Ther Drug Monit 2021 Jul 20. Epub 2021 Jul 20.
Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway. Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Background: Separation gels are often used in collection tubes, but adsorption of drugs onto the gel may cause falsely low concentrations in therapeutic drug monitoring. In this study, the stability of apixaban, edoxaban, rivaroxaban, flecainide, amiodarone, and desethylamiodarone was assessed in tubes, with and without gel separators.
Methods: Drug-free blood was spiked and stored for up to 7 d in non-gel tubes and gel tubes from two manufacturers (Vacuette and Vacutainer). Read More