3,006,455 results match your criteria gene


Worse outcome and distinct mutational pattern in follicular lymphoma with anti-HBc positivity.

Blood Adv 2021 Oct 14. Epub 2021 Oct 14.

Group of Applied Clinical Research in Hematology, Cancer Research Program-IMIM (Hospital del Mar Medical Research Institute) Barcelona, Spain.

Epidemiological studies have demonstrated the association between hepatitis B virus (HBV) infection and B-cell non-Hodgkin lymphomas (NHL), mainly for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). We studied a cohort of 121 FL patients for HBV infection status, clinical features and gene mutational profile. Anti-HBc was detectable in sixteen patients (13. Read More

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October 2021

Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model.

Blood Adv 2021 Oct 14. Epub 2021 Oct 14.

Hannover Medical School, Hannover, Germany.

Primary or secondary immunodeficiencies are characterized by disruption of the cellular and humoral immunity. Respiratory infections are a major cause of morbidity and mortality among immunodeficient or immunocompromised patients with Staphylococcus aureus being a common offending organism. We here propose an adoptive macrophage transfer approach aiming to enhance impaired pulmonary immunity against S. Read More

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October 2021

THE NEUROPEPTIDE CORTISTATIN REGULATES DERMAL AND PULMONARY FIBROSIS IN AN EXPERIMENTAL MODEL OF SYSTEMIC SCLEROSIS.

Neuroendocrinology 2021 Oct 14. Epub 2021 Oct 14.

Introduction: Scleroderma, or systemic sclerosis, is a complex connective tissue disorder characterized by autoimmunity, vasculopathy and progressive fibrosis of skin and internal organs. Because its aetiology is unknown, the identification of genes/factors involved in disease severity, differential clinical forms and associated-complications is critical for understanding its pathogenesis and designing novel treatments. Neuroendocrine mediators in skin emerge as potential candidates. Read More

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October 2021

Genetic and Epigenetic Control of Puberty.

Sex Dev 2021 Oct 14:1-10. Epub 2021 Oct 14.

Institute of Human Genetics, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.

Puberty is a complex transitional phase in which reproductive capacity is achieved. There is a very wide variation in the age range of the onset of puberty, which follows a familial, ethnic, and sex pattern. The hypothalamic-pituitary-gonadal axis and several genetic, environmental, and nutritional factors play an important role in the onset of and throughout puberty. Read More

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October 2021

Hepatorenal protective efficacy of flavonoids from Ocimum basilicum extract in diabetic albino rats: A focus on hypoglycemic, antioxidant, anti-inflammatory and anti-apoptotic activities.

Biomed Pharmacother 2021 Oct 12;144:112287. Epub 2021 Oct 12.

Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt. Electronic address:

Plant derived phytochemical therapy is a bright candidate for treatment of diabetes and its associated complications. Ocimum baslicum is used as an anti-diabetic traditional medicine. Hence, the present study investigated the effect of Hail Ocimum extract (HOE) and its total flavonoids (HOETF) against hepatorenal damage in experimental diabetes induced by high-fat diet (HFD) and injection of streptozotocin (STZ) in rats. Read More

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October 2021

In vitro anti-motile effects of Rhoifolin, a flavonoid extracted from Callicarpa nudiflora on breast cancer cells via downregulating Podocalyxin-Ezrin interaction during Epithelial Mesenchymal Transition.

Phytomedicine 2021 Jan 28;93:153486. Epub 2021 Jan 28.

School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:

Background: Callicarpa nudiflora (C. nudiflora), which is a medical herb in genus of Callicarpa, widely grows in the southern part of China. Several investigations had shown that this herb exerts anti-tumor effects. Read More

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January 2021

Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS.

Mar Pollut Bull 2021 Oct 9;173(Pt A):113011. Epub 2021 Oct 9.

