761 results match your criteria gelling agents

Phase behavior and rheological properties of basil seed gum/whey protein isolate mixed dispersions and gels.

Food Sci Nutr 2021 Apr 18;9(4):1881-1895. Epub 2021 Feb 18.

Department of Food Science and Technology Sari Agricultural Sciences and Natural Resources University Sari Iran.

Many food formulations comprise proteins and polysaccharides simultaneously, contributing in the functional properties in food systems. In this study, the effects of basil seed gum (BSG) addition to whey protein isolate (WPI) dispersions were investigated through phase behavior, steady shear flow, and small amplitude oscillatory shear tests (SAOS). The phase behavior of WPI-BSG mixed solutions was dependent on the initial concentration of biopolymers, while the effect of BSG was predominant. Read More

View Article and Full-Text PDF

Bioadhesive-Thermosensitive Vaginal Gel of the Gel Flake-Solid Dispersion of Itraconazole for Enhanced Antifungal Activity in the Treatment of Vaginal Candidiasis.

ACS Appl Mater Interfaces 2021 Apr 11. Epub 2021 Apr 11.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, United Kingdom.

The poor solubility of itraconazole (ITZ) has limited its efficacy in the treatment of vaginal candidiasis. Accordingly, the improvement of ITZ solubility using a solid dispersion technique was important to enhance its antifungal activity. Besides, as the purpose of this research was to develop local-targeting formulations, bioadhesive-thermosensitive vaginal gel combined with the gel-flake system was found to be the most suitable choice. Read More

View Article and Full-Text PDF

Physicochemical characterization and emulsifying properties evaluation of RG-I enriched pectic polysaccharides from Cerasus humilis.

Carbohydr Polym 2021 May 16;260:117824. Epub 2021 Feb 16.

College of Food Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong Province, China. Electronic address:

Rhamnogalacturonan I (RG-I) enriched pectic polysaccharides were extracted from Cerasus humilis fruits (RPCF, RG-I: 74.46 %). Structural characterization including FTIR, XRD, NMR, HPAEC and SEM demonstrated that RPCF was a high-methoxy acetylated pectin macromolecule with abundant arabinose and galactose side chains (DM: 53. Read More

View Article and Full-Text PDF

Nanoemulgel, an Innovative Carrier for Diflunisal Topical Delivery with Profound Anti-Inflammatory Effect: in vitro and in vivo Evaluation.

Int J Nanomedicine 2021 22;16:1457-1472. Epub 2021 Feb 22.

Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

Purpose: Rheumatoid arthritis is an autoimmune disorder that directly affects joints. However, other body organs including heart, eyes, skin, blood vessels and lungs may also be affected. The purpose of this study was to design and evaluate a nanoemulgel formulation of diflunisal (DIF) and solubility enhanced diflunisal (DIF-IC) for enhanced topical anti-inflammatory activity. Read More

View Article and Full-Text PDF

The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases.

Mar Drugs 2021 Feb 26;19(3). Epub 2021 Feb 26.

MARE-Marine and Environmental Sciences Centre, Faculty of Science and Technology, University of Coimbra, 3000-548 Coimbra, Portugal.

Edible marine algae are rich in bioactive compounds and are, therefore, a source of bioavailable proteins, long chain polysaccharides that behave as low-calorie soluble fibers, metabolically necessary minerals, vitamins, polyunsaturated fatty acids, and antioxidants. Marine algae were used primarily as gelling agents and thickeners (phycocolloids) in food and pharmaceutical industries in the last century, but recent research has revealed their potential as a source of useful compounds for the pharmaceutical, medical, and cosmetic industries. The green, red, and brown algae have been shown to have useful therapeutic properties in the prevention and treatment of neurodegenerative diseases: Parkinson, Alzheimer's, and Multiple Sclerosis, and other chronic diseases. Read More

View Article and Full-Text PDF
February 2021

Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies.

AAPS PharmSciTech 2021 Feb 17;22(3):77. Epub 2021 Feb 17.

Department of Chemical Engineering and Department of Anesthesiology, University of Florida, Gainesville, Florida, 32611, USA.

