29,978 results match your criteria generation antioxidant


Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants.

Int Wound J 2021 May 5. Epub 2021 May 5.

Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León, Mexico.

Wound healing is a complex process of communication between growth factors, reactive species of oxygen, cells, signalling pathways, and cytokines in the extracellular matrix, in which growth factors are the key regulators. In humans, the main regulators of the cellular responses in wound healing are five growth factors, namely EGF, bFGF, VEGF, and TGF-β1. On the other hand, antioxidants such as astaxanthin, beta-carotene, epigallocatechin gallate, delphinidin, and curcumin have been demonstrated to stimulate cell proliferation, migration and angiogenesis, and control inflammation, to suggest a practical approach to design new strategies to treat non-healing cutaneous conditions. Read More

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Genus : phytochemicals, industrial importance and biological relevance.

Nat Prod Res 2021 May 5:1-16. Epub 2021 May 5.

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

species (Chaetomiaceae) are a wealthy source of enzymes such as laccases, cutinases, glucuronoyl esterases, feruloyl esterases, 1,4-β-endoglucanase and lytic polysaccharide monooxygenases that reported to have various biotechnological and industrial applications in dye decolorization, bio-refinery, biomass utilization, ester biosynthesis and biodegradation. Different metabolites have been reported from this genus as depsides, azaphilones, pyrazines, naphthodianthrones and anthraquinones derivatives. These metabolites have attracted research interest due to their fascinating structures and diverse bioactivities, including antimicrobial, cytotoxic, antioxidant, anti-diabetic, and superoxide anion generation, phospholipase, prostaglandins synthesis and proteasome inhibitory activities. Read More

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Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis.

Cell Rep Med 2021 Apr 20;2(4):100246. Epub 2021 Apr 20.

Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel.

Multiple sclerosis (MS) is an immune-mediated disease whose precise etiology is unknown. Several studies found alterations in the microbiome of individuals with MS, but the mechanism by which it may affect MS is poorly understood. Here we analyze the microbiome of 129 individuals with MS and find that they harbor distinct microbial patterns compared with controls. Read More

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ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Anti-Aging Research Center, Dongeui University, Busan 47340, Korea.

Coptidis Rhizoma is the dried rhizome from the Franch. that has been shown to have a number of beneficial pharmacological properties including antioxidant, anti-inflammatory, and anti-cancer effects. However, the anti-cancer effects of Coptidis Rhizoma on hepatocellular carcinoma (HCC) remain unclear. Read More

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The Effect of Quasi-Spherical Gold Nanoparticles on Two-Photon Induced Reactive Oxygen Species for Cell Damage.

Nanomaterials (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 333323, Taiwan.

The performance of quasi-spherical gold nanoparticles (GNPs) on the generation of reactive oxygen species (ROS) to cause cell damage, as irradiated by a two-photon laser, is studied. In this mechanism, hot electrons are generated from GNPs as irradiated by the two-photon laser, reacting with the molecules in the medium to produce ROS. We used laser scanning confocal microscopy with a low-fluence femtosecond Ti:Sapphire laser of 800 nm to observe the generated ROS in A431 cells, which were incubated with GNPs in advance. Read More

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Protective Effects of 1,25 Dihydroxyvitamin D3 against High-Glucose-Induced Damage in Human Umbilical Vein Endothelial Cells Involve Activation of Nrf2 Antioxidant Signaling.

J Vasc Res 2021 May 4:1-10. Epub 2021 May 4.

Department of Cardiology, Affiliated Hospital of Putian University, Affiliated Putian Hospital, Southern Medical University, Putian, China.

Aim: To explore the protective effects and related mech-anisms of 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) on en-dothelial dysfunction under hyperglycemic conditions.

Methods: Cultured human umbilical vein endothelial cells (HUVECs) were treated with normal glucose (glucose concentration of 5.5 mmol/L), high glucose (glucose concentration of 33 mmol/L), and high glucose plus 1,25(OH)2D3, respectively. Read More

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How the brain fights fatty acids' toxicity.

