52,075 results match your criteria generic


Characterization of eight unknown impurities and analysis of their source in xinfujunsu and injection by liquid chromatography coupled with ion trap/time-of-flight mass spectrometry.

J Pharm Biomed Anal 2021 Jul 24;204:114279. Epub 2021 Jul 24.

Zhejiang Institute for Food and Drug Control, National Medical Product Administration Key Laboratory for Core Technology of Generic Drug Evaluation, Hangzhou 310052, China. Electronic address:

Eight unknown impurities in xinfujunsu and its injection were characterized by liquid chromatography coupled with ion trap/time-of-flight mass spectrometry (LC-IT-TOF MS). In order to determine the m/z values of the molecular ions and predict the formulas of all detected impurities, full scan LC-MS in positive ion mode was firstly executed to obtain the m/z value of the molecules. Then LC-MS, LC-MS and LC-MS were carried out on target compounds to obtain as much structural information as possible. Read More

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Testing the content for a targeted age-relevant intervention to promote cervical screening uptake in women aged 50-64 years.

Br J Health Psychol 2021 Aug 2. Epub 2021 Aug 2.

Cancer Prevention Group, School of Cancer and Pharmaceutical Sciences, King's College London, UK.

Objectives: Low uptake of cervical screening in women in their 50s and 60s leaves them at elevated risk of cancer in older age. An age-targeted intervention could be an effective way to motivate older women to attend cervical screening. Our primary objective was to test the impact of different candidate messages on cervical screening intention strength. Read More

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Polypharmacy and mortality association by chronic kidney disease status: The REasons for Geographic And Racial Differences in Stroke Study.

Pharmacol Res Perspect 2021 Aug;9(4):e00823

Department of Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.

Many Americans take multiple medications simultaneously (polypharmacy). Polypharmacy's effects on mortality are uncertain. We endeavored to assess the association between polypharmacy and mortality in a large U. Read More

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Measuring health-related quality of life and well-being: a head-to-head psychometric comparison of the EQ-5D-5L, ReQoL-UI and ICECAP-A.

Eur J Health Econ 2021 Aug 2. Epub 2021 Aug 2.

Centre for Health Systems and Policy Research, Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.

Objective: This study aimed to assess the psychometric properties of three generic preference-based measures and compare their performance in a sample of Hong Kong general population.

Methods: Data used for this analysis were obtained from a cross-sectional telephone-based survey in July 2020. Participants were asked to complete several measures, including The EuroQol five-dimensional five levels (EQ-5D-5L), Recovering Quality of Life-Utility Index (ReQoL-UI) and ICEpop CAPability measure for adults (ICECAP-A). Read More

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A systematic review and meta-analysis of the effectiveness of individual-level interventions to reduce occupational stress perceptions among teachers.

Arch Environ Occup Health 2021 Aug 2:1-15. Epub 2021 Aug 2.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Teachers are largely affected by OS, during their most productive years, leading to catastrophic physical, psychological, and economic burden on themselves, families and society by large. Teachers are responsible for producing the workforce of any nation, and thus have a major impact indirectly on the economy and health of a nation. There are several individual-level interventions conducted to reduce occupational stress (OS) among teachers. Read More

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Diabetes Self-Management Education and Support to Improve Outcomes for Children and Young Adults With Type 1 Diabetes: An Umbrella Review of Systematic Reviews.

Sci Diabetes Self Manag Care 2021 Aug 1:26350106211031809. Epub 2021 Aug 1.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: The objectives of this umbrella review were to describe various aspects of diabetes self-management education and support (DSMES)-related interventions and their effect on clinical, behavioral, and psychosocial outcomes among children and young adults with type 1 diabetes (T1DM) and identify gaps in current DSMES-related research.

Methods: An umbrella review of systematic reviews on DSMES interventions was conducted in accordance with the PRISMA 2009 statement. Four international medical databases were searched for eligible review articles published in English in the last 10 years that dealt with children and youths with T1DM and were conducted in accordance with a priori protocol. Read More

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A Prospective, Observational, Multicentre Study Concerning Nontechnical Skills in Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy.

Eur Urol Open Sci 2020 Jul 3;19:37-44. Epub 2020 Jul 3.

Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands.

Introduction And Hypotheses: valuation of surgical skills, both technical and nontechnical, is possible through observations and video analysis. Besides technical failures, adverse outcomes in surgery can also be related to hampered communication, moderate teamwork, lack of leadership, and loss of situational awareness. Even though some surgeons are convinced about nontechnical skills being an important part of their professionalisation, there is paucity of data about a possible relationship between nontechnical skills and surgical outcome. Read More

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How to improve access to medical imaging in low- and middle-income countries ?

EClinicalMedicine 2021 Aug 17;38:101034. Epub 2021 Jul 17.

