133,634 results match your criteria general anesthetic


Gabra6100Q Allele Sprague-Dawley Rats Have a Higher Sensitivity to Hypnosis Induced by Isoflurane and Ethanol than the Wild Type Rats.

Neurosci Lett 2021 Jul 28:136142. Epub 2021 Jul 28.

Department of Anesthesiology, Pharmacology and Physiology, Rutgers-New Jersey Medical School, Newark, NJ, USA. Electronic address:

Background: The neurobiological mechanisms underlying how general anesthetics render a patient's unconsciousness (hypnosis) remains elusive. The role of the cerebellum in hypnosis induced by general anesthetics is unknown. Gabra6 allele Sprague-Dawley (SD) rats have a naturally occurring single nucleotide polymorphism in the GABA receptor α6 subunit gene that is expressed exclusively in cerebellum granule cells. Read More

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New-Onset Atrial Fibrillation After Cardiac Surgery is a Significant Risk Factor for Long-Term Stroke: An Eight-Year Prospective Cohort Study.

J Cardiothorac Vasc Anesth 2021 Jul 8. Epub 2021 Jul 8.

Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Objectives: This study sought to determine the incidence and significance of new-onset atrial fibrillation as a risk factor for long-term stroke and mortality after cardiac surgery.

Design: A prospective cohort study.

Setting: Two large tertiary public hospitals. Read More

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Clinical guide to perioperative management for videothoracoscopy lung resection (Section of Cardiac, Vascular and Thoracic Anesthesia, SEDAR; Spanish Society of Thoracic Surgery, SECT; Spanish Society of Physiotherapy).

Rev Esp Anestesiol Reanim 2021 Jul 27. Epub 2021 Jul 27.

Sección de Anestesia Cardiaca, Vascular y Torácica, SEDAR, Anestesiología, Reanimación y T. Dolor. Hospital Universitario La Fe de Valencia, Universitat de València, Valencia, España.

The introduction of video-assisted thoracoscopic (VATS) techniques has led to a new approach in thoracic surgery. VATS is performed by inserting a thoracoscope through a small incisions in the chest wall, thus maximizing the preservation of muscle and tissue. Because of its low rate of morbidity and mortality, VATS is currently the technique of choice in most thoracic procedures. Read More

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Sex, drugs, and anaesthesia research.

Br J Anaesth 2021 Jul 27. Epub 2021 Jul 27.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA. Electronic address:

In this issue of the British Journal of Anaesthesia, Joksimovic and colleagues report significant sex differences in sensitivity to the behavioural and neurophysiological effects of 3β-OH, a novel neurosteroid anesthetic. Female rats were more sensitive to the effects of 3β-OH than male rats, although the mechanims remain unclear. Sex differences have been understudied in anaesthesia research, and this article by Joksimovic and colleagues emphasizes the need to devote more effort to understanding these differences. Read More

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Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.

J Chem Neuroanat 2021 Jul 27:102009. Epub 2021 Jul 27.

Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, 832000, China. Electronic address:

The pathogenesis of Perioperative neurocognitive disorders (PND) is a synergistic effect of many factors. Up to now, the exact mechanism remains unclear. The dopamine pathway in the brain is one of the paths involved in the means of cognitive function. Read More

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Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma.

J Hepatol 2021 Jul 27. Epub 2021 Jul 27.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) microenvironment is hypovascularized, with a prominent development of lymphatic vessels. This leads to a rapid cancer spread into regional lymph nodes and the liver parenchyma, precluding curative treatments. Here, we investigated which factors released in the iCCA stroma drive the inhibition of angiogenesis, promoting lymphangiogenesis. Read More

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Anesthesia Method, Tourniquet Use, and Persistent Postsurgical Pain after Total Knee Arthroplasty: A Prespecified Secondary Analysis of a Randomized Trial.

Anesthesiology 2021 Jul 30. Epub 2021 Jul 30.

Background: Persistent postsurgical pain after total knee arthroplasty is a common problem and a major reason for patient dissatisfaction. This secondary analysis aimed to investigate the effects of anesthesia (spinal vs. general) and tourniquet use on persistent pain after total knee arthroplasty. Read More

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DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy .

Int J Radiat Biol 2021 Jul 30:1-29. Epub 2021 Jul 30.

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Purpose: Patient immobilization by general volatile anesthesia (VA) may be necessary during medical radiology treatment, and its use has increased in recent years. Although ionizing radiation (IR) is a well-known genotoxic and cytotoxic agent, and VA exposure has caused a range of side effects among patients and occupationally exposed personnel, there are no studies to date comparing DNA damage effects from combined VA and single fractional IR dose exposure.

