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A genome-proteome-based approach for xylan degradation by Cohnella sp. AR92.

Environ Microbiol Rep 2022 Aug 8. Epub 2022 Aug 8.

PROIMI - CONICET (National Scientific and Technical Research Council), Tucumán, Argentina.

Several members of Cohnella genus have been reported as xylanolytic bacteria with significant capacity as carbohydrate-active enzyme producers (CAZymes), whose mechanisms involving xylan degradation are a key goal for suitable applications in bio-based industries. Using Cohnella sp. AR92 bacterium, we ensembled a genomic-proteomic approach to assess plant biomass conversion targeting its xylanolytic set of enzymes. Read More

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Impact of Starmerella bacillaris and Zygosaccharomyces bailii on ethanol reduction and Saccharomyces cerevisiae metabolism during mixed wine fermentations.

Food Res Int 2022 Sep 8;159:111649. Epub 2022 Jul 8.

Institute for Integrative Systems Biology, I2SysBio, University of Valencia-CSIC, Paterna, Spain. Electronic address:

The bulk of grape juice fermentation is carried out by the yeast Saccharomyces cerevisiae, but non-Saccharomyces yeasts can modulate many sensorial aspects of the final products in ways not well understood. In this study, some of such non-conventional yeasts were screened as mixed starter cultures in a defined growth medium in both simultaneous and sequential inoculations. One strain of Starmerella bacillaris and another of Zygosaccharomyces bailii were chosen by their distinct phenotypic footprint and their ability to reduce ethanol levels at the end of fermentation. Read More

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September 2022

Transcriptome analysis revealed the role of capsular polysaccharides in desiccation tolerance of foodborne Staphylococcus aureus.

Food Res Int 2022 Sep 30;159:111602. Epub 2022 Jun 30.

School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China; Food Procession Research Institude, Anhui Agricultural University, Hefei, Anhui 230036, China. Electronic address:

Staphylococcus aureus (S. aureus) is a momentous factor affecting food safety. It can survive under long-term desiccation stress and contaminate foods that have intermediate to low water activities. Read More

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September 2022

Effect of germination on the main chemical compounds and 5-methyltetrahydrofolate metabolism of different quinoa varieties.

Food Res Int 2022 Sep 1;159:111601. Epub 2022 Jul 1.

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address:

This study determined the content of macronutrients and micronutrients to investigate the nutritional value and health benefits of six varieties of quinoa seeds and sprouts. Germination markedly increased the contents of proteins, reducing sugars, free amino acids, vitamins, and phytochemicals such as phenolic and carotenoid compounds, with variation among different quinoa varieties. Relatively high levels of 5-methyltetrahydrofolate (5-MTHF) were found in 6-day-old quinoa sprouts, especially in the LL-1 variety (1747. Read More

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September 2022

Sublethal HPH treatment is a sustainable tool that induces autolytic-like processes in the early gene expression of Saccharomyces cerevisiae.

Food Res Int 2022 Sep 30;159:111589. Epub 2022 Jun 30.

Department of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, Campus of Food Science, Piazza Goidanich 60, Cesena, FC, Italy; Interdepartmental Centre for Agri-Food Industrial Research, Campus of Food Science, Via Quinto Bucci 336, Cesena, FC, Italy. Electronic address:

Sublethal HPH treatments have been demonstrated to impact the technological properties and functions of treated microorganisms by inducing specific enzymes/genes or modulating membrane structures and inducing autolysis. In this work, the early effects of a 100 MPa HPH treatment on the winery starter Saccharomyces cerevisiae ALEAFERM AROM grown in synthetic must were assessed. While there were no differences in cell cultivability during the first 48 h between treated and untreated cells, a reduction in volatile metabolites released by HPH-treated cells during the first 2 h was observed. Read More

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September 2022

An LC-MS-based metabolomic approach provides insights into the metabolite profiles of Ginkgo biloba L. at different developmental stages and in various organs.

Food Res Int 2022 Sep 9;159:111644. Epub 2022 Jul 9.

