1,742 results match your criteria generally persisted


Gestational Age and Neonatal Electrocardiograms.

Pediatrics 2021 Nov 24. Epub 2021 Nov 24.

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Interpretation of the neonatal electrocardiogram (ECG) is challenging due to the profound changes of the cardiovascular system in this period. We aimed to investigate the impact of gestational age (GA) on the neonatal ECG and create GA-specific reference values.

Methods: The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation of neonates. Read More

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November 2021

Association between residential greenness and overweight/obesity among rural adults in northwestern China.

Environ Res 2021 Nov 10:112358. Epub 2021 Nov 10.

Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China; Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou, 511436, China. Electronic address:

Background: Living in greener areas may reduce adiposity, but epidemiological evidence on this topic is still inconsistence and limited, especially in rural areas.

Methods: We performed a cross-sectional study among 4651 Uyghur adults in rural areas in Xinjiang province, northwestern China, from May to September 2016. We measured residential greenness levels using satellite-derived Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI) in 100 m, 300 m, 500 m, and 1000 m buffers around each home address. Read More

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November 2021

Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure.

Neurotoxicology 2021 Oct 29;88:79-87. Epub 2021 Oct 29.

Section for Drug Abuse Research, Dept. of Forensic Sciences, Division of Laboratory Medicine, Oslo University Hospital, PO Box 4404, Nydalen, 0403, Oslo, Norway. Electronic address:

Persistent organic pollutants (POPs) can reach the fetal brain and contribute to developmental neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken embryos to a POP mixture, containing 29 different compounds with concentrations based on blood levels measured in the Scandinavian human population. The mixture was injected into the allantois at embryonic day 13 (E13), aiming at a theoretical concentration of 10 times human blood levels. Read More

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October 2021

Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial.

J Am Heart Assoc 2021 Nov 6;10(22):e021094. Epub 2021 Nov 6.

Canadian VIGOUR Centre University of Alberta Edmonton Canada.

Background Although safety and tolerability of vericiguat were established in the VICTORIA (Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction) trial in patients with heart failure with reduced ejection fraction, some subgroups may be more susceptible to symptomatic hypotension, such as older patients, those with lower baseline systolic blood pressure (SBP), or those concurrently taking angiotensin receptor neprilysin inhibitors. We described the SBP trajectories over time and compared the occurrence of symptomatic hypotension or syncope by treatment arm in potentially vulnerable subgroups in VICTORIA. We also evaluated the relation between the efficacy of vericiguat and baseline SBP. Read More

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November 2021

Third molar development in a London population of White British and Black British or other Black ethnicity.

J Forensic Sci 2021 Nov 3. Epub 2021 Nov 3.

Department of Radiology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

Population differences in dental development between Black and White ethnic groups have been debated but not previously studied in the UK. Using inappropriate data for dental age estimation (DAE) could lead to erroneous results and injustice. Data were collected from dental panoramic radiographs of 5590 subjects aged 6-24 years in a teaching hospital archive. Read More

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November 2021

Achieving efficacy in subjects with sustained pegvaliase-neutralizing antibody responses.

Mol Genet Metab 2021 Nov 4;134(3):235-242. Epub 2021 Oct 4.

BioMarin Pharmaceutical Inc., 105 Digital Drive, Novato, CA 94949, USA. Electronic address:

Pegvaliase (Palynziq®) is an enzyme substitution therapy using PEGylated recombinant Anabaena variabilis phenylalanine ammonia lyase (PAL) to reduce blood phenylalanine (Phe) levels in adults with phenylketonuria (PKU). In Phase 3 clinical studies, all subjects treated with pegvaliase developed anti-drug antibodies. To specifically evaluate pegvaliase-neutralizing antibodies (NAbs) and assess impact on pegvaliase efficacy, a novel hybrid ligand-binding/tandem mass spectrometry NAb assay was developed. Read More

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November 2021

Relationships between in vivo surface and ex vivo electrical impedance myography measurements in three different neuromuscular disorder mouse models.

PLoS One 2021 29;16(10):e0259071. Epub 2021 Oct 29.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.

Electrical impedance myography (EIM) using surface techniques has shown promise as a means of diagnosing and tracking disorders affecting muscle and assessing treatment efficacy. However, the relationship between such surface-obtained impedance values and pure muscle impedance values has not been established. Here we studied three groups of diseased and wild-type (WT) animals, including a Duchenne muscular dystrophy model (the D2-mdx mouse), an amyotrophic lateral sclerosis (ALS) model (the SOD1 G93A mouse), and a model of fat-related atrophy (the db/db diabetic obese mouse), performing hind limb measurements using a standard surface array and ex vivo measurements on freshly excised gastrocnemius muscle. Read More

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October 2021

Which peer reviewers voluntarily reveal their identity to authors? Insights into the consequences of open-identities peer review.