Material And Methods: We investigate whether there is a difference in white blood cells DNA damage response (by the alkaline comet assay) in 185 healthy Swiss albino mice divided into 37 groups, anesthetized with isoflurane/sevoflurane/halothane and exposed to 1 or 2 Gy of IR. Read More

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Comparison of the effect of electromyogram activity during emergence on anesthetic depth monitoring between phase lag entropy and bispectral index: a prospective observational study.

Ann Palliat Med 2021 Jul 14. Epub 2021 Jul 14.

Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Background: The bispectral index (BIS) is the most widely used algorithm for measuring anesthetic depth. The BIS has been demonstrated as inaccurate when neuromuscular blocking drugs (NMBDs) are used. Compared with BIS, phase lag entropy (PLE), which measures the anesthetic depth based on a 4-channel EEG signal, is less affected by EMG. Read More

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Machine Learning Algorithm Using Electronic Chart-Derived Data to Predict Delirium After Elderly Hip Fracture Surgeries: A Retrospective Case-Control Study.

Front Surg 2021 13;8:634629. Epub 2021 Jul 13.

Department of Anesthesiology, Peking University People's Hospital, Beijing, China.

Elderly patients undergoing hip fracture repair surgery are at increased risk of delirium due to aging, comorbidities, and frailty. But current methods for identifying the high risk of delirium among hospitalized patients have moderate accuracy and require extra questionnaires. Artificial intelligence makes it possible to establish machine learning models that predict incident delirium risk based on electronic health data. Read More

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Asleep Speech Mapping Using Orofacial Muscles as Surrogates for Motor Speech in Patients Who Cannot Tolerate Awake Surgery: A Case Series.

Cureus 2021 Jun 23;13(6):e15861. Epub 2021 Jun 23.

Neurological Surgery, Northwell Health, New York, USA.

Background Bi-polar electrical cortical stimulation during awake craniotomy has been the gold standard for mapping eloquent cortex to preserve speech. Unfortunately, not all patients can tolerate awake surgery. Monopolar hi-frequency electrical stimulation can be conducted while a patient is under general anesthesia. Read More

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Utility of High-frequency Jet Ventilation in Atrial Fibrillation Ablation.

J Innov Card Rhythm Manag 2021 Jul 15;12(7):4590-4593. Epub 2021 Jul 15.

Department of Medicine, Division of Cardiology, Einstein Medical Center, Philadelphia, PA, USA.

Atrial fibrillation (AF) is the most common clinically significant arrhythmia that causes major morbidity and mortality. Catheter ablation focusing on pulmonary vein isolation is increasingly used for the treatment of symptomatic AF. Advances in ablation technologies and improved imaging and mapping have enhanced treatment efficiency but only modestly improved the efficacy. Read More

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Distal Patellar Tendon Avulsion Associated with an ACL Tear in a Teenager: A Case Report and Review of the Literature.

Case Rep Orthop 2021 15;2021:6686487. Epub 2021 Jul 15.

Service of Pediatric Orthopedics, Children's Hospital of Geneva, University Hospitals of Geneva, Switzerland.

Distal patellar tendon avulsions are rare injuries in healthy individuals, and to date, no case affecting skeletally mature teenagers and adolescents has been reported. In the majority of cases, distal patellar tendon avulsions are associated with severe intra-articular knee lesions, signifying a high-energy trauma. We present the case of a 15. Read More

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Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1.

Sci Rep 2021 Jul 29;11(1):15490. Epub 2021 Jul 29.

Department of Anesthesia and Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Long-lasting cognitive impairment in juveniles undergoing repeated general anesthesia has been observed in numerous preclinical and clinical studies, yet, the underlying mechanisms remain unknown and no preventive treatment is available. We found that daily intranasal insulin administration to juvenile mice for 7 days prior to repeated isoflurane anesthesia rescues deficits in hippocampus-dependent memory and synaptic plasticity in adulthood. Moreover, intranasal insulin prevented anesthesia-induced apoptosis of hippocampal cells, which is thought to underlie cognitive impairment. Read More

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The effect of perioperative packed red blood cells transfusion on patient outcomes after liver transplant for hepatocellular carcinoma.

HPB (Oxford) 2021 Jul 5. Epub 2021 Jul 5.

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada; Multi-Organ Transplant, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada. Electronic address:

Background: The impact of packed Red Blood Cell (pRBC) transfusion on oncological outcomes after liver transplantation (LT) for Hepatocellular Carcinoma (HCC) remains controversial. We evaluated the impact of pRBC transfusion on HCC recurrence and overall survival (OS) after LT for HCC.

Methods: Patients with HCC transplanted between 2000 and 2018 were included and stratified by receipt of pRBC transfusion. Read More

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Comparison between acupuncture therapy and gabapentin for chronic pain: a pilot study.

Acupunct Med 2021 Jul 29:9645284211026683. Epub 2021 Jul 29.

MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: We examined whether the effect of true electroacupuncture on pain and functionality in chronic pain participants can be differentiated from that of medication (gabapentin) by analyzing quantitative sensory testing (QST).