Department of Radiology University of Zagreb School of Medicine, Zagreb, Croatia.

Imaging has become key in the care pathway of communicable and non-communicable diseases. Yet, there are major shortages of imaging equipment and workforce in low- and middle-income countries (LMICs). The International Society of Radiology outlines a plan to upscale the role of imaging in the global health agenda and proposes a holistic approach for LMICs. Read More

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Validation of a Simple and Reliable Method for the Determination of Aflatoxins in Soil and Food Matrices.

ACS Omega 2021 Jul 16;6(29):18684-18693. Epub 2021 Jul 16.

iES Landau, Institute for Environmental Sciences, Group of Organic and Ecological Chemistry, University of Koblenz-Landau, Fortstraße 7, 76829 Landau, Germany.

Aflatoxins (AFs) are toxic fungal secondary metabolites that are commonly detected in food commodities. Currently, there is a lack of generic methods capable of determining AFs both at postharvest stages in agricultural products and preharvest stages, namely, the agricultural soil. Here, we present a simple and reliable method for quantitative analysis of AFs in soil and food matrices at environmentally relevant concentrations for the first time, using the same extraction procedure and chromatography, either by HPLC-FLD or LC-MS. Read More

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Total Coliform and Generic Levels, and Presence in Eight Experimental Aquaponics and Hydroponics Systems: A Brief Report Highlighting Exploratory Data.

Horticulturae 2020 Sep 30;6(3). Epub 2020 Jul 30.

Department of Environmental Studies and Sciences, Ithaca College, Ithaca, NY 14850, USA.

Although many studies have investigated foodborne pathogen prevalence in conventional produce production environments, relatively few have investigated prevalence in aquaponics and hydroponics systems. This study sought to address this knowledge gap by enumerating total coliform and generic levels, and testing for presence in circulating water samples collected from five hydroponic systems and three aquaponic systems (No. of samples = 79). Read More

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September 2020

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy.

Theranostics 2021 26;11(16):7844-7868. Epub 2021 Jun 26.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be impeded by tumor resistance mechanisms and normal tissue toxicity. Read More

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Determination of Cutpoints for Symptom Burden in Oncology Patients Receiving Chemotherapy.

J Pain Symptom Manage 2021 Jul 29. Epub 2021 Jul 29.

School of Medicine, University of California, San Francisco, CA.

Context: Cutpoints can be used as a threshold for screening symptom(s) that warrant intervention(s) and for monitoring patients' responses to these interventions.

Objectives: In a sample of oncology patients undergoing chemotherapy, study purposes were to determine the optimal cutpoints for low, moderate, and high symptom burden and determine if these cutpoints distinguished among the symptom groups in any demographic, clinical, and stress characteristics, as well as QOL outcomes.

Methods: Total of 1329 patients completed a modified version of the Memorial Symptom Assessment Scale (38 symptoms). Read More

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Lesser toe deformity classification: A simplified approach with treatment influence.

Foot (Edinb) 2021 May 4;48:101819. Epub 2021 May 4.

Podiatric Medicine and Surgery Residency and Fellowship Program, Director, Department of Orthopedics, University of Louisville, 142 Chenoweth Lane, Louisville, KY, 40207, USA.

Deformities of the lesser toes are one of the most commonly treated conditions by foot and ankle surgeons. Despite their frequency, a standardized classification has yet to take hold among providers. Generic nomenclature with the addition of multiple adjunctive descriptors continues to be the standard leading to international confusion. Read More

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Effect of Polymer Source on In Vitro Drug Release from PLGA Microspheres.

Int J Pharm 2021 Jul 28:120907. Epub 2021 Jul 28.

University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT 06269.

Determination of the qualitative (Q1) sameness of poly (lactic-co-glycolic acid) (PLGA) polymers can be very challenging due to PLGA being a random copolymer with inherent heterogeneity. Performance variation of PLGA microsphere drug product as a result of altered PLGA characteristics has been recognized as a critical limiting factor in product development. It has been reported that PLGA characteristics and degradation profiles are sensitive to minor differences in the manufacturing and control processes. Read More

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Quality of life in patients with Mycosis Fungoides and Sézary Syndrome: a systematic review of the literature.

J Eur Acad Dermatol Venereol 2021 Jul 31. Epub 2021 Jul 31.

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.

Cutaneous T-cell Lymphoma's (CTCL) are a rare, heterogenous group of T-cell lymphomas that primarily manifest in the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) are considered the claswsic types of CTCL. The diverse manifestation of CTCL results in a wide range of symptoms with a possible mild to severe impact on Quality of Life (QoL) depending on the disease stage. Read More

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Protein structure prediction using deep learning distance and hydrogen-bonding restraints in CASP14.