Currently, periodontitis is treated by oral dosage forms (antibiotics) which shows systemic side effects and failed to reach the therapeutic concentration (above minimum inhibitory concentration, MIC) in the periodontal pocket. The present study aimed to overcome the above issues, by designing tailored doxycycline hyclate laden in situ gel by Poloxamer 407, chitosan, and polyethylene glycol 600. The in situ gel-forming system has attracted attention owing to its ability of sustained drug release above MIC, easy administration (syringeability), and high drug retention (localization) in the periodontal cavity. Read More

View Article and Full-Text PDF
February 2021

Preparation of Novel Functional Drug Particles Embedded in a Gelling-Swelling Layer (PEGS) for Taste Masking and Subsequent Rapid Drug Release.

Chem Pharm Bull (Tokyo) 2021 Apr 29;69(4):383-390. Epub 2021 Jan 29.

School of Pharmaceutical Sciences, Mukogawa Woman's University.

The purpose of this research was to develop novel functional drug particles embedded in a gelling-swelling layer (PEGS) which are capable of achieving both taste-masking of unpalatable drugs and rapid drug elution. The functional particles had a three-layer structure consisting of a core drug layer, a gelling-swelling layer and an outer water-penetration control layer containing a water-insoluble polymer. The concept of formulation design was as follows: when water reaches the gelling-swelling layer, pulverized fine gelling-swelling particles gellate and swell from water absorption to form a rigid layer, thereby preventing drug release. Read More

View Article and Full-Text PDF

Polydopamine-coated curdlan hydrogel as a potential carrier of free amino group-containing molecules.

Carbohydr Polym 2021 Mar 16;256:117524. Epub 2020 Dec 16.

Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1, 20-093, Lublin, Poland. Electronic address:

Curdlan hydrogel obtained after thermal gelling exhibits elasticity and high water-absorbing capacity. However, its modifications leading to the increase of biofunctionality usually alter its solubility and reduce mechanical parameters. Therefore, curdlan hydrogel was modified by deposition of polydopamine to improve its capacity to bind biologically active molecules with free amino groups. Read More

View Article and Full-Text PDF

Chitosan Microbeads Produced by One-Step Scalable Stirred Emulsification: A Promising Process for Cell Therapy Applications.

ACS Biomater Sci Eng 2020 01 31;6(1):288-297. Epub 2019 Dec 31.

Laboratory of Endovascular Biomaterials (LBeV), Centre de recherche du CHUM (CRCHUM), 900 Saint-Denis Street, Montreal, Quebec H2X 0A9, Canada.

Cell microencapsulation is a promising approach to improve cell therapy outcomes by protecting injected cells from rapid dispersion and allowing bidirectional diffusion of nutrients, oxygen, and waste that promote cell survival in the target tissues. Here, we describe a simple and scalable emulsification method to encapsulate animal cells in chitosan microbeads using thermosensitive gel formulations without any chemical modification and cross-linker. The process consists of a water-in-oil emulsion where the aqueous phase droplets contain cells (L929 fibroblasts or human mesenchymal stromal cells), chitosan acidic solution and gelling agents (sodium hydrogen carbonate and phosphate buffer or beta-glycerophosphate). Read More

View Article and Full-Text PDF
January 2020

Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques.

Sci Rep 2021 Jan 14;11(1):1317. Epub 2021 Jan 14.

College of Pharmaceutical and Food Sciences, University of Antioquia, Street 67, 53-108, Medellin, Colombia.

To compare the encapsulation of annatto extract by external gelation (EG) and internal gelation (IG) and to maximize process yield (% Y), two central composite designs were proposed. Calcium chloride (CaCl) concentration (0.3-3. Read More

View Article and Full-Text PDF
January 2021

Overview of in situ gelling injectable hydrogels for diabetic wounds.

Drug Dev Res 2021 Jan 12. Epub 2021 Jan 12.

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India.

Diabetes mellitus (DM) is an endocrine disorder that causes increased blood glucose than usual due to insulin impairment. In DM, several complications arise in which diabetic wound (DW) is the most devastating complication. About 25% of patients with DM expected to develop DWs in their lifetime and undergo limb amputations. Read More

View Article and Full-Text PDF
January 2021

The use of gelling agents to preserve burnt teeth within the dental alveoli for dental human identification - a study utilising sheep mandibles.

Forensic Sci Med Pathol 2021 Mar 6;17(1):72-77. Epub 2021 Jan 6.

Forensic Odontology Unit, University of Adelaide, Level 3 Helen Mayo South Frome Rd., Adelaide, South Australia, 5067, Australia.

