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Automatic Estimation of Multidimensional Personality From a Single Sound-Symbolic Word.

Front Psychol 2021 22;12:595986. Epub 2021 Apr 22.

Department of Informatics, The University of Electro-Communications, Chofu, Japan.

Researchers typically use the "big five" traits (Extroversion, Agreeableness, Conscientiousness, Neuroticism, and Openness) as a standard way to describe personality. Evaluation of personality is generally conducted using self-report questionnaires that require participants to respond to a large number of test items. To minimize the burden on participants, this paper proposes an alternative method of estimating multidimensional personality traits from only a single word. Read More

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Whole genome sequencing reveals high differentiation, low levels of genetic diversity and short runs of homozygosity among Swedish wels catfish.

Heredity (Edinb) 2021 May 7. Epub 2021 May 7.

Department of Ecology and Genetics, Animal Ecology, Uppsala University, Uppsala, Sweden.

The use of genetic markers in the context of conservation is largely being outcompeted by whole-genome data. Comparative studies between the two are sparse, and the knowledge about potential effects of this methodology shift is limited. Here, we used whole-genome sequencing data to assess the genetic status of peripheral populations of the wels catfish (Silurus glanis), and discuss the results in light of a recent microsatellite study of the same populations. Read More

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Loss of EZH2-like or SU(VAR)3-9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina.

Epigenetics Chromatin 2021 May 7;14(1):22. Epub 2021 May 7.

Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198, Gif-sur-Yvette, France.

Background: Selective gene silencing is key to development. It is generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate. Conversely, H3K9me3-enriched heterochromatin prevents differentiation but constitutes protection against transposable elements. Read More

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Racial and Ethnic Disparities in Bronchiolitis Management in Free-Standing Children's Hospitals.

Acad Emerg Med 2021 May 7. Epub 2021 May 7.

University of Nebraska Medical Center, Children's Hospital Medical Center, Omaha, Nebraska, USA.

Objective: Variation in bronchiolitis management by race and ethnicity within emergency departments (EDs) has been described in single-center and prospective studies, but large-scale assessments across EDs and inpatient settings are lacking. Our objective is to describe the association between race and ethnicity and bronchiolitis management across 37 US free-standing children's hospitals from 2015 to 2018.

Methods: Using the Pediatric Health Information System, we analyzed ED and inpatient visits from November 2015 to November 2018 of children with bronchiolitis 3 to 24 months old. Read More

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Virus Detection: A Review of the Current and Emerging Molecular and Immunological Methods.

Front Mol Biosci 2021 20;8:637559. Epub 2021 Apr 20.

School of Biotechnology, Dublin City University, Dublin, Ireland.

Viruses are ubiquitous in the environment. While many impart no deleterious effects on their hosts, several are major pathogens. This risk of pathogenicity, alongside the fact that many viruses can rapidly mutate highlights the need for suitable, rapid diagnostic measures. Read More

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High-Quality Nursing Care for the Elderly in the Department of Otolaryngology.

J Healthc Eng 2021 19;2021:5542562. Epub 2021 Apr 19.

Zhongnan Hospital of Wu Han University, Wuhan, Hubei 430071, China.

ENT patients have different types of diseases and clinical symptoms, and generally, patients have a low level of understanding of their professional knowledge about their ENT diseases. In this paper, quality nursing interventions in otorhinolaryngology require nursing staff to implement relevant nursing interventions in the process of implementing relevant nursing care, which should be based on patients' needs, and guide patients to perform rehabilitation exercises according to their individual conditions, in addition to establishing continuous nursing interventions with patients at the time of discharge with the help of modern technology. By comparing the nursing satisfaction of patients in the observation group and the control group, it was found that the nursing satisfaction of patients in the observation group who received humanistic nursing was higher, and the difference was statistically significant compared with that of the control group ( < 0. Read More

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Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid.

ACS Appl Mater Interfaces 2021 May 7. Epub 2021 May 7.

Department of Microelectronic Science and Engineering, School of Physical Science and Technology, Ningbo University, Ningbo 315211, P. R. China.

Surface-enhanced Raman scattering (SERS) substrates based on graphene and its derivatives have recently attracted attention among those interested in the detection of trace molecules; however, these substrates generally show poor uniformity, an unsatisfactory enhancement factor, and require a complex fabrication process. Herein, we design and fabricate three-dimensional (3D) graphene/silicon (3D-Gr/Si) heterojunction SERS substrates to detect various types of molecules. Notably, the detection limit of 3D-Gr/Si can reach 10 M for rhodamine 6G (R6G) and rhodamine B (RB), 10 M for crystal violet (CRV), copper(II) phthalocyanine (CuPc), and methylene blue (MB), 10 M for dopamine (DA), 10 M for bovine serum albumin (BSA), and 10 M for melamine (Mel), which is superior to most reported graphene-based SERS substrates. Read More

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Data integration and visualization techniques for post-cytometric analysis of complex datasets.

