2,497 results match your criteria general disposition

Health-seeking behaviour of foreign workers in Singapore: Insights from emergency department visits.

Ann Acad Med Singap 2021 Apr;50(4):315-324

Department of Emergency Medicine, Singapore General Hospital, Singapore.

Introduction: Foreign workers (FWs) on work permit face unique health challenges and potential barriers to healthcare. We aimed to examine the epidemiology, attendance patterns, disposition, and adherence to follow-up, by FWs on work permit to two emergency departments (EDs) in Singapore.

Methods: In this retrospective observational study, we included consecutive FWs on work permit who registered at the EDs of two public restructured hospitals from 1 May 2016 to 31 October 2016. Read More

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A Case-Control Study of Major genetic pre-disposition risk alleles in developing DDD in the Northeast US population: Effects of Gene-Gene Interactions.

Spine (Phila Pa 1976) 2021 May 10. Epub 2021 May 10.

Center for Evidence-Based Imaging (CEBI) Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Study Design: A case-control study of risk alleles for Degenerative Disc Disease (DDD) using magnetic resonance (MR) imaging for phenotyping.

Objective: We aim to provide the first statistically adequately powered study of the relationship between the presence of common risk alleles and occurrence of DDD in Eastern US population.

Summary Of Background Data: Many genetic pre-disposing factors have been identified in elevating the risk of DDD, including common variants in VDR, COL1A1, AGC1, COL9A2/3 genes. Read More

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The thiol-based reduction of Bi(V) and Sb(V) anti-leishmanial complexes.

J Inorg Biochem 2021 Apr 29;221:111470. Epub 2021 Apr 29.

School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. Electronic address:

Low molecular weight thiols including trypanothione and glutathione play an important function in the cellular growth, maintenance and reduction of oxidative stress in Leishmania species. In particular, parasite specific trypanothione has been established as a prime target for new anti-leishmania drugs. Previous studies into the interaction of the front-line Sb(V) based anti-leishmanial drug meglumine antimoniate with glutathione, have demonstrated that a reduction pathway may be responsible for its effective and selective nature. Read More

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Incidence and characteristics of medical emergencies related to dental treatment: a retrospective single-center study.

Acute Med Surg 2021 Jan-Dec;8(1):e651. Epub 2021 May 1.

Department of Emergency, Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: Although uncommon, medical emergencies arise in general dental practice. Inadequate data on their severity and frequency makes targeting medical education for general dental practitioners difficult. This also makes planning for unexpected events challenging for practitioners and makes collaborating with emergency physicians burdensome. Read More

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Shedding a light on the physical stability of suspensions micronised with intensified vibratory milling; A trend observed with decreasing particle size as a function of time.

Int J Pharm 2021 May 6:120687. Epub 2021 May 6.

Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven (KU Leuven), O&N II Herestraat 49 - box 921, 3000 Leuven, Belgium. Electronic address:

Intensified vibratory milling is a nanonisation and micronisation technology which can be used to enable the oral bioavailability of poorly soluble compounds. The generated nano- and microsuspensions entail a large surface area which enhances the compounds dissolution rate, yet this large surface area is thermodynamically unfavourable and hence spontaneous destabilisation may occur, i.e. Read More

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A descriptive study on reasons for prolonged hospital stay in a tertiary hospital in Singapore.

J Nurs Manag 2021 May 9. Epub 2021 May 9.

Nursing Division, Singapore General Hospital, 31 Third Hospital Avenue, Bowyer Block B, Level 2, 168753, Singapore.

Background: Our healthcare is facing with the challenges of bed crunch and increasing number of patients with prolonged hospital stay.

Aims: This study aimed to determine factors contributing to the prolonged hospital stay in a tertiary hospital in Singapore.

Methods: A random sample of 600 medical records of patients' staying in hospital for more than 21 days were retrieved. Read More

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Challenges in Predicting Discharge Disposition for Trauma and Emergency General Surgery Patients.