Authors:
Charles W Fox

Proc Biol Sci 2021 Oct 27;288(1961):20211399. Epub 2021 Oct 27.

Department of Entomology, University of Kentucky, Lexington KY, USA.

Identifying reviewers is argued to improve the quality and fairness of peer review, but is generally disfavoured by reviewers. To gain some insight into the factors that influence when reviewers are willing to have their identity revealed, I examined which reviewers voluntarily reveal their identities to authors at the journal , at which reviewer identities are confidential unless reviewers sign their comments to authors. I found that 5. Read More

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October 2021

Pharmacokinetics of the Melanocortin Type 1 Receptor Agonist PL8177 After Subcutaneous Administration.

Drugs R D 2021 Dec 25;21(4):431-443. Epub 2021 Oct 25.

Palatin Technologies, Inc., 4C Cedar Brook Drive, Cranbury, NJ, 08512, USA.

Background And Objective: PL8177 is a selective melanocortin 1 receptor agonist in development for the treatment of various immunologic and inflammatory conditions. Here we describe the pharmacokinetics of PL8177 after subcutaneous (sc) delivery in animals and humans.

Methods: Mice, rats, and dogs were administered sc PL8177 at single doses of 1. Read More

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December 2021

Spontaneous Recovery of Hemophagocytic Lymphohistiocytosis Due to Primary Epstein-Barr Virus Infection in an Adult Patient.

Am J Case Rep 2021 Oct 17;22:e933272. Epub 2021 Oct 17.

Department of Infectious Diseases, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Chiba, Japan.

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening systemic hyperinflammatory condition. Most adult HLH cases are secondary to infection, malignancy, and rheumatic diseases. Epstein-Barr virus (EBV) infection is the most frequent cause of infection-induced HLH. Read More

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October 2021

Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in .

Molecules 2021 Sep 26;26(19). Epub 2021 Sep 26.

Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown St., Liverpool L69 7ZB, UK.

Pyrithione (2-mercaptopyridine-N-oxide) is a metal binding modified pyridine, the antibacterial activity of which was described over 60 years ago. The formulation of zinc-pyrithione is commonly used in the topical treatment of certain dermatological conditions. However, the characterisation of the cellular uptake of pyrithione has not been elucidated, although an unsubstantiated assumption has persisted that pyrithione and/or its metal complexes undergo a passive diffusion through cell membranes. Read More

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September 2021

Hemorrhagic disseminated intravascular coagulation after 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: A case report.

Medicine (Baltimore) 2021 Oct;100(40):e27455

UNICANCER, Comprehensive Cancer Centre F. Baclesse, Department of Nuclear Medicine, Caen, France.

Rationale: Peptide receptor radionuclide therapy with 177Lu-Dotatate represents a major breakthrough in the treatment of metastatic well differentiated neuroendocrine tumors. This treatment is generally well tolerated. Reported severe long-term hematological side effects are rare and include hematopoietic neoplasms and bone marrow failure. Read More

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October 2021

Oculomotor feedback rapidly reduces overt attentional capture.

Cognition 2021 12 28;217:104917. Epub 2021 Sep 28.

Texas A&M University, Department of Psychology, 4235 TAMU, College Station, TX 77843-4235, United States of America.

People often have limited awareness of the extent to which their attention is captured by salient-but-irrelevant stimuli. In the present study, we examined how providing feedback concerning the frequency of oculomotor capture by such stimuli modulates the control of attention. Our results show that the provision of oculomotor feedback produces a rapid and dramatic decrease in the frequency of distractor fixations. Read More

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December 2021

Marking through molts: An evaluation of visible implant elastomer to permanently mark individuals in a lower termite species.

Ecol Evol 2021 Sep 18;11(18):12834-12844. Epub 2021 Aug 18.

Centre for Ecology and Conservation College of Life and Environmental Sciences University of Exeter Cornwall UK.

Advances in individual marking methods have facilitated detailed studies of animal populations and behavior as they allow tracking of individuals through time and space. Hemimetabolous insects, representing a wide range of commonly used model organisms, present a unique challenge to individual marking as they are not only generally small-bodied, but also molt throughout development, meaning that traditional surface marks are not persistent.Visible implant elastomer (VIE) offers a potential solution as small amounts of the inert polymer can be implanted under the skin or cuticle of an animal. Read More

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September 2021

Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection.

BMC Genomics 2021 Sep 27;22(1):698. Epub 2021 Sep 27.

School of Biological Sciences, Washington State University, Pullman, Washington, USA.

Background: Transmissible cancers lie at the intersection of oncology and infectious disease, two traditionally divergent fields for which gene expression studies are particularly useful for identifying the molecular basis of phenotypic variation. In oncology, transcriptomics studies, which characterize the expression of thousands of genes, have identified processes leading to heterogeneity in cancer phenotypes and individual prognoses. More generally, transcriptomics studies of infectious diseases characterize interactions between host, pathogen, and environment to better predict population-level outcomes. Read More

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September 2021

Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel -Deficient Zebrafish Model.