Nanjing Forestry University, Co-Innovation Center for Sustainable Forestry in Southern China, 159 Longpan Road, Nanjing 210037, China. Electronic address:

Ginkgo (Ginkgo biloba L.) is a tree valued for the high medicinal and nutritional value of its leaves and seeds. However, the metabolite profiles of ginkgo leaves and seeds and their changes during development have not been comprehensively analyzed, which hinders improvements in the utilization of ginkgo. Read More

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September 2022

Analysis of 90 Listeria monocytogenes contaminated in poultry and livestock meat through whole-genome sequencing.

Food Res Int 2022 Sep 8;159:111641. Epub 2022 Jul 8.

School of Food and Health, Beijing Technology and Business University, Beijing, China. Electronic address:

Listeria monocytogenes is a food-borne pathogen that can cause human listeriosis. The main cause of L.monocytogenes poisoning is the consumption of contaminated or processed foods, of which meat is the main one. Read More

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September 2022

Effect of photoperiod on polyphenol biosynthesis and cellular antioxidant capacity in mung bean (Vigna radiata) sprouts.

Food Res Int 2022 Sep 9;159:111626. Epub 2022 Jul 9.

School of Food Science and Engineering, Ministry of Education Engineering Research Centre of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China. Electronic address:

This study investigated the effects of photoperiods on the metabolic regulation of polyphenol biosynthesis, as well as antioxidant activities in mung bean sprouts. Mung bean sprouts exposed to three different photoperiods: constant dark (light/dark, 0/24 h), semilight (light/dark, 12/12 h) and constant light (light/dark, 24/0 h). The results showed that the DFR, F6H, F3'5'H, F3'H, and F3H genes in the polyphenol biosynthetic pathway, as well as PHOT1/2, HY5, and MYBs, were strongly stimulated by photoperiods in sprouts. Read More

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September 2022

Effect of low-intensity magnetic field on the growth and metabolite of Grifola frondosa in submerged fermentation and its possible mechanisms.

Food Res Int 2022 Sep 20;159:111537. Epub 2022 Jun 20.

School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China; Institute of Food Physical Processing, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, China. Electronic address:

This study aimed to investigate the effects of low intensity alternating magnetic field on the submerged fermentation of Grifola frondosa, and its possible mechanism was also explored. Under the optimal shaking flask conditions, amino acids in mycelium with magnetic field treatment significantly increased, and the morphology of mycelium obviously changed. During the scale-up magnetic field-assisted fermentation, Mycelium biomass increased by 12%. Read More

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September 2022

Should and will "cultured meat" become a reality in our plates?

Adv Food Nutr Res 2022 25;101:181-212. Epub 2022 May 25.

INRAE, University of Clermont-Ferrand, VetAgro Sup, Saint Genès Champanelle, France.

Produced from proliferating cells in bioreactors with a controlled culture medium, "cultured meat" has been presented by its supporters, who are mainly private actors (start-ups), as a sustainable solution to meet the growing demand for animal proteins without weaknesses of animal husbandry in terms of environmental impact, animal welfare or even health. The aim of this chapter is to take stock of current knowledge on the potential benefits and pitfalls of this novel product. Since robust scientific arguments are lacking on these aspects, there is no consensus on the health and nutritional qualities of "cultured meat" for human consumption and on its potential low environmental impact. Read More

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Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity.

Life Sci Space Res (Amst) 2022 Aug 15;34:45-52. Epub 2022 Jun 15.

Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, UAE; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, UAE. Electronic address:

Background: Hind-limb unloaded (HLU) mouse model exhibits skeletal muscle atrophy and weakness mimicking the conditions such as prolonged spaceflight. However, the molecular mechanisms and interventions of muscle loss during muscle unloading remain elusive. Dysfunction of protein folding by ednoplasmic reticulum (ER), a condition called ER stress, is implicated in diseases of various cell types, but its contribution to skeletal muscle detriment remains elusive. Read More

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Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish.