Methods: We recruited chronic back and neck pain participants who received six sessions (twice weekly) of true electroacupuncture versus sham electroacupuncture or 3 weeks of gabapentin versus placebo treatment. QST profiles, pain scores, and functionality profile were obtained at baseline (visit 1) and after three sessions (visit 4) or six sessions (visit 7) of acupuncture or 3 weeks of gabapentin or placebo. Read More

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Evaluation of skin test indications for general anesthetics in real life: a prospective cohort study.

Braz J Anesthesiol 2021 Jul 26. Epub 2021 Jul 26.

Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul, Turkey. Electronic address:

Background: In daily practice, atopic patients and those who have other drug allergies are referred to allergy clinics for evaluation of possible general anesthetic allergy despite the fact that it is not recommended in recent guidelines.

Objective: The aim of this prospective study is to determine the negative predictive value of skin tests for common general anesthetic drugs prior to general anesthesia in atopic patients and in patients who had drug allergies by including the data of those who had previously tolerated or reacted to general anesthesia.

Methods: A database program was constituted to collect the preoperative skin test data of patients referred to our clinic between 2013 and 2018. Read More

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Hemodynamic impact of increasing time between fentanyl and propofol administration during anesthesia induction: a randomised, clinical trial.

Braz J Anesthesiol 2021 Jul 26. Epub 2021 Jul 26.

Hospital Central de la Defensa Gómez Ulla-IMIDEF, Critical Care and Pain Unit, Department of Anesthesia, Madrid, Spain.

Background And Objective: Anesthesia induction can produce severe propofol dose-dependent hypotension. Fentanyl coadministration reduces the catecholaminergic response to orotracheal intubation allowing propofol dose reduction. The aim of this study is to determine whether the hemodynamic response is improved by increasing the time between fentanyl and propofol administration and reducing the dose of the latter without increasing the time to achieve optimal hypnosis. Read More

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Development of a recovery-room discharge checklist (SAMPE Checklist) for safe handover and its comparison with Aldrete and White scoring systems.

Braz J Anesthesiol 2021 Jul 26. Epub 2021 Jul 26.

Hospital de Clínicas de Porto Alegre (HCPA), Serviço de Anestesia e Medicina Perioperatória, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Departamento de Cirurgia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-Graduação em Ciências Médicas, Porto Alegre, RS, Brazil. Electronic address:

Background: The postoperative care transition from the postanesthetic recovery room (PACU) to the common ward or even home discharge represents a critical step of the surgical patients' handover. Although some systems have been proposed to measure the ability to discharge after an anesthetic-surgical procedure effectively, there is no consensus defining which variables should necessarily be evaluated by these instruments. The instruments routinely used do not evaluate important domains for discharge and are laborious to fill, which compromises the professionals' adhesion. Read More

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The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats.

PLoS One 2021 29;16(7):e0255310. Epub 2021 Jul 29.

IDEXX Laboratories, Inc., One IDEXX Drive, Westbrook, ME, United States of America.

The objective of this study was to evaluate the benefits and inherent risks of dental cleaning procedures, based on serum and urine biomarkers for kidney function and tissue damage, in dogs and cats. Thirty-one asymptomatic, mostly older dogs (14 neutered male and 17 ovariohysterectomized female dogs of various breeds between 3 and 14 years old) and cats (19 neutered male and 12 ovariohysterectomized female domestic short hair cats between 2 and 16 years old) diagnosed with periodontal disease on physical exam, and recommended by their veterinarian to have dental cleaning under general anesthesia were evaluated in a prospective study. Serum and urine samples were collected from dogs and cats 1 week before, 6 hours after, and again 1 week after the dental cleaning procedure. Read More

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Anti-nociceptive Effects of Dexmedetomidine Infusion Plus Modified Intercostal Nerve Block During Single-port Thoracoscopic Lobectomy: A Double-blind, Randomized Controlled Trial.

Pain Physician 2021 Aug;24(5):E565-E572

Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

Background: Multimodal general anesthesia based on modified intercostal nerve block (MINB) has been found as a novel method to achieve an intraoperative opioid-sparing effect. However, there is little information about the effective method to inhibit visceral nociceptive stress during single-port thoracoscopic surgery.

Objective: To investigate whether a low-dose dexmedetomidine infusion followed by MINB might be an alternative method to blunt visceral stress effectively. Read More

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Quadratus Lumborum Block is an Effective Postoperative Analgesic Technique in Pediatric Patients Undergoing Lower Abdominal Surgery: A Meta-Analysis.

Pain Physician 2021 Aug;24(5):E555-E563

Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou First People's Hospital Qianjiang New City Campus, The Affiliated Women's Hospital of Hangzhou Normal University), Hangzhou, China.

Background: Quadratus lumborum (QL) block has shown promising analgesic efficacy in the adult population in previous meta-analyses. However, the response of the pediatric group to pain stimulation is stronger than that in the adult population, and the management of pediatric pain is constrained by limited available analgesia agents. All data analyzed during this study are collected from published articles. Read More

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Epidural Injections for Lumbar Radiculopathy or Sciatica: A Comparative Systematic Review and Meta-Analysis of Cochrane Review.

Pain Physician 2021 Aug;24(5):E539-E554

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: Epidural injections are one of the commonly performed procedures in managing low back and lower extremity pain. In the past, Pinto et al and Chou et al performed systematic reviews and meta-analyses with a recent update from Oliveira et al showing lack of effectiveness of epidural steroid injections in managing lumbar radiculopathy. In contrast, multiple other systematic reviews and meta-analyses have supported the efficacy and use of epidural injections utilizing fluoroscopic guidance. Read More

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Benefits of Transversus Abdominis Plane Block on Postoperative Analgesia after Bariatric Surgery: A Systematic Review and Meta-Analysis.

Pain Physician 2021 Aug;24(5):345-358

Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.

Background: Patients undergoing bariatric surgery present unique analgesic challenges, including poorly controlled pain, increased prevalence of obstructive sleep apnea, and opioid-induced respiratory depression. The transversus abdominis plane (TAP) has been demonstrated to be a safe and effective component of multimodal analgesia for a variety of abdominal surgeries.

Objective: To determine the benefits of the TAP block on postoperative analgesia and recovery in patients undergoing bariatric surgery. Read More

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Efficacy of exenatide, ozone, and methyl prednisolone for the recovery of infraorbital nerve paresthesia after injury in rats.

Dent Res J (Isfahan) 2021 24;18:35. Epub 2021 May 24.

Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Infraorbital nerve injury often occurs due to zygomatic complex fracture. There is no standard protocol to restore the sensory and motor function of the nerve after injury. Some medications are used to improve nerve function. Read More

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Processed Multiparameter Electroencephalogram-Guided General Anesthesia Management Can Reduce Postoperative Delirium Following Carotid Endarterectomy: A Randomized Clinical Trial.

Front Neurol 2021 12;12:666814. Epub 2021 Jul 12.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Patients undergoing carotid endarterectomy (CEA) for severe carotid stenosis are vulnerable to postoperative delirium, a complication frequently associated with poor outcome. This study investigated the impact of processed electroencephalogram (EEG)-guided anesthesia management on the incidence of postoperative delirium in patients undergoing CEA. This single-center, prospective, randomized clinical trial on 255 patients receiving CEA under general anesthesia compared the outcomes of patient state index (PSI) monitoring [SEDLine Brain Function Monitor (Masimo, Inc, Irvine, CA)] (standard group, = 128) with PSI combined with density spectral array(DSA) -guided monitoring (intervention group, = 127) to reduce the risk of intraoperative EEG burst suppression. Read More

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Infant and Child MRI: A Review of Scanning Procedures.

Front Neurosci 2021 12;15:666020. Epub 2021 Jul 12.

FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.

Magnetic resonance imaging (MRI) is a safe method to examine human brain. However, a typical MR scan is very sensitive to motion, and it requires the subject to lie still during the acquisition, which is a major challenge for pediatric scans. Consequently, in a clinical setting, sedation or general anesthesia is often used. Read More

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Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement.

J Pain Res 2021 19;14:2201-2208. Epub 2021 Jul 19.

Department of Pain Medicine, First Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.

Purpose: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics. Read More

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Is hypotensive anaesthesia guided by invasive intraarterial monitoring required for orthognathic surgery? - A retrospective review of anaesthetic practice and intraoperative blood loss in orthognathic surgery in a tertiary hospital.

Indian J Anaesth 2021 Jul 23;65(7):525-532. Epub 2021 Jul 23.

Department of Anaesthesiology and Critical Care Medicine, Singapore, Sri Ramachandra Medical Centre Porur, Chennai, Tamil Nadu, India.

Background And Aims: Orthognathic surgeries for maxillofacial deformities are commonly performed globally and are associated with significant blood loss. This can distort the surgical field and necessitate blood transfusion with its concomitant risks. We aimed to review if invasive intraarterial (IA) line monitoring and/or hypotensive anaesthesia is required for orthognathic surgeries, and their effects on intraoperative blood loss and transfusion requirements. Read More

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Opioid-sparing effects of medical cannabis or cannabinoids for chronic pain: a systematic review and meta-analysis of randomised and observational studies.

BMJ Open 2021 Jul 28;11(7):e047717. Epub 2021 Jul 28.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada

Objective: To assess the efficacy and harms of adding medical cannabis to prescription opioids among people living with chronic pain.

Design: Systematic review.

Data Sources: CENTRAL, EMBASE and MEDLINE. Read More

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