169,912 results match your criteria general level


Effects of lycopene in intestinal ischemia reperfusion injury via intestinal immunoglobulin A.

J Surg Res 2021 Jun 12;267:63-70. Epub 2021 Jun 12.

Abant İzzet Baysal University Faculty of Medicine, Department of Histology and Embryology, Bolu, Turkey.

Background: Intestinal ischemia causes an inflammatory response that may become intense by reperfusion and result in bacterial translocation. Intestinal immunoglobulin A is known to be a barrier against bacterial translocation. Lycopene is a compound with antioxidant and anti-inflammatory properties. Read More

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An investigation into time-variant subsidence potentials using inclusive multiple modelling strategies.

J Environ Manage 2021 Jun 12;294:112949. Epub 2021 Jun 12.

Department of Civil Engineering, University of Maragheh, Maragheh, East Azerbaijan, Iran. Electronic address:

Groundwater over-abstraction due to the absence of an effective management plan is often one of the main reasons for land subsidence in aquifer areas. This paper investigates this environmental problem at Salmas plain, Iran, by using the ALPRIFT framework, an acronym of a set of seven general-purpose data layers, introduced recently by the authors. It is capable of mapping Subsidence Vulnerability Indices (SVI) and the paper investigates an innovation to transform it into Time-variant SVI (TSVI) mapping capabilities through a three module strategy: Module 1: maps SVI; Module 2: develops a predictive model for Groundwater Levels (GWL); Module 3: combines both modules to produces TSVI maps. Read More

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Relationship between mindfulness and general health among couples in Mainland China: A crossover perspective.

Soc Sci Med 2021 Jun 2;281:114095. Epub 2021 Jun 2.

School of Business, Central South University, Changsha, 410083, China. Electronic address:

Rationale: Previous research has indicated that mindfulness can be beneficial both intrapersonally and interpersonally. Although mindfulness has been shown to improve an individual's health, much less is known about whether these health benefits extend to the individual's spouse.

Objective: The present study aims to establish a crossover model to expound ''how'' and ''why'' mindfulness might be associated with both the individual's and the spouse's general health. Read More

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Low dietary quercetin intake by food frequency questionnaire analysis is not associated with hypertension occurrence.

Clin Nutr 2021 May 12;40(6):3748-3753. Epub 2021 May 12.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address:

Background & Aims: Quercetin is one of the most abundant flavonoids in plant kingdom. Because of its strong anti-inflammatory and antioxidant effect, it is of potential in anti-hypertension. The objective of the present study was to explore the relationship between dietary quercetin and hypertension incidence in a Chinese population. Read More

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Effect of osteoporosis on adjacent segmental degeneration following posterior lumbar interbody fusion under whole body vibration.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

School of Chinese medicine, Jinan university, Guangzhou, China. Electronic address:

Background: Adjacent segmental degeneration (ASD) is one of the common complications following posterior lumbar interbody fusion (PLIF). Both whole body vibration (WBV) and osteoporosis are important factors associated with the biomechanics of the lumbar spine. However, up to now, no literature has been published to investigate the effect of osteoporosis on ASD following PLIF under WBV. Read More

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Going Beyond the State Law: Investigating High School Sport-Related Concussion Protocols.

J Athl Train 2020 Jun 18. Epub 2020 Jun 18.

A.T. Still University, Athletic Training Programs, School of Osteopathic Medicine in Arizona, 5850 E Still Circle, Mesa, Arizona 85206, United States,

Context: State laws provide general guidelines for sport-related concussion (SRC) management, but do not comprehensively address the multiple layers of management for this complex injury. While high schools are encouraged to develop a SRC protocol that includes both state law tenets and additional management practices, the execution of this warrants examination.

Objective: To investigate state law compliance and practice components included in high school SRC protocols, and determine whether the degree of sports medicine coverage influenced protocol quality. Read More

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Segmentation and recognition of breast ultrasound images based on an expanded U-Net.

PLoS One 2021 15;16(6):e0253202. Epub 2021 Jun 15.

UItrasonic Diagnosis Department, Chengcheng County Hospital, Weinan, Shanxi province, China.

