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Crohn Disease Active Inflammation Assessment with Iodine Density from Dual-Energy CT Enterography: Comparison with Histopathologic Analysis.

Radiology 2021 Aug 3:204405. Epub 2021 Aug 3.

From the Departments of Radiology (B.D., M.N., A.M.), Pathology (S.S.), Surgery (F.R.), and Gastroenterology (S.C.), NYU Langone Health, 660 1st Ave, New York, NY 10016; Department of Internal Medicine, NYU Grossman School of Medicine, New York, NY 10016 (H.G.); and Siemens Healthineers, Malvern, Pa (T.O.).

Background Dual-energy CT enterography (DECTE) has been shown to be useful in characterizing Crohn disease activity compared with clinical markers of inflammation but, to the knowledge of the authors, comparison has not been made with histopathologic specimens. Purpose To compare mucosal iodine density obtained at DECTE from Crohn disease-affected bowel with histopathologic specimens from surgically resected ileocolectomy bowel segments or terminal ileum colonoscopic biopsies in the same patients. Materials and Methods This was a retrospective study. Read More

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A DNAzyme-Based Dual-Stimuli Responsive Electrochemiluminescence Resonance Energy Transfer Platform for Ultrasensitive Anatoxin-a Detection.

Anal Chem 2021 Aug 3. Epub 2021 Aug 3.

Key Laboratory of Chem-Biosensing and Key Laboratory of Functional Molecular Solids of Anhui Province, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.

An effective and precise electrochemiluminescence resonance energy transfer (ECL-RET), including the efficient regulation over the proximity of a donor and an acceptor and the reliable stimuli responsive as well as the avoidance of undesirable probes leakage, etc., is significant for the development of an accurate and sensitive ECL detection method; yet, the current literature in documentation involves only a limited range of such ECL-RET systems. Herein, we propose an ECL-RET strategy with dually quenched ultralow background signals and a dual-stimuli responsive, accurate signal output for the ultrasensitive and reliable detection of anatoxin-a (ATX-a). Read More

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Arbutin exerts anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade.

J Biochem Mol Toxicol 2021 Aug 2:e22857. Epub 2021 Aug 2.

Scigen Research and Innovation Pvt. Ltd., Thanjavur, Tamil Nadu, India.

Gliomas are a type of brain cancer that occurs in the supporting glial cells of the brain. It is highly malignant and accounts for 80% of brain tumors with high mortality and morbidity. Phytomedicines are potent alternatives for allopathic drugs which cause side effects. Read More

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Selective Cytotoxicity of Single and Dual Anti-CD19 and Anti-CD138 Chimeric Antigen Receptor-Natural Killer Cells against Hematologic Malignancies.

J Immunol Res 2021 11;2021:5562630. Epub 2021 Jul 11.

Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Natural killer (NK) cells are part of the first line of defense that rapidly respond to malignant transformed cells. Chimeric antigen receptor- (CAR-) engineered NK cells, although are still at the preliminary stage, have been shown to be alternative to CAR-T cells, mainly due to the absence of graft-versus-host disease and safer clinical profile. Allogeneic human NK cell line NK-92 cells, equipped by CAR, are being developed for clinical applications. Read More

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Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy.

Oxid Med Cell Longev 2021 21;2021:5583215. Epub 2021 Jul 21.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.

Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins, lipids, and DNA. Under physiological conditions, ROS are mainly generated in the mitochondria during aerobic metabolism. Under pathological conditions, excessive ROS disrupt cellular homeostasis. Read More

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Combined transcriptomic and metabolic analyses reveal potential mechanism for fruit development and quality control of Chinese raspberry (Rubus chingii Hu).

Plant Cell Rep 2021 Jul 31. Epub 2021 Jul 31.

School of Pharmaceutical, Chemical and Materials Engineering, Taizhou University, Taizhou, 318000, People's Republic of China.

Key Message: Combined transcriptomic and metabolic analyses reveal that fruit of Rubus chingii Hu launches biosynthesis of phenolic acids and flavonols at beginning of fruit set and then coordinately accumulated or converted to their derivatives. Rubus chingii Hu (Chinese raspberry) is an important dual functional food with nutraceutical and pharmaceutical values. Comprehensively understanding the mechanisms of fruit development and bioactive components synthesis and regulation could accelerate genetic analysis and molecular breeding for the unique species. Read More

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Observing dual-mode second-harmonic generation in an isotropic nonlinear elastic plate.