J Surg Res 2021 May 5;265:278-288. Epub 2021 May 5.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Background: Changes in discharge disposition and delays in discharge negatively impact the patient and hospital system. Our objectives were to determine the accuracy with which trauma and emergency general surgery (TEGS) providers could predict the discharge disposition for patients and determine the factors associated with incorrect predictions.

Methods: Discharge dispositions and barriers to discharge for 200 TEGS patients were predicted individually by members of the multidisciplinary TEGS team within 24 h of patient admission. Read More

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Outcomes for in-hospital cardiac arrest for COVID-19 patients at a rural hospital in Southern California.

Am J Emerg Med 2021 Apr 27;47:244-247. Epub 2021 Apr 27.

Department of Emergency Medicine, University of California, San Diego, CA, United States of America; Department of Emergency Medicine, El Centro Regional Medical Center, El Centro, CA, United States of America.

Background: In-hospital cardiac arrest (IHCA) carries a high mortality and providing resuscitation to COVID-19 patients presents additional challenges for emergency physicians. Our objective was to describe outcomes of COVID-19 patients suffering IHCA at a rural hospital in Southern California.

Methods: Single-center retrospective observational study. Read More

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Trauma Response for Elderly Anticoagulated Patients: An Initiative to Reduce Trauma Resource Utilization in the Emergency Department.

J Trauma Nurs 2021 May-Jun 01;28(3):159-165

The Iowa Clinic, Des Moines (Drs Pelaez and Sidwell); Trauma Services, UnityPoint Health, Des Moines, Iowa (Mss Spilman and Fuchsen); and General Surgery Residency Program, Iowa Methodist Medical Center, Des Moines, Iowa (Dr Semmens).

Background: Trauma centers are challenged to have appropriate criteria to identify injured patients needing a trauma activation; one population that is difficult to triage is injured elderly patients taking anticoagulation or antiplatelet (ACAP) medications with suspected head injury.

Objective: The study purpose was to evaluate a hospital initiative to improve the trauma triage response for this population.

Methods: A retrospective study at a Level I trauma center evaluated revised trauma response criteria. Read More

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Association of Omental Adipocyte Hypertrophy and Fibrosis With Human Obesity and Type 2 Diabetes.

Obesity (Silver Spring) 2021 May 4. Epub 2021 May 4.

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, China.

Objective: Morphological alterations including adipocyte hypertrophy and fibrosis deposition are important surrogate markers of visceral adipose tissue function, but the relationships between these morphological changes and type 2 diabetes mellitus (T2DM) and impaired insulin sensitivity are poorly defined.

Methods: Omental adipose tissue was obtained from 66 individuals with obesity but without T2DM (OB group), 93 individuals with both obesity and T2DM (T2DM group), and 15 individuals with normal BMI and normal glucose tolerance (NGT group). Adipocyte diameter and volume were measured through pathological section analysis. Read More

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Race is an Independent Predictor for Non-Routine Discharges after Spine Surgery for Spinal Intradural/Cord Tumors.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurosurgery, John Hopkins School of Medicine, Baltimore, MD.

Objective: The aim of this study was to determine if race was an independent predictor of extended length of stay (LOS), non-routine discharge, and increased healthcare costs following surgery for spinal intradural/cord tumors.

Methods: A retrospective cohort study was performed using National Inpatient Sample (NIS) database from 2016 through 2017. All adult (>18 years-old) inpatients who underwent surgical intervention for a benign or malignant spinal intradural/cord tumor were identified using ICD-10-CM diagnosis and procedural coding systems. Read More

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Clinical Outcomes of COVID-19 Patients Treated with Convalescent Plasma or Remdesivir Alone and in Combination at a Community Hospital in California's Central Valley.

J Pharm Pharm Sci 2021 ;24:210-219

University of the Pacific, Thomas J. Long School of Pharmacy, Stockton CA, USA.