This paper establishes a fully automatic real-time image segmentation and recognition system for breast ultrasound intervention robots. It adopts the basic architecture of a U-shaped convolutional network (U-Net), analyses the actual application scenarios of semantic segmentation of breast ultrasound images, and adds dropout layers to the U-Net architecture to reduce the redundancy in texture details and prevent overfitting. The main innovation of this paper is proposing an expanded training approach to obtain an expanded of U-Net. Read More

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Do working conditions contribute differently to gender gaps in self-rated health within different occupational classes? Evidence from the Swedish Level of Living Survey.

Authors:
Sara Kjellsson

PLoS One 2021 15;16(6):e0253119. Epub 2021 Jun 15.

Swedish Institute for Social Research, Stockholm University, Stockholm, Sweden.

Socioeconomic inequality in health among women is often referred to as smaller than health inequality among men. However, we know less about differences in health between men and women within the same socioeconomic groups. In this article the lack of attention to potential socioeconomic variation in gender health inequality is argued as unfortunate, as it can obscure how mechanisms, such as e. Read More

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Use of a Tourniquet and Spinal Anesthesia Increases Satisfactory Outcomes After Total Knee Arthroplasty: A Randomized Study.

J Bone Joint Surg Am 2021 Jun 15. Epub 2021 Jun 15.

Department of Anesthesiology, Intensive Care, and Pain Medicine, Peijas Hospital, HUS Helsinki University Hospital, Helsinki, Finland.

Background: Total knee arthroplasty (TKA) is usually performed successfully with or without a tourniquet and under spinal anesthesia (SA) or general anesthesia (GA). However, 10% to 34% of patients experience dissatisfaction and pain after TKA. We aimed to compare the effects of tourniquet use and SA or GA on TKA outcomes. Read More

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Morbidity and Mortality Trends of Pancreatitis: An Observational Study.

Surg Infect (Larchmt) 2021 Jun 15. Epub 2021 Jun 15.

Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Pancreatitis accounts for more than $2.5 billion of healthcare costs and remains the most common gastrointestinal (GI) admission. Few contemporary studies have assessed temporal trends of incidence, complications, management, and outcomes for acute pancreatitis in hospitalized patients at the national level. Read More

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Mangiferin Promotes Bregs Level, Activates Nrf2 Antioxidant Signaling, and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro.

Curr Med Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiovascular Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.

Recent studies indicated that regulatory B cells (Bregs) and nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signaling pathway play important roles in the pathogenesis of chronic graft-versus-host disease (cGVHD). Mangiferin (MA), a polyphenol compound, has been reported to activate Nrf2/antioxidant-responsive element (ARE) signaling pathway. This study was aimed to investigate the effects of MA on Bregs and Nrf2 antioxidant signaling in murine splenic mononuclear cells (MNCs) in vitro. Read More

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Between-group minimally important change versus individual treatment responders.

Qual Life Res 2021 Jun 15. Epub 2021 Jun 15.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Purpose: Estimates of the minimally important change (MIC) can be used to evaluate whether group-level differences are large enough to be important. But responders to treatment have been based upon group-level MIC thresholds, resulting in inaccurate classification of change over time. This article reviews options and provides suggestions about individual-level statistics to assess whether individuals have improved, stayed the same, or declined. Read More

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The AGE Presents Introduction to Geroscience video lecture series.

Geroscience 2021 Jun 15. Epub 2021 Jun 15.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA.

The AGE Presents Introduction to Geroscience video lecture series is a collection of high-quality didactic video lectures and associated teaching materials focused on foundational topics in aging biology. The videos are made freely available on YouTube and are targeted toward an audience familiar with concepts learned in the first year of a college undergraduate biology/biomedical major. Members of the American Aging Association also receive the original lecture slides and lecture notes, with additional course materials to be developed in the future. Read More

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Adolescents' Experiences, Emotions, and Coping Strategies Associated With Exposure to Media-Based Vicarious Racism.

JAMA Netw Open 2021 Jun 1;4(6):e2113522. Epub 2021 Jun 1.

Division of Advanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Importance: Adolescents frequently encounter racism vicariously through online news and social media and may experience negative emotional responses due to these exposures. To mitigate potential adverse health impacts, including negative emotional health, it is important to understand how adolescents cope with these exposures.

Objectives: To examine adolescents' responses to online and media-based vicarious racism exposure and to explore coping strategies, particularly positive coping strategies, that may be used to combat negative emotions. Read More

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What Is the Risk of Intraoperative Cerebral Oxygen Desaturation in Patients Undergoing Shoulder Surgery in the Beach Chair Position?

Clin Orthop Relat Res 2021 06 15. Epub 2021 Jun 15.

Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Previous studies have shown that intraoperative cerebral desaturation in patients undergoing shoulder surgery in the beach chair position varies widely, from 0% to 80%. To our knowledge, the risk of intraoperative cerebral desaturation is not known after all identified intraoperative modifiable physiologic parameters that influence cerebral blood flow have been controlled for.

Questions/purposes: (1) What is the risk of intraoperative cerebral desaturation during shoulder surgery with the patient in the beach chair position when patients received combined general anesthesia and an interscalene block, and what other factors associated with intraoperative cerebral desaturation can be identified? (2) Is intraoperative cerebral desaturation associated with 24-hour cognitive decline? (3) What factors are associated with intraoperative hypotension?

Methods: Between April and December 2020, 51 patients underwent elective shoulder surgery in the beach chair position at one center. Read More

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Interobserver agreement and clinical disparity between the Graf method and femoral head coverage measurement in developmental dysplasia of the hip screening: A prospective observational study of 198 newborns.

Medicine (Baltimore) 2021 Jun;100(24):e26291

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital.

Abstract: Ultrasonography is the ideal tool for assessing hip morphology in infants younger than 6-month-old. This study assessed the interobserver agreement and clinical disparities of the 2 most widely used ultrasound (US) methods, the Graf method, and femoral head coverage (FHC) measurement.A prospective observational study (STROBE compliant) of 2024 newborns was conducted between January 2017 and December 2018. Read More

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Clinicopathological analysis and genomic profiling of a rare histiocyte-rich rhabdomyoblastic tumor: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26105

Department of General Surgery, Shenzhen University General Hospital & Carson International Cancer Research Centre, Shenzhen, P.R. China.

Rationale: Skeletal muscle tumors are traditionally classified as rhabdomyomas or rhabdomyosarcomas. However, some soft tissue tumors cannot easily be identified as benign or malignant. We report a case of a histiocyte-rich rhabdomyoblastic tumor, with pathologic characteristics distinct from either rhabdomyoma or rhabdomyosarcoma. Read More

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Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials.

Pathog Glob Health 2021 Jun 15:1-11. Epub 2021 Jun 15.

Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS), Italy.

 Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19, but its association with mortality is unclear. We reviewed published literature for evidence of an association between HCQ (with or without azithromycin (AZM)) and total mortality in COVID-19 patients. Articles were retrieved until April 29, 2021 by searching in seven databases. Read More

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Clinical Characteristics of Patients with Adrenal Insufficiency and Fever.

J Korean Med Sci 2021 Jun 14;36(23):e152. Epub 2021 Jun 14.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: Because persistent fever often occurs in adrenal insufficiency, it might be confused with infectious diseases. This study aimed to identify clinical characteristics and risk factors of patients with adrenal insufficiency and fever.

Methods: All adult patients (n = 150) admitted to a tertiary care hospital in South Korea and diagnosed with adrenal insufficiency between 1 March 2018, and 30 June 2019, were recruited. Read More

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Studying human nociceptors: from fundamentals to clinic.

Brain 2021 Jun 15. Epub 2021 Jun 15.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Chronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due to poor efficacy and tolerability. There has been a failure in translating promising preclinical drug targets into clinic use. Read More

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EMS Program Graduates Who Did Not Retest After Initial Attempt on The National Certification Exam.

Prehosp Emerg Care 2021 Jun 15:1-12. Epub 2021 Jun 15.

National Registry of Emergency Medical Technicians, Columbus, Ohio.

Becoming an EMS professional in most of the United States requires successful completion of the National Certification process. While multiple attempts are allowed, some candidates who are unsuccessful on their first cognitive examination attempt do not return despite personal investment. We describe the demographic and testing characteristics of EMT and paramedic candidates that do not return for a second examination attempt after an initial unsuccessful attempt on the National EMS Certification Cognitive Examination. Read More

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Impact of the model of long-term follow-up care on adherence to guideline-recommended surveillance among survivors of adolescent and young adult cancers.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

University of Toronto, Institute of Medical Science, Toronto, Canada.

Purpose: Adolescent and young adult cancer survivors require lifelong healthcare to address the late effects of therapy. We examined the impact of different provider models of long-term follow-up (LTFU) care on adherence to recommended surveillance.

Methods: We conducted a retrospective cohort study using administrative health databases in Ontario, Canada. Read More

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Daratumumab provides a survival benefit in relapsed and refractory Multiple Myeloma, independent of baseline clinical characteristics: A meta-analysis.