Ultrasonics 2021 Jul 20;117:106525. Epub 2021 Jul 20.

Centre for Nondestructive Evaluation and Department of Mechanical Engineering, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India. Electronic address:

In this paper, we discuss the observation of simultaneously propagating dual-mode second-harmonic fundamental symmetric (s) mode and a vertical-shear horizontal (sh) mode generated on an aluminium plate of 1 mm thickness while excited with a fundamental shear horizontal (SH) mode in a large domain. The experimental observations, and numerical models, were used to confirm the presence of dual-mode second-harmonics. The two wavemodes would separate from each other in the time-domain, wherein the travel length exceeded a minimum cut-off length of 40λ. Read More

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Thematic Analysis of Military Medical Ethics Publications From 2000 to 2020-A Bibliometric Approach.

Mil Med 2021 Jul 31. Epub 2021 Jul 31.

Conflict and Health Research Group, King's College London, Strand, London WC2R 2LS, UK.

Introduction: There has been external criticism of the compliance of military health personnel with internationally agreed principles in military medical ethics (MME). In response, a number of authors have called for clarity on the principles and topics within the domain of MME. This complements an increased acknowledgment of the need for education in MME for military health personnel. Read More

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Bioprinting of dual ECM scaffolds encapsulating limbal stem/progenitor cells in active and quiescent statuses.

Biofabrication 2021 Jul 30. Epub 2021 Jul 30.

University of California San Diego Department of Nanoengineering, University of California San Diego, La Jolla, San Diego, California, 92093-0403, UNITED STATES.

Limbal stem cell deficiency (LSCD) and corneal disorders are among the top global threats for human vision. Emerging therapies that integrate stem cell transplantation with engineered hydrogel scaffolds for biological and mechanical support are becoming a rising trend in the field. However, methods for high-throughput fabrication of hydrogel scaffolds, as well as knowledge of the interaction between limbal stem/progenitor cells (LSCs) and the surrounding extracellular matrix (ECM) are still much needed. Read More

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Prediction of Intracerebral Hemorrhage After Endovascular Treatment of Acute Ischemic Stroke: Combining Quantitative Parameters on Dual-Energy CT with Clinical Related Factors.

J Stroke Cerebrovasc Dis 2021 Jul 27;30(10):106001. Epub 2021 Jul 27.

Departments of Radiology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei 050000, China.

Objectives: To evaluate the predictive value of dual-energy CT (DECT) quantitative parameters and clinical influence factors for intracerebral hemorrhage (ICH) complications after endovascular treatment in patients with acute ischemic stroke (AIS).

Methods: Seventy-two consecutive patients who underwent brain DECT immediately after endovascular treatment for AIS from November 2017 to October 2019 were included. Retrospectively, the volume of brain parenchymal hyperdensity area (HDA), the maximum iodine concentration, and maximum CT value on DECT images was evaluated and measured by two radiologists blinded to any clinical information independently. Read More

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Facile construction of dual heterojunction [email protected]/MXene hybrid with efficient and stable catalytic activity for phenol degradation with peroxymonosulfate under visible light irradiation.

J Hazard Mater 2021 Jul 18;420:126686. Epub 2021 Jul 18.

CSIRO Manufacturing, Private Bag 10, Clayton South, VIC 3169, Australia. Electronic address:

Photocatalysis and peroxymonosulfate (PMS) based advanced oxidation processes (AOP) are emerging technology for the degradation of refractory organic pollutant in the field of water treatment. Here we report a novel [email protected]/MXene (CTM) hybrid through a facile sonication-hydrothermal method for efficient degradation of phenol via an integrated PMS activation-photocatalysis process. Benefiting from the proper position and superior suitability of the band structure, a dual interfacial charge transport channel was constructed, boosting the separation of photo-generated charge carriers and generating sufficient potential difference for redox reaction. Read More

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Machine learning models for predicting the activity of AChE and BACE1 dual inhibitors for the treatment of Alzheimer's disease.

