14,333 results match your criteria genes changed

Gene expression profiles in the brain of phenylketonuria mouse model reversed by the low phenylalanine diet therapy.

Metab Brain Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road 1665#, Shanghai, 200092, China.

To gain insight into the potential protective mechanisms of low phenylalanine diet (LPD) in phenylketonuria (PKU), gene expression profiles were studied in the cerebral cortex and hippocampus of a PKU mouse model (BTBR-Pah). PKU mice were fed with low Phe diet (LPD-PKU group) and normal diet (PKU group). Wild-type mice were treated with normal diet (WT group) as control. Read More

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September 2021

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang-si, Gyeonggi-Do, South Korea.

Background: Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. Read More

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September 2021

Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway.

Life Sci 2021 Sep 11:119950. Epub 2021 Sep 11.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. Electronic address:

Background: The steroid receptor RNA activator 1 (SRA1) gene is involved in the progression of various cancers via different molecular mechanisms mediated by long non-coding RNA SRA (lncRNA SRA). This study aimed to evaluate the lncRNA SRA effect on the tumor progression of colorectal cancer (CRC).

Methods: SRA1 expression was assessed in the cancer genome atlas datasets, CRC cell lines, and tumor specimens. Read More

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September 2021

Metabolic maturation during postnatal right ventricular development switches to heart-contraction regulation due to volume overload.

J Cardiol 2021 Sep 10. Epub 2021 Sep 10.

Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. Electronic address:

Background: Metabolic maturation is one of the primary processes of postnatal cardiomyocyte development. How volume overload (VO), a pathological state of the right ventricle (RV) in children with congenital heart disease (CHD) and patients with heart failure, affects cardiomyocyte metabolic maturation is unclear.

Methods And Results: A fistula between the abdominal aorta and inferior vena cava on postnatal day 7 (P7) was created in a mouse model to induce a young-aged RV VO. Read More

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September 2021

Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity.

mBio 2021 Sep 14:e0159221. Epub 2021 Sep 14.

Department of Microbiology, Immunology, and Physiology, School of Medicine, Meharry Medical Collegegrid.259870.1, Nashville, Tennessee, USA.

Trypanosoma brucei, the infective agent for African trypanosomiasis, possesses a homologue of the translocase of the mitochondrial inner membrane 50 (TbTim50). It has a pair of characteristic phosphatase signature motifs, DXDX(T/V). Here, we demonstrated that, besides its protein phosphatase activity, the recombinant TbTim50 binds and hydrolyzes phosphatidic acid in a concentration-dependent manner. Read More

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September 2021

Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites.

Gynecol Obstet Invest 2021 Aug 18;86(4):388-397. Epub 2021 Aug 18.

Department of Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China.

Objectives: The aim of this study was to investigate the effects of berberine on polycystic ovary syndrome (PCOS) with insulin resistance (IR).

Design: This study performed 16S rRNA sequencing and metabolomic analysis on dehydroepiandrosterone (DHEA)-induced PCOS rats treated with berberine, focusing on the improvement of PCOS-IR by modifying gut microbiota and metabolism.

Methods: Forty-two female Sprague Dawley rats were randomly divided into 4 experimental groups of 8 rats each (PCOS + HFD, PCOS + HFD + BBR, NCD + PCOS, and NCD + PCOS + BBR groups). Read More

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Lipid degrading microbe consortium driving micro-ecological evolvement of activated sludge for cooking wastewater treatment.

Sci Total Environ 2021 Sep 3;804:150071. Epub 2021 Sep 3.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, Sichuan, PR China.

In this study, a lipid degrading microbe consortium (LDMC) was assembled to improve the performance of activated sludge (AS) on cooking wastewater purification. LDMC can rapidly degrade high-level oil (efficiency beyond 93.0% at 5. Read More

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September 2021

Heterocyclic androstane and estrane D-ring modified steroids: microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes.

