38,165 results match your criteria gel studied

The promiscuous potential of cellulase in degradation of polylactic acid and its jute composite.

Chemosphere 2021 Apr 1;278:130443. Epub 2021 Apr 1.

Swedish Centre for Resource Recovery, University of Borås, Borås, Sweden.

It has been suggested that cellulolytic enzymes can be effective on the degradation of PLA samples. The idea was investigated by examining the impact of cellulase on degradation of PLA and PLA-jute (64/36) composite in an aqueous medium. The obtained results demonstrated 55% and 61% thickness reduction in PLA and PLA-jute specimens after four months of treatment, respectively. Read More

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Remodeling of an microvessel exposed to cyclic mechanical stretch.

APL Bioeng 2021 Jun 2;5(2):026102. Epub 2021 Apr 2.

Integrative Vascular Biology Laboratory, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC),13092 Berlin, Germany.

In the lungs, vascular endothelial cells experience cyclic mechanical strain resulting from rhythmic breathing motions and intraluminal blood pressure. Mechanical stress creates evident physiological, morphological, biochemical, and gene expression changes in vascular endothelial cells. However, the exact mechanisms of the mechanical signal transduction into biological responses remain to be clarified. Read More

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The STING phase-separator suppresses innate immune signalling.

Nat Cell Biol 2021 Apr 8;23(4):330-340. Epub 2021 Apr 8.

Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing, China.

Biomolecular condensates (biocondensates) formed via liquid-liquid phase-separation of soluble proteins have been studied extensively. However, neither the phase-separation of endoplasmic reticulum (ER) transmembrane protein nor a biocondensate with organized membranous structures has been reported. Here, we have discovered a spherical ER membranous biocondensate with puzzle-like structures caused by condensation of the ER-resident stimulator of interferon genes (STING) in DNA virus-infected or 2'3'-cGAMP (cyclic GMP-AMP)-treated cells, which required STING transmembrane domains, an intrinsically disordered region (IDR) and a dimerization domain. Read More

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Gold(III) complexes with thiosemicarbazonate ligands as potential anticancer agents: cytotoxicity and interactions with biomolecular targets.

Eur J Pharm Sci 2021 Apr 4:105834. Epub 2021 Apr 4.

Núcleo de Desenvolvimento de Compostos Bioativos (NDCBio), Universidade Federal do Triângulo Mineiro, Uberaba, Brazil. Electronic address:

Gold(III) complexes have been studied for the past years due to their anticancer properties and great affinity to biotargets, such as enzymes and proteins, which support their pharmacological applications. Within this scope, in this work the antiproliferative activities of two Au(III)-thiosemicarbazonate complexes, [AuClL] (1, L: (E,Z)-N-ethyl-N'-(3-nitroso-kN)butan-2-ylidene)carbamohydrazonothioato-kN,S) and [Au(Hdamp)L]Cl (2, L: N-(N'',N''-diethylaminothiocarbonyl)-N'(N''', N'''-dimethylcarbothioamide)benzamidineto-kN,kS and Hdamp: 2-(N,N-dimethylaminomethyl)-phenyl-C), and their affinities to possible biological targets were investigated. Three different tumor cell lines were used to perform the cytotoxicity assays, including one cisplatin-resistant model, and the results showed lower EC for 1 over 2 in every case: B16F10 (4. Read More

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Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Co-Transporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice.

Diabetes 2021 Apr 5. Epub 2021 Apr 5.

Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC H2X 0A9, Canada

We investigated the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) overexpression in renal proximal tubular cells (RPTCs) on blood glucose, kidney injury and sodium-glucose co-transporter 2 (Sglt2) expression in diabetic Akita transgenic (Tg) mice. Immortalized human RPTCs (HK2) stably transfected with plasmid containing the promoter, human kidneys from patients with diabetes were also studied. Nrf2 overexpression was associated with increased blood glucose, glomerular filtration rate, urinary albumin-creatinine ratio, tubulointerstitial fibrosis and Sglt2 expression in Akita Tg mice compared to their Akita littermates. Read More

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Enhancement of Static and Dynamic Sag Performance of Water-Based Mud Using a Synthetic Clay.