Purpose: The purpose of this study was to compare how treatment with convalescent plasma (CP) monotherapy, remdesivir (RDV) monotherapy, and combination therapy (CP + RDV) in patients with COVID-19 affected clinical outcomes.

Methods: Patients with COVID-19 infection who were admitted to the hospital received CP, RDV, or combination of both. Mortality, discharge disposition, hospital length of stay (LOS), intensive care unit (ICU) LOS, and total ventilation days were compared between each treatment group and stratified by ABO blood group. Read More

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Hospital Variation in 30-Day Readmissions Following Transcatheter Aortic Valve Replacement.

J Am Heart Assoc 2021 May 3:e021350. Epub 2021 May 3.

Cardiology Division Department of Medicine Massachusetts General HospitalHarvard Medical School Boston MA.

Background Data on hospital variation in 30-day readmission rates after transcatheter aortic valve replacement (TAVR) are limited. Further, whether such variation is explained by differences in hospital characteristics and hospital practice patterns remains unknown. Methods and Results We used the 2017 Nationwide Readmissions Database to identify hospitals that performed at least 5 TAVRs. Read More

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Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications.

Front Neurosci 2021 14;15:604197. Epub 2021 Apr 14.

Massachusetts General Hospital, Boston, MA, United States.

The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administered solute within the cerebrospinal fluid (CSF). This disposition is one of key factors in defining the subsequent transport of the solute to its intended target. Read More

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Interhospital transfer status for spinal metastasis patients in the United States is associated with more severe clinical presentations and higher rates of inpatient complications.

Neurosurg Focus 2021 May;50(5):E4

Departments of1Neurosurgery and.

Objective: In patients with metastatic spinal disease (MSD), interhospital transfer can potentially impact clinical outcomes as the possible benefits of transferring a patient to a higher level of care must be weighed against the negative effects associated with potential delays in treatment. While the association of clinical outcomes and transfer status has been examined in other specialties, the relationship between transfer status, complications, and risk of mortality in patients with MSD has yet to be explored. The purpose of this study was to examine the impact of transfer status on in-hospital mortality and clinical outcomes in patients diagnosed with MSD. Read More

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Development of a Population Pharmacokinetic Model for Cyclosporine from Therapeutic Drug Monitoring Data.

Biomed Res Int 2021 8;2021:3108749. Epub 2021 Apr 8.

Pharmaceutical Sciences Department, Faculty of Chemistry, Universidad de la República, Uruguay, General Flores, 2124 Montevideo, Uruguay.

Aim: To develop a population pharmacokinetic model for Uruguayan patients under treatment with cyclosporine (CsA) that can be applied to TDM. . A total of 53 patients under treatment with CsA were included. Read More

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Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells.

Int J Mol Sci 2021 Apr 7;22(8). Epub 2021 Apr 7.

Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.

1,2-unsaturated pyrrolizidine alkaloids (PAs) are secondary plant metabolites occurring as food contaminants that can cause severe liver damage upon metabolic activation in hepatocytes. However, it is yet unknown how these contaminants enter the cells. The role of hepatic transporters is only at the beginning of being recognized as a key determinant of PA toxicity. Read More

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Errors in adult trauma resuscitation: a systematic review.

CJEM 2021 Apr 29. Epub 2021 Apr 29.

Division of Emergency Medicine, Department of Medicine, University of Toronto, C. David Naylor Building, 6 Queen's Park Crescent West, Third Floor, Room 304, Toronto, ON, M5S 3H2, Canada.

Introduction: Trauma resuscitation at dedicated trauma centers typically consist of ad-hoc teams performing critical tasks in a time-limited manner. This creates a high stakes environment apt or avoidable errors. Reporting of errors in trauma resuscitation is generally center-dependent and lacks common terminology. Read More

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Predictive Value of the Risk Assessment and Prediction Tool (RAPT) Score for Primary Hip and Knee Arthroplasty Patients: A Single-Center Study.