Life Sci Space Res (Amst) 2022 Aug 21;34:21-29. Epub 2022 May 21.

SMV124A, Gene Therapy Laboratory, Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, TN 632 014, India. Electronic address:

Microgravity and hypergravity-induced changes affect both molecular and organismal responses as demonstrated in various animal models. In addition to its inherent advantages, zebrafish have been shown to be incredibly resilient to altered gravity conditions. To understand the effects of altered gravity on animal physiology, especially the cardiovascular system, we used 2 h centrifugations to simulate short-term hypergravity and investigated its effects on zebrafish development. Read More

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T Cell Transcriptome in Chromosome 22q11.2 Deletion Syndrome.

J Immunol 2022 Aug 8. Epub 2022 Aug 8.

Department of Pediatrics, Children's Mercy Kansas City, University of Missouri Kansas City School of Medicine, Kansas City, MO.

Phenotypic variations of chromosome 22q11.2 deletion syndrome (22qDS) have unclear explanations. T cell lymphopenia in 22qDS related to varying degrees of thymic hypoplasia contributes to the phenotypic heterogeneity. Read More

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Duck CD8 T Cell Response to H5N1 Highly Pathogenic Avian Influenza Virus Infection In Vivo and In Vitro.

J Immunol 2022 Aug 8. Epub 2022 Aug 8.

National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China;

Domestic ducks are the important host for H5N1 highly pathogenic avian influenza virus (HPAIV) infection and epidemiology, but little is known about the duck T cell response to H5N1 AIV infection. In infection experiments of mallard ducks, we detected significantly increased CD8 cells and augmented expression of cytotoxicity-associated genes, including granzyme A and IFN-γ, in PBMCs from 5 to 9 d postinfection when the virus shedding was clearly decreased, which suggested the importance of the duck cytotoxic T cell response in eliminating H5N1 infection in vivo. Intriguingly, we found that a CD8 population of PBMCs was clearly upregulated in infected ducks from 7 to 9 d postinfection compared with uninfected ducks. Read More

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Detection and validation of cis-regulatory motifs in osmotic stress-inducible synthetic gene switches via computational and experimental approaches.

Funct Plant Biol 2022 Aug 9. Epub 2022 Aug 9.

Synthetic cis-regulatory modules can improve our understanding of gene regulatory networks. We applied an ensemble approach for de novo cis motif discovery among the promoters of 181 drought inducible differentially expressed soybean (Glycine max L.) genes. Read More

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Mol Pharmacol 2022 Aug 8. Epub 2022 Aug 8.

Yazd, Iran, Islamic Republic of.

Structurally rearranged extrachromosomal circular DNAs (eccDNAs) have been identified in tumor cells, many of which carrying regions related to cancer-driver recurrent oncogenes (e.g. , and In a tumor cell, eccDNAs are carrying regions associated with oncogene amplification (>10-fold amplified-copy numbers in human tumors) and poor outcome across multiple cancers. Read More

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Effect of ABCB1 gene variants on rivaroxaban pharmacokinetic and hemorrhage event occurred in patients with non-valvular atrial fibrillation.

Biopharm Drug Dispos 2022 Aug 8. Epub 2022 Aug 8.

Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, China.

Hemorrhage events occurred most frequently in non-valvular atrial fibrillation (NVAF) anticoagulant therapy. Rivaroxaban was widely used for routine anticoagulation care. Genetic polymorphisms are thought to contribute to the wide intraindividual variability seen in rivaroxaban metabolism and anticoagulant response. Read More

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The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR.

Mol Metab 2022 Aug 5:101566. Epub 2022 Aug 5.

Department of Medicine, Division of Endocrinology, David Geffen School of Medicine at UCLA. 650 Charles E. Young Dr., Los Angeles, CA 90095 USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA. 650 Charles E. Young Dr., Los Angeles, CA 90095 USA; Molecular Biology Institute, University of California, Los Angeles, CA, USA at UCLA; Institut de Biologia Molecular de Barcelona, IBMB, CSIC, Baldiri Reixac 4-8, Barcelona, Catalonia, 08028, Spain. Electronic address:

Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can reverse established NASH is unknown.