Mol Divers 2021 Jul 29. Epub 2021 Jul 29.

Computational Biology and Bioinformatics Lab, Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.

Multi-target directed ligand-based 2D-QSAR models were developed using different N-benzyl piperidine derivatives showing inhibitory activity toward acetylcholinesterase (AChE) and β-Site amyloid precursor protein cleaving enzyme (BACE1). Five different classes of molecular descriptors belonging to spatial, structural, thermodynamics, electro-topological and E-state indices were used for machine learning by linear method, genetic function approximation (GFA) and nonlinear method, support vector machine (SVM) and artificial neural network (ANN). Dataset used for QSAR model development includes 57 AChE and 53 BACE1 inhibitors. Read More

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Insights into the Dual Shuttle Catalytic Mechanism of Guanine Deaminase.

J Phys Chem B 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry, Indian Institute of Technology-Bombay, Mumbai 400076, India.

Guanine deaminases (GD) are essential enzymes that help in regulating the nucleobase pool. Since the deamination reaction can result in the accumulation of mutagenic bases that can lead to genomic instability, these enzymes are tightly regulated and are nonpromiscuous. Here, we delineate the basis of their substrate fidelity via entailing the reaction mechanism of deamination by employing density functional theory (DFT) calculations on NE0047, a GD from . Read More

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Fine-tuning of dual-SMAD inhibition to differentiate human pluripotent stem cells into neural crest stem cells.

Cell Prolif 2021 Jul 29:e13103. Epub 2021 Jul 29.

Department of Biomedical Science, Graduate School of CHA University, Sungnam, Korea.

Objectives: The derivation of neural crest stem cells (NCSCs) from human pluripotent stem cells (hPSCs) has been commonly induced by WNT activation in combination with dual-SMAD inhibition. In this study, by fine-tuning BMP signalling in the conventional dual-SMAD inhibition, we sought to generate large numbers of NCSCs without WNT activation.

Materials And Methods: In the absence of WNT activation, we modulated the level of BMP signalling in the dual-SMAD inhibition system to identify conditions that efficiently drove the differentiation of hPSCs into NCSCs. Read More

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Regulation of CYP3A4 and CYP3A5 by a lncRNA: a potential underlying mechanism explaining the association between CYP3A4*1G and CYP3A metabolism.

Pharmacogenet Genomics 2021 Jul 26. Epub 2021 Jul 26.

Department of Pharmacotherapy and Translational Research, College of Pharmacy, Center for Pharmacogenomics, University of Florida, Gainesville, Florida, USA.

The cytochrome P450 3A4 (CYP3A4) enzyme is the most abundant drug-metabolizing enzyme in the liver, displaying large inter-person variability with unknown causes. In this study, we found that the expression of CYP3A4 is negatively correlated with AC069294.1 (ENSG00000273407, ENST00000608397. Read More

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Dual-energy CT imaging with limited-angular-range data.

Phys Med Biol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA, Chicago, UNITED STATES.

In dual-energy computed tomography (DECT), low- and high-kVp data are collected often over a full-angular range (FAR) of 360. While there exists strong interest in DECT with low- and high-kVp data acquired over limited-angular ranges (LARs), there remains little investigation of image reconstruction in DECT with LAR data.: We investigate image reconstruction with minimized LAR artifacts from low- and high-kVp data over LARs of ≤180by using a directional-total-variation (DTV) algorithm. Read More

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Dual-Energy CT-Derived Electron Density for Diagnosing Metastatic Mediastinal Lymph Nodes in Non-Small Cell Lung Cancer: Comparison With Conventional CT and FDG PET/CT Findings.

AJR Am J Roentgenol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City 890-8544, Japan.

Accurate nodal staging is essential to guide treatment selection in patients with non-small cell lung cancer (NSCLC). To our knowledge, measurement of electron density (ED) using dual-energy CT (DECT) is unexplored for this purpose. To assess the utility of ED from DECT in diagnosing metastatic mediastinal lymph nodes in patients with NSCLC, in comparison with conventional CT and FDG PET/CT. Read More

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Automated treatment planning of prostate stereotactic body radiotherapy with focal boosting on a fast-rotating O-ring linac: Plan quality comparison with C-arm linacs.

