155,797 results match your criteria generalized


CoVrimer: A tool for aligning SARS-CoV-2 primer sequences and selection of conserved/degenerate primers.

Genomics 2021 Jul 19. Epub 2021 Jul 19.

Interdisciplinary Neuroscience Program, Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey. Electronic address:

As mutations in SARS-CoV-2 virus accumulate rapidly, novel primers that amplify this virus sensitively and specifically are in demand. We have developed a webserver named CoVrimer by which users can search for and align existing or newly designed conserved / degenerate primer pair sequences against the viral genome and assess the mutation load of both primers and amplicons. CoVrimer uses mutation data obtained from an online platform established by NGDC-CNCB (12 May 2021) to identify genomic regions, either conserved or with low levels of mutations, from which potential primer pairs are designed and provided to the user for filtering based on generalized and SARS-CoV-2 specific parameters. Read More

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Rethinking emotional eating: Retrospective and momentary indices of emotional eating represent distinct constructs.

Appetite 2021 Jul 19:105604. Epub 2021 Jul 19.

Center for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA. Electronic address:

Emotional eating (EE) has been proposed as a key weight loss barrier. However, most investigations of EE rely on retrospective self-reports, which may have poor construct validity. This study evaluated concordance between a common self-report EE measure and a novel method for assessing momentary EE using ecological momentary assessment (EMA). Read More

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The effect of esketamine in patients with treatment-resistant depression with and without comorbid anxiety symptoms or disorder.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Department of Neuroscience, Janssen Research & Development, LLC, San Diego, California, USA.

Background: Comorbid anxiety is generally associated with poorer response to antidepressant treatment. This post hoc analysis explored the efficacy of esketamine plus an antidepressant in patients with treatment-resistant depression (TRD) with or without comorbid anxiety.

Methods: TRANSFORM-2, a double-blind, flexible-dose, 4-week study (NCT02418585), randomized adults with TRD to placebo or esketamine nasal spray, each with a newly-initiated oral antidepressant. Read More

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Effect of silver diamine fluoride on hyperplastic gingivitis in an adult with intellectual disability-A case report.

Spec Care Dentist 2021 Jul 22. Epub 2021 Jul 22.

National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore.

Silver diamine fluoride 38% (SDF) may possess therapeutic effects beyond desensitization, caries prevention and arresting. We report the case of a 41-year-old male with intellectual disability. He had generalized gingivitis on a reduced periodontium and presented with enlarged gingiva with mobile teeth, particularly on the upper anterior and upper left. Read More

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PrEP monitoring and HIV incidence after PrEP initiation in France: 2016-18 nationwide cohort study.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

INSERM U1259, Université de Tours, France.

Background: Clinical trials have demonstrated that oral pre-exposure prophylaxis (PrEP) has high efficacy in preventing HIV transmission. In many countries, HIV testing is recommended prior to PrEP initiation, 1 month after and quarterly thereafter. We assessed the uptake of HIV testing and estimated the incidence of HIV infections after oral PrEP initiation, by using the French national health database (SNDS). Read More

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Experimental study protocol of the project "MOtor function and VItamin D: Toolkit for motor performance and risk Assessment (MOVIDA)".

PLoS One 2021 22;16(7):e0254878. Epub 2021 Jul 22.

Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, Rome, Italy.

Musculoskeletal injuries, a public health priority also in the military context, are ascribed to several risk factors, including: increased reaction forces; low/reduced muscle strength, endurance, body mass, Vitamin D level, and bone density; inadequate lifestyles and environment. The MOVIDA Project-funded by the Italian Ministry of Defence-aims at developing a transportable toolkit (assessment instrumentation, assessment protocols and reference/risk thresholds) which integrates motor function assessment with biological, environmental and behavioural factors to help characterizing the risk of stress fracture, stress injury or muscle fatigue due to mechanical overload. The MOVIDA study has been designed following the STROBE guidelines for observational cross-sectional studies addressing healthy adults, both militaries and civilians, with varying levels of physical fitness (sedentary people, recreational athletes, and competitive athletes). Read More

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Clinical and Histopathological Spectrum of Delayed Adverse Cutaneous Reactions Following COVID-19 Vaccination.

J Cutan Pathol 2021 Jul 22. Epub 2021 Jul 22.

The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York.

Background: As more people become vaccinated against the SARS-CoV-2 virus, reports of delayed cutaneous hypersensitivity reactions are beginning to emerge.

Methods: In this IRB-approved retrospective case series, biopsies of potential cutaneous adverse reactions from the Pfizer-BioNTech or Moderna mRNA vaccine were identified and reviewed. Clinical information was obtained through the requisition form, referring clinician, or medical chart review. Read More

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Can self-protective behaviors increase unrealistic optimism? Evidence from the COVID-19 pandemic.

