6 results match your criteria generic lt4

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Levothyroxine Formulations: Pharmacological and Clinical Implications of Generic Substitution.

Adv Ther 2019 09 4;36(Suppl 2):59-71. Epub 2019 Sep 4.

Department of Endocrinology and Internal Medicine, Aalborg University Hospital, Aalborg, Denmark.

Oral levothyroxine (LT4) is the standard therapy for patients with hypothyroidism. Oral LT4 is available in several formulations, including tablets, soft gel capsules and oral solution. Multiple brand-name and generic LT4 tablets are available. Read More

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September 2019

Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females.

Med Hypotheses 2019 Oct 2;131:109299. Epub 2019 Jul 2.

Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia; Faculty of Stomatology in Pancevo, University Business Academy in Novi Sad, Pancevo, Serbia.

Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients' quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Read More

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October 2019

Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy.

PLoS One 2016 3;11(6):e0156925. Epub 2016 Jun 3.

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Background: Hypothyroidism is often diagnosed, and subsequently treated, due to health-related quality of life (HRQL) issues. However, HRQL following treatment has never previously been assessed in longitudinal descriptive studies using validated instruments.

Objective: To investigate disease-specific (ThyPRO) and generic (SF-36) HRQL, following levothyroxine therapy in patients with hypothyroidism due to autoimmune thyroiditis. Read More

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Generic levothyroxine compared with synthroid in young children with congenital hypothyroidism.

J Clin Endocrinol Metab 2013 Feb 4;98(2):653-8. Epub 2013 Jan 4.

Department of Pediatrics, Division of Endocrinology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-9170, USA.

Context: Clinicians who prescribe levothyroxine (LT4) for hypothyroidism often feel strongly about using a brand-name drug instead of a generic.

Objective: The objective of the study was to determine whether Synthroid resulted in better control of congenital hypothyroidism than generic LT4.

Design: This was a 5-year retrospective study. Read More

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February 2013

Adverse event reporting in patients treated with levothyroxine: results of the pharmacovigilance task force survey of the american thyroid association, american association of clinical endocrinologists, and the endocrine society.

Endocr Pract 2010 May-Jun;16(3):357-70

Harvard Medical School, Boston, Massachusetts Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Objective: To survey physicians to determine whether potency and consistency issues with levothyroxine sodium (LT4) have been resolved and to assess current experience regarding safety of substituting LT4 products.

Methods: Members of the American Association of Clinical Endocrinologists, American Thyroid Association, and The Endocrine Society collaborated to create a survey instrument that would effectively sample the clinical experience of their society members and frequent prescribers of LT4. More than 18,000 e-mailed requests for information were generated, and the Web sites of each society provided links to the data collection form. Read More

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September 2010

A study in normal human volunteers to compare the rate and extent of levothyroxine absorption from Synthroid and Levoxine.

Authors:
J A Berg G H Mayor

J Clin Pharmacol 1992 Dec;32(12):1135-40

Boots Pharmaceuticals, Inc., Lincolnshire, Illinois 60069.

Numerous branded and generic formulations of levothyroxine (LT4) sodium tablets are currently available. Results from previous studies attempting to examine the comparative bioavailability of these formulations are difficult to interpret because of subject heterogeneity, single time-point blood sampling, varying degrees of hypothyroidism, and other factors. This study was devised to compare the rate and extent of absorption of LT4 from different LT4 sodium tablet formulations, in a simple model using a single-dose two-way single-blind, randomized cross-over design in 30 normal, healthy, nonpregnant, female subjects. Read More

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December 1992
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