194,058 results match your criteria generated study

Contralateral Masking in the Measurement of Auditory Brainstem Responses with Air-Conducted Tone Burst Stimuli in Individuals with Unilateral Hearing Loss.

J Am Acad Audiol 2021 May 7. Epub 2021 May 7.

Department of Audiology and Speech Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Background:  Contralateral noise masking is an important aspect of auditory brainstem response (ABR) measurements.

Purpose:  The primary aim of this study is to determine how contralateral white noise (WN) masking influences the amplitude and the latency of V wave generated during ABR measurements, using tone burst (TB), in adult ears with normal hearing (NH). The secondary aim of this study is to ascertain the need of contralateral masking in ABR measurements with the TB stimuli using a 3A insertion earphone, and to propose the applicability of WN masking in unilateral sensorineural hearing loss (USNHL). Read More

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Diurnal evolutions and sources of water-soluble chromophoric aerosols over Xi'an during haze event, in Northwest China.

Sci Total Environ 2021 Apr 29;786:147412. Epub 2021 Apr 29.

School of Environmental Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Atmospheric brown carbon and their chemical behavior potentially impacts the climate and air quality. Due to lack of researches on the atmospheric chromophores by using online experimental instrument, so using the offline EEM approaches to study their types, sources and chemical processes. In this study, PILS-EEM-TOC system (Particle into liquid sampler coupled with excitation-emission matrix and total organic carbon) was developed in order to distinguish the hourly evolutions and sources of water-soluble chromophoric organic matters in atmospheric fine particles. Read More

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Vapor flow control in dune sediments under dry bare soil conditions.

Sci Total Environ 2021 Apr 30;786:147404. Epub 2021 Apr 30.

Instituto Geológico y Minero de España, Plaza de España, 41013 Seville, Spain.

The study presents daily values of inward and outward vapor flux crossing the soil-atmosphere boundary in dependence on meteorological parameters and soil moisture. Measurements of vapor flux, soil moisture and meteorological parameters were evaluated during days without rainfall between 2015 and 2019. Vapor flux data were obtained at 1 min intervals by a precision lysimeter installed in the Doñana National Park, southwest Spain. Read More

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Soil legacy of arbuscular mycorrhizal fungus Gigaspora margarita: The potassium-sequestering glomalin improves peanut (Arachis hypogaea) drought resistance and pod yield.

Microbiol Res 2021 Apr 29;249:126774. Epub 2021 Apr 29.

Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, China. Electronic address:

In agroecosystems, drought stress severely threatens crops development. Although potassium (K) is required in amounts by crops under drought stress, the mobilization and availablity of K are limited by the soil water status. Arbuscular mycorrhizal (AM) fungi can form mutualistic associations with most crops and play direct or indirect roles in the host drought resistance. Read More

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Valorization of sorghum distillery residue to produce bioethanol for pollution mitigation and circular economy.

Environ Pollut 2021 Apr 26;285:117196. Epub 2021 Apr 26.

Sugar Business Division, Taiwan Sugar Corporation, Tainan, 701, Taiwan.

This research aims to study the wet torrefaction (WT) and saccharification of sorghum distillery residue (SDR) towards hydrochar and bioethanol production. The experiments are designed by Box-Behnken design from response surface methodology where the operating conditions include sulfuric acid concentration (0, 0.01, and 0. Read More

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Light rare earth elements hinder bone development via inhibiting type H vessels formation in mice.

Ecotoxicol Environ Saf 2021 May 4;218:112275. Epub 2021 May 4.

Department of Orthopedics, Southwest Hospital, Third Military Medical University, Army Medical University, Chongqing 400038, China. Electronic address:

Light rare earth elements (LREEs) are widely used in medical, industrial, and agricultural fields. Wide application of light rare earth and exposure to these elements in human society leads to increasing accumulation of LREE in human skeletal system. However, the effects of LREEs on human bone health is not clear. Read More

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Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum.

