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Clinical benefits of a Bayesian model for plasma-derived factor VIII/VWF after one year of pharmacokinetic-guided prophylaxis in severe/moderate hemophilia A patients.

Thromb Res 2021 Jul 15;205:99-105. Epub 2021 Jul 15.

Hospital Universitari i Politècnic La Fe, Pharmacy Department, Valencia, Spain.

Introduction: Individual pharmacokinetic (PK) profiling in hemophilia A (HA) helps to individualize prophylaxis using population PK models (popPK). A specific popPK model for plasma-derived factor VIII containing von-Willebrand Factor (pdFVIII/VWF) was developed.

Aim: To compare standard versus PK-driven prophylaxis, using a generic or a specific popPK model for pdFVIII/VWF. Read More

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Effectiveness and tolerability of dolutegravir and abacavir/lamivudine administered as two separate pills compared to their equivalent single-tablet regimen in a multicentre cohort in Spain.

J Int AIDS Soc 2021 Jul;24(7):e25758

National Epidemiology Centre, Instituto de Salud Carlos III, Madrid, Spain.

Introduction: We aimed to assess the effectiveness and tolerability of dolutegravir (DTG), abacavir (ABC) and lamivudine (3TC) administered as branded STR (DTG/ABC/3TC) or as two separate pills (DTG and either branded ABC/3TC [DTG+(ABC/3TC)b] or generic ABC/3TC [DTG+(ABC/3TC)g]).

Methods: We included individuals from the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) who received DTG/ABC/3TC, DTG+(ABC/3TC)b or DTG+(ABC/3TC)g during 2015 to 2018. We used multivariable logistic regression to compare the proportion of antiretroviral-naïve individuals who achieved viral suppression (VS) (viral load ≤50 copies/mL) at 24 weeks of initiating with DTG+(ABC/3TC)b or DTG+(ABC/3TC)g versus DTG/ABC/3TC. Read More

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Collection and Reporting of Patient-reported Outcome Measures in Arthroplasty Registries: Multinational Survey and Recommendations.

Clin Orthop Relat Res 2021 Jul 21. Epub 2021 Jul 21.

Department of Orthopaedic Surgery, Kaiser Permanente South Bay Medical Center, Harbor City, CA, USA.

Background: Patient-reported outcome measures (PROMs) are validated questionnaires that are completed by patients. Arthroplasty registries vary in PROM collection and use. Current information about registry collection and use of PROM is important to help improve methods of PROMs data analysis, reporting, comparison, and use toward improving clinical practice. Read More

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Equivalence testing of a newly developed interviewer-led telephone script for the EORTC QLQ-C30.

Qual Life Res 2021 Jul 20. Epub 2021 Jul 20.

Quality of Life Department, EORTC, Brussels, Belgium.

Purpose: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life-Core Questionnaire (QLQ-C30) is a widely used generic self-report measure of health-related quality of life (HRQOL) for cancer patients. However, no validated voice script for interviewer-led telephone administration was previously available. The aim of this study was to develop a voice script for interviewer administration via telephone. Read More

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Patient-reportedimpact of myasthenia gravis in the real world: protocol for a digital observational study (MyRealWorld MG).

BMJ Open 2021 Jul 20;11(7):e048198. Epub 2021 Jul 20.

argenx BV, Ghent, Belgium.

Introduction: Myasthenia gravis (MG) is a rare, chronic, autoimmune disease, mediated by immunoglobulin G antibodies, which causes debilitating muscle weakness. As with most rare diseases, there is little patient-reported data with which to understand and address patient needs. This study explores the impact of MG in the real world from the patient perspective. Read More

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Examining the effect of an education intervention on nurses' medicines management knowledge.

Nurs Manag (Harrow) 2021 Jul 20. Epub 2021 Jul 20.

University of Oslo, Norway.

Background: Suboptimal medicines management due to inadequate knowledge can cause risks to patient safety and affect the quality of care and patient outcomes.

Aim: To examine the effect of an educational programme on nurses' knowledge of medicines management.