Dental comparison is one of the primary methods of scientific identification of severely incinerated human remains. However, due to the fragile nature of the remains dental structures may be lost or damaged during recovery and transportation, limiting the amount of evidence available for examination. In addition to protecting the head, stabilization of the oral structures with an adhesive substance that will not interfere with the dental examination is ideal. Read More

View Article and Full-Text PDF

Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent Update on Potential Investigation.

Pharmaceutics 2020 Dec 22;13(1). Epub 2020 Dec 22.

Undergraduate, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.

The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of blindness in both the paediatric and adult population, especially if immunodeficient. Globally, there are 1. Read More

View Article and Full-Text PDF
December 2020

Effect of red seaweed sulfated galactans on initial steps of complement activation in vitro.

Carbohydr Polym 2021 Feb 21;254:117251. Epub 2020 Oct 21.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku, 159, Vladivostok, 690022, Russia.

The research described here presents data on the effect of galactans of red algae, carrageenans (λ/μ/ν-, κ-, κ/β-, and ι/κ-types), and agar on complement system activation in normal human serum. The experiments were based on well surfaces coated with triggering agents for binding initiating complement components -C3 and C4. The sulfated galactans inhibited C3 binding to lipopolysaccharide with direct dependence on the sulfation degree of polysaccharides. Read More

View Article and Full-Text PDF
February 2021

Novel viscoelastic gelling agent with unique physico-chemical properties.

Food Chem 2021 May 27;344:128715. Epub 2020 Nov 27.

Faculty of Agriculture and Life Sciences, Lincoln University, PO Box 84, Lincoln 7647, Canterbury, New Zealand.

A novel innovative viscoelastic gelling agent (novel gel, NG) has been developed by combining citric acid (CA) and disodium 5-guanylate (DG). NG has the potential to replace other gelling agents such as gelatine, which has been commonly used in foods, dietary supplements, pharmaceutical and cosmetic products including ointments and sprays. NG has unique physico-chemical properties, including a wide range of concentration-dependent, temperature-sensitive gel strengths. Read More

View Article and Full-Text PDF

Cellulose Pulp- and Castor Oil-Based Polyurethanes for Lubricating Applications: Influence of Action on Barley and Wheat Straws.

Polymers (Basel) 2020 Nov 27;12(12). Epub 2020 Nov 27.

Pro2TecS-Chemical Process and Product Technology Research Centre, Departamento de Ingeniería Química, ETSI, Campus de "El Carmen", Universidad de Huelva, 21071 Huelva, Spain.

The replacement of mineral oils and non-renewable gelling agents is an imperative requirement for the lubricant industry in the near future. In this framework, cellulose pulp and castor oil are proposed as sustainable substitutes for these components. Biological treatment has been explored and evaluated to enhance the dispersing and thickening properties of cellulose pulp in oil media. Read More

View Article and Full-Text PDF
November 2020

A rheological approach to assess the printability of thermosensitive chitosan-based biomaterial inks.

Biomed Mater 2020 11 27;16(1):015003. Epub 2020 Nov 27.

Biomedical Engineering Institute, School of Medicine, Université de Montréal, Montreal, Canada. Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Canada.

For extrusion-based bioprinting, the inks must be printable and rapidly present sufficient mechanical properties to support additional layers and provide a cohesive, manipulable structure. Thermosensitive hydrogels may be interesting candidates. However, the use of these materials is particularly challenging, since their rheological properties evolve with time and temperature. Read More

View Article and Full-Text PDF
November 2020

Nose-to-brain delivery of teriflunomide-loaded lipid-based carbopol-gellan gum nanogel for glioma: Pharmacological and in vitro cytotoxicity studies.

Int J Biol Macromol 2021 Jan 10;167:906-920. Epub 2020 Nov 10.

Department of Pharmaceutics, Sinhgad Technical Education Society's, Sinhgad Institute of Pharmacy (affiliated to Savitribai Phule Pune University), Narhe, Pune 411 041, India.

The research work was intended to formulate teriflunomide (TFM) loaded nano lipid-based (TNLC) carbopol-gellan gum in situ gel (TNLCGHG) and to investigate its therapeutic efficacy against glioma, a brain and spine tumor. Nanoformulation was developed using gellan gum and carbopol 974P as gelling and mucoadhesive agents, respectively, Glyceryl di-behenate and Glyceryl mono-linoleate blend as lipids, and Gelucire 44/14: water blend as surfactant system. Globule size, PDI, zeta potential, encapsulation efficiency, mucoadhesive strength, and nasal permeation were found to be 117. Read More

View Article and Full-Text PDF
January 2021

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders.