School of Applied Sciences, University of Brighton, Lewes Road, Brighton BN2 4AT, United Kingdom; Centre for Aquatic Environments, University of Brighton, Lewes Road, Brighton BN2 4AT, United Kingdom. Electronic address:

Pharmaceutically active compounds have been considered contaminants of emerging concern, in response to evidence that these substances may adversely affect aquatic organisms. Here we expose mussels for 7 days to metformin, the most commonly prescribed anti-diabetes treatment, at a concentration of 40 μg/L and a high temperature of 20 °C. The apoptosis-related genes HSP70, CASP8, BCL2 and FAS showed variation in expression in gonadal tissue. Read More

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October 2021

Immune defense, detoxification, and metabolic changes in juvenile Eriocheir sinensis exposed to acute ammonia.

Aquat Toxicol 2021 Oct 8;240:105989. Epub 2021 Oct 8.

Institute of Plant Nutrition and Environmental Resources, Liaoning Academy of Agricultural Sciences, Shenyang, Liaoning 110661, China. Electronic address:

Ammonia-N accumulation in the rice-crab co-culture system may have negative effects on the health of juvenile Eriocheir sinensis. In this study, physiological, transcriptomic, and metabolomic analyses were performed to explore the toxic responses in the hepatopancreas of juvenile E. sinensis exposed to 0, 0. Read More

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October 2021

A deletion in the N gene may cause diagnostic escape in SARS-CoV-2 samples.

Diagn Microbiol Infect Dis 2021 Sep 17;102(1):115540. Epub 2021 Sep 17.

Unit of Microbiology, The Great Romagna Area Hub Laboratory, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna.

Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance. Read More

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September 2021

Placental Changes in the serotonin transporter (Slc6a4) knockout mouse suggest a role for serotonin in controlling nutrient acquisition.

Placenta 2021 Oct 1;115:158-168. Epub 2021 Oct 1.

Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA; MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO, 65211, USA; Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO, 65211, USA; Genetics Area Program, University of Missouri, Columbia, MO, 65211, USA. Electronic address:

Introduction: The mouse placenta accumulates and possibly produces serotonin (5-hydroxytryptamine; 5-HT) in parietal trophoblast giant cells (pTGC) located at the interface between the placenta and maternal deciduum. However, the roles of 5-HT in placental function are unclear. This lack of information is unfortunate, given that selective serotonin-reuptake inhibitors are commonly used to combat depression in pregnant women. Read More

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October 2021

Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/[email protected] in rats: Synthesis, characterization, biochemical, radio-biodistribution, molecular and histopathological studies.

Bioorg Chem 2021 Oct 8;117:105412. Epub 2021 Oct 8.

Radioactive Isotopes and Generators Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, 13759 Cairo, Egypt. Electronic address:

This study aimed to synthesize a nano-structure between selenium, Vit. C, and Vit. E (Vit-E/[email protected]) as a promising protective and therapeutic agent for hepatocellular carcinoma. Read More

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October 2021

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase.

Transl Oncol 2021 Oct 11;15(1):101239. Epub 2021 Oct 11.

Department of Medical, Surgical and Experimental Sciences, Division of Experimental Pathology and Oncology, Italy. Electronic address:

Background: GNMT (glycine N-methyltransferase) is a tumor suppressor gene, but the mechanisms mediating its suppressive activity are not entirely known.

Methods: We investigated the oncosuppressive mechanisms of GNMT in human hepatocellular carcinoma (HCC). GNMT mRNA and protein levels were evaluated by quantitative RT-PCR and immunoblotting. Read More

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October 2021

Exogenous silicon enhances the systemic defense of cucumber leaves and roots against CA-induced autotoxicity stress by regulating the ascorbate-glutathione cycle and photosystem II.

Ecotoxicol Environ Saf 2021 Oct 11;227:112879. Epub 2021 Oct 11.

College of Horticulture, Gansu Agricultural University, Lanzhou 730070, China; Gansu Provincial Key Laboratory of Arid Land Crop Science, Gansu Agricultural University, Lanzhou 730070, China. Electronic address:

Cinnamic acid (CA), one of the main autotoxins secreted by cucumber roots during continuous cropping, inhibits plant growth and reduces yield. Silicon (Si) is an environmentally friendly element that alleviates abiotic stresses in plants, but the mechanism underlying its resistance to autotoxicity remain unclear. Here, we used 0. Read More

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October 2021

IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation.