Cureus 2021 Mar 25;13(3):e14112. Epub 2021 Mar 25.

Trauma and Orthopaedics, Kettering General Hospital, Kettering, GBR.

The Risk Assessment and Prediction Tool (RAPT) was developed to predict patient discharge destination for arthroplasty operations. However, since Enhanced Recovery After Surgery (ERAS) programs have been utilized in the UK, the RAPT score has not been validated for use. The aim of the current study was to evaluate the predictive validity of the RAPT score in an ERAS environment with short length of stay. Read More

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Practical alternative to hospitalization for emergency department patients (PATH): A feasibility study.

Healthc (Amst) 2021 Apr 23;9(3):100545. Epub 2021 Apr 23.

Penn Medicine Center for Health Care Innovation, University of Pennsylvania, USA; Division of General Internal Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, USA.

Objective: We sought to determine the feasibility of the Practical Alternative to Hospitalization (PATH) program, an intervention that offers ED clinicians an outpatient care pathway for patients initially designated for inpatient admission or observation.

Methods: We evaluated a novel care delivery model that was piloted at a tertiary academic medical center in December 2019. An advanced practice provider screened patients designated for inpatient admission or observation and identified eligible participants. Read More

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Development of new combination anti-leishmanial complexes: Triphenyl Sb(V) mono-hydroxy mono-quinolinolates.

J Inorg Biochem 2021 Jun 10;219:111385. Epub 2021 Feb 10.

School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. Electronic address:

In seeking to develop single entity combination anti-Leishmanial complexes six heteropletic organometallic Sb(V) hydroxido quinolinolate complexes of general formula [SbPh(CHNORR')(OH)] have been synthesised and characterised, derived from a series of halide substituted quinolinols (8-hydroxyquinolines). Single crystal X-ray diffraction on all the complexes show a common distorted six-coordinate octahedral environment at the Sb(V) centre, with the aryl groups and nitrogen atom of quinolinolate ligand bonding in the equatorial planes, with the two oxygen atoms (hydroxyl and quinolinolate) occupying the axial plane in an almost linear configuration. Each complex was tested for their anti-promastigote activity and mammalian cytotoxicity and a selectivity indices established. Read More

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Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity.

Psychiatr Serv 2021 Apr 23:appips202000081. Epub 2021 Apr 23.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).

Objective: Acetaminophen is a common cause of intentional and inadvertent overdoses among children and adolescents worldwide. Little is known about characteristics and clinical outcomes of these youths. The primary goal of this naturalistic study was to describe the psychiatric characteristics, medical management, outcomes, and dispositions of children and adolescents evaluated for excessive acetaminophen exposure. Read More

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The Efficacy of In-Reach Rehabilitation in Morbidly Obese Post Septic Patients: Two Retrospective Case Reports.

J Rehabil Med Clin Commun 2020 27;3:1000042. Epub 2020 Nov 27.

Department of Rehabilitation Medicine, Royal Prince Alfred Hospital and St Vincent's Hospital, Sydney, NSW, Australia.

Objective: To report the functional outcomes of two patients with morbid obesity (> 250 kg) who received in-reach rehabilitation after hospitalization for sepsis in Sydney, Australia.

Case Reports: A retrospective review of hospital charts was performed with the informed consent of both patients. Body mass index, demographics, length of stay, functional status at admission and discharge, medical comorbidities, social history, hospital course, equipment needs, therapy methods used, and discharge disposition were compared. Read More

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November 2020

Experience of resources management on coronavirus disease 2019 epidemic at a tertiary medical center in Northern Taiwan.

J Chin Med Assoc 2021 05;84(5):545-549

Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes infectious symptoms including fever, cough, respiratory and gastrointestinal symptoms, and even loss of smell/taste and to date had caused 489 000 people to be infected with 32 000 deaths. This article aims to develop some strategies in dealing with the COVID-19 epidemic to prevent nosocomial infection and ensure the safety of healthcare workforce and employees.