Polymers (Basel) 2020 Oct 20;12(10). Epub 2020 Oct 20.

Department of Health and Human Development, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.

Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetables, as a microbial and viral protection product, and as a gelling, thickening, stabilizing or emulsifying agent. Its biocompatibility, biodegradability, nontoxicity and the possibility of it being used in quantum satis doses prompted scientists to explore new properties for alginate usage. Read More

View Article and Full-Text PDF
October 2020

Naphthalimide Imidazolium-Based Supramolecular Hydrogels as Bioimaging and Theranostic Soft Materials.

ACS Appl Mater Interfaces 2020 Oct 19;12(43):48442-48457. Epub 2020 Oct 19.

Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Sezione di Chimica, Viale delle Scienze, Università degli Studi di Palermo, Edificio 17, Palermo 90128, Italy.

1,8-Naphthalimide-based imidazolium salts differing for the alkyl chain length and the nature of the anion were synthesized and characterized to obtain fluorescent probes for bioimaging applications. First, their self-assembly behavior and gelling ability were investigated in water and water/dimethyl sulfoxide binary mixtures. Only salts having longer alkyl chains were able to give supramolecular hydrogels, whose properties were investigated by using a combined approach of fluorescence, resonance light scattering, and rheology measurements. Read More

View Article and Full-Text PDF
October 2020

Encapsulation of two fermentation agents, Lactobacillus sakei and calcium ions in microspheres.

Colloids Surf B Biointerfaces 2021 Jan 7;197:111387. Epub 2020 Oct 7.

University of Zagreb, Faculty of Agriculture, Department of Chemistry, Croatia. Electronic address:

Alginate microspheres loaded with two fermentation active agents, calcium cations and strain LS0296 identified as Lactobacillus sakei, have been prepared and characterized. The role of calcium cation is twofold, it acts as gelling cation and as fermentation active agent. Encapsulation and the presence of calcium ions in the same compartment do not inhibit the activity of LS0296. Read More

View Article and Full-Text PDF
January 2021

Purification and characterization of novel exopolysaccharides produced from Lactobacillus paraplantarum KM1 isolated from human milk and its cytotoxicity.

J Genet Eng Biotechnol 2020 Oct 2;18(1):56. Epub 2020 Oct 2.

Microbiology Research Laboratory, Department of Basic Sciences, Dr Y S Parmar University of Horticulture and Forestry, Nauni, Solan, HP, 173230, India.

Background: Microbial origin polysaccharides have gained popularity due to lesser toxicity, better degradability and selectivity as compared to their synthetic counterparts and can be used as emulsifier, stabilizer, thickener, texturizer, flocculating and gelling agent. Here main emphasis on exopolysaccharide production from potential lactic acid bacteria that has GRAS status.

Results: This work was aimed at isolating, purifying and characterizing an extracellular polysaccharide (EPS) produced by a foodgrade lactic acid bacteria Lactobacillus paraplantarum KM1. Read More

View Article and Full-Text PDF
October 2020

Therapeutic Uses of Red Macroalgae.

Molecules 2020 Sep 25;25(19). Epub 2020 Sep 25.

Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.

Red Seaweed "Rhodophyta" are an important group of macroalgae that include approximately 7000 species. They are a rich source of structurally diverse bioactive constituents, including protein, sulfated polysaccharides, pigments, polyunsaturated fatty acids, vitamins, minerals, and phenolic compounds with nutritional, medical, and industrial importance. Polysaccharides are the main components in the cell wall of red algae and represent about 40-50% of the dry weight, which are extensively utilized in industry and pharmaceutical compounds, due to their thickening and gelling properties. Read More

View Article and Full-Text PDF
September 2020

Food hydrocolloids: Functional, nutraceutical and novel applications for delivery of bioactive compounds.

Int J Biol Macromol 2020 Dec 28;165(Pt A):554-567. Epub 2020 Sep 28.

Division of Food Science and Technology, Sher-e-Kashmir University of Agriculture Science and Technology, Jammu 180009, India.