ACS Omega 2021 Mar 16;6(12):8179-8188. Epub 2021 Mar 16.

Department of Petroleum Engineering, College of Petroleum Engineering & Geosciences, King Fahd University of Petroleum & Minerals, 31261 Dhahran, Saudi Arabia.

Fluid homogeneity and stability are of high importance as they greatly affect the fluid performance in drilling operations. Solid settlement or solid sag is a severe issue that occurs in weighted drilling muds, especially at elevated temperatures, where the weight material tends to settle down causing well control problems. This study evaluates the effectiveness of a synthetic clay (laponite) to prevent the static and dynamic sag tendency of barite-weighted drilling fluid for elevated-temperature drilling applications. Read More

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Investigating the Impact of Collagen-Chitosan Derived from on Second-Degree Burn in Rats Model.

Regen Ther 2021 Dec 18;18:12-20. Epub 2021 Mar 18.

Department of Foreign Languages, Tehran University of Medical Sciences, Iran.

Background: The present study focused on burning as one of the main causes of mortality with detrimental economic and social effects in the world. The purpose of this study was to investigate the impact of collagen-chitosan gel extracted from and shrimp skin in the treatment of second degree burn healing among rats.

Materials & Method: To fulfill the purpose of the study, chitosan and collagen were extracted respectively from shrimp and skin waste by the acid-based method and were evaluated by using Pico Tag, SDS-PAGE. Read More

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December 2021

Protein-protein interactions at high concentrations: effects of ArgHCl and NaCl on the stability, viscosity and aggregation mechanisms of protein solution.

Int J Pharm 2021 Mar 31:120535. Epub 2021 Mar 31.

Key Laboratory of Drug Targeting and Novel Drug Delivery System Ministry of Education, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, PR China. Electronic address:

The aim of this work was to use the diffusion coefficient ration (D/D) as a parameter to characterize the stability of protein at high concentration, to compare the effects of ArgHCl and NaCl on the interaction of highly concentrated proteins under different pH conditions, and to explore the correlation with protein stability. For this purpose, a high-concentration bovine serum albumin solution (BSA) was selected as the model system, and the diffusion coefficient, aggregation degree, conformational stability, and solution viscosity of the protein were studied by dynamic light scattering (DLS) and spectral detection techniques. The result showed that there was a significant correlation between the D/D and the protein aggregation. Read More

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Development of Electrochemical DNA Biosensor for Equine Hindgut Acidosis Detection.

Sensors (Basel) 2021 Mar 26;21(7). Epub 2021 Mar 26.

School of Natural Sciences, Bangor University, Bangor, Gwynedd, Wales LL57 2UW, UK.

The pH drop in the hindgut of the horse is caused by lactic acid-producing bacteria which are abundant when a horse's feeding regime is excessively carbohydrate rich. This drop in pH below six causes hindgut acidosis and may lead to laminitis. Lactic acid-producing bacteria and have been found to produce high amounts of L-lactate and D-lactate, respectively. Read More

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A Gel Polymer Electrolyte Reinforced Membrane for Lithium-Ion Batteries via the Simultaneous-Irradiation of the Electron Beam.

Membranes (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department of Energy Engineering, Dankook University, Cheonan 31116, Korea.

In this research, a series of innovative and stable cross-linked gel polymer reinforced membranes (GPRMs), were successfully prepared and investigated for application in lithium-ion batteries. Herein, a gel directly within the commercial polyethylene (PE) separator is supported via electron-beam simultaneous irradiation cross-linking of commercial liquid electrolyte and poly(ethylene glycol) methacrylate (PEGMA) oligomers. The physical and electrochemical properties of the GPRMs were characterized by SEM, TEM, mechanical durability, heating shrinkage, and ion conductivity, etc. Read More

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Comparative Study on Pale, Soft and Exudative (PSE) and Red, Firm and Non-Exudative (RFN) Pork: Protein Changes during Aging and the Differential Protein Expression of the Myofibrillar Fraction at 1 h Postmortem.

Foods 2021 Mar 30;10(4). Epub 2021 Mar 30.

Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.

In this paper, the protein changes during aging and the differences in the myofibrillar protein fraction at 1 h postmortem of pale, soft and exudative (PSE), and red, firm and non-exudative (RFN) pork (LT) were comparatively studied. The PSE and RFN groups were screened out based on the differences in their pH and lightness () at 1 h, and their purge loss at 24 h postmortem. Based on the measured MFI, desmin degradation, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis, PSE meat presented more significant changes in the myofibrillar protein fraction compared to RFN meat during postmortem aging. Read More

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Multilayered Porous Titanium-Based 3rd Generation Biomaterial Designed for Endosseous Implants.

Materials (Basel) 2021 Mar 31;14(7). Epub 2021 Mar 31.

Department of Science and Technology, Faculty of Materials and Environmental Engineering, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania.

This work proposes a novel complex multi-layered material consisting of porous titanium as a substrate and a complex coating consisting of a chitosan film engulfing microsphere loaded with growth factors such as BMP2 (bone morphogenic protein 2) and IGF1 (insulin-like growth factor-1). The microspheres were obtained through deposition of dual layers of calcium cross linked pectin-chitosan/pectin polyelectrolyte onto a BSA (bovine serum albumin) gel core. The multilayer was conceived to behave like a 3rd generation biomaterial, by slow delivery of viable growth factors around implants, and to assist the healing of implantation wound and the development of new vital bone. Read More

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Obtaining and Properties of a Photocatalytic Composite Material of the "SiO-TiO" System Based on Various Types of Silica Raw Materials.

Nanomaterials (Basel) 2021 Mar 29;11(4). Epub 2021 Mar 29.

Moscow Automobile and Road Construction University, 125319 Moscow, Russia.

Compositions and technology for obtaining a photocatalytic composite material (PCM) by deposition of titanium dioxide particles synthesized by the sol-gel method on a silica support of various types (microsilica, gaize and diatomite) have been developed. The properties (chemical and mineral composition, dispersion, specific surface area, porosity, ζ-potential, acid-base properties, and microstructure) of microsilica, gaize and diatomite were studied to assess the effectiveness of using a photocatalytic agent as a carrier. In terms of specific viscosity (η = 45), the concentration of the precursor (tetrabutoxytitanium-TBT) is set at 22 vol. Read More

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Synthesis and Characterization of Silver-Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles.

Gels 2021 Mar 24;7(2). Epub 2021 Mar 24.

Department of Materials Science and Engineering, Institute of Space Technology Islamabad, Islamabad 44000, Pakistan.

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Read More

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Inorganic Fillers in Composite Gel Polymer Electrolytes for High-Performance Lithium and Non-Lithium Polymer Batteries.

Nanomaterials (Basel) 2021 Mar 1;11(3). Epub 2021 Mar 1.

Department of Chemical and Biological Engineering, Gachon University, Seongnam 13120, Korea.

Among the various types of polymer electrolytes, gel polymer electrolytes have been considered as promising electrolytes for high-performance lithium and non-lithium batteries. The introduction of inorganic fillers into the polymer-salt system of gel polymer electrolytes has emerged as an effective strategy to achieve high ionic conductivity and excellent interfacial contact with the electrode. In this review, the detailed roles of inorganic fillers in composite gel polymer electrolytes are presented based on their physical and electrochemical properties in lithium and non-lithium polymer batteries. Read More

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PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis.

Cells 2021 Mar 15;10(3). Epub 2021 Mar 15.

Department of Biosciences and Nutrition, Karolinska Institutet, 14157 Huddinge, Sweden.

Poly-ADP-ribose polymerase (PARP)-family ADP-ribosyltransferases function in various signaling pathways, predominantly in the nucleus and cytosol. Although PARP inhibitors are in clinical practice for cancer therapy, the enzymatic activities of individual PARP family members are yet insufficiently understood. We studied PARP10, a mono-ADP-ribosyltransferase and potential drug target. Read More

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Cyclosporine Lipid Nanocapsules as Thermoresponsive Gel for Dry Eye Management: Promising Corneal Mucoadhesion, Biodistribution and Preclinical Efficacy in Rabbits.

