Front Behav Neurosci 2021 22;15:649129. Epub 2021 Mar 22.
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, Unites States.
The cholinergic system plays a crucial role in nervous system function with important effects on developmental processes, cognition, attention, motivation, reward, learning, and memory. Nicotine, the reinforcing component of tobacco and e-cigarettes, directly acts on the cholinergic system by targeting nicotinic acetylcholine receptors (nAChRs) in the brain. Activation of nAChRs leads to a multitude of immediate and long-lasting effects in specific cellular populations, thereby affecting the addictive properties of the drug. Read More