Cell Calcium 2021 Apr 30;97:102417. Epub 2021 Apr 30.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Background: The roles of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and subfamily A, member 1 (TRPA1) in mechanisms of gastrointestinal motility are complex. This study aimed to clarify the effects of several TRPV1 and TRPA1 ligands on the electrical potentials generated by pacemaker cells in the mouse-isolated ileum.

Method: The pacemaker potentials of ileal segments of mice were recorded extracellularly using a 60-channel microelectrode array. Read More

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Structure-based design approach of potential BCL-2 inhibitors for cancer chemotherapy.

Comput Biol Med 2021 Apr 30;134:104455. Epub 2021 Apr 30.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, 560054, Karnataka, India. Electronic address:

B-cell lymphoma 2 (BCL-2) family is one of the chief regulators of cellular apoptosis. The intricate interactions between pro-apoptotic and anti-apoptotic genes of the BCL-2 family dictate the apoptotic balance of the cell. An overexpression of the anti-apoptotic members of BCL-2 is indicative of cell death evasion and cancer metastasis. Read More

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Phylogenetics and historical biogeography of Solanum section Brevantherum (Solanaceae).

Mol Phylogenet Evol 2021 May 4:107195. Epub 2021 May 4.

Programa de Pós-Graduação em Biodiversidade, Universidade Federal do Oeste do Pará, Rua Vera Paz, sn, Santarém, PA, 68040-255, Brazil; Programa de Pós-Graduação em Botânica, Instituto Nacional De Pesquisas Da Amazônia, Av. André Araújo, 2936 - Aleixo, Manaus, AM, 69060-001, Brazil.

Patterns of diversification in Neotropical plants have been studied intensively over the past decades. Most studies have focused on groups that migrated to and radiated into the Neotropics, however, with little focus on understanding diversification patterns in indigenous Neotropical groups. This study focuses on Solanum section Brevantherum Seithe (Solanaceae), a group of Neotropical nightshade shrubs or treelets defined mostly by terminal inflorescences with long peduncles, plurifoliate sympodial units and porrect-stellate, dendritic-echinoid, or lepidote trichomes. Read More

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Replication competence of canine distemper virus in cell lines expressing signaling lymphocyte activation molecule (SLAM) of goat, sheep and dog origin.

Microb Pathog 2021 May 4:104940. Epub 2021 May 4.

Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute (IVRI), Izatnagar, 243122, Bareilly, Uttar Pradesh, India.

Cellular receptors play an important role in entry and cell to cell spread of morbillivirus infections. The cells expressing SLAM and Nectin-4 have been used for successful and efficient isolation of canine distemper virus (CDV) in high titre. There are several methods for generation of cells expressing receptor molecules. Read More

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Epitope mapping of severe acute respiratory syndrome-related coronavirus nucleocapsid protein with a rabbit monoclonal antibody.

Virus Res 2021 May 4:198445. Epub 2021 May 4.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510182, China. Electronic address:

The emergency SARS-CoV-2, a member of severe acute respiratory syndrome-related coronaviruses (SARSr-CoV), is still greatly harming the health of mankind. SARS-CoV-2-specific monoclonal antibodies (MAbs), which can identify SARS-CoV-2 from common human coronaviruses, are considered to extensively apply to developing rapid and reliable antigen assays. In this study we generated a rabbit MAb (RAb) detecting SARS-CoV-2 nucleocapsid protein (NP), which has cross-reaction with SARS-CoV-1 NP, but not with NPs of MERS and common human CoVs (OC43, NL63, 229E, and HKU1). Read More

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Latent class regression improves the predictive acuity and clinical utility of survival prognostication amongst chronic heart failure patients.

PLoS One 2021 7;16(5):e0243674. Epub 2021 May 7.

Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom.