Pharmaceutics 2021 Mar 9;13(3). Epub 2021 Mar 9.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21523, Egypt.

An ophthalmic cyclosporine (CsA) formulation based on Lipid nanocapsules (LNC) was developed for dry eye management, aiming to provide targeting to ocular tissues with long-term drug levels and maximum tolerability. CsA-LNC were of small particle size (41.9 ± 4. Read More

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Local Use of Hydrogel with Amiodarone in Cardiac Surgery: Experiment and Translation to the Clinic.

Gels 2021 Mar 10;7(1). Epub 2021 Mar 10.

Bakulev National Medical Research Center for Cardiovascular Surgery, Department of Surgical Treatment for Interactive Pathology, Rublevskoe shosse 135, 121552 Moscow, Russia.

The objective of this study was to study the use of the hydrogel biopolymer based on sodium alginate ("Colegel") with a drug substance-amiodarone-for the prevention of postoperative atrial fibrillation (POAF) in cardiac surgery. The experimental part of the study was performed on 46 rabbits. Five groups were formed: in the first group, the dose of amiodarone in hydrogel was 1 mg; in the second group-3 mg; in the third group-6 mg; in the fourth group, hydrogel was used without amiodarone; in the fifth group, 60 mg amiodarone was administered intravenously. Read More

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Chloroaluminate Gel Electrolytes Prepared with Copolymers Based on Imidazolium Ionic Liquids and Deep Eutectic Solvent AlCl:Urea.

Polymers (Basel) 2021 Mar 27;13(7). Epub 2021 Mar 27.

Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

Polymer gel electrolytes (PGEs) have been prepared with copolymers based on imidazolium ionic liquids and the deep eutectic mixture of AlCl:urea (uralumina) as liquid electrolyte. The copolymers were synthesized by photopolymerization of vinylpirrolidone or methylmethacrylate with imidazolium bis (trifluoromethane sulfonyl) imide (TFSI) ionic liquid monomer and mixed in an increasing range of wt.% with uralumina. Read More

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Analysis of Genes and Insertion Sequences Related to Carbapenem Resistance in Clinical Strains Isolated in Warsaw, Poland.

Int J Mol Sci 2021 Mar 2;22(5). Epub 2021 Mar 2.

Department of Pharmaceutical Microbiology, Medical University of Warsaw, PL 02-097 Warsaw, Poland.

is an important cause of nosocomial infections worldwide. The elucidation of the carbapenem resistance mechanisms of hospital strains is necessary for the effective treatment and prevention of resistance gene transmission. The main mechanism of carbapenem resistance in is carbapenemases, whose expressions are affected by the presence of insertion sequences (ISs) upstream of genes. Read More

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Experimental Study of High Performance Synchronous Grouting Materials Prepared with Clay.

Materials (Basel) 2021 Mar 11;14(6). Epub 2021 Mar 11.

School of Civil Engineering, Beijing Jiaotong University, Beijing 100044, China.

Shield construction discharges a large amount of soil and muck. The utilization of discharged soil of shield always has high energy consumption and a low utilization rate. Meanwhile, synchronous grouting is a key process for shield tunneling. Read More

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Insights into the Action Mechanism of the Antimicrobial Peptide Lasioglossin III.

Int J Mol Sci 2021 Mar 11;22(6). Epub 2021 Mar 11.

Department of Chemical Sciences, University of Naples Federico II, Via Cintia, 4, 80126 Naples, Italy.

Lasioglossin III (LL-III) is a cationic antimicrobial peptide derived from the venom of the eusocial bee . LL-III is extremely toxic to both Gram-positive and Gram-negative bacteria, and it exhibits antifungal as well as antitumor activity. Moreover, it shows low hemolytic activity, and it has almost no toxic effects on eukaryotic cells. Read More

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Dispersions of Zirconia Nanoparticles Close to the Phase Boundary of Surfactant-Free Ternary Mixtures.

Langmuir 2021 Apr 2. Epub 2021 Apr 2.

Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy.