Neurochem Int 2021 May 1:105050. Epub 2021 May 1.

Institut für Inflammation und Neurodegeneration (Neurobiochemie), Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Straße 44, D-39120 Magdeburg, Germany. Electronic address:

Neurons spurn hydrogen-rich fatty acids for energizing oxidative ATP synthesis, contrary to other cells. This feature has been mainly attributed to a lower yield of ATP per reduced oxygen, as compared to glucose, and the use of fatty acids as hydrogen donor is accompanied by severe β-oxidation-associated ROS generation. Neurons are especially susceptible to detrimental activities of ROS due to their poor antioxidative equipment. Read More

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Assessment of the biological activity of fish muscle protein hydrolysates using in vitro model systems.

Food Chem 2021 Apr 20;359:129852. Epub 2021 Apr 20.

School of Food and Nutritional Science, University College Cork, T12 YN60 Cork, Ireland. Electronic address:

The generation of biologically active fish protein hydrolysates (FPH) is a useful technique to produce value-added products with potential application in the functional food and nutraceutical industries. Fish muscle is an attractive substrate for the production of protein hydrolysates due to its rich protein content, containing 15-25% of total fish protein. This paper reviews the production of protein hydrolysates from fish muscle, most commonly via enzymatic hydrolysis, and their subsequent bioactivities including anti-obesity, immunomodulatory, antioxidant, angiotensin I-converting enzyme (ACE)-inhibitory, anti-microbial, and anti-cancer activities as measured by in vitro testing methods. Read More

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Perfluorooctanoic acid (PFOA) changes nutritional compositions in lettuce (Lactuca sativa) leaves by activating oxidative stress.

Environ Pollut 2021 Apr 29;285:117246. Epub 2021 Apr 29.

Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing, 100044, China. Electronic address:

Perfluorooctanoic acid (PFOA) is a typical persistent organic pollutant commonly detected in ecosystem. Insights into the risks of PFOA in crops, from the perspectives of food nutritional compositions, are sparse. In this study, the physiological responses to PFOA induced oxidative stress were investigated in lettuce (Lactuca sativa) leaves hydroponically exposed to 5 and 50 μg/L PFOA. Read More

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Metabolic regulation adapting to high methanol environment in the methylotrophic yeast Ogataea methanolica.

Microb Biotechnol 2021 May 3. Epub 2021 May 3.

The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Since methylotrophic yeasts such as Ogataea methanolica can use methanol as a sole carbon feedstock, they could be applied to produce valuable products from methanol, a next-generation energy source synthesized from natural gases, using genetic engineering tools. In this study, metabolite profiling of O. methanolica was conducted under glucose (Glc) and low and high methanol (L- and H-MeOH) conditions to show the adaptation mechanism to a H-MeOH environment. Read More

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Brain Energy Deficit as a Source of Oxidative Stress in Migraine: A Molecular Basis for Migraine Susceptibility.

Neurochem Res 2021 Apr 30. Epub 2021 Apr 30.

Department of Psychology, University of Maine, Orono, ME, 04469, USA.

People with migraine are prone to a brain energy deficit between attacks, through increased energy demand (hyperexcitable brain) or decreased supply (mitochondrial impairment). However, it is uncertain how this precipitates an acute attack. Here, the central role of oxidative stress is adduced. Read More

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Thymoquinone reduces mitochondrial damage and death of cardiomyocytes induced by clozapine.

Naunyn Schmiedebergs Arch Pharmacol 2021 May 3. Epub 2021 May 3.

Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

The generation of a reactive nitrenium ion by microsomal/mitochondrial cytochrome P450 (CYPs) from clozapine (CLZ) has been suggested as the main cause of cardiotoxicity by this drug. Previous studies indicated that thymoquinone (TQ) as an active constituent of Nigella sativa has pharmacological effects such as antioxidant, reactive oxygen species (ROS) scavenger, and inhibitory effect on CYPs enzymes. Therefore, we hypothesized that TQ with these pharmacological effects can reduce CLZ-induced toxicity in isolated cardiomyocytes and mitochondria. Read More

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Total flavonoids of combined with calcium attenuate osteoporosis by reducing reactive oxygen species generation.