Method: A pre and post-design was used to evaluate the effectiveness of an educational medicines management programme. Read More

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Prophylactic Intraoperative Uterine Artery Embolization During Cesarean Section or Cesarean Hysterectomy in Patients with Abnormal Placentation: A Systematic Review and Meta-Analysis.

Cardiovasc Intervent Radiol 2021 Jul 19. Epub 2021 Jul 19.

Department of Medical Imaging, Chi Mei Medical Center, NO. 901, Zhonghua Rd., Yongkang Dist., Tainan City, 710, Taiwan.

Purpose: To evaluate the effectiveness and safety of prophylactic intraoperative uterine artery embolization (UAE) performed immediately after fetal delivery during planned cesarean section or cesarean hysterectomy in patients with placenta accreta spectrum disorder or placenta previa.

Methods: A systematic search was conducted on Ovid MEDLINE and Embase, PubMed, Web of Science, and Cochrane databases. Studies were selected using the Population/Intervention/Comparison/Outcomes (PICO) strategy. Read More

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The Development of a Covid-19 Control Measures Risk Matrix for Occupational Hygiene Protective Measures.

Ann Work Expo Health 2021 Jul 19. Epub 2021 Jul 19.

The University of Manchester, Centre for Occupational and Environmental Health, Manchester, UK.

The British Occupational Hygiene Society (BOHS) Covid-19 Working Group developed a control banding matrix to provide guidance for employers and others to help assess the risks of Covid-19 infection during the pandemic. The matrix was based on occupational hygiene principles and the judgement of the occupational health practitioners involved; since objective data on workers' exposure were unavailable. Users of the matrix identify one of five exposure categories based on generic job descriptions and example occupations, and these categories are linked to generic guidance on interventions at source, on the exposure pathway and for individual workers. Read More

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Effectiveness of a Novel Smartphone Health Education Intervention in Enhancing Knowledge, Attitudes, and Practices for the Prevention of Respiratory Tract Infections Among Private Hajj Pilgrims From Malaysia.

Front Public Health 2021 1;9:594204. Epub 2021 Jul 1.

School of Computer Sciences, Universiti Sains Malaysia, George Town, Malaysia.

This study was aimed to develop and evaluate the efficacy of a health education program for increasing knowledge, changing attitudes, and promoting prevention practices to reduce the incidence of RTIs among Malaysian Hajj pilgrims. A quasi-experimental study was done among 130 Hajj pilgrims attending Hajj orientation course organized by a private Hajj tour companies. Hajj pilgrims assigned to intervention group ( = 65) and control group ( = 65). Read More

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Systematic review on the use of patient-reported outcome measures in brain tumor studies: part of the Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) initiative.

Neurooncol Pract 2021 Aug 13;8(4):417-425. Epub 2021 Feb 13.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

Background: The Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) working group aims to provide guidance on the use of PROs in brain tumor patients. PRO measures should be of high quality, both in terms of relevance and other measurement properties. This systematic review aimed to identify PRO measures that have been used in brain tumor studies to date. Read More

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Developing a competence framework for nurses in pharmaceutical care: A Delphi study.

Nurse Educ Today 2021 Apr 24;104:104926. Epub 2021 Apr 24.

Research Group Care for the Chronically Ill, HU University of Applied Sciences Utrecht, Utrecht, the Netherlands. Electronic address:

Background: Nurses play an important role in pharmaceutical care. They are involved in: detecting clinical change; communicating/discussing pharmacotherapy with patients, their advocates, and other healthcare professionals; proposing and implementing medication-related interventions; and ensuring follow-up of patients and medication regimens. To date, a framework of nurses' competences on knowledge, skills, and attitudes as to interprofessional pharmaceutical care tasks is missing. Read More

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Accuracy of predicting chemical body composition of growing pigs using dual-energy X-ray absorptiometry.

Animal 2021 Jul 14;15(8):100307. Epub 2021 Jul 14.

Agroscope, Swine Research Unit, Tioleyre 4, 1725 Posieux, Switzerland.

Studies in animal science assessing nutrient and energy efficiency or determining nutrient requirements benefit from gathering exact measurements of body composition or body nutrient contents. Those are acquired by standardized dissection or by grinding the body followed by wet chemical analysis, respectively. The two methods do not result in the same type of information, but both are destructive. Read More

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Pharmacokinetics and Bioequivalence of a Generic Fixed-Dose Combination Tablet of Metformin Hydrochloride/Vildagliptin Versus a Branded Product in Healthy Chinese Subjects Under Fed and Fasting Conditions.