The present study aimed to compare the predictive acuity of latent class regression (LCR) modelling with: standard generalised linear modelling (GLM); and GLMs that include the membership of subgroups/classes (identified through prior latent class analysis; LCA) as alternative or additional candidate predictors. Using real world demographic and clinical data from 1,802 heart failure patients enrolled in the UK-HEART2 cohort, the study found that univariable GLMs using LCA-generated subgroup/class membership as the sole candidate predictor of survival were inferior to standard multivariable GLMs using the same four covariates as those used in the LCA. The inclusion of the LCA subgroup/class membership together with these four covariates as candidate predictors in a multivariable GLM showed no improvement in predictive acuity. Read More

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Estimation of Apnea-Hypopnea Index using Deep Learning on 3D Craniofacial Scans.

IEEE J Biomed Health Inform 2021 May 7;PP. Epub 2021 May 7.

Obstructive sleep apnea (OSA) is characterized by decreased breathing events that occur through the night, with severity reported as the apnea-hypopnea index (AHI), which is associated with certain craniofacial features. In this study, we used data from 1366 patients collected as part of Stanford Technology Analytics and Genomics in Sleep (STAGES) across 11 US and Canadian sleep clinics and analyzed 3D craniofacial scans with the goal of predicting AHI, as measured using gold standard nocturnal polysomnography (PSG). First, the algorithm detects pre-specified landmarks on mesh objects and aligns scans in 3D space. Read More

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Effects of a powered mobility summer camp as perceived by school staff: a qualitative study.

Disabil Rehabil Assist Technol 2021 May 7:1-8. Epub 2021 May 7.

School of Occupational Therapy, Hebrew University, Jerusalem, Israel.

Purpose: Powered mobility has a positive effect on social skills, self-esteem and overall development of children with motor impairments, but almost all previous studies were conducted with pre-school children. The aim of this study was to explore change beyond mobility following a therapeutic powered mobility summer camp for school-aged children and adolescents with severe cerebral palsy, as perceived by school staff.

Materials And Methods: The participants in the therapeutic camp, which ran for 3 weeks, 5 days a week, three times over the summers 2018-2019, were children ages 7-19 (median age 11) with severe cerebral palsy who needed assistance in mobility and had limited hand function. Read More

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Modeling Amyloid Aggregation Kinetics: A Case Study with Sup35NM.

J Phys Chem B 2021 May 7. Epub 2021 May 7.

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

Understanding the aggregation mechanism of amyloid proteins, such as Sup35NM, is essential to understanding amyloid diseases. Significant recent work has focused on using the fluorescence of thioflavin T (ThT), which undergoes a red shift when bound to amyloid aggregates, to monitor amyloid fibril formation. In the present study, the progression of the total mass of aggregates during fibril formation is monitored for initial monomer concentrations in order to infer the relevant aggregation mechanisms. Read More

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Has Carbon Emissions Trading Reduced PM in China?

Environ Sci Technol 2021 May 7. Epub 2021 May 7.

Business School, Hunan University, Changsha 410082, China.

China today has an urgent need to develop low-carbon policies that also address local air pollution. This study uses a difference-in-differences model to estimate the extent to which China's Emissions Trading Scheme (ETS), which directly addresses CO emissions, has also generated cobenefits by reducing PM. Using monthly PM concentration and weather data for 297 Chinese cities from January 2005 to December 2017, we find that (1) China's ETS has reduced PM concentrations by 4. Read More

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Dual-Fluorescence Labeling Pseudovirus for Real-Time Imaging of Single SARS-CoV-2 Entry in Respiratory Epithelial Cells.

ACS Appl Mater Interfaces 2021 May 7. Epub 2021 May 7.

CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

The pseudovirus strategy makes studies of highly pathogenic viruses feasible without the restriction of high-level biosafety facility, thus greatly contributing to virology and is used in the research studies of SARS-CoV-2. Here, we generated a dual-color pseudo-SARS-CoV-2 virus using a human immunodeficiency virus-1 pseudovirus production system and the SARS-CoV-2 spike (S) glycoprotein, of which the membrane was labeled with a lipophilic dye (DiO) and the genomic RNA-related viral protein R (Vpr) of the viral core was fused with mCherry. With this dual-color labeling strategy, not only the movement of the whole virus but also the fate of the labeled components can be traced. Read More

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Genomic appraisal of Klebsiella PGPB isolated from soil to enhance the growth of barley.