The achievement of a homogeneous dispersion of nanoparticles is of paramount importance in supporting their technological application. In wet processing, stable dispersions were largely obtained via surfactant or surface functionalization: although effective, the use of dispersant can alter, or even impair, the functional properties of the resulting nanostructured systems. Herein, we report a novel integrated modeling and experimental approach to obtain stable ZrO nanoparticle (NP) dispersions at native dimensions (about 5 nm) in homogeneous ternary mixtures of solvents (i. Read More

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Laser-Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split-Face Study in France.

Lasers Surg Med 2021 Apr 1. Epub 2021 Apr 1.

Dermatologic Laser Center, Hôpital de la Conception, Aix-Marseille Univ., APHM, 13005, Marseille, France.

Background And Objectives: Combining the efficacy of ablative fractional carbon dioxide lasers (AFXL) to laser-assisted hyaluronic acid delivery (LAHAD) has not yet been studied. The objective of our study was to evaluate the safety and the efficacy of laser-assisted hyaluronic acid (HA) delivery with AFXL in facial skin remodeling.

Study Design/materials And Methods: We conducted a prospective, double-blinded, randomized split-face study on 20 patients from 30 to 70 years old, with a skin phototype from I to IV. Read More

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Multiresistant and bla-Carrying Salmonella ser. Typhimurium Isolated During a Salmonellosis Outbreak in an Equine Hospital in Argentina.

J Equine Vet Sci 2021 Apr 3;99:103404. Epub 2021 Feb 3.

Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Enfermedades Infecciosas, Argentina.

Salmonella spp. causes digestive clinical signs in horses. Foals and hospitalized animals are more susceptible to the disease. Read More

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Cu vacancies enhanced photoelectrochemical activity of metal-organic gel-derived CuO for the detection of l-cysteine.

Talanta 2021 Jun 3;228:122261. Epub 2021 Mar 3.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

Defect engineering in the photoelectrochemical (PEC) process of photoelectrodes has been extensively studied. But insufficient attention has been received about the impact of metal vacancies (V) in PEC process. Herein, the influence of Cu vacancies (V) on PEC performance of copper oxide (CuO) derived from Cu-based metal-organic gel (Cu-MOG) precursor was reported. Read More

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Purification of rad-waste arising from irradiated natural tin target towards tellurium-125m/antimony-125 radioisotope generator elaboration.

Appl Radiat Isot 2021 Mar 18;172:109690. Epub 2021 Mar 18.

Analytical Chemistry Department, Hot Laboratories and Waste Management Center, Atomic Energy Authority, Cairo, Egypt; Radioactive Waste Management Unit, Hot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority, Cairo, Egypt. Electronic address:

The present study introduces a new approach based on an irradiated tin target's impurity to produce aSb/Te radioisotope generator. A prepared generator gel matrix of zirconium-silico-tungstate was loaded with 6660 MBq (180 mCi) activity of the separated antimony. The loading and elution method has been studied as a function of the concentration of HSO acid solution. Read More

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Rotenone-induced necrosis in insect cells via the cytoplasmic membrane damage and mitochondrial dysfunction.

Pestic Biochem Physiol 2021 Mar 11;173:104801. Epub 2021 Feb 11.

Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Rotenone, a selective inhibitor of mitochondrial complex I, has been extensively studied on kinds of neuron and neuroblast in Parkinson's disease. However, little is known about the potential mechanism of this promising botanical insecticide upon insect cells. In the article, cell proliferation of two Lepidoptera cell lines, Spodoptera litura SL-1 cells and Spodoptera frugiperda Sf9 cells, were all inhibited by rotenone in a time- and dose-dependent manner. Read More

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Wearable lignin-based hydrogel electronics: A mini-review.

Int J Biol Macromol 2021 Mar 22;181:45-50. Epub 2021 Mar 22.

College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou City, Fujian Province 350002, People's Republic of China; Limerick Pulp and Paper Centre, Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B5A3, Canada. Electronic address:

In recent years, various biomacromolecule-based hydrogels have been extensively and deeply studied in the field of wearable electronics. However, the application of lignin-based hydrogels in flexible devices is still in its infancy. This is mainly due to the significant differences in physical and chemical properties of industrially extracted lignin. Read More

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