Clin Pharmacol Drug Dev 2021 Jul 17. Epub 2021 Jul 17.

Phase I Clinical Trial Unit, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.

The purpose of this study was to compare the bioequivalence and safety of test and reference preparations of fixed-dose combination tablets of metformin hydrochloride/vildagliptin 850 mg/50 mg in healthy volunteers under fasting and fed conditions for marketing authorization in China. A single-dose, randomized, open-label, 2-way crossover study was conducted. Blood samples were collected up to 36 hours after dosing in each period with a 7-day washout. Read More

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Physical activity and sedentary behaviour counselling: Attitudes and practices of mental health professionals.

PLoS One 2021 16;16(7):e0254684. Epub 2021 Jul 16.

Institute for Health and Sport, Victoria University, Footscray, Australia.

Background: Despite recent interest in the mental health benefits of increasing physical activity (PA) and reducing sedentary behaviour (SB), little is known about PA and SB counselling provided by mental health professionals. Therefore, the aim of this study was to explore the attitudes and practices of mental health professionals in recommending more PA and less SB to their clients.

Methods: Quantitative data were collected using a modified version of the Exercise in Mental Illness Questionnaire in a sample of 17 Australian mental health professionals. Read More

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Health-Related Quality of Life in Patients With Different Diseases Measured With the EQ-5D-5L: A Systematic Review.

Front Public Health 2021 29;9:675523. Epub 2021 Jun 29.

School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.

The EQ-5D-5L is a generic preference-based questionnaire developed by the EuroQol Group to measure health-related quality of life (HRQoL) in 2005. Since its development, it has been increasingly applied in populations with various diseases and has been found to have good reliability and sensitivity. This study aimed to summarize the health utility elicited from EQ-5D-5L for patients with different diseases in cross-sectional studies worldwide. Read More

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Preoperative versus Post-operative Radiotherapy for Extremity Soft tissue Sarcoma: a Systematic Review and Meta-analysis of Long-term Survival.

J Plast Reconstr Aesthet Surg 2021 Jun 9. Epub 2021 Jun 9.

The Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, UK.

Background: The role of perioperative radiotherapy in the management of resectable extremity soft tissue sarcoma (ESTS) is widely recognised for local tumour control, wound complications (WC) and long-term function. However, debate continues regarding its implications on long-term survival. This study aimed to determine whether the timing of perioperative radiotherapy affects long-term survival outcomes in adults with ESTS. Read More

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Skills, competencies, and policies for advanced practice critical care nursing in Europe: A scoping review.

Nurse Educ Pract 2021 Jul 5;54:103142. Epub 2021 Jul 5.

School of Nursing and Midwifery, Plymouth University, UK. Electronic address:

Objectives: Management of critically ill patients is changing due a rise in population age, comorbidity and complexity. To accommodate these changes, the demand is increasing for advanced practice nurses. More knowledge is needed regarding the role of advanced practice critical care nurses in European countries. Read More

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Overexpression of transcription factor BLIMP1/prdm1 leads to growth inhibition and enhanced secretory capacity in Chinese hamster ovary cells.

Metab Eng 2021 Jul 13;67:237-249. Epub 2021 Jul 13.

Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, UK; Department of Chemical Engineering and Analytical Science, Biochemical and Bioprocess Engineering Group, University of Manchester, Manchester, UK. Electronic address:

Chinese hamster ovary (CHO) cells present inherent limitations for processing and secretion of large amounts of recombinant proteins, especially for those requiring complex post-translational processing. To tackle these limitations, we engineered CHO host cells (CHOK1 and CHOS) to overexpress the transcription factor BLIMP1/prdm1 (a master regulator of the highly-secreting phenotype of antibody-producing plasma cells), generating novel CHO cell lines (referred to as CHOB). The CHOB cell lines exhibited decreased cell densities, prolonged stationary phase and arrested cell cycle in G1/G0 phase but simultaneously had significantly greater product titre for recombinant IgG1 (> 2-fold increase) coupled with a significantly greater cell-specific productivities (> 3-fold increase). Read More

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Effect of Physician-Delivered COVID-19 Public Health Messages and Messages Acknowledging Racial Inequity on Black and White Adults' Knowledge, Beliefs, and Practices Related to COVID-19: A Randomized Clinical Trial.