Pharmacol Res Perspect 2021 Aug;9(4):e00797

Radiology Department, The People's Hospital of Pingyi County, Linyi, China.

Daratumumab was approved in patients with relapsed or refractory multiple myeloma (MM) who previously received proteasome inhibitors or immunomodulatory drugs. However, the efficacy and safety of the addition of daratumumab in subpopulations of patients with relapsed or refractory MM is still unknown. We systematically searched MEDLINE, EMBASE, and Cochrane for randomized controlled trials (inception to September 2020). Read More

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Polycyclic aromatic hydrocarbons (PAHs), arsenic, chromium and lead in warty crab (Eriphia verrucosa): occurrence and risk assessment.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

Department of Veterinary Medicine and Animal Production, Division of Toxicology, University of Naples Federico II, 80137, Naples, Italy.

This study assesses the PAH and heavy metal levels in muscle of warty crabs (Eriphia verrucosa), from the northern coast of the Campania region improving the data on toxic contaminants in this crustacean. The results showed a minimal PAH contamination; the mean concentrations were as follows: 0.2, 1. Read More

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Do standards of care and early outcomes of periprosthetic fractures change during the COVID-19 pandemic? A multicentre study.

J Orthop Traumatol 2021 Jun 14;22(1):22. Epub 2021 Jun 14.

Department of Orthopaedic Surgery, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127, Bergamo, Italy.

Background: Periprosthetic fractures (PPFs) are a growing matter for orthopaedic surgeons, and patients with PPFs may represent a frail target in the case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of this study is to investigate whether hospital reorganisations during the most severe phase of the SARS-CoV-2 pandemic affected standards of care and early outcomes of patients treated for PPFs in Northern Italy.

Materials And Methods: Data were retrieved from a multicentre retrospective orthopaedics and traumatology database, including 14 hospitals. Read More

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The Influence of Low- and High-Negative-Pressure Liposuction and Different Harvesting Sites on the Viability and Yield of Adipocytes and Other Nucleated Cells.

Aesthetic Plast Surg 2021 Jun 14. Epub 2021 Jun 14.

General Surgery Department, Hand Unit, Locarno's Regional Hospital, Via Ospedale 1, 6600, Locarno, Switzerland.

Background: The volume effect of fat grafting is highly dependent on the presence of viable adipocytes and other nucleated cells within the lipoaspirate. We suspected that one of the crucial factors influencing cell viability is the negative pressure applied during the fat graft harvesting and the suitability of various harvest sites when compared to others. Despite much discussion, there is no consensus on the optimal negative pressure or the best site for harvesting so we designed an experiment to test this. Read More

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Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.

Nat Commun 2021 06 14;12(1):3601. Epub 2021 Jun 14.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. Read More

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Patient characteristics associated with the use of pharmacist-administered vaccination services and predictors of service utilization.

J Am Pharm Assoc (2003) 2021 May 29. Epub 2021 May 29.

Background: Data on the impact of pharmacists as vaccinators are available; however, research on understanding the characteristics of users of pharmacist-administered vaccinations is scarce.

Objectives: This study aimed to identify the characteristics of the users of pharmacist-administered vaccinations and recognize predictors of utilizing these services.

Methods: Data were obtained from a cross-sectional online survey, and the sample size was 26,173 respondents from all over the United States. Read More

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Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing.

Carbohydr Polym 2021 Sep 21;268:118239. Epub 2021 May 21.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address:

Composite dressing composed of Rhizochitosan and Regenplex™ to promote wound healing were assessed. Rhizochitosan was fabricated by deacetylation of Rhizochitin, which obtained by simply depigmenting sporangium-free mycelial mattress produced from Rhizopus stolonifer F6. Physicochemical characterizations of Rhizochitosan demonstrated that it contained 13. Read More

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September 2021

Evidence Based Approach to Capacity Assessment for Hospitalized Patients.

CNS Spectr 2021 Apr;26(2):150

Creighton University, Omaha, NE, USA.

Medical decision-making capacity (MDMC) is inherent to the legal and ethical principles of respect for autonomy and is an essential element of informed consent. Qualitative and quantitative evidence to support a final decision of capacity should be the gold standard. General hospital policies and state laws mandate that a licensed provider make the final determination of capacity, but they do not specifically mandate who is responsible for those assessments. Read More

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