Proteins 2021 Jul 30. Epub 2021 Jul 30.

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.

In this article, we report 3D structure prediction results by two of our best server groups ("Zhang-Server" and "QUARK") in CASP14. These two servers were built based on the D-I-TASSER and D-QUARK algorithms, which integrated four newly developed components into the classical protein folding pipelines, I-TASSER and QUARK, respectively. The new components include: (i) a new multiple sequence alignment (MSA) collection tool, DeepMSA2, which is extended from the DeepMSA program; (ii) a contact-based domain boundary prediction algorithm, FUpred, to detect protein domain boundaries; (iii) a residual convolutional neural network-based method, DeepPotential, to predict multiple spatial restraints by co-evolutionary features derived from the MSA; and (iv) optimized spatial restraint energy potentials to guide the structure assembly simulations. Read More

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Implementation of a Pregnancy Prevention Programme (PPP) with a Controlled Distribution System (CDS) for the Generic Teratogenic Phthalimides Thalidomide, Lenalidomide and Pomalidomide.

Ther Innov Regul Sci 2021 Jul 30. Epub 2021 Jul 30.

Chief Medical Office and Patient Safety, Global Drug Development, Novartis Pharma GmbH, Wehr, Germany.

Thalidomide (α-phthalimidoglutaride) was marketed in the 1950s and early 1960s; it was promoted as a sedative-hypnotic agent with minimal hangover. It was available in some countries as an over-the-counter medicine. Publications reporting profound teratogenic effects with thalidomide brought about major revisions to the monitoring of the safety of medicines. Read More

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Photothermal mediated rolling circle amplification toward specific and direct in situ mRNA detection.

Biosens Bioelectron 2021 Jul 21;192:113507. Epub 2021 Jul 21.

Department of Biochemistry and Molecular Biology. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Dong Dan San Tiao #5, Beijing, 100005, PR China. Electronic address:

Rolling circle amplification (RCA) had the prospect of assisting clinic diagnosis with advantage in in situ mRNA detection at single cell level. However, for direct mRNA detection, RCA had relatively low detection specificity and efficiency. Here, we introduced 4-(10, 15, 20-Triphenylporphyrin-5-yl)phenylamine (TPP) modified Au nanoparticle (Au-TPP) to improve the specificity of in-situ RCA. Read More

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Dichotomous thinking about social groups: Learning about one group can activate opposite beliefs about another group.

Cogn Psychol 2021 Jul 27;129:101408. Epub 2021 Jul 27.

University of California, Davis, United States.

Across three studies (N = 607), we examined people's use of a dichotomizing heuristic-the inference that characteristics belonging to one group do not apply to another group-when making judgments about novel social groups. Participants learned information about one group (e.g. Read More

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Computational model of endochondral ossification: simulating growth of a long bone.

Bone 2021 Jul 27:116132. Epub 2021 Jul 27.

Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA; Department of Bioengineering, Northeastern University, Boston, MA, USA. Electronic address:

Mechanical loading is a crucial factor in joint and bone development. Using a computational model, we investigated the role of mechanics on cartilage growth rate, ossification of the secondary center, formation of the growth plate, and overall bone shape. A computational algorithm was developed and implemented into finite element models to simulate the endochondral ossification for symmetric and asymmetric motion in a generic diarthrodial joint. Read More

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Bioequivalence assessment of pharmaceutical aerosol products through IVIVC.

Authors:
Dennis Sandell

Adv Drug Deliv Rev 2021 Jul 27:113895. Epub 2021 Jul 27.

S5 Consulting, Ekvägen 8, 27562 Blentarp, Sweden. Electronic address:

Many pharmaceutical developers of generic orally inhaled products (OIPs) are facing significant issues in passing the regulatory requirement to show pharmacokinetic (PK) bioequivalence (BE) to the originator product. The core of the issue is that no reliable in vitro-in vivo correlation (IVIVC) is available to guide their development. In this paper, several issues are identified and means to improve the data used for developing an IVIVC are discussed. Read More

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Novel mechanism for oscillations in catchbonded motor-filament complexes.

Biophys J 2021 Jul 27. Epub 2021 Jul 27.

Department of Physics, Savitribai Phule Pune University, Pune, India. Electronic address:

Generation of mechanical oscillations is ubiquitous to a wide variety of intracellular processes ranging from activity of muscle fibres to oscillations of the mitotic spindle. The activity of motors plays a vital role in maintaining the integrity of the mitotic spindle structure and in generating spontaneous oscillations. While the structural features and properties of the individual motors are well characterized, their implications on the functional behaviour of motor-filament complexes is more involved. Read More

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Transient electromagnetic singularities in random three-dimensional optical fields.