J Appl Clin Med Phys 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.

Purpose: The integration of auto-segmentation and automated treatment planning methods on a fast-rotating O-ring linac may improve the time efficiency of online adaptive radiotherapy workflows. This study investigates whether automated treatment planning of prostate SBRT with focal boosting on the O-ring linac could generate plans that are of similar quality as those obtained through manual planning on clinical C-arm linacs.

Methods: For 20 men with prostate cancer, reference treatment plans were generated on a TrueBeam STx C-arm linac with HD120 MLC and a TrueBeam C-arm linac with Millennium 120 MLC using 6 MV flattened dual arc VMAT. Read More

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New function of a well-known promoter: enhancer activity of minimal CMV promoter enables efficient dual-cassette transgene expression.

J Gene Med 2021 Jul 27:e3380. Epub 2021 Jul 27.

Cell and Molecular Therapy Program, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Co-expression of multiple genes in single vectors has achieved varying degrees of success by employing two promoters and/or with application of viral 2A-peptide or internal ribosome entry-site (IRES). However, promoter interference, potential functional-interruption of expressed-proteins by 2A-generated residual peptides or weaker translation of IRES-mediated downstream gene curtail their utilization. Thus, there is the need of single vectors that robustly express multiple proteins for enhanced gene therapy applications. Read More

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Site selection of straw collection and storage facilities considering carbon emission reduction.

Environ Sci Pollut Res Int 2021 Jul 27. Epub 2021 Jul 27.

School of Transportation, Jilin University, Changchun, 130025, China.

Straw recycling has generated high collection and transportation costs. Scientifically informed collection, storage, and transportation methods can reduce automobile exhaust emissions and high transportation costs. According to the relevant statistics, China's total theoretical straw resources reached 920 million tons in 2020. Read More

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Pricing through health apps generated data-Digital dividend as a game changer: Discrete choice experiment.

PLoS One 2021 26;16(7):e0254786. Epub 2021 Jul 26.

WHU -Otto Beisheim School of Management, Chair of Digital Marketing, Vallendar, GER.

Objectives: The objective of this paper is to study under which circumstances wearable and health app users would accept a compensation payment, namely a digital dividend, to share their self-tracked health data.

Methods: We conducted a discrete choice experiment alternative, a separated adaptive dual response. We chose this approach to reduce extreme response behavior, considering the emotionally-charged topic of health data sales, and to measure willingness to accept. Read More

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Water-Soluble Blue Fluorescent Nonconjugated Polymer Dots from Hyaluronic Acid and Hydrophobic Amino Acids.

ACS Omega 2021 Jul 9;6(28):17890-17901. Epub 2021 Jul 9.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Fluorescent polymers have been increasingly investigated to improve their water solubility and biocompatibility to enhance their performance in drug delivery and theranostic applications. However, the environmentally friendly synthesis and dual functionality of such systems remain a challenge due to the complicated synthesis of conventional fluorescent materials. Herein, we generated a novel blue fluorescent polymer dot through chemical conjugation of hydrophobic amino acids to hyaluronic acid (HA) under one-pot green chemistry conditions. Read More

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Evaluation of dual-energy CT derived radiomics signatures in predicting outcomes in patients with advanced gastric cancer after neoadjuvant chemotherapy.

Eur J Surg Oncol 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Rui Jin 2nd Road, Shanghai, 200025, China. Electronic address:

Background: To investigate the prognostic value of dual-energy CT (DECT) based radiomics to predict disease-free survival (DFS) and overall survival (OS) for patients with advanced gastric cancer (AGC) after neoadjuvant chemotherapy (NAC).

Methods: From January 2014 to December 2018, a total of 156 AGC patients were enrolled and randomly allocated into a training cohort and a testing cohort at a ratio of 2:1. Volume of interest of primary tumor was delineated on eight image series. Read More

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Optical Simulation and Experimental Assessment with Time-Walk Correction of TOF-PET Detectors with Multi-Ended Readouts.

Sensors (Basel) 2021 Jul 8;21(14). Epub 2021 Jul 8.

Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen 518107, China.