Genes Genomics 2021 May 7. Epub 2021 May 7.

Department of Microbiology and Biotechnology, School of Sciences, Gujarat University, Ahmedabad, 380009, India.

Background: PGPR has substituted chemical fertilizers to enhance the nutrient profile of the soil. Although gene encoding for PGP activity is present in PGPB their activity changes in response to conditions.

Objective: To study comparative genomics for three Klebsiella strains and their PGPR activity in response to in vitro and soil condition. Read More

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A GIS-based groundwater pollution potential using DRASTIC, modified DRASTIC, and bivariate statistical models.

Environ Sci Pollut Res Int 2021 May 7. Epub 2021 May 7.

Department of Watershed Management Engineering, Sari Agricultural Science and Natural Resources University, Sari, Iran.

The objective of the current study is groundwater vulnerability assessment using DRASTIC, modified DRASTIC, and three statistical bivariate models (frequency ratio (FR), evidential belief function (EBF), and weights-of-evidence (WOE)) for Sari-Behshahr plain, Iran. A total of 218 wells were sampled for nitrate concentration measurement in 2015. Datasets were generated using results from 109 wells having nitrate concentrations greater than 50 mg/L. Read More

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Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons.

Hum Mol Genet 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka, Japan.

Syntaxin-binding protein 1 (STXBP1; also called MUNC18-1), encoded by STXBP1, is an essential component of the molecular machinery that controls synaptic vesicle docking and fusion. De novo pathogenic variants of STXBP1 cause a complex set of neurological disturbances, namely STXBP1 encephalopathy (STXBP1-E) that includes epilepsy, neurodevelopmental disorders, and neurodegeneration. Several animal studies have suggested the contribution of GABAergic dysfunction in STXBP1-E pathogenesis. Read More

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Postmarketing Safety Monitoring After Influenza Vaccination Using a Mobile Health App: Prospective Longitudinal Feasibility Study.

JMIR Mhealth Uhealth 2021 May 7;9(5):e26289. Epub 2021 May 7.

PhD Programme Epidemiology, Hannover Biomedical Research School, Hannover Medical School, Hannover, Germany.

Background: For the safety monitoring of vaccinations postlicensure, reports of adverse events after immunization (AEFIs) are crucial. New technologies such as digital mobile apps can be used as an active approach to capture these events. We therefore conducted a feasibility study among recipients of the influenza vaccination using an app for assessment of the reporting of AEFIs. Read More

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The Value of Web-Based Patient Education Materials on Transarterial Chemoembolization: Systematic Review.

JMIR Cancer 2021 May 7;7(2):e25357. Epub 2021 May 7.

Department of Radiology, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, United States.

Background: Thousands of web searches are performed related to transarterial chemoembolization (TACE), given its palliative role in the treatment of liver cancer.

Objective: This study aims to assess the reliability, quality, completeness, readability, understandability, and actionability of websites that provide information on TACE for patients.

Methods: The five most popular keywords pertaining to TACE were searched on Google, Yahoo, and Bing. Read More

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A novel use for an old drug: resistance reversal in by combining dihydroartemisinin with fluconazole.

Future Microbiol 2021 May 7. Epub 2021 May 7.

Department of Pharmacy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.

To investigate the effects of dihydroartemisinin combined with fluconazole against and to explore the underlying mechanisms. Checkerboard microdilution assay and time-kill curve method were employed to evaluate the static and dynamic antifungal effects against . Reactive oxygen species (ROS) was measured by a fluorescent probe. Read More

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Determination of the Aggregation Number of Pyrene-Labeled Gemini Surfactant Micelles by Pyrene Fluorescence Quenching Measurements.

Langmuir 2021 May 7. Epub 2021 May 7.

Department of Chemistry, Institute for Polymer Research, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.