J Exp Psychol Appl 2021 Jul 22. Epub 2021 Jul 22.

Brazilian School of Public and Business Administration (EBAPE).

People tend to believe they are more (less) likely to experience positive (negative) outcomes than similar others. While research has consistently shown that feeling unrealistically optimistic about future events influences the adoption of self-protective behaviors, much less is known about the opposite relationship. We address this gap by examining whether and how self-protective behaviors influence unrealistic optimism in the context of the COVID-19 pandemic. Read More

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A pilot randomized controlled trial of smartphone-assisted mindfulness-based intervention with contingency management for smokers with mood disorders.

Exp Clin Psychopharmacol 2021 Jul 22. Epub 2021 Jul 22.

School of Nursing.

Cigarette smoking disproportionately affects individuals with mood disorders, but smoking cessation interventions have modest effects in this population. Home mindfulness practice during abstinence incentivized via contingency management (CM) may help those in affective distress quit smoking.

Method: Adult smokers receiving outpatient psychiatric treatment for mood disorders were randomized to receive a smartphone-assisted mindfulness-based smoking cessation intervention with contingency management (SMI-CM, = 25) or enhanced standard treatment (EST, = 24) with noncontingent rewards. Read More

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Behavioral and Occupational Health in Military Firefighters: An Understudied Population.

Behav Modif 2021 Jul 22:1454455211033515. Epub 2021 Jul 22.

Wilford Hall Ambulatory Surgical Center, San Antonio, TX, USA.

To our knowledge, no studies on health conditions in U.S. military firefighters exist. Read More

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Clinical and etiological profile of epilepsy at the regional hospital center of Tahoua (Niger): A 4-year retrospective study.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Medicine and Medical Specialties, Regional Hospital Center of Tahoua, Tahoua, Niger.

Objective: We aimed to evaluate epilepsy management at the regional hospital center (RHC) of Tahoua (Niger) to determine the intrahospital deficiencies to optimize to improve the management of people with epilepsy.

Methods: A descriptive retrospective study was carried out at the Psychiatric Unit of the RHC of Tahoua between January 1, 2016 and December 31, 2019. We collected from the registers of consultation all patients followed by nurse technicians in mental health for epilepsy whose diagnosis was made by nonspecialist physicians or internists. Read More

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Racial Differences in Generalized Anxiety Disorder During the COVID-19 Pandemic among Brazilian University Students: a National Survey.

J Racial Ethn Health Disparities 2021 Jul 21. Epub 2021 Jul 21.

Programa de Pós-Graduação em Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

There is evidence that during the COVID-19 pandemic, there was an increase in anxiety and depression rates among college students. However, little is known about how generalized anxiety disorder (GAD) developed among individuals of different race/skin color. This study aimed to determine whether there are racial differences in GAD in Brazilian university students during the COVID-19 pandemic. Read More

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Short-term effects of ambient air pollution and meteorological factors on tuberculosis in semi-arid area, northwest China: a case study in Lanzhou.

Environ Sci Pollut Res Int 2021 Jul 21. Epub 2021 Jul 21.

Gansu Key Laboratory for Environmental Pollution Prediction and Control, College of Earth and Environmental Sciences, Lanzhou University, 222 South Tianshui Road, Chengguan District, Lanzhou, 730000, Gansu Province, People's Republic of China.

To investigate the short-term effects of ambient air pollution and meteorological factors on daily tuberculosis (TB), semi-parametric generalized additive model was used to assess the impacts of ambient air pollutants and meteorological factors on daily TB case from 2005 to 2010 in Chengguan District, Lanzhou, China. Then a non-stratification parametric model and a stratification parametric model were applied to study the interactive effect of air pollutants and meteorological factors on daily TB. The results show that sulfur dioxide (SO), nitrogen dioxide (NO), and particulate matter with aerodynamic diameter less than 10μm (PM) were positively correlated with daily TB case; the excess risk (ER) and 95% confidence interval (CI) were 1. Read More

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Role of Threat and Coping Appraisal in Protection Motivation for Adoption of Preventive Behavior During COVID-19 Pandemic.

Front Public Health 2021;9:678566. Epub 2021 Jul 5.

World Health Organization RNTCP Technical Support Network, Swasthya Bhawan, Kolkata, India.

With more than 100 million cases and over 2 million deaths globally, the COVID-19 pandemic continues to remain a major threat. Identifying the behavioral factors influencing preventive behaviors for COVID-19 are crucial in devising public health policies to promote essential strategies to combat the pandemic in an efficient manner. The current study was therefore conducted to estimate the prevalence of COVID-19 preventive behaviors and measure their association with behavioral constructs like threat perception, response efficacy, and self-efficacy, as per socio-demographic background. Read More

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Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a Hybrid and Dataset.