Cytometry A 2021 May 6. Epub 2021 May 6.

Quantitative Biology Unit, National Cytometry Platform, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

The increasing number of measurable markers and the need to integrate flow cytometry datasets with data generated by other high throughput technologies, require the use of innovative tools, easy enough to be used by people with diverse levels of informatics skills. Flow cytometry analysis software has principally been designed for single sample analysis and it does not cover all the successive analysis steps such as integration with metadata and complex visualization. Here, we illustrated the use of data integration and visualization tools generally used in the business sector to analyze datasets generated by mass and flow cytometry. Read More

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A Stalled Revolution? Misoprostol and the Pharmaceuticalization of Reproductive Health in Francophone Africa.

Siri Suh

Front Sociol 2021 12;6:590556. Epub 2021 Apr 12.

Brandeis University, Waltham, MA, United States.

Misoprostol entered the global market under the name Cytotec in the mid-1980s for the treatment of gastric ulcers. Decades of research have since demonstrated the safety and effectiveness of off-label use of misoprostol as a uterotonic in pregnant women to prevent and treat post-partum hemorrhage, treat incomplete abortion, or terminate first-trimester pregnancy. Global health experts emphasize misoprostol's potential to revolutionize access to reproductive health care in developing countries. Read More

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Recent Advances in Multimetal and Doped Transition-Metal Phosphides for the Hydrogen Evolution Reaction at Different pH values.

ACS Appl Mater Interfaces 2021 May 6. Epub 2021 May 6.

Institut für Chemie and IRIS Adlershof, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.

Hydrogen is a fuel with a potentially zero-carbon footprint viewed as a viable alternative to fossil fuels. It can be produced in a large scale via electrochemical water splitting using electricity derived from renewable sources, but this would require highly active, inexpensive, and stable hydrogen evolution reaction (HER) catalysts to replace the Pt benchmark. Transition-metal phosphides (TMPs) are potential Pt replacements owing to their generally high activity as well as versatility as HER catalysts for different pH media. Read More

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Comparison of sparse biclustering algorithms for gene expression datasets.

Brief Bioinform 2021 May 5. Epub 2021 May 5.

Cambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK.

Motivation: Gene clustering and sample clustering are commonly used to find patterns in gene expression datasets. However, genes may cluster differently in heterogeneous samples (e.g. Read More

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Evaluation of the efficiency of corticosteroids in treating adult with sepsis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25610

Department of Infectious Diseases, Weifang People's Hospital, Weifang, Shandong Province, China.

Background: Sepsis is a worldwide health problem that is a leading cause of mortality due to infection. Sepsis is prevalent in infections that are complicated with organ failure. Generally, sepsis is intricate and impaired corticosteroid metabolism leads to complex outcomes. Read More

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Developing more generalizable prediction models from pooled studies and large clustered data sets.

Stat Med 2021 May 5. Epub 2021 May 5.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Prediction models often yield inaccurate predictions for new individuals. Large data sets from pooled studies or electronic healthcare records may alleviate this with an increased sample size and variability in sample characteristics. However, existing strategies for prediction model development generally do not account for heterogeneity in predictor-outcome associations between different settings and populations. Read More

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Current clinical and research fluid biomarkers to aid risk stratification of pancreatic cystic lesions.

Rev Esp Enferm Dig 2021 May 5. Epub 2021 May 5.

Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, España.

Pancreatic cystic lesions (PCL) are composed of a heterogeneous group of entities that are increasingly diagnosed, generally as incidental findings in asymptomatic patients. In conjunction with this growing incidence, the potential for malignant transformation of mucin-producing cysts makes PCL a challenging clinical conundrum for the clinician, patient, and healthcare system. Cyst characterization based on morphology is often difficult and inaccurate, therefore several intracystic fluid biomarkers have been evaluated as ancillary testing to enhance the difficult balance between sparing a patient from an unnecessary high-risk pancreatic surgery and missing the opportunity to prevent or diagnose pancreatic adenocarcinoma at an early disease stage. Read More

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The Role of the Excitation:Inhibition Functional Balance in the mPFC in the Onset of Antidepressants.

Neuropharmacology 2021 May 1:108573. Epub 2021 May 1.

Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing, China; Beijing Institute of Basic Medical Sciences, Beijing, China. Electronic address:

Currently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to months to produce a therapeutic response, but the mechanism of action underlying the delayed onset of antidepressant-like action remains to be elucidated. The balance between excitatory glutamatergic pyramidal neurons and inhibitory γ-aminobutyric acid (GABA) interneurons, i.e. Read More

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Anatomy of strike-slip fault tsunami genesis.

