Spine (Phila Pa 1976) 2021 May 10. Epub 2021 May 10.
Center for Evidence-Based Imaging (CEBI) Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Study Design: A case-control study of risk alleles for Degenerative Disc Disease (DDD) using magnetic resonance (MR) imaging for phenotyping.
Objective: We aim to provide the first statistically adequately powered study of the relationship between the presence of common risk alleles and occurrence of DDD in Eastern US population.
Summary Of Background Data: Many genetic pre-disposing factors have been identified in elevating the risk of DDD, including common variants in VDR, COL1A1, AGC1, COL9A2/3 genes. Read More