Front Neurosci 2021 10;15:682054. Epub 2021 Sep 10.

Department of Child Health Care, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Mutations of the gene are found in some autism spectrum disorder (ASD) patients, and animal models harboring mutations exhibit a variety of ASD-like behaviors, presenting a unique opportunity to explore the underlying neuropathological mechanisms and potential pharmacological treatments. The histone deacetylase (HDAC) valproic acid (VPA) has demonstrated neuroprotective and neuroregenerative properties, suggesting possible therapeutic utility for ASD. Therefore, -associated ASD-like symptoms present a convenient model to evaluate the potential benefits, therapeutic window, and optimal dose of VPA. Read More

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September 2021

Healthcare Resource Utilization After Living Liver Donation: A Retrospective Case-control Study.

Transplantation 2021 Sep 23. Epub 2021 Sep 23.

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Department of Information Statistics, Andong National University, Andong, South Korea. Department of Statistics, Kyungpook National University, Daegu, South Korea. Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Background: Living liver donation is generally considered safe, but donors may experience short or long-term complications. The purpose of this study was to assess healthcare resource utilization after liver donation in living liver donors in comparison to the general population.

Methods: Outpatient or emergency department visits and hospital admissions were compared between living liver donors who underwent hepatic resection for living liver donation between 2004 and 2018 and the matched general population. Read More

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September 2021

Vitamin D supplementation and cardiometabolic risk factors among diverse schoolchildren: a randomized clinical trial.

Am J Clin Nutr 2021 Sep 22. Epub 2021 Sep 22.

Tufts University School of Medicine, Boston, MA, USA.

Background: There remains a lack of evidence demonstrating a potential relationship between vitamin D and cardiometabolic risk among children.

Objective: We examined the effect of three different doses of vitamin D on cardiometabolic risk factors among children at risk for deficiency.

Design: Racially diverse schoolchildren aged 8-15 years were randomized in a double-blind fashion to supplementation with 600, 1000, or 2000 IU/day for 6 months. Read More

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September 2021

Double-chamber plethysmography oscillometry to detect baseline airflow obstruction in a model of asthma in two mouse strains.

Exp Lung Res 2021 Oct 20;47(8):390-401. Epub 2021 Sep 20.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Canada.

Aim Of The Study: The current gold standard to assess respiratory mechanics in mice is oscillometry, a technique from which several readouts of the respiratory system can be deduced, such as resistance and elastance. However, these readouts are often not altered in mouse models of asthma. This is in stark contrast with humans, where asthma is generally associated with alterations when assessed by either oscillometry or other techniques. Read More

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October 2021

Geographic disparities and socio-demographic predictors of pertussis risk in Florida.

PeerJ 2021 31;9:e11902. Epub 2021 Aug 31.

Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, Tennessee, United States.

Background: Pertussis is a toxin-mediated respiratory illness caused by that can result in severe complications and death, particularly in infants. Between 2008 and 2011, children less than 3 months old accounted for 83% of the pertussis deaths in the United States. Understanding the geographic disparities in the distribution of pertussis risk and identifying high risk geographic areas is necessary for guiding resource allocation and public health control strategies. Read More

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Age-Specific and Sex-Specific Trends in Life-Sustaining Care After Acute Stroke.

J Am Heart Assoc 2021 09 13;10(18):e021499. Epub 2021 Sep 13.

ICES Toronto Canada.

Background Temporal trends in life-sustaining care after acute stroke are not well characterized. We sought to determine contemporary trends by age and sex in the use of life-sustaining care after acute ischemic stroke and intracerebral hemorrhage in a large, population-based cohort. Methods and Results We used linked administrative data to identify all hospitalizations for acute ischemic stroke or intracerebral hemorrhage in the province of Ontario, Canada, from 2003 to 2017. Read More

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September 2021

Manipulating turn residues on de novo designed β-hairpin peptides for selectivity against drug-resistant bacteria.

Acta Biomater 2021 11 8;135:214-224. Epub 2021 Sep 8.

Department of Pharmacy, National University of Singapore, 117543, Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering, 119077, Singapore, Singapore. Electronic address:

Synthetic β-hairpin antimicrobial peptides (AMPs) offer a useful source for the development of novel antimicrobial agents. β-hairpin peptides generally consist of two side strands bridged by a reverse turn. In literature, most studies focused on the modifications of the side strands to manipulate the stability and activity of β-hairpin peptides, and much less is known about the impact of the turn region. Read More

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November 2021

Exploring women's decisions of where to give birth in the Peruvian Amazon; why do women continue to give birth at home? A qualitative study.

