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The promiscuous potential of cellulase in degradation of polylactic acid and its jute composite.

Chemosphere 2021 Apr 1;278:130443. Epub 2021 Apr 1.

Swedish Centre for Resource Recovery, University of Borås, Borås, Sweden.

It has been suggested that cellulolytic enzymes can be effective on the degradation of PLA samples. The idea was investigated by examining the impact of cellulase on degradation of PLA and PLA-jute (64/36) composite in an aqueous medium. The obtained results demonstrated 55% and 61% thickness reduction in PLA and PLA-jute specimens after four months of treatment, respectively. Read More

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Rescue of Failed XEN-45 Gel Implant by Nd: YAG Shock Wave to Anterior Chamber Tip to Dislodge Hidden Intraluminal Occlusion.

J Glaucoma 2021 Apr 6. Epub 2021 Apr 6.

Glaucoma Associates of Texas, Dallas, Texas.

Purpose: To inform ophthalmic surgeons in a timely manner of the hidden problem of clear intraluminal cellular debris as a cause for XEN-45 failure and to describe low energy neodymium-doped yttrium aluminum garnet (Nd:YAG) laser revision with periluminal anterior chamber tip shockwave treatment to improve flow to the bleb.

Patients And Methods: Six patients with visibly patent stent lumen post XEN-45 surgery. These eyes developed rising intraocular pressure (IOP) with a history of excellent prior bleb formation and were treated successfully with Nd:YAG laser shockwave therapy to disperse assumed intraluminal cellular debris. Read More

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Outcomes of Repository Corticotropin Gel for Ocular Sarcoidosis.

Ocul Immunol Inflamm 2021 Apr 7:1-5. Epub 2021 Apr 7.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.

: To evaluate the utility and side effect profile of subcutaneous repository corticotropin gel (RCI) in ocular sarcoidosis. Retrospective chart review. Among six identified patients on RCI therapy, 4 had uveitis, one had optic neuritis and one had uveitis and optic neuritis secondary to sarcoidosis. Read More

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Postoperative complications of Ab-Interno XEN implantation in primary angle closure glaucoma.

Am J Clin Exp Immunol 2021 15;10(1):44-47. Epub 2021 Feb 15.

Wilmer Eye Institute, Johns Hopkins Medical Institute Bethesda 20817, Maryland.

The XEN Gel Stent offers a unique Ab-interno approach for managing glaucoma and has shown a favorable risk profile relative to traditional trabeculectomy. XEN implantation has almost exclusively been reported in patients with open angle glaucoma and data in patients with angle closure glaucoma is limited. We report a postoperative complication of the XEN Gel Stent in a patient with primary angle closure glaucoma. Read More

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February 2021

Bacterial Re-Colonization Occurs Early after Lung Transplantation in Cystic Fibrosis Patients.

J Clin Med 2021 Mar 19;10(6). Epub 2021 Mar 19.

Department of Cardiology, Section for Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.

Most cystic fibrosis (CF) patients referred for lung transplantation are chronically infected with Gram-negative opportunistic pathogens. It is well known that chronic infections in CF patients have a significant impact on lung-function decline and survival before transplantation. The rate and timing of re-colonization after transplantation have been described, but the impact on survival after stratification of bacteria is not well elucidated. Read More

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Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation.

Pharmaceutics 2021 Mar 3;13(3). Epub 2021 Mar 3.

Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, 1649-003 Lisbon, Portugal.

Innovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a fusion-emulsification method, to increase skin permeation and in vivo activity of two relevant NSAIDs: A liquid molecule (etofenamate) and a solid one (ibuprofen), formulated in a 2% hydroxypropyl methylcellulose gel through the gelation of SLN suspensions. Compritol 888 ATO and Tween 80 were used as a solid lipid and a surfactant, respectively. Read More

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Potential of Tailored Amorphous Multiporous Calcium Silicate Glass for Pulp Capping Regenerative Endodontics - A Preliminary Assessment.

J Dent 2021 Mar 30:103655. Epub 2021 Mar 30.

University of Tennessee Health Science Center, College of Dentistry, Department of Bioscience Research, Memphis, TN, 38163, United States. Electronic address:

Introduction/objective: The tailored amorphous multi-porous (TAMP) material fabrication technology has led to a new class of bioactive materials possessing versatile characteristics. It has not been tested for dental applications. Thus, we aimed to assess its biocompatibility and ability to regenerate dental mineral tissue. Read More

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Translating Evidence to Advanced Parkinson's Disease Patients: A Systematic Review and Meta-Analysis.

Mov Disord 2021 Apr 2. Epub 2021 Apr 2.

Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.

In the advanced stages of Parkinson's disease (PD), patients frequently experience disabling motor complications. Treatment options include deep brain stimulation (DBS), levodopa-carbidopa intestinal gel (LCIG), and continuous subcutaneous apomorphine infusion (CSAI). Choosing among these treatments is influenced by scientific evidence, clinical expertise, and patient preferences. Read More

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Ten-Year Safety Data for Eurosilicone's Round and Anatomical Silicone Gel Breast Implants.

Aesthet Surg J Open Forum 2019 Jun 27;1(2):ojz012. Epub 2019 Apr 27.

GC Aesthetics (the parent company of Eurosilicone), Glasgow, UK.

Background: Although silicone breast implants have been available for over 60 years, their safety and efficacy continue to be assessed via long-term clinical and vigilance studies. Complications often associated with breast implant surgery include but are not limited to capsular contracture and rupture.

Objective: The authors investigate and evaluate the safety and performance of Eurosilicone's (Eurosilicone S. Read More

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Dysmenorrhoea as a risk factor for pain with intrauterine device insertion.

BMJ Sex Reprod Health 2021 Mar 31. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, Division of Family Planning Services and Research, Stanford University School of Medicine, Stanford, California, USA.

Background: Understanding predictors of pain with gynaecological procedures may facilitate individualised counselling and pain management. We aimed to study the effect of dysmenorrhoea on intrauterine device (IUD) insertion pain.

Methods: This was a planned secondary analysis of a randomised trial evaluating self-administered lidocaine gel versus placebo for IUD insertion pain. Read More

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Clinical Application of Stromal Vascular Fraction Gel in Unilateral Vocal Fold Paralysis.

J Voice 2021 Mar 27. Epub 2021 Mar 27.

Department of Otolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China. Electronic address:

Purpose: To investigate the therapeutic effect of the stromal vascular fraction gel (SVF gel) in unilateral vocal fold paralysis.

Methods: A retrospective study was performed on 22 patients who underwent SVF gel autotransplantation for unilateral vocal fold paralysis between June 2017 and December 2018. Fat was removed from the medial thigh under anesthesia and the SVF gel was prepared using standard techniques and injected using a suspension microlaryngoscopy. Read More

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Nano-Bio Fusion Gingival Gel in the management of fixed orthodontic treatment-induced gingivitis: An empirical study.

Am J Orthod Dentofacial Orthop 2021 Mar 24. Epub 2021 Mar 24.

Periodontics Department, College of Dentistry, Jouf University, Sakākā, Saudi Arabia.

Introduction: This research aimed to investigate the effect of Nano-Bio