Ecotoxicol Environ Saf 2021 Oct 11;227:112892. Epub 2021 Oct 11.

Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China; Anhui Medical University, 81 Meishan Road, Hefei 230032, China; College of Life Science, Henan Normal University, 46 Jianshe Road, Xinxiang 473007, China; School of Pharmacy, Jiamusi University, Jiamusi, Heilongjiang 154007, China. Electronic address:

Exposure to ultraviolet B (UVB) has been demonstrated to induce DNA damage as well as angiogenesis-related photo-damages, which are implicated in a variety of medical problems, including sunburn, photo-aging and skin cancers. However, the molecular mechanism related to UVB-induced photo-injuries remained fully elucidated. Here we revealed that one of the catalytic subunits of the IKK complex, IKKα, played a critical role in mediating UVB-induced apoptotic responses in two kinds of UVB sensitive cells, human keratinocyte (HaCat) and mouse embryonic fibroblasts (MEFs). Read More

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October 2021

Interleukin-37 inhibits inflammation activation and disease severity of PM2.5-induced airway hyperresponsiveness.

Ecotoxicol Environ Saf 2021 Oct 11;227:112890. Epub 2021 Oct 11.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. Electronic address:

We have shown in the past studies that fine particulate matter (PM2.5) exposure increases airway hyperresponsiveness and leads to lung inflammation damage. Interleukin (IL)-37 plays a inhibitory role in inflammation activation and maintenance. Read More

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October 2021

Investigating ABCD1 mutations in a Taiwanese cohort with hereditary spastic paraplegia phenotype.

Parkinsonism Relat Disord 2021 Oct 9;92:7-12. Epub 2021 Oct 9.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Background: Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder caused by mutations in the ABCD1 gene. The clinical manifestations of ALD vary widely with some patients presenting with adrenomyeloneuropathy (AMN) that resembles the phenotype of hereditary spastic paraplegia (HSP). The aim of this study is to investigate the frequency, spectrum, and clinical features of ABCD1 mutations in Taiwanese patients with HSP phenotype. Read More

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October 2021

The soybean Phytoglobin1 (GmPgb1) is involved in water deficit responses through changes in ABA metabolism.

J Plant Physiol 2021 Oct 2;267:153538. Epub 2021 Oct 2.

Dept of Plant Science, University of Manitoba, Winnipeg, R3T2N2, MB, Canada. Electronic address:

Soybean (Glycine max), a major grain crop worldwide, is susceptible to severe yield loss due to drought. Soybean plants over-expressing and downregulating the soybean Phytoblobin1 (GmPgb1) were evaluated for their ability to cope with polyethylene glycol (PEG)-induced water deficit. Sense transformation of GmPgb1, which was more expressed in shoot tissue relative to roots, increased overall plant performance and tolerance to water stress by attenuating the PEG depression of photosynthetic gas exchange parameters and chlorophyll content, as well as reducing leaf injury and promoting root growth. Read More

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October 2021

Nanoparticle-assisted detection of nucleic acids in a polymeric nanopore with a large pore size.

Biosens Bioelectron 2021 Oct 8;196:113697. Epub 2021 Oct 8.

Department of Chemistry, Illinois Institute of Technology, 3101 S Dearborn St, Chicago, IL, 60616, USA. Electronic address:

Rapid and accurate detection of nucleic acids is of paramount importance in many fields, including medical diagnosis, gene therapy and virus identification. In this work, by taking advantage of two DNA hybridization probes, one of which was immobilized on the surface of gold nanoparticles, while the other was free in solution, detection of short length nucleic acids was successfully achieved using a large size (20 nm tip diameter) polyethylene terephythalate (PET) nanopore. The sensor was sensitive and selective: DNA samples with concentrations at as low as 0. Read More

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October 2021

Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.