JAMA Netw Open 2021 07 1;4(7):e2117115. Epub 2021 Jul 1.

Department of Economics, Massachusetts Institute of Technology, Cambridge.

Importance: Social distancing is critical to the control of COVID-19, which has disproportionately affected the Black community. Physician-delivered messages may increase adherence to these behaviors.

Objectives: To determine whether messages delivered by physicians improve COVID-19 knowledge and preventive behaviors and to assess the differential effectiveness of messages tailored to the Black community. Read More

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Screening for distress in women with gynaecological cancer: Adaptation of the distress thermometer for gynaecological oncology patients.

Eur J Cancer Care (Engl) 2021 Jul 13:e13486. Epub 2021 Jul 13.

Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.

Objective: Generic distress screening tools may not recognise the unique concerns reported in some cancer populations. The face and content validity of a screening tool derived from the National Cancer Comprehensive Network distress thermometer and problem list and adapted specifically for women with gynaecological cancer is presented.

Methods: Building on existing work, panels of clinicians and researchers, and focus groups with women treated for gynaecological cancer, developed a nuanced distress screening tool. Read More

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"I've had horrible things said about me": An inductive content analysis of nursing academic experiences of contra-power harassment from undergraduate nursing students.

Nurse Educ Pract 2021 Jun 25;54:103132. Epub 2021 Jun 25.

Deputy Dean Education and Professional Practice & Associate dean Student Experience, Faculty of health and Social Care, Bournemouth University, Bournemouth BH1 3LH, UK. Electronic address:

Aim: The aim of this study was to describe the experiences of nursing academics exposure to contra-power harassment by under-graduate nursing students.

Background: Contra-power harassment by nursing students is a growing phenomenon which is defined as the harassment of those ni formal positions of power by those who are not. Harassing behaviours can include verbal, physical and sexual and digital harassment through mediums such as social media. Read More

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Continuing trends in U.S. brand-name and generic drug competition.

J Med Econ 2021 Jul 12. Epub 2021 Jul 12.

Analysis Group, Inc., Boston, MA.

Objective: To provide updated evidence in a series of analyses of U.S. trends over the past two decades in key financial metrics for branded drugs: market exclusivity periods (MEPs, the time between launch and first generic entry) for new molecular entities (NMEs); the probability, timing and number of patent challenges under Paragraph IV of the Hatch-Waxman Act; and the intensity of generic penetration. Read More

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Topology-based sparsification of graph annotations.

Bioinformatics 2021 07;37(Suppl_1):i169-i176

Department of Computer Science, Biomedical Informatics Group, ETH Zurich, Zurich, Switzerland.

Motivation: Since the amount of published biological sequencing data is growing exponentially, efficient methods for storing and indexing this data are more needed than ever to truly benefit from this invaluable resource for biomedical research. Labeled de Bruijn graphs are a frequently-used approach for representing large sets of sequencing data. While significant progress has been made to succinctly represent the graph itself, efficient methods for storing labels on such graphs are still rapidly evolving. Read More

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Evolutionary relationships among the snakelike pygopodid lizards: a review of phylogenetic studies of an enigmatic Australian adaptive radiation.

Authors:
W Bryan Jennings

PeerJ 2021 29;9:e11502. Epub 2021 Jun 29.

Department of Evolution, Ecology, & Organismal Biology, University of California, Riverside, Riverside, California, United States of America.

Here, I review phylogenetic studies of the lizard family Pygopodidae, a group of 47 extant species that diversified in Australia and New Guinea. The goal of this study was to examine published phylogenetic and phylogenomic hypotheses on pygopodids to identify the strengths and weaknesses in our understanding of their phylogeny. Many parts of the pygopodid family tree are well established by multiple independent tree inferences including: (1) all multispecies genera (i. Read More

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Prescription Opioids Higher Among Knee Arthroplasty Recipients Randomized to Inpatient Rehabilitation.