Authors:
Isaac Freund

Opt Lett 2021 Aug;46(15):3789-3792

We show that on all generic circular or elliptical paths in a random three-dimensional electromagnetic field, the electric and magnetic field vectors generate a cylinder throughout most of the optical cycle. At some point in the cycle, however, this cylinder transforms into a twisted ribbon with two sequential 180° twists. This ribbon exists for a short time and then unwinds, regenerating the cylinder. Read More

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Multilevel Survival Modeling with Structured Penalties for Disease Prediction from Imaging Genetics data.

IEEE J Biomed Health Inform 2021 Jul 30;PP. Epub 2021 Jul 30.

This paper introduces a framework for disease prediction from multimodal genetic and imaging data. We propose a multilevel survival model which allows predicting the time of occurrence of a future disease state in patients initially exhibiting mild symptoms. This new multilevel setting allows modeling the interactions between genetic and imaging variables. Read More

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In Situ Membrane Biotinylation Enables the Direct Labeling and Accurate Kinetic Analysis of Small Extracellular Vesicles in Circulation.

Anal Chem 2021 Jul 30. Epub 2021 Jul 30.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

Circulating small extracellular vesicles (sEVs) are naturally occurring nanosized membrane vesicles that convey bioactive molecules between cells. Conventionally, to evaluate their behaviors in vivo, circulating sEVs have to be isolated from the bloodstream, then labeled with imaging materials in vitro, and finally injected back into the circulation of animals for subsequent detection. The tedious isolation-labeling-reinfusion procedures might have an undesirable influence on the natural properties of circulating sEVs, thereby changing their behaviors and the detected kinetics in vivo. Read More

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Association between Clinical Vision Measures and Visual Perception and Soccer Referees' On-field Performance.

Optom Vis Sci 2021 Jul;98(7):789-801

School of Optometry and Vision Science, University of Bradford, Bradford, United Kingdom.

Significance: The decisions taken by soccer officials are critically important to game management. Understanding the underlying processes that mediate expert performance in soccer refereeing may lead to a better standard of officiating. Vision is the dominant source of incoming information upon which officials rely to make their on-field decisions. Read More

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Exercise for depression and depressive symptoms in older adults: an umbrella review of systematic reviews and Meta-analyses.

Aging Ment Health 2021 Jul 30:1-11. Epub 2021 Jul 30.

Department of Nephrology and Biostatistics, Universidade de Caxias do Sul (UCS), Caxias do Sul, Brazil.

Objectives: We aimed to gather and update the evidence on the impact of exercise on late-life depression.

Method: We conducted an umbrella review of meta-analyses of randomized controlled trials (RCTs) that assessed the effects of an exercise intervention for depression in older adults (e.g. Read More

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Dodecagonal quasicrystals of oil-swollen ionic surfactant micelles.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455;

A delicate balance of noncovalent interactions directs the hierarchical self-assembly of molecular amphiphiles into spherical micelles that pack into three-dimensional periodic arrays, which mimic intermetallic crystals. Herein, we report the discovery that adding water to a mixture of an ionic surfactant and -decane induces aperiodic ordering of oil-swollen spherical micelles into previously unrecognized, aqueous lyotropic dodecagonal quasicrystals (DDQCs), which exhibit local 12-fold rotational symmetry and no long-range translational order. The emergence of these DDQCs at the nexus of dynamically arrested micellar glasses and a periodic Frank-Kasper (FK) σ phase approximant sensitively depends on the mixing order of molecular constituents in the assembly process and on sample thermal history. Read More

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The relation of 12 lead ECG to the cardiac anatomy: The normal CineECG.

J Electrocardiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Cardiology, University Medical Center Utrecht, the Netherlands.

Background: The interpretation of the 12‑lead ECG is notoriously difficult and requires experts to distinguish normal from abnormal ECG waveforms. ECG waveforms depend on body build and electrode positions, both often different in males and females. To relate the ECG waveforms to cardiac anatomical structures is even more difficult. Read More

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Sudden Sensorineural Hearing Loss and Metabolic Syndrome: A Systematic Review and Meta-Analysis.

Otol Neurotol 2021 Jul 27. Epub 2021 Jul 27.

Michael G. DeGroote School of Medicine, Faculty of Medicine Faculty of Health Sciences, McMaster University Division of Otolaryngology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Objective: The objective of this systematic review and meta-analysis is to examine the association between sudden sensorineural hearing loss (SSNHL) and risk of metabolic syndrome (MetS), and the association between MetS and prognosis of SSNHL.

Databases Reviewed: We systematically searched MEDLINE, Embase, and Cochrane Central Register electronic databases from their dates of conception to February 4, 2020.

Methods: We included observational studies analyzing 1) the prevalence of MetS among SSNHL patients, or 2) the prognosis of SSNHL patients in MetS patients. Read More

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