Methods: This is a prospectively registered and retrospective descriptive study investigating the clinical characteristics, results of diagnostic tests, and patients' disposition from February 1, 2020, to April 30, 2020, at a tertiary medical center in Northern Taiwan. Read More

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Cost and Health Care Resource Utilization Differences After Spine Surgery for Bony Spine versus Primary Intradural Spine Tumors.

World Neurosurg 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurosurgery, John Hopkins School of Medicine, Baltimore, Maryland, USA.

Objective: The aim of this study was to compare complication rates, length of stay (LOS), and hospital costs after spine surgery for bony spine tumors and intradural spinal neoplasms.

Methods: A retrospective cohort study was performed using the National Inpatient Sample database from 2016 to 2017. All adult inpatients who underwent surgical intervention for a primary intradural spinal tumor or primary/metastatic bony spine tumor were identified using International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis/procedural coding systems. Read More

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Plutonium Disposition: Using and Explaining Complex Risk-Related Methods.

Risk Anal 2021 Apr 16. Epub 2021 Apr 16.

Cox Associates, Denver, CO, 80218, USA.

Applying risk assessment and management tools to plutonium disposition is a long-standing challenge for the U.S. government. Read More

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Emergency Department Patients Who Leave Before Treatment Is Complete.

West J Emerg Med 2021 Feb 26;22(2):148-155. Epub 2021 Feb 26.

Emergency Services Institute, Cleveland Clinic Health System, Cleveland, Ohio.

Introduction: Emergency department (ED) patients who leave before treatment is complete (LBTC) represent medicolegal risk and lost revenue. We sought to examine LBTC return visits characteristics and potential revenue effects for a large healthcare system.

Methods: This retrospective, multicenter study examined all encounters from January 1-December 31, 2019 at 18 EDs. Read More

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February 2021

Deep vein thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019-positive patients predicted for higher mortality and prolonged intensive care unit and hospital stays in a multisite healthcare system.

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Division of Vascular Medicine of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn.

Objective: We assessed the incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE) in hospitalized patients with coronavirus disease 2019 (COVID-19) compared with that in a matched cohort with similar cardiovascular risk factors and the effects of DVT and PE on the hospital course.

Methods: We performed a retrospective review of prospectively collected data from COVID-19 patients who had been hospitalized from March 11, 2020 to September 4, 2020. The patients were randomly matched in a 1:1 ratio by age, sex, hospital of admission, smoking history, diabetes mellitus, and coronary artery disease with a cohort of patients without COVID-19. Read More

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Synthesis, Characterization, and Water Oxidation Activity of Isomeric Ru Complexes.

Inorg Chem 2021 Apr 8;60(8):5791-5803. Epub 2021 Apr 8.

Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.

The synthesis and characterization of the isomeric ruthenium complexes with the general formula and [Ru(trpy)(qc)X] (trpy is 2,2':6',2″-terpyridine, qc is 8-quinolinecarboxylate, and , X = Cl, = 0; and , X=OH, = 1) with respect to the relative disposition of the carboxylate and X ligands are reported. For comparison purposes, another set of ruthenium complexes with general formula and [Ru(trpy)(pic)(OH)] (pic is 2-picolinate (-, -)) have been prepared. The complexes with a qc ligand show a more distorted geometry compared to the complexes with a pic ligand. Read More

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Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum.

Front Synaptic Neurosci 2021 18;13:618391. Epub 2021 Mar 18.

Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.

Dysfunction at synapses is thought to be an early change contributing to cognitive, psychiatric and motor disturbances in Huntington's disease (HD). In neurons, mutant Huntingtin collects in aggregates and distributes to the same sites as wild-type Huntingtin including on membranes and in synapses. In this study, we investigated the biochemical integrity of synapses in HD mouse striatum. Read More

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