Front Physiol 2021 5;12:699291. Epub 2021 Jul 5.

Institute of Biomedical Engineering, Karlsruhe Institute for Technology, Karlsruhe, Germany.

In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to the isolation of the pulmonary veins, fibrotic sites are considered a suitable target for catheter ablation. However, it remains an open challenge to find fibrotic areas and to differentiate their density and transmurality. Read More

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Generalized Score Matching for Non-Negative Data.

J Mach Learn Res 2019 Apr;20

Department of Biostatistics, University of Washington, Seattle, WA, U.S.A.

A common challenge in estimating parameters of probability density functions is the intractability of the normalizing constant. While in such cases maximum likelihood estimation may be implemented using numerical integration, the approach becomes computationally intensive. The score matching method of Hyvärinen (2005) avoids direct calculation of the normalizing constant and yields closed-form estimates for exponential families of continuous distributions over . Read More

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Knowledge-Guided Biclustering via Sparse Variational EM Algorithm.

10th IEEE Int Conf Big Knowl (2019) 2019 Nov 30;2019:25-32. Epub 2019 Dec 30.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, USA.

A biclustering in the analysis of a gene expression data matrix, for example, is defined as a set of biclusters where each bicluster is a group of genes and a group of samples for which the genes are differentially expressed. Although many data mining approaches for biclustering exist in the literature, only few are able to incorporate prior knowledge to the analysis, which can lead to great improvements in terms of accuracy and interpretability, and all are limited in handling discrete data types. We propose a generalized biclustering approach that can be used for integrative analysis of multi-omics data with different data types. Read More

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November 2019

[Which quality of life for the sarcopenic patient?]

Geriatr Psychol Neuropsychiatr Vieil 2021 Jul 20. Epub 2021 Jul 20.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgique, Membres du Groupe Expert Nutrition en Gériatrie (GEGN) sous l'égide de la SFGG.

Sarcopenia is defined as a progressive and generalized loss of muscle strength, muscle mass and physical performance with advancing age. Among the multiple consequences of sarcopenia, the reduction in the quality of life associated with it can undeniably be considered as a major consequence. Quality of life is measured via generic or specific questionnaires. Read More

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Ileoileal knotting: a rare cause of intestinal obstruction: a case report.

J Med Case Rep 2021 Jul 22;15(1):397. Epub 2021 Jul 22.

Department of Surgery, Ethio-Tebib General Hospital, Addis Ababa, Ethiopia.

Background: Ileoileal knotting is one of the rarest causes of intestinal obstruction. The pathology involves knotting of the ileum around itself, leading to mechanical intestinal obstruction that can rapidly evolve to gangrene.

Case Presentation: Here we will discuss the case of an 18-year-old Oromo girl who presented with sudden onset of severe abdominal pain and signs of generalized peritonitis. Read More

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Delaying sexual onset: outcome of a comprehensive sexuality education initiative for adolescents in public schools.

BMC Public Health 2021 Jul 21;21(1):1439. Epub 2021 Jul 21.

Center for Health Systems Research, National Institute of Public Health, Avenida Universidad 655, Colonia Santa María de Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico.

Background: A common risk behavior in adolescence is the early initiation of unprotected sex that exposes adolescents to an unplanned pregnancy or sexually transmitted infections. Schools are an ideal place to strengthen adolescents' sexual knowledge and modify their behavior, guiding them to exercise responsible sexuality. The purpose of this article was to evaluate the knowledge of public secondary school teachers who received training in comprehensive education in sexuality (CES) and estimate the counseling's effect on students' sexual behavior. Read More

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Characteristics of Hospitalizations and Emergency Department Visits due to Generalized Pustular Psoriasis in the United States.

Curr Med Res Opin 2021 Jul 22. Epub 2021 Jul 22.

Dermatology Research and Education Foundation, Irvine, CA, USA.

Objectives: Generalized pustular psoriasis (GPP) is a rare and severe, inflammatory skin disease. GPP is characterized by recurrent flares that consist of disseminated erythematous skin rash with sterile neutrophil-filled pustules that can result in an emergency department (ED) visit or hospital stay due to systemic complications. This study characterizes hospitalizations, ED visits, and inpatient treatment due to GPP in the United States (US). Read More

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Therapeutic approach to difficult-to-treat typical absences and related epilepsy syndromes.

Expert Rev Clin Pharmacol 2021 Jul 21. Epub 2021 Jul 21.

Regional Epilepsy Centre, Great Metropolitan "BMM" Hospital, Reggio Calabria, Italy.