ACR Open Rheumatol 2021 Jul 10. Epub 2021 Jul 10.

Ingham Institute, Liverpool, New South Wales, Australia.

Objective: To determine whether the purchase of prescription opioids was lower among people randomized to inpatient rehabilitation (IR) compared with those discharged directly home following total knee arthroplasty (TKA).

Method: A secondary analysis of a previous clinical trial in which participants were randomized 3 to 5 days after -surgery to 10 days of IR and a home program or to a home program alone. The primary outcome for this secondary analysis was the purchase of opioid-based pain relief up to 10-weeks after surgery, which was captured via patient diaries. Read More

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The effects of child anxiety and depression on concordance between parent-proxy and self-reported health-related quality of life for pediatric liver transplant patients.

Pediatr Transplant 2021 Jul 9:e14072. Epub 2021 Jul 9.

Maritime Intestinal Research Alliance, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada.

Background: HRQOL is a key outcome following pediatric LT. Parent-proxy reports may substitute for patients unable to report their own HRQOL. This study compared parent-proxy and self-reported HRQOL in children who have undergone LT. Read More

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Structure-aware machine learning identifies microRNAs operating as Toll-like receptor 7/8 ligands.

RNA Biol 2021 Jul 9:1-10. Epub 2021 Jul 9.

Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

MicroRNAs (miRNAs) can serve as activation signals for membrane receptors, a recently discovered function that is independent of the miRNAs' conventional role in post-transcriptional gene regulation. Here, we introduce a machine learning approach, BrainDead, to identify oligonucleotides that act as ligands for single-stranded RNA-detecting Toll-like receptors (TLR)7/8, thereby triggering an immune response. BrainDead was trained on activation data obtained from experiments on murine microglia, incorporating sequence and intra-molecular structure, as well as inter-molecular homo-dimerization potential of candidate RNAs. Read More

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Hepatitis B virus infection and risk of gastric cancer: a systematic review and meta-analysis.

Minerva Gastroenterol (Torino) 2021 Jul 9. Epub 2021 Jul 9.

Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA -

Introduction: Hepatitis B virus (HBV) infection is a well-established risk factor for hepatocellular carcinoma. Recent studies have also suggested a higher risk of several extrahepatic cancers in patients with chronic HBV infection, including gastric cancer, even though the results are somewhat inconsistent. The current study was conducted to comprehensively investigate whether patients with HBV infection are at a higher risk of incident gastric cancer compared with individuals without HBV infection using systematic review and meta-analysis technique. Read More

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Factors Associated With Health-Related Quality of Life 2 Years After Left Ventricular Assist Device Implantation: Insights From INTERMACS.

J Am Heart Assoc 2021 Jul 9;10(14):e021196. Epub 2021 Jul 9.

University of Alabama at Birmingham Hospital Birmingham AL.

Background Factors related to health-related quality of life (HRQOL) 2 years after left ventricular assist device (LVAD) implantation are unknown. We sought to determine whether preimplant intended goal of LVAD therapy (heart transplant candidate [short-term group], uncertain heart transplant candidate [uncertain group], and heart transplant ineligible [long-term group]) and other variables were related to HRQOL 2 years after LVAD implantation. Methods and Results Our LVAD sample (n=1620) was from INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). Read More

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[REiNS] Current Recommendations for Patient-Reported Outcome Measures Assessing Domains of Quality of Life in Neurofibromatosis Clinical Trials.

Neurology 2021 Jul 6. Epub 2021 Jul 6.

REiNS International Collaboration patient representative, USA.

Objective: To review and recommend patient-reported outcome (PRO) measures assessing multidimensional domains of quality of life (QOL) to use as clinical endpoints in medical and psychosocial trials for children and adults with neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis.

Methods: The PRO working group of the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration used systematic methods to review, rate, and recommend existing self-report and parent-report PRO measures of generic and disease-specific QOL for neurofibromatosis (NF) clinical trials. Recommendations were based on four main criteria: patient characteristics, item content, psychometric properties, and feasibility. Read More

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