Exp Ther Med 2021 Jun 14;21(6):618. Epub 2021 Apr 14.

Chengdu Lilai Biotechnology Co., Ltd., Chengdu, Sichuan 610041, P.R. China.

In the present study, the effects of total flavonoids of Rhizoma Drynariae (TFRD) and calcium carbonate (CaCO) on osteoporosis (OP) were assessed in a rat model of OP. For this purpose, 36 Sprague-Dawley rats, aged 3 months, were randomly divided into a group undergoing sham surgery (sham-operated group), model group (OP group), CaCO group (OP + CaCO group), TFRD group (OP + TFRD group), TFRD combined with CaCO group (OP + TFRD + CaCO group) and TFRD and CaCO combined with N-acetyl cysteine group (OP + TFRD + CaCO + NAC group). The rat model of OP was established by bilateral ovariectomy. Read More

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Negative Air Ions Alleviate Particulate Matter-Induced Inflammation and Oxidative Stress in the Human Keratinocyte Cell Line HaCaT.

Ann Dermatol 2021 Apr 8;33(2):116-121. Epub 2021 Mar 8.

Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Background: Recent studies have revealed that particulate matter induces inflammation, oxidative stress, and several skin diseases. Experimental results have also shown that negative air ions are highly effective in removing particulate matter-induced inflammation.

Objective: The present study aimed to investigate whether negative air ions can inhibit inflammatory responses and reduce oxidative stress in HaCaT cells exposed to particulate matters. Read More

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Naringin-generated ROS promotes mitochondria-mediated apoptosis in Candida albicans.

IUBMB Life 2021 May 2. Epub 2021 May 2.

School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea.

Naringin is a flavonoid which has a therapeutic effect. However, the details of its antifungal mechanism have not yet been fully elucidated. This study focused on clarifying the relationship between naringin and Candida albicans, to understand its mode of antifungal action. Read More

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RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen.

BMC Genomics 2021 May 1;22(1):318. Epub 2021 May 1.

Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, HI, 96822, Honolulu, USA.

Background: The mechanism of egg formation in the oviduct of laying hens is tightly controlled; each segment of the oviduct contributes a unique component of the egg. Several genes/proteins are involved in the synthesis of a completely healthy egg. This implies a time- and tissue-specific expression of genes and proteins in the different oviductal segments. Read More

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Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells.

J Hazard Mater 2021 Jul 5;413:125287. Epub 2021 Feb 5.

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Chinese Academy of Sciences; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China. Electronic address:

Arsenic (As) and its compounds have been classified as Group I carcinogenic agents by the International Agency for Research on Cancer (IARC); however, there is few specific and efficient antidotes used for As detoxification. The present study aimed to investigate the protective effects of silver nanoparticles (AgNPs) at non-toxic concentrations on As(Ⅲ) induced genotoxicity and the underlying mechanism. Our data showed that AgNPs pretreatment significantly inhibited the generation of phosphorylated histone H2AX (γ-H2AX, marker of nuclear DNA double strand breaks) and the mutation frequencies induced by As(Ⅲ) exposure. Read More

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Ohmic heating processing of milk for probiotic fermented milk production: Survival kinetics of Listeria monocytogenes as contaminant post-fermentation, bioactive compounds retention and sensory acceptance.

Int J Food Microbiol 2021 Apr 21;348:109204. Epub 2021 Apr 21.