As a commonly used solution, the multi-ended readout can measure the depth-of-interaction (DOI) for positron emission tomography (PET) detectors. In the present study, the effects of the multi-ended readout design were investigated using the leading-edge discriminator (LED) triggers on the timing performance of time-of-flight (TOF) PET detectors. At the very first, the photon transmission model of the four detectors, namely, single-ended readout, dual-ended readout, side dual-ended readout, and triple-ended readout, was established in Tracepro. Read More

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Dual-Arm Coordinated Control Strategy Based on Modified Sliding Mode Impedance Controller.

Sensors (Basel) 2021 Jul 7;21(14). Epub 2021 Jul 7.

School of Mechanical Engineering, Anhui University of Technology, Ma'anshan 243032, China.

To meet the high-accuracy position/force control requirements of dual-arm robots for handling a target object, a control algorithm for dual-arm robots based on the modified sliding mode impedance controller MSMIC(tanh) is proposed. First, the combinative kinematics equation of the dual-arm robots and the unified dynamics model combining the manipulated object is established. Second, according to the impedance control motion model for the object, the desired joint angular accelerations of the manipulators are obtained, and the sliding mode controller based on the hyperbolic tangent function as the switch function is introduced to design the coordinated control strategy for dual-arm robots. Read More

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Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA 23219, USA.

Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear. In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form. To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations. Read More

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Neighborhood-level Asian American Populations, Social Determinants of Health, and Health Outcomes in 500 US Cities.

Ethn Dis 2021 15;31(3):433-444. Epub 2021 Jul 15.

Department of Population Health, NYU Grossman School of Medicine, New York, NY.

Introduction: The US Asian American (AA) population is projected to double by 2050, reaching ~43 million, and currently resides primarily in urban areas. Despite this, the geographic distribution of AA subgroup populations in US cities is not well-characterized, and social determinants of health (SDH) and health measures in places with significant AA/AA subgroup populations have not been described. Our research aimed to: 1) map the geographic distribution of AAs and AA subgroups at the city- and neighborhood- (census tract) level in 500 large US cities (population ≥66,000); 2) characterize SDH and health outcomes in places with significant AA or AA subgroup populations; and 3) compare SDH and health outcomes in places with significant AA or AA subgroup populations to SDH and health outcomes in places with significant non-Hispanic White (NHW) populations. Read More

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Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells.

Front Immunol 2021 5;12:690437. Epub 2021 Jul 5.

Department of Medicine, Division of Hematology/Oncology, University of Virginia, Charlottesville, VA, United States.

Adoptive T cell therapies for solid tumors is challenging. We generated metabolically enhanced co-activated-T cells by transducing intracellular co-stimulatory (41BB, ICOS or ICOS-27) and CD3ζ T cell receptor signaling domains followed by arming with bispecific antibodies (BiAbs) to produce armed "Headless CAR T cells" (hCART). Various hCART armed with BiAb directed at CD3ϵ and various tumor associated antigens were tested for: 1) specific cytotoxicity against solid tumors targets; 2) repeated and dual sequential cytotoxicity; 3) survival and cytotoxicity under hypoxic condition; and 4) cytokine secretion. Read More

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Comparative Investigation of Fifteen Xenobiotic Metabolizing -Acetyltransferase (NAT) Homologs from Bacteria.

Appl Environ Microbiol 2021 Jul 21:AEM0081921. Epub 2021 Jul 21.

Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.

Arylamines constitute a large group of industrial chemicals detoxified by certain bacteria through conjugation reactions catalyzed by -acetyltransferase (NAT) enzymes. NAT homologs, mostly from pathogenic bacteria, have been the subject of individual studies that do not facilitate direct comparisons. By implementing a practicable pipeline, we present comparative investigation of fifteen NAT homologs from ten bacteria, mainly bacilli, streptomycetes, and one alphaproteobacterium. Read More

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Centriole is the pivot coordinating dynamic signaling for cell proliferation and organization during early development in the vertebrates.

Cell Biol Int 2021 Jul 21. Epub 2021 Jul 21.

Drug Safety Division, ICMR-National Institute of Nutrition, Hyderabad, 500007, India.

Vertebrates have an elaborate and functionally segmented body. It evolves from a single cell by systematic cell proliferation but attains a complex body structure with exquisite precision. This development requires two cellular events: cell cycle and ciliogenesis. Read More

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