Proc Natl Acad Sci U S A 2021 May;118(19)

Graduate Aerospace Laboratories, California Institute of Technology, Pasadena, CA 91125

Tsunami generation from earthquake-induced seafloor deformations has long been recognized as a major hazard to coastal areas. Strike-slip faulting has generally been considered insufficient for triggering large tsunamis, except through the generation of submarine landslides. Herein, we demonstrate that ground motions due to strike-slip earthquakes can contribute to the generation of large tsunamis (>1 m), under rather generic conditions. Read More

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What are the risk factors for admission to the pediatric intensive unit among pediatric patients with COVID-19?

Ital J Pediatr 2021 May 3;47(1):103. Epub 2021 May 3.

Università degli Studi di Milano, Milan, Italy.

Background: Although with exceptions, evidence seems to indicate that children have lower susceptibility than adults to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. When infected, children generally remain asymptomatic or develop mild disease. A small number of pediatric cases required admission to the pediatric intensive care unit (PICU), respiratory support with a mechanical ventilation and additional life-saving interventions. Read More

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Transient dynamics during kelp forest recovery from fishing across multiple trophic levels.

Ecol Appl 2021 May 3:e2367. Epub 2021 May 3.

Department of Environmental Science and Policy, University of California Davis, Davis.

Outcomes of management efforts to recover or restore populations of harvested species can be highly dependent on environmental and community context. Predator-prey interactions can alter recovery trajectories, and the timing of management actions within multi-trophic level harvest scenarios may influence the dynamics of recovery and lead to management trade-offs. Recent work using a generalist predator-prey model suggests that management promoting synchronized recovery of predators and prey leads to faster and less variable recovery trajectories than sequential recovery (predator- or prey-first). Read More

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Frequency of positive oral food challenges and their outcomes in the allergy unit of a tertiary-care pediatric hospital.

Allergol Immunopathol (Madr) 2021 1;49(3):120-130. Epub 2021 May 1.

Allergy Unit, Meyer Children's Hospital, Florence, Italy;

Introduction And Objective: The oral food challenge (OFC) is the gold standard to diagnose food allergy (FA); however, it is not a procedure free from the risk of having significant allergic reactions, even life-threatening.The aims of our study were to evaluate the frequency of positive OFCs performed in children with a suspected diagnosis of IgE- and non-IgE-mediated (food protein-induced enterocolitis syndrome (FPIES)) FA and how the failed challenges were managed.

Materials And Methods: A retrospective chart review was done on all children who have had OFCs in a tertiary-care pediatric allergy unit from 2017 to 2019. Read More

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Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis.

J Rheumatol 2021 May 1. Epub 2021 May 1.

Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare's Mercy Hospital, St. John's Newfoundland, Canada A1C 5B8.

Objective: Evaluate safety of guselkumab (monoclonal antibody targeting IL-23p19) in psoriatic arthritis (PsA) patients through 1year (1Y) of the Phase-3 DISCOVER-1&2 trials.

Methods: Patients with active PsA (N=1120; biologic-naïve except the118 TNFi-treated DISCOVER-1 patients) were randomized to subcutaneous guselkumab 100 mg every 4 weeks (Q4W) or at Week 0, Week4, then Q8W; or placebo. At Week24, placebo patients switched to guselkumab 100 mg Q4W. Read More

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Clinical characteristics and long-term outcomes for patients who undergo cytoreductive surgery for thoracic meningiomas: a retrospective analysis.

Neurosurg Focus 2021 May;50(5):E18

1Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.

Objective: Primary spinal meningiomas represent a rare indolent neoplasm usually situated in the intradural-extramedullary compartment. They have a predilection for afflicting the thoracic spine and most frequently present with sensory and/or motor symptoms. Resection is the first-line treatment for symptomatic tumors, whereas other clinical factors will determine the need for adjuvant therapy. Read More

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Misinterpreting the adaptive value of phenotypic plasticity in studies on plant adaptation to new and variable environments.

Stephen P Bonser

Plant Biol (Stuttg) 2021 May 1. Epub 2021 May 1.

Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.

Phenotypic plasticity is an important mechanism for plant adaptation to variable environments, and plant responses to changing climates. However, plasticity in fitness or performance traits (i.e. Read More

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Paradigm shift: the primary function of the "Adiponectin Receptors" is to regulate cell membrane composition.

Marc Pilon

Lipids Health Dis 2021 Apr 30;20(1):43. Epub 2021 Apr 30.

Dept. Chemistry and Molecular Biology, Univ. Gothenburg, Box 462, S-405 30, Gothenburg, Sweden.

The ADIPOR1 and ADIPOR2 proteins (ADIPORs) are generally considered as adiponectin receptors with anti-diabetic properties. However, studies on the yeast and C. elegans homologs of the mammalian ADIPORs, and of the ADIPORs themselves in various mammalian cell models, support an updated/different view. Read More

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Perspectives on the Management of Surplus Dairy Calves in the United States and Canada.