Methods: N-acetylgalactosamine-siRNA conjugates, an FDA approved method to deliver siRNA selectively to hepatocytes, were used to knockdown hepatocyte-Drp1 in mice (NAG-Drp1si). Read More

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mTORC1 is required for epigenetic silencing during β-cell functional maturation.

Mol Metab 2022 Aug 5:101559. Epub 2022 Aug 5.

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Sino-French Research Center for Life Sciences and Genomics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is a key molecule that links nutrients, hormones, and growth factors to cell growth/function. Our previous studies have shown that mTORC1 is required for β-cell functional maturation and identity maintenance; however, the underlying mechanism is not fully understood. This work aimed to understand the underlying epigenetic mechanisms of mTORC1 in regulating β-cell functional maturation. Read More

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Acute hypoxia promotes the liver angiogenesis of largemouth bass (Micropterus salmoides) by HIF - Dependent pathway.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Electronic address:

A 24-hour hypoxia exposure experiment was conducted to determine how hypoxia exposure induce liver angiogenesis in largemouth bass. Nitrogen (N) was pumped into water to exclude dissolved oxygen into 1.2 ± 0. Read More

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Dietary of Lactobacillus paracasei and Bifidobacterium longum improve nonspecific immune responses, growth performance, and resistance against Vibrio parahaemolyticus in Penaeus vannamei.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

Department of Aquaculture, National Taiwan Ocean University, Keelung City, Taiwan. Electronic address:

This study investigated the effects of two probiotics, namely Lactobacillus paracasei and Bifidobacterium longum, as feed additives on growth performance, nonspecific immunity, immune-related gene expression, and disease resistance against Vibrio parahaemolyticus in Penaeus vannamei. The experimental diets were prepared using L. paracasei and B. Read More

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Molecular characterization and expression analysis of interleukin-15 (IL-15) genes in orange-spotted grouper (Epinephelus coioides) in response to Vibrio harveyi challenge.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

Shenzhen Institute of Guangdong Ocean University, Shenzhen, 518120, China; Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 51820, China; College of Fishery, Guangdong Ocean University, Zhanjiang, 524025, China; Guangdong Provincial Key Laboratory of Aquaic Animal Disease Control and Healthy Culture, Zhanjiang, 524025, China. Electronic address:

As a member of the γc family, interleukin 15 plays an important function in the immune response. In this study, we cloned an IL15 from Epinephelus coioides (named Ec-IL15). The open reading frame of Ec-IL15 is 528 bp, encoding 175 amino acids. Read More

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Methionine played a positive role in improving the intestinal digestion capacity, anti-inflammatory reaction and oxidation resistance of grass carp, Ctenopharyngodon idella, fry.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

Tongwei Co, Ltd, Healthy Aquaculture Key Laboratory of Sichuan Province, Chengdu, 610093, China. Electronic address:

A study was carried out to appraisal the function of methionine on intestinal digestion and the health of grass carp (Ctenopharyngodon idella) fry (initial weight 0.36 ± 0.01 g). Read More

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Involvement of galectin-9 from koi carp (Cyprinus carpio) in the immune response against Aeromonas veronii infection.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

Beijing Key Laboratory of Fishery Biotechnology&Fisheries Research Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing, PR China; National Freshwater Fisheries Engineering Technology Research Center, Beijing, PR China. Electronic address:

Galectins are β-galactoside sugar binding proteins which function as important pattern recognition receptors (PRRs) in innate immunity. Here, we identified a galectin-9 gene from koi carp (Cyprinus carpio), named kGal-9. The ORF of kGal-9 is 963 bp in length, which encodes a polypeptide of 320 amino acids without either signal peptide. Read More

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The first identified invertebrate LGP2-like homolog gene in the Pacific oyster Crassostrea gigas.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

School of Agriculture, Ludong University, Yantai, 264025, China. Electronic address:

The LGP2 (Laboratory of Genetics and Physiology 2) protein is a member of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLRs) family, which is a class of antiviral pattern recognition receptors located in the cytoplasm. However, few studies have investigated the function of LGP2 in invertebrates. In this study, the complete coding sequence of the LGP2 gene of the Pacific oyster, Crassostrea gigas, was obtained and named CgLGP2-like. Read More

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Early immune response of two common carp breeds to koi herpesvirus infection.