Instituto Federal do Paraná (IFPR), Paranavaí 87703-536, Brazil. Electronic address:

The survival kinetics of Listeria monocytogenes (9 log CFU/mL) as a post-fermentation contaminant in probiotic fermented milk (Lactobacillus acidophilus La-5, 8-9 log CFU/mL) processed with milk subjected to ohmic heating (0, 4, 6, and 8 V/cm; CONV, OH, OH, OH, 90-95 °C/5 min) was investigated using Weibull predictive model. Additionally, the presence of bioactive compounds (antioxidant activity, inhibition of the enzymes α-glucosidase, α-amylase, and angiotensin-converting) and sensory analysis (consumer test) of probiotic fermented milks were evaluated. Overall, OH provided a decrease in the viability of Listeria monocytogenes, suitable Lactobacillus acidophilus counts, and satisfactory results in the gastrointestinal tract survival. Read More

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Relative effectiveness of arbuscular mycorrhiza and polyamines in modulating ROS generation and ascorbate-glutathione cycle in Cajanus cajan under nickel stress.

Environ Sci Pollut Res Int 2021 Apr 30. Epub 2021 Apr 30.

Department of Botany, Panjab University, Chandigarh, 160014, India.

Nickel (Ni) is a fundamental micronutrient in plants but hampers plant growth and metabolism at elevated levels in the soil by inducing oxidative stress. In the recent years, use of polyamines (PAs) and arbuscular mycorrhiza (AM) have gained importance for their roles in enabling plants to withstand Ni toxicity. However, information about their comparative effectiveness in alleviating Ni stress is scanty. Read More

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Scavenging reactive oxygen species mimics the anoxic response in goldfish pyramidal neurons.

J Exp Biol 2021 Apr 30. Epub 2021 Apr 30.

Department of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada, M3A 3A7, Canada.

Goldfish are one of a few species able to avoid cellular damage during month-long periods in severely hypoxic environments. By suppressing action potentials in excitatory glutamatergic neurons, the goldfish brain decreases its overall energy expenditure. Co-incident with reductions in O2 availability is a natural decrease in cellular reactive oxygen species (ROS) generation, which has been proposed to function as part of a low oxygen signal transduction pathway. Read More

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Genome-wide identification of superoxide dismutase gene families and their expression patterns under low-temperature, salt and osmotic stresses in watermelon and melon.

3 Biotech 2021 Apr 26;11(4):194. Epub 2021 Mar 26.

College of Horticulture, Gansu Agricultural University, Lanzhou, 730070 Gansu China.

The growth and development of watermelon and melon are affected by abiotic stresses such as cold, salinity and drought. Plant superoxide dismutase (SOD) proteins exerted great effects on plant growth, development and response to abiotic stresses. However, little is known about the characteristics of watermelon and melon SOD gene families and their expression patterns under abiotic stresses. Read More

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Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.

Front Pharmacol 2021 13;12:643972. Epub 2021 Apr 13.

Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.

The industrial activities of the last century have caused massive increases in human exposure to heavy metals. Mercury, lead, chromium, cadmium, and arsenic have been the most common heavy metals that induced human poisonings. Here, we reviewed the mechanistic action of these heavy metals according to the available animal and human studies. Read More

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Hesperidin alleviates insulin resistance by improving HG-induced oxidative stress and mitochondrial dysfunction by restoring miR-149.

Diabetol Metab Syndr 2021 Apr 29;13(1):50. Epub 2021 Apr 29.

School of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang, People's Republic of China.

Background: Hesperidin, a natural flavanone, has been proven to have multiple protective effects in diabetic rats, such as antioxidant, anti-inflammatory and anti-apoptotic effects. However, the molecular mechanisms underlying the effects of hesperidin are not well elucidated.

Methods: LO2 cells were stimulated with high glucose (HG, 33 mM) for 24 h to establish a model of oxidative stress. Read More

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Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid-Conducting SLC25 Gene Family Transporters.

Antioxidants (Basel) 2021 Apr 26;10(5). Epub 2021 Apr 26.

Department of Mitochondrial Physiology, Institute of Physiology of the Czech Academy of Sciences, Vídeňská 1084, 14220 Prague, Czech Republic.