J Steroid Biochem Mol Biol 2021 Sep 9:105997. Epub 2021 Sep 9.

Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Serbia. Electronic address:

D-ring-fused and D-homo lactone compounds in estratriene and androstane series were synthesized using microwave-assisted reaction conditions. Microwave-irradiated synthesis methods were convenient and effective, and provided high yields with short reaction times. Their inhibition of C-lyase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities were studied in in vitro enzyme assays. Read More

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September 2021

The effects of cadmium on the development of Drosophila and its transgenerational inheritance effects.

Toxicology 2021 Sep 8;462:152931. Epub 2021 Sep 8.

College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, China. Electronic address:

A new focus in toxicology research is the impact of parental exposure to environmental toxic substances on the characteristics of offspring. In the present study, newly produced eggs of Drosophila melanogaster were treated with different concentrations of cadmium (0, 1, 2, 4, 8 mg/kg) to study the effects of development. The results showed that cadmium changed the larval body length and weight, prolonged the pupation and eclosion time, and changed the relative expression levels of development-related genes (baz, β-Tub60D, tj). Read More

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September 2021

Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish.

Molecules 2021 Aug 29;26(17). Epub 2021 Aug 29.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.

The models of oxidative damage-induced aging were established by adding ethanol (CHOH), hydrogen peroxide (HO) and 6-hydroxydopamine (6-OHDA) to zebrafish embryos in this research. To find effective protective drugs/foods, Salvianolic acid B (Sal B) was added after the embryos were treated by these oxidative reagents. After being treated with ethanol, HO and 6-OHDA, the morphological changes were obvious and the deformities included spinal curvature, heart bleeding, liver bleeding, yolk sac deformity and pericardial edema, and the expression of oxidative stress-related genes , and and aging-related genes and were significantly up-regulated compared to the control group. Read More

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Transcriptomic analyses of the acute aerial and ammonia stress response in the gill and liver of large-scale loach (Paramisgurnus dabryanus).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Sep 7;250:109185. Epub 2021 Sep 7.

College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China. Electronic address:

The large-scale loach (Paramisgurnus dabryanus) is one of the most commercially important cultured species. Ammonia nitrogen accumulation is one of the key issue which limited production and animal health in aquaculture, but few of information is available on the molecular mechanisms of ammonia detoxification. We performed transcriptomic analyses of the gill and liver of large-scale loach subjected to 48 h of aerial and ammonia exposure. Read More

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September 2021

Application of a Mapping Method in the Analysis of Electroretinogram in Patients with Retinitis Pigmentosa.

Semin Ophthalmol 2021 Sep 9:1-7. Epub 2021 Sep 9.

Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Retinitis pigmentosa (RP) is a group of degenerative retinal diseases characterized by mutations in genes affecting retinal pigment epithelium (RPE) function, as well as mutations directly involving photoreceptors. This paper aims to evaluate a nonlinear method to distinguish between the RP and normal eye based on the Electroretinogram (ERG) signal.

Method: ERG signal was recorded from 28 eyes of patients with the RP and 32 normal eyes. Read More

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September 2021

Early phase of effective treatment induces distinct transcriptional changes in Mycobacterium tuberculosis expelled by pulmonary tuberculosis patients.

Sci Rep 2021 Sep 8;11(1):17812. Epub 2021 Sep 8.

The Foundation for Medical Research, Dr. Kantilal J. Sheth Memorial Building, 84-A, RG Thadani Marg, Worli, Mumbai, Maharashtra, 400018, India.

Effective treatment reduces a tuberculosis patient's ability to infect others even before they test negative in sputum or culture. Currently, the basis of reduced infectiousness of the Mycobacterium tuberculosis (Mtb) with effective treatment is unclear. We evaluated changes in aerosolized bacteria expelled by patients through a transcriptomic approach before and after treatment initiation (up to 14 days) by RNA sequencing. Read More

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September 2021

General Caspase Inhibition in Primary Chondrogenic Cultures Impacts Their Transcription Profile Including Osteoarthritis-Related Factors.