Introduction: typical absences (TAs), are brief, generalized epileptic seizures of abrupt onset and termination clinically manifesting with impairment of awareness and associated with 3 Hz spike-wave discharges on EEG. TAs may occur in different idiopathic generalized epilepsies (IGE). Despite treatment with adequate anti-seizure medications (ASMs), TAs may persist in ~25% of subjects. Read More

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Association between the use of social networking sites and mental health of young generation in Bangladesh: A cross-sectional study.

J Community Psychol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.

The social networking sites (SNS) are popular among people of all levels. Here we aimed to evaluate the relationship between the use of SNS and the mental health of the young generation in Bangladesh. We conducted this cross-sectional study among 791 subjects aged between 15 and 40 years. Read More

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Generalizable cursor click decoding using grasp-related neural transients.

J Neural Eng 2021 Jul 21. Epub 2021 Jul 21.

University of Pittsburgh, 3520 Fifth Avenue, Suite 300, Pittsburgh, Pennsylvania, 15213, UNITED STATES.

Intracortical brain-computer interfaces (iBCI) have the potential to restore independence for individuals with significant motor or communication impairments. One of the most realistic avenues for clinical translation of iBCI technology is to enable control of a computer cursor-i.e. Read More

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Using Marginal Structural Models to analyze Randomized Clinical Trials with non-adherence and lost to follow up.

Ann Epidemiol 2021 Jul 18. Epub 2021 Jul 18.

Barry Commoner Center for Health and the Environment, Queens College, CUNY, Flushing, New York.

Background: In the presence of non-adherence and lost to follow up, results of an Intention to Treat (ITT) analysis may be biased as it is measuring the effect of assignment rather than the effect of treatment. Given that Marginal Structural Models (MSMs) adjust for such issues, this study examines the use of MSMs to assess the validity of ITT analyses in the presence of non-adherence and lost to follow up in an existing randomized clinical trial on asthma treatment.

Methods: Inverse probability weights were obtained from a pooled logistic regression assessing the probability of staying on assigned treatment (adherence) and of remaining uncensored (censored) for subjects at each visit by treatment arm. Read More

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A comparison of two teaching procedures to establish generalized intraverbal-tacting in children with autism.

J Appl Behav Anal 2021 Jul 21. Epub 2021 Jul 21.

Queen's University, United Kingdom.

Previous research has investigated generalized intraverbal-tacting by teaching children with autism to respond using autoclitic frames. The present study compared the effectiveness and efficiency of a Frame and a No Frame procedure across counterbalanced stimulus sets with 4 children with autism. In the Frame condition, children were taught to respond using autoclitic frames (e. Read More

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Factors affecting breastfeeding in women with epilepsy.

Epilepsia 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Objective: This study aimed to compare rates of breastfeeding initiation and maintenance in women with epilepsy (WWE) with those of the general population and to identify factors affecting breastfeeding patterns in WWE.

Methods: We retrospectively reviewed data for the following variables in pregnant WWE (n = 102) and healthy women without epilepsy (n = 112): demographic characteristics (age, race, ethnicity), epilepsy type (focal or generalized onset), antiseizure medication(s), psychiatric comorbidities, postpartum seizure control, breastfeeding counseling, and lactation consultation. Fisher exact test and logistic regression analyses were performed to compare the rates of breastfeeding initiation and continuation in pregnant WWE with those of healthy pregnant women and to determine factors associated with rates of breastfeeding initiation and maintenance. Read More

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Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States.

Cancer 2021 Jul 21. Epub 2021 Jul 21.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: US population-based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV-associated cancers. Using this framework, HPV prevalence among high-grade cervical precancers and invasive cervical cancers were compared before and after HPV vaccine availability.

Methods: Archived tissue from 2 studies of cervical precancers and invasive cervical cancers diagnosed from 1993-2005 (prevaccine) were identified from 7 central cancer registries in Florida; Hawaii; Iowa; Kentucky; Louisiana; Los Angeles County, California; and Michigan; from 2014 through 2015 (postvaccine) cases were identified from 3 registries in Iowa, Kentucky, and Louisiana. Read More

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Temporal and regional variation in catch across an extensive coastal recreational fishery: Exploring the utility of survey methods to guide and assess spatio-temporal management initiatives.

PLoS One 2021 21;16(7):e0254388. Epub 2021 Jul 21.

Kewagama Research, Doonan, Queensland, Australia.

As global research into recreational fishing gains momentum due to the pursuit's biological, social and economic impacts, information on regional and temporal patterns of recreational exploitation will continue to enable objective assessment and development of management initiatives for exploited species. This paper demonstrates the utility of offsite survey methods in assessing spatial and temporal differences in recorded catches from a large, diffuse and heterogenous coastal recreational fishery. Using the estuarine recreational fishery that operates along the coast of New South Wales, Australia as a case study, survey data was employed to quantify annual (June 2013-May 2014) state-wide estuarine catch. Read More

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