read More

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October 2021

Identification and Evaluation of Wheat-Aegilops bicornis Lines with Resistance to Powdery Mildew and Stripe Rust.

Plant Dis 2021 Oct 13. Epub 2021 Oct 13.

Crop Research Institute, 56644, Shandong Academy of Agricultural Sciences, 202 Gongyebei Road, Jinan, Shandong, China, Jinan, Shandong, China, 250100;

Wheat pathogens, especially those causing powdery mildew and stripe rust, seriously threaten yield worldwide. Utilizing newly identified disease resistance genes from wheat relatives is an effective strategy to minimize disease damage. In this study, chromosome-specific molecular markers for the 3Sb and 7Sb chromosomes of Aegilops bicornis were developed using PCR-based landmark unique gene (PLUG) primers for screening wheat-Ae. Read More

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October 2021

Viral load and rebound in children with coronavirus 2019 during the first outbreak in Daegu city.

Clin Exp Pediatr 2021 Oct 12. Epub 2021 Oct 12.

Department of Pediatrics, School of Medicine, Catholic University of Daegu, Daegu, Korea.

Background: Viral load and shedding duration are highly associated with the transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, limited studies have reported on viral load or shedding in children and adolescents infected with sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Purpose: This study aimed to investigate the natural course of viral load in asymptomatic or mild pediatric cases. Read More

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October 2021