Front Vet Sci 2021 13;8:661453. Epub 2021 Apr 13.

Department of Population Medicine, University of Guelph, Guelph, ON, Canada.

The care of surplus dairy calves is a significant issue for the United States and Canadian dairy industries. Surplus dairy calves commonly experience poor welfare as evidenced by high levels of mortality and morbidity, and negative affective states resulting from limited opportunities to express natural behaviors. Many of these challenges are a result of a disaggregated production system, beginning with calf management at the dairy farm of origin and ending at a calf-raising facility, with some calves experiencing long-distance transportation and commingling at auction markets or assembly yards in the interim. Read More

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A Case of Atypical Bartonellosis in a 4-Year-Old Immunocompetent Child.

Microorganisms 2021 Apr 28;9(5). Epub 2021 Apr 28.

Pediatric Clinic, Pietro Barilla Children's Hospital, University of Parma, Via Gramsci 14, 43126 Parma, Italy.

In most cases, infection due to causes a mild disease presenting with a regional lymphadenopathy frequently associated with a low-grade fever, headache, poor appetite and exhaustion that spontaneously resolves itself in a few weeks. As the infection is generally transmitted by cats through scratching or biting, the disease is named cat scratch disease (CSD). However, in 5-20% of cases, mainly in immunocompromised patients, systemic involvement can occur and CSD may result in major illness. Read More

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Eco-Friendly Dye-Sensitized Solar Cells Based on Water-Electrolytes and Chlorophyll.

Materials (Basel) 2021 Apr 23;14(9). Epub 2021 Apr 23.

Department of Chemical & Biomolecular Engineering, Seoul National University of Science & Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Korea.

Organic solvents used for electrolytes of dye-sensitized solar cells (DSSCs) are generally not only toxic and explosive but also prone to leakage due to volatility and low surface tension. The representative dyes of DSSCs are ruthenium-complex molecules, which are expensive and require a complicated synthesis process. In this paper, the eco-friendly DSSCs were presented based on water-based electrolytes and a commercially available organic dye. Read More

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Machine Learning-Based Classification of Lignocellulosic Biomass from Pyrolysis-Molecular Beam Mass Spectrometry Data.

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Renewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, 15013 Denver West Pkwy, Golden, CO 80401, USA.

High-throughput analysis of biomass is necessary to ensure consistent and uniform feedstocks for agricultural and bioenergy applications and is needed to inform genomics and systems biology models. Pyrolysis followed by mass spectrometry such as molecular beam mass spectrometry (py-MBMS) analyses are becoming increasingly popular for the rapid analysis of biomass cell wall composition and typically require the use of different data analysis tools depending on the need and application. Here, the authors report the py-MBMS analysis of several types of lignocellulosic biomass to gain an understanding of spectral patterns and variation with associated biomass composition and use machine learning approaches to classify, differentiate, and predict biomass types on the basis of py-MBMS spectra. Read More

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Diet-Cognition Associations Differ in Mild Cognitive Impairment Subtypes.

Nutrients 2021 Apr 17;13(4). Epub 2021 Apr 17.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100050, China.

Cognitive function is not generally associated with diet, and there is debate over that association. Moreover, little is known about such associations with the specific cognitive domains and subtypes of mild cognitive impairment (MCI). We analyzed data of 4309 Chinese adults aged 55 and over from the Community-based Cohort Study on Nervous System Diseases from 2018-2019. Read More

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Cre mRNA Is Not Transferred by EVs from Endothelial and Adipose-Derived Stromal/Stem Cells during Vascular Network Formation.

Int J Mol Sci 2021 Apr 14;22(8). Epub 2021 Apr 14.

AUVA Research Centre, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria.

Coculture systems employing adipose tissue-derived mesenchymal stromal/stem cells (ASC) and endothelial cells (EC) represent a widely used technique to model vascularization. Within this system, cell-cell communication is crucial for the achievement of functional vascular network formation. Extracellular vesicles (EVs) have recently emerged as key players in cell communication by transferring bioactive molecules between cells. Read More

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EcoQBNs: First Application of Ecological Modeling with Quantum Bayesian Networks.

Bruce G Marcot

Entropy (Basel) 2021 Apr 9;23(4). Epub 2021 Apr 9.

Forest Service, Pacific Northwest Research Station, Portland, OR 97208, USA.

A recent advancement in modeling was the development of quantum Bayesian networks (QBNs). QBNs generally differ from BNs by substituting traditional Bayes calculus in probability tables with the quantum amplification wave functions. QBNs can solve a variety of problems which are unsolvable by, or are too complex for, traditional BNs. Read More

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