Fish Shellfish Immunol 2022 Aug 5. Epub 2022 Aug 5.

Department of Infection Diseases and Preventive Medicine, Veterinary Research Institute, Brno, 621 00, Czech Republic. Electronic address:

Economic importance of common carp (Cyprinus carpio L.) increases every year. Viral diseases are major threat for carp aquaculture and cause significant economic losses. Read More

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Daytime restricted feeding Promotes Circadian Desynchrony and Metabolic Disruption with Changes in Bile Acids profiles and Gut Microbiota in C57BL/6 Male Mice.

J Nutr Biochem 2022 Aug 5:109121. Epub 2022 Aug 5.

School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, Jiangsu, P.R. China.. Electronic address:

Fasting/feeding cycles regulate clock-lipid-bile acid (BA) metabolic homeostasis, and gut microbiota also participates in connecting circadian rhythms with BA metabolism. To investigate the cyclical nature of microbial-metabolism-host interactions, sixty male C57BL/6 mice were randomized into three feeding regimens with a chow diet: 24 h ad libitum (AC), 12 h nighttime feeding (NC) or 12 h daytime feeding (DC). Five weeks later, the mice were sacrificed at six-hour intervals over 24 hours. Read More

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The clock component OsLUX regulates rice heading through recruiting OsELF3-1 and OsELF4s to repress Hd1 and Ghd7.

J Adv Res 2022 Aug 5. Epub 2022 Aug 5.

China National Center for Rice Improvement and State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006, China. Electronic address:

Introduction: Circadian clocks coordinate internal physiology and external environmental factors to regulate cereals flowering, which is critical for reproductive growth and optimal yield determination.

Objectives: In this study, we aimed to confirm the role of OsLUX in flowering time regulation in rice. Further research illustrates how the OsELF4s-OsELF3-1-OsLUX complex directly regulates flowering-related genes to mediate rice heading. Read More

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Silicon nanoparticles in higher plants: Uptake, action, stress tolerance, and crosstalk with phytohormones, antioxidants, and other signalling molecules.

Environ Pollut 2022 Aug 5:119855. Epub 2022 Aug 5.

Department of Plant Physiology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, Bratislava, Slovakia; Institute of Chemistry, Slovak Academy of Sciences, Dubravska Cesta 9, Bratislava, Slovakia.

Silicon is absorbed as uncharged mono-silicic acid by plant roots through passive absorption of Lsi1, and influx transporter belonging to the aquaporin protein family. Lsi2 then actively effluxes silicon from root cells towards the xylem from where it is exported by Lsi6 for silicon distribution and accumulation to other parts. Recently, it was proposed that silicon nanoparticles (SiNPs) might share a similar route for their uptake and transport. Read More

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Integrated analysis of long-noncoding RNA and circular RNA expression in Peste-des-Petits-Ruminants Virus (PPRV) infected marmoset B lymphocyte (B95a) cells.

Microb Pathog 2022 Aug 5:105702. Epub 2022 Aug 5.

Veterinary Biotechnology Division, Indian Veterinary Research Institute, Uttar Pradesh, 243122, India. Electronic address:

Peste-des-Petits-Ruminants (PPR) or goat plague is an important viral disease of sheep and goats caused by the small ruminant morbilli virus or PPR virus (PPRV). Long non coding RNAs (lncRNA) and circular RNAs (circRNA) play a pivotal role in several biological processes including regulation of virus-host interactions. The present study explored the expression of lncRNA, circRNA and their functions in PPRV infected B-lymphocyte (B95a) cells. Read More

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