Cartilage 2021 Sep 8:19476035211044823. Epub 2021 Sep 8.

Department of Physiology, University of Veterinary Sciences, Brno, Czech Republic.

Objective: The knowledge about functions of caspases, usually associated with cell death and inflammation, keeps expanding also regarding cartilage. Active caspases are present in the growth plate, and caspase inhibition in limb-derived chondroblasts altered the expression of osteogenesis-related genes. Caspase inhibitors were reported to reduce the severity of cartilage lesions in osteoarthritis (OA), and caspase-3 might represent a promising biomarker for OA prognosis. Read More

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September 2021

HIF-1 is involved in the regulation of expression of metallothionein and apoptosis incidence in different oxygen conditions in the white shrimp Litopenaeus vannamei.

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 5;262:111072. Epub 2021 Sep 5.

Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera Gustavo Enrique Astiazarán Rosas, No. 46, Col La Victoria, Hermosillo, Sonora 83304, Mexico. Electronic address:

The white shrimp Litopenaeus vannamei is exposed to hypoxic conditions in natural habitats and in shrimp farms. Hypoxia can retard growth, development and affect survival in shrimp. The hypoxia-inducible factor 1 (HIF-1) regulates many genes involved in glucose metabolism, antioxidant proteins, including metallothionein (MT) and apoptosis. Read More

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September 2021

Mouse Ptchd3 is a non-essential gene.

Gene 2020 Dec 13;763S:100032. Epub 2020 Mar 13.

Department of Biology, Marshall University, Huntington WV25755, USA. Electronic address:

Mouse Ptchd3 (patched domain containing 3) was previously identified as a male germ-cell specific gene. The protein product of this gene has been found on the surface of mouse, rat and human sperm. Since Ptchd3 contains a conserved patched domain, we hypothesize that it functions as a membrane receptor for the hedgehog ligand. Read More

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December 2020

Overexpression of four MiTFL1 genes from mango delays the flowering time in transgenic Arabidopsis.

BMC Plant Biol 2021 Sep 7;21(1):407. Epub 2021 Sep 7.

College of Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530004, Guangxi, China.

Background: TERMINAL FLOWER 1 (TFL1) belongs to the phosphatidylethanolamine-binding protein (PEBP) family, which is involved in inflorescence meristem development and represses flowering in several plant species. In the present study, four TFL1 genes were cloned from the mango (Mangifera indica L.) variety 'SiJiMi' and named MiTFL1-1, MiTFL1-2, MiTFL1-3 and MiTFL1-4. Read More

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September 2021

DEHP exposure to lactating mice affects ovarian hormone production and antral follicle development of offspring.

J Hazard Mater 2021 08 20;416:125862. Epub 2021 Apr 20.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

Di (2-ethylhexyl) phthalate (DEHP) is widely used as a plastic additive and it could induce reproduction defects and fertility in mammals as environmental endocrine disruptor. However, the effects and potential mechanism of DEHP exposure during lactation stage on follicular development of offspring are still unclear. In this study, we found that the total primordial follicle number and antral follicles in the suckling of mice exposed to DEHP during lactation was significantly reduced. Read More

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Polystyrene microplastics impact the occurrence of antibiotic resistance genes in earthworms by size-dependent toxic effects.

Guanghui Xu Yong Yu

J Hazard Mater 2021 08 20;416:125847. Epub 2021 Apr 20.

Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China. Electronic address:

Microplastics (MPs) and antibiotic resistance genes (ARGs) are two classes of emerging and prevalent contaminants in terrestrial environments. To date, effects of MPs on the occurrence of ARGs in terrestrial invertebrates remain uncertain. Here we exposed earthworms to a soil amended with polystyrene MPs at two environmentally relevant concentrations to elucidate the occurrence and mechanisms of ARGs in earthworms impacted by MPs with different sizes. Read More

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The resistome of the bovine gastrointestinal tract.