Nowadays, the consumers' understanding of the relation between diet and health has bought a profound change in their dietary pattern and lifestyle transformation. They aspire more to natural and health-full food products with desired quality and functionality. The emergence of this consciousness among consumers has become one of the driving factors for designing food products that can meet both their specific nutritional needs and health benefits. Read More

View Article and Full-Text PDF
December 2020

Isolation and FTIR-ATR and H NMR Characterization of Alginates from the Main Alginophyte Species of the Atlantic Coast of Morocco.

Molecules 2020 Sep 22;25(18). Epub 2020 Sep 22.

CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos, s/n, 4450-208 Matosinhos, Portugal.

Alginates are widely used as gelling agents in textile print pastes, medical industries, impression material in dentistry, and anticoagulant material in toothpaste. In the present study, the content and spectroscopic characterization (H NMR and FT-IR) of the sodium alginates were investigated in the eight brown seaweeds , f. , , , , , , and harvested from the NW Atlantic coast of Morocco. Read More

View Article and Full-Text PDF
September 2020

The Effect of Cultivation Method of Strawberry ( Duch.) cv. Honeoye on Structure and Degradation Dynamics of Pectin during Cold Storage.

Molecules 2020 Sep 21;25(18). Epub 2020 Sep 21.

Institute of Agrophysics, Polish Academy of Sciences, Doświadczalna 4, 20-290 Lublin, Poland.

The high quality and long shelf life of strawberry fruit are largely dependent on the cultivation method. The goal of this experiment was to study the effect of different cultivation methods on molecular structure and rheological properties of pectin extracted from strawberry quality parameters during cold storage. Three methods of cultivation of strawberry cv. Read More

View Article and Full-Text PDF
September 2020

Effects of structural and conformational characteristics of citrus pectin on its functional properties.

Food Chem 2021 Mar 12;339:128064. Epub 2020 Sep 12.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Ultrasonic degradation has become a fascinating strategy for preparing modified pectin, contributing to the improvement of pectin's functional characteristics. In this study, the impacts of structural and conformational characteristics of original and ultrasound-treated citrus pectins on their functional properties were examined. The results showed that compared with ultrasound-treated pectins, untreated pectin presented higher rheological and gelling properties primarily attributed to its larger weight-average molecular weight (M), degree of methoxylation, amount of neutral sugar side chains, and z-average radius of gyration, as well as the more extended flexible-chain conformation. Read More

View Article and Full-Text PDF

Design, Characterization, and Application of a pH-Triggered In Situ Gel for Ocular Delivery of Vinpocetine.

AAPS PharmSciTech 2020 Sep 4;21(7):253. Epub 2020 Sep 4.

Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, No. 1, QianJiang Road, Hefei, AnHui, People's Republic of China.

We developed a pH-triggered in situ gel (ISG) for ocular delivery of vinpocetine to achieve systemic absorption and a brain-targeting effect in rats. Carbopol acted as a gelling agent combined with hydroxypropyl methylcellulose (HPMC) as a viscosity-enhancing agent. The concentration of Carbopol (0. Read More

View Article and Full-Text PDF
September 2020

Alginate as Promising Natural Polymer for Pharmaceutical, Food, and Biomedical Applications.

Curr Drug Deliv 2020 ;17(9):755-775

Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar (M.P.) 470 003, India.

Alginates are biopolymers usually obtained from brown seaweed, brown algae (Ochrophyta, Phaeophyceae), and bacteria (Azatobacter vineland and Pseudomonas species) belonging to the family of polycationic copolymers. They are biocompatible, biodegradable, non-antigenic, and non-toxic biopolymer with molecular mass ranges from 32,000-40,000 g/mol in commercial grades. These can be used as edible films or coatings in food industries and also some natural or chemical additives could be incorporated into them to modify their functional, mechanical, nutritional as well as organoleptic properties. Read More

View Article and Full-Text PDF
January 2020

Effect of gellan gum, xylitol and natamycin on Zygosaccharomyces bailii growth and rheological characteristics in low sugar content model systems.

Int J Biol Macromol 2020 Dec 7;164:1657-1664. Epub 2020 Aug 7.

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Industrias, Buenos Aires, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Tecnología de Alimentos y Procesos Químicos (ITAPROQ), Buenos Aires, Argentina. Electronic address:

This study evaluated the effect of some natural additives and the structure imparted by them on microbial growth and rheological characteristics in acidic model foods with reduced glycidic content. Systems were formulated using gellan gum, as gelling agent; xylitol, as a depressor; and natamycin, as antimicrobial. Additive-free control systems were prepared. Read More

View Article and Full-Text PDF
December 2020