PLoS One 2021 10;16(9):e0257135. Epub 2021 Sep 10.

Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.

Background: Despite improvements in maternal mortality globally, hundreds of women continue to die daily. The World Health Organisation therefore advises all women in low-and-middle income countries to give birth in healthcare facilities. Barriers to seeking intrapartum care have been described in Thaddeus and Maine's Three Delays Model, however these decisions are complex and often unique to different settings. Read More

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November 2021

Is My Cough a Cold or Covid? A Qualitative Study of COVID-19 Symptom Recognition and Attitudes Toward Testing in the UK.

Front Public Health 2021;9:716421. Epub 2021 Aug 18.

Weston Education Centre, King's College London, London, United Kingdom.

Key to reducing the spread of COVID-19 in the UK is increased use of the NHS Test and Trace (NHSTT) system. This study explored one of the main issues that determine whether people engage with NHSTT, how people understand symptoms that may indicate the presence of COVID-19 and that should trigger a request for a test. In this qualitative study, a series of semi-structured telephone interviews were conducted with 40 people (21 members of the general population, 19 students). Read More

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September 2021

The argument against screening for bladder cancer in neuro-urological patients.

Authors:
Blayne Welk

World J Urol 2021 Aug 19. Epub 2021 Aug 19.

Department of Surgery and Epidemiology and Biostatistics (Urologist), Western University, Room B4-667, St Joseph's Health Care, 268 Grosvenor Street, London, ON, N6A 4V2, Canada.

Purpose: The objective of this article was to present the case against screening people with neuro-urological disease for bladder cancer.

Methods: Literature around bladder cancer in neuro-urological patients (primarily spinal cord injured patients [SCI]) was identified.

Results: Bladder cancer is more common among patients with spinal cord injury, although the absolute risk is still low (between 0. Read More

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Persistent disparities in SARS-CoV-2 test percent positivity by neighborhood in New York City, March 1-July 25, 2020.

Ann Epidemiol 2021 11 12;63:46-51. Epub 2021 Aug 12.

Division of Disease Control, New York City Department of Health and Mental Hygiene, Long Island City, NY.

Purpose: To examine neighborhood-level disparities in SARS-CoV-2 molecular test percent positivity in New York City (NYC) by demographics and socioeconomic status over time to better understand COVID-19 inequities.

Methods: Across 177 neighborhoods, we calculated the Spearman correlation of neighborhood characteristics with SARS-CoV-2 molecular test percent positivity during March 1-July 25, 2020 by five periods defined by trend in case counts: increasing, declining, and three plateau periods to account for differential testing capacity and reopening status.

Results: Percent positivity was positively correlated with neighborhood racial and ethnic characteristics and socioeconomic status, including the proportion of the population who were Latino and Black non-Latino, uninsured, Medicaid enrollees, transportation workers, or had low educational attainment. Read More

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November 2021

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial.

Nat Med 2021 08 12;27(8):1410-1418. Epub 2021 Aug 12.

Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.

Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. We conducted a single-arm open-label phase 1 trial ( NCT03215810 ) of TILs administered with nivolumab in 20 patients with advanced non-small cell lung cancer following initial progression on nivolumab monotherapy. The primary end point was safety and secondary end points included objective response rate, duration of response and T cell persistence. Read More

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Attentional capture in multiple object tracking.

J Vis 2021 08;21(8):16

Institute of Psychology, Karlsruhe University of Education, Karlsruhe, Germany.

Attentional processes are generally assumed to be involved in multiple object tracking (MOT). The attentional capture paradigm is regularly used to study conditions of attentional control. It has up to now not been used to assess influences of sudden onset distractor stimuli in MOT. Read More

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Regular Healthcare Provider Status Does Not Moderate Racial/Ethnic Differences in Human Papillomavirus (HPV) and HPV Vaccine Knowledge.

Vaccines (Basel) 2021 Jul 20;9(7). Epub 2021 Jul 20.

Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Background: Racial/ethnic minorities generally have a lower knowledge of human papillomavirus (HPV) and the HPV vaccine than non-Hispanic Whites. They are also less likely to have a regular healthcare provider (HCP). Given the role of HCPs in disseminating health information, we evaluated whether racial/ethnic disparities in HPV knowledge are moderated by regular HCP status. Read More

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Neural Evidence for Representational Persistence Within Events.

J Neurosci 2021 09 30;41(37):7909-7920. Epub 2021 Jul 30.

Department of Psychology, Columbia University, New York, New York 10027.

How does the brain process continuous experiences so they can be remembered? Evidence suggests that people perceive their experience as a series of distinct and meaningful events. Information encountered within the same event shows greater temporal integration into memory as well as enhanced neural representational similarity. Although these data support the theory that the brain builds and maintains a mental model of the current event that represents recently encountered stimulus information, this hypothesis has not been directly tested. Read More

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September 2021