A cationic gemini surfactant referred to as Py-3-12 and composed of two alkylated diammonium bromide head groups, a propyl spacer, and dodecyl and 1-pyrenehexyl hydrophobic tails was synthesized. Its critical micellar concentration (CMC) was determined to equal 0.15 (±0. Read More

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Establishment of an Agrobacterium-mediated genetic transformation and CRISPR/Cas9-mediated targeted mutagenesis in Hemp (Cannabis Sativa L.).

Plant Biotechnol J 2021 May 7. Epub 2021 May 7.

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, Hunan, China.

Hemp (Cannabis sativa L.) is an annual and typically dioecious crop. Due to the therapeutic potential for human diseases, phytocannabinoids as a medical therapy is getting more attention recently. Read More

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Retrospective investigation of the neutrophil-to-lymphocyte ratio in dogs with pneumonia: 49 cases (2011-2016).

J Vet Emerg Crit Care (San Antonio) 2021 May 7. Epub 2021 May 7.

Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK.

Objective: To assess the utility of the neutrophil-to-lymphocyte ratio (NLR) in predicting outcome in canine pneumonia compared with routine hematological parameters and systemic inflammatory response syndrome (SIRS) scores.

Design: Retrospective study.

Setting: University teaching hospital. Read More

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The miR164-GhCUC2-GhBRC1 module regulates plant architecture through abscisic acid in cotton.

Plant Biotechnol J 2021 May 7. Epub 2021 May 7.

State Key Laboratory of Cotton Biology, Institute of Cotton Research of Chinese Academy of Agricultural Sciences, Anyang, China.

Branching determines cotton architecture and production, but the underlying regulatory mechanisms remain unclear. Here, we report that the miR164-GhCUC2 (CUP-SHAPED COTYLEDON2) module regulates lateral shoot development in cotton and Arabidopsis. We generated OE-GhCUC2m (overexpression GhCUC2m) and STTM164 (short tandem target mimic RNA of miR164) lines in cotton and heterologous expression lines for gh-miR164, GhCUC2 and GhCUC2m in Arabidopsis to study the mechanisms controlling lateral branching. Read More

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The role of the potential field on occurrence and flow of octane in quartz nanopores.

Phys Chem Chem Phys 2021 May 7. Epub 2021 May 7.

College of Science, China University of Petroleum (East China), Qingdao 266580, P. R. China.

Occurrence and flow of hydrocarbons in nanopores are two important issues in the effective exploitation of shale oil reservoirs. In this study, molecular dynamics simulations are employed to investigate the mechanisms about occurrence and flow of octane in slit-shaped quartz nanopores. We show that the occurrence state of octane and, therefore, its flow behavior are profoundly affected by the potential field from quartz walls and adsorption layers if the nanopore width w becomes less than 50 Å. Read More

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Cefepime use: A need for antimicrobial stewardship.

Infect Dis Now 2021 Jan 18. Epub 2021 Jan 18.

Service des maladies infectieuses et tropicales, Unicaen, CHU de Caen Normandie, Normandie université, 14000 Caen, France.

Objectives: Unlike other 3GCs, Cefepime is a cephalosporin that has, in animal model studies, shown a low risk of selecting resistant mutants. It also enables carbapenems to be saved in treatment of Pseudomonasaeruginosa and the CESP group (Citrobacter, Enterobacter, Serratia and Providencia, as well as the genus Klebsiellaaerogenes, Morganella and Hafnia), consequently producing cephalosporinase. We aimed to determine whether its prescription in a French teaching hospital met criteria for proper use. Read More

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January 2021

Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium.

Elife 2021 May 7;10. Epub 2021 May 7.

Plant and Microbial Biology, University of Zürich, Zürich, Switzerland.

In multicellular organisms, sexual reproduction requires the separation of the germline from the soma. In flowering plants, the female germline precursor differentiates as a single spore mother cell (SMC) as the ovule primordium forms. Here, we explored how organ growth contributes to SMC differentiation. Read More

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