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca-independent phospholipase A2γ (iPLA2γ), is addressed to the mitochondrial matrix (or peroxisomes), where it may manifest its unique activity to cleave phospholipid side-chains from both sn-1 and sn-2 positions, consequently releasing either saturated or unsaturated fatty acids (FAs), including oxidized FAs. Moreover, iPLA2γ is directly stimulated by HO and, hence, is activated by redox signaling or oxidative stress. This redox activation permits the antioxidant synergy with mitochondrial uncoupling proteins (UCPs) or other SLC25 mitochondrial carrier family members by FA-mediated protonophoretic activity, termed mild uncoupling, that leads to diminishing of mitochondrial superoxide formation. Read More

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Phenolic Compounds of sp. as Modulators of Oral Cavity Lactoperoxidase System.

Antioxidants (Basel) 2021 Apr 26;10(5). Epub 2021 Apr 26.

Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.

Lactoperoxidase (LPO) together with its (pseudo)halogenation cycle substrates, HO and thiocyanate ions oxidized to hypothiocyanite ions, form one of the main systems involved in antimicrobial defense within the oral cavity. In bacterial diseases such as dental caries, lactoperoxidase is oxidized to a form known as Compound II, which is characterized by its inability to oxidize SCN, resulting in a decreased generation of antimicrobial products. sp. Read More

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The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

Sistemas de Biotecnología y Recursos Naturales, 47625 Valladolid, Spain.

Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role in cellular signaling and regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing ROS becomes pathological and leads to oxidative stress and disease. Read More

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Pathophysiology of Mitochondrial Dysfunction in Human Spermatozoa: Focus on Energetic Metabolism, Oxidative Stress and Apoptosis.

Antioxidants (Basel) 2021 Apr 28;10(5). Epub 2021 Apr 28.

Andrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

The dogma of mitochondria as the major source of energy in supporting sperm motility should be critically reconsidered in the light of several experimental data pointing to a major role of glycolysis in mammalian spermatozoa. In this light, the reported positive correlation between the mitochondrial membrane potential (ΔΨm) and motility of ejaculated spermatozoa cannot be explained convincingly by an impaired mitochondrial ATP generation only. Evidence has been produced suggesting that, in human sperm, dysfunctional mitochondria represent the main site of generation of reactive oxygen species (ROS). Read More

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Tannylated Calcium Carbonate Materials with Antacid, Anti-Inflammatory, and Antioxidant Effects.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

Department of Systems Biotechnology, Chung-Ang University, Gyeonggi 17546, Korea.

Calcium carbonate (CaCO)-based materials have received notable attention for biomedical applications owing to their safety and beneficial characteristics, such as pH sensitivity, carbon dioxide (CO) gas generation, and antacid properties. Herein, to additionally incorporate antioxidant and anti-inflammatory functions, we prepared tannylated CaCO (TA-CaCO) materials using a simple reaction between tannic acid (TA), calcium (Ca), and carbonate (CO) ions. TA-CaCO synthesized at a molar ratio of 1:75 (TA:calcium chloride (CaCl)/sodium carbonate (NaCO)) showed 3-6 μm particles, comprising small nanoparticles in a size range of 17-41 nm. Read More

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Anti-Inflammatory Principles from the Needles of Hayata and In Silico Studies of Their Potential Anti-Aging Effects.

Antioxidants (Basel) 2021 Apr 13;10(4). Epub 2021 Apr 13.

Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan.

needle tea are very popular in Eastern countries such as Japan, Russia, Korea, and China. Pine needle tea is claimed to have significant anti-aging effects, but no clear evidence has supported this until now. In the present study, five undescribed compounds (-) as well as seventy-two known compounds were purified and characterized from the bioactive fraction of methanol extracts of needles. Read More

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Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules.

Int J Mol Sci 2021 Apr 20;22(8). Epub 2021 Apr 20.

Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interrégionale CRS, CH-1066 Epalinges, Switzerland.

An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage of red blood cells (RBCs). It leads to the gradual exhaustion of RBC antioxidant protective system and, consequently, to a deleterious state of oxidative stress that plays a major role in the apparition of the so-called storage lesions. The present study describes the use of a test (called TSOX) based on fluorescence and label-free morphology readouts to simply and quickly evaluate the oxidant and antioxidant properties of various compounds in controlled conditions. Read More

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