Curr Opin Biotechnol 2021 Sep 4;73:213-219. Epub 2021 Sep 4.

Environmental Microbial and Food Safety Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, USA.

The gastrointestinal tracts of beef and dairy cattle are reservoirs of antimicrobial-resistant bacteria, and our knowledge of the ecology of resistance in these animals has changed with the advent of novel molecular technologies. Application of metagenomics and qPCR to the study of bovine gut ecology has demonstrated that there is overlap, with some differences, between beef and dairy cattle fecal resistomes, that treatment with antimicrobials often transiently influences the resistome, and young calves carry a high abundance of ARGs. Future work should harness emerging metagenome sequencing technologies to better describe the taxa harboring ARGs and collocated non-resistance genes and use these data along with identifying the multiplicity of factors driving resistance to develop strategies to reduce AMR carriage in cattle. Read More

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September 2021

Formation of viable but nonculturable state of Staphylococcus aureus under frozen condition and its characteristics.

Int J Food Microbiol 2021 Aug 27;357:109381. Epub 2021 Aug 27.

College of Food Science and Engineering, Jilin University, 5333 Xi'an Road, Changchun 130062, PR China. Electronic address:

Viable but nonculturable (VBNC) state of microorganisms has attracted much attention due to its characteristics, including the difficulty in detection by culture-based methods, virulence retention, high resistance, and so on. As a foodborne pathogen, Staphylococcus aureus is widely distributed, and has been found to enter the VBNC state under some environmental stresses, posing a potential threat to human health. Freezing is a common condition for food storage. Read More

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Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat.

Toxicol Appl Pharmacol 2021 Sep 4;430:115713. Epub 2021 Sep 4.

Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD, USA. Electronic address:

To study the complex processes involved in liver injuries, researchers rely on animal investigations, using chemically or surgically induced liver injuries, to extrapolate findings and infer human health risks. However, this presents obvious challenges in performing a detailed comparison and validation between the highly controlled animal models and development of liver injuries in humans. Furthermore, it is not clear whether there are species-dependent and -independent molecular initiating events or processes that cause liver injury before they eventually lead to end-stage liver disease. Read More

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September 2021

The pattern of DNA methylation alteration, and its association with the changes of gene expression and alternative splicing during phosphate starvation in tomato.

Plant J 2021 Sep 7. Epub 2021 Sep 7.

Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China.

DNA methylation is changed and associates with gene expression alterations in plant response to phosphate starvation (Pi-), a common stress that impacts plant growth and productivity. However, in the horticultural model species tomato, the dynamics of DNA methylation and its relation with the changes of gene transcription and alternative splicing (AS) under Pi- are unknown. Here, we performed integrative methylome and transcriptome analyses of tomato seedlings under Pi deficient and sufficient conditions. Read More

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September 2021

Comparative Analysis of Genomic and Transcriptome Sequences Reveals Divergent Patterns of Codon Bias in Wheat and Its Ancestor Species.

Front Genet 2021 20;12:732432. Epub 2021 Aug 20.

School of Life Science, Shanxi University, Taiyuan, China.

The synonymous codons usage shows a characteristic pattern of preference in each organism. This codon usage bias is thought to have evolved for efficient protein synthesis. Synonymous codon usage was studied in genes of the hexaploid wheat (AABBDD) and its progenitor species, (AA), (DD), and (AABB). Read More

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Positive selection of skeleton-related genes during duck domestication revealed by whole genome sequencing.

BMC Ecol Evol 2021 Sep 6;21(1):165. Epub 2021 Sep 6.

Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Yuanmingyuan West Road 2#, Beijing, 100193, China.

Background: Domestication alters several phenotypic, neurological, and physiological traits in domestic animals compared to those in their wild ancestors. Domestic ducks originated from mallards, and some studies have shown that spot-billed ducks may have also made minor genetic contributions to domestication. Compared with the two ancestral species, domestic ducks generally differ in body size and bone morphology. Read More

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September 2021

Lipidomic metabolism associated with acetic acid priming-induced salt tolerance in Carex rigescens.

Plant Physiol Biochem 2021 Sep 1;167:665-677. Epub 2021 Sep 1.

Department of Turfgrass Science and Engineering, College of Grassland Science and Technology, China Agricultural University, Beijing, 100193, PR China. Electronic address:

Acetic acid priming may mitigate salt stress to plants by modulating lipid metabolism. Carex rigescens is a stress-tolerant turfgrass species with a widespread distribution in north China. The objective of this study was to figure out whether modification of lipid profiles, including the contents, compositions and saturation levels of leaf lipids, may contribute to acetic acid modulated salt tolerance in C. Read More

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September 2021

Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy.

Free Neuropathol 2021 17;2. Epub 2021 Aug 17.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston MA.

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative tauopathy found in individuals with a history of repetitive head impacts (RHI). Previous work has demonstrated that neuroinflammation is involved in CTE pathogenesis, however, the specific inflammatory mechanisms are still unclear. Here, using RNA-sequencing and gene set enrichment analysis (GSEA), we investigated the genetic changes found in tissue taken from the region CTE pathology is first found, the cortical sulcus, and compared it to neighboring gryal crest tissue to identify what pathways were directly related to initial hyperphosphorylated tau (p-tau) deposition. Read More

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Polystyrene nanoplastics exacerbated the ecotoxicological and potential carcinogenic effects of tetracycline in juvenile grass carp (Ctenopharyngodon idella).

Sci Total Environ 2021 Aug 30;803:150027. Epub 2021 Aug 30.

College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), 528478, China; Institute of Eco-Environmental Research, Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Biophysical and Environmental Science Research Center, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

This study aims to evaluate the ecotoxicity effects of single tetracycline (TC) exposure and mixture exposure in presence of polystyrene nanoplastics (PS-NPs, 80 nm) on juvenile Ctenopharyngodon idella. We carried out single and combined exposure of TC (5000 μg/L) and PS-NPs (20, 200, 2000 μg/L) for 7 days. Compared to TC single exposure, co-exposure to PS-NPs and TC significantly changed the levels of antioxidant entities, including T-AOC, SOD, and CAT in the liver and intestine of C. Read More

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Phenol promoted caproate production via two-stage batch anaerobic fermentation of organic substance with ethanol as electron donor for chain elongation.

Water Res 2021 Aug 27;204:117601. Epub 2021 Aug 27.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, China; Shanghai Technical Service Platform for Pollution Control and Resource Utilization of Organic Wastes, Shanghai, 200438, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China. Electronic address:

The conversion of organic wastes/wastewater into medium chain fatty acids (MCFAs) such as caproate has attracted much attention, while the effects of toxic compounds on the process have rarely been studied. The present study investigated the effects of phenol (0-1.5 g/L), which is a toxicant and present in various organic wastes, on the caproate production in the chain elongation (CE) process with ethanol as electron donor via two-stage batch anaerobic fermentation of glucose. Read More

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Crocus sativus (saffron) petals extract and its active ingredient, anthocyanin improves ovarian dysfunction, regulation of inflammatory genes and antioxidant factors in testosterone-induced PCOS mice.

J Ethnopharmacol 2021 Sep 2;282:114594. Epub 2021 Sep 2.

Mashhad University of Medical Sciences, Mashhad, Iran.. Electronic address:

Ethnopharmacological Relevance: Saffron petal has traditionally been used to treat a variety of diseases, such as gynecological disease such as primary dysmenorrhea and premenstrual tension. Polycystic Ovary Syndrome (PCOS) is a form of gynecological disease that causes amenorrhea, infertility, menopausal and urogenital disorders. This disease may be treated with saffron petals. Read More

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September 2021