Int Immunopharmacol 2021 Oct 11;101(Pt A):108183. Epub 2021 Oct 11.

Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. Electronic address:

Glioma is the most commonly diagnosed primary tumor of central nervous system. Previous studies found that the six-transmembrane epithelial antigen of prostate (STEAP) family can regulate the biological behaviors of several cancers. However, the role of STEAP family in glioma remains unclear. Read More

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October 2021

Removal of phytotoxins in filter sand used for drinking water treatment.

Water Res 2021 Aug 27;205:117610. Epub 2021 Aug 27.

Greater Copenhagen Utility HOFOR, Parkstien 10, 2450, Copenhagen, Denmark. Electronic address:

Phytotoxins - toxins produced by plants - are contaminants with the potential to impair drinking water quality. They encompass a large group of toxic, partially persistent compounds that have been detected in seepage waters and in shallow wells used for drinking water production. If phytotoxins enter wells used for drinking water production, it is essential to know if the drinking water treatment processes will remove them from the water phase. Read More

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Synergistic bioreduction of Te(Ⅳ) using S(0) as electron donor.

Bioresour Technol 2021 Sep 8;343:125896. Epub 2021 Sep 8.

Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Mechanical Engineering, City University of Hong Kong, Kowloon Tang, Hong Kong; College of Engineering, Tunghai University, Taichung 40770 Taiwan. Electronic address:

This study for the first time bioreduced Te(IV) using elemental sulfur (S) as electron donor, achieving 91.17%±0.8% conversion with reaction rate of 0. Read More

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September 2021

Novel insights into the regulation of LATS2 kinase in prehierarchical follicle development via the Hippo pathway in hen ovary.

Poult Sci 2021 Sep 3;100(12):101454. Epub 2021 Sep 3.

Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, USA.

The large tumor suppressor homolog 2 (LATS2), one of the central regulators of the Hippo/MST signaling pathway, plays an inhibitory role in ovarian function and different organ development and growth in mammals. However, the exact roles and molecular regulatory mechanisms of LATS2 in chicken granulosa cell (GC) proliferation, differentiation, and steroidogenesis required for ovarian follicle growth, development, and follicular selection remain poorly understood. This study demonstrated that the LATS2 protein was predominantly localized in the oocytes and undifferentiated GCs of various-sized prehierarchical follicles of the hen ovary. Read More

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September 2021

CiRS-7/CDR1as; An oncogenic circular RNA as a potential cancer biomarker.

Pathol Res Pract 2021 Sep 29;227:153639. Epub 2021 Sep 29.

Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Circular RNAs (circRNAs) as a new class of non-coding RNAs (ncRNAs) play role in gene regulation in multicellular organisms via various interactions with nucleic acids, proteins and particularly microRNAs. They have been found to be involved in a number of biological functions particularly in regulation of cell cycle, and extracellular interactions. Thus, dysregulation of circRNAs is found to be associated with several human diseases and especially numerous types of cancers. Read More

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September 2021

The large mimosoid genus Inga Mill. (tribe Ingeae, Caesalpinioideae) is nodulated by diverse Bradyrhizobium strains in its main centers of diversity in Brazil.

Syst Appl Microbiol 2021 Oct 1;44(6):126268. Epub 2021 Oct 1.

Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil. Electronic address:

Inga (Caesalpinioideae) is the type genus of the Ingeae tribe in the mimosoid clade. It comprises about 300 species, all trees or treelets, and has an exclusively neotropical distribution, with Brazil as its main center of diversity. In this study, we analyzed the diversity of 40 strains of rhizobia isolated from root nodules collected from ten species of Inga belonging to different types of vegetation in Brazil. Read More

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October 2021

MUD1, a RING-v E3 ubiquitin ligase, has an important role in the regulation of pectin methylesterification in Arabidopsis seed coat mucilage.

Plant Physiol Biochem 2021 Oct 9;168:230-238. Epub 2021 Oct 9.

Key Laboratory for Tobacco Gene Resources, Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, 266101, China; College of Agronomy, Qingdao Agricultural University, Qingdao, Shandong, 266109, China. Electronic address:

Pectin is one of the major components of plant primary cell wall polysaccharides. The degree of pectin methylesterification (DM) plays an important role in the process of plant growth. However, little is known about the underlying regulatory mechanisms during the process of pectin demethylesterification. Read More

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October 2021

Identification of SPX family genes in the maize genome and their expression under different phosphate regimes.

Plant Physiol Biochem 2021 Oct 6;168:211-220. Epub 2021 Oct 6.

Collaborative Innovation Center of Henan Grain Crops / State Key Laboratory of Wheat and Maize Crop Science, College of Life Sciences, Henan Agricultural University, Zhengzhou, 450002, China. Electronic address:

Many studies have revealed that SPX (SYG1/Pho81/XPR1) family genes play a key role in signal transduction related to phosphorus (P) deficiency in plants. Here, we identified 33 SPX gene family members in maize through genome-wide analysis and classified them into 4 subfamilies according to SPX structural characteristics (SPX, SPX-MFS, SPX-EXS and SPX-RING). The promoter regions of ZmSPXs are rich in biotic/abiotic-related stress elements. Read More

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October 2021

Expression of the pyrroline-5-carboxylate reductase (P5CR) gene from the wild grapevine Vitis yeshanensis promotes drought resistance in transgenic Arabidopsis.

Plant Physiol Biochem 2021 Oct 6;168:188-201. Epub 2021 Oct 6.

College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture, Yangling, Shaanxi, 712100, China; State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Proline accumulation is one of the most common reactions in plants under drought stress. Pyrroline-5-carboxylate reductase (P5CR) is the final enzyme and plays an important role in proline biosynthesis. The Chinese wild grapevine Vitis yeshanensis J. Read More

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October 2021

Next-generation sequencing sheds light on the interaction between virus and cell during foot-and-mouth disease virus persistent infection.

Vet Microbiol 2021 Sep 30;263:109247. Epub 2021 Sep 30.

College of Life Sciences, Wuhan University, Wuhan 430072, China; China Center for Type Culture Collection, Wuhan University, Wuhan 430072, China. Electronic address:

Foot-and-mouth disease virus (FMDV) infection can be either persistent or acute in susceptible animals. The mechanisms involved in FMDV replication and clearance during persistent infection remain unclear. To identify host factors that are critical for FMDV replication during persistent infection, we used RNA-seq to compare the transcriptomes of infected (BHK-Op) cells and bystander (BHK-VEC) cells, which are exposed to FMDV but not infected. Read More

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September 2021

Goose nephritic astrovirus infection increases autophagy, destroys intercellular junctions in renal tubular epithelial cells, and damages podocytes in the kidneys of infected goslings.

Vet Microbiol 2021 Oct 8;263:109244. Epub 2021 Oct 8.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.

Goose nephritic astrovirus (GNAstV) has recently been identified, which causes kidney swelling and visceral gout in goslings. However, the pathological changes in kidney tissue due to GNAstV infection have not yet been described. In the study, fifty goslings were orally infected with GNAstV, and fifty goslings received PBS as a control. Read More

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October 2021

Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer.

Photodiagnosis Photodyn Ther 2021 Oct 11:102581. Epub 2021 Oct 11.

Department of Stomatology, PLA Strategic Support Force Medical Center, Beijing, 100101, China;; PLA 306 Clinical College of Anhui Medical University, Hefei, 230001, China.. Electronic address:

Background: Rationally designed nanostructured materials can produce ideal drug carriers that plays an increasingly important role in cancer treatment. In comparison with conventional drug combination approaches, using co-delivery systems of multiple drugs achieves sophisticated targeting strategies and multifunctionality.

Methods: First, a nano-co-delivery of chitosan/tripolyphosphate (CS-TPP) was synthesized and characterized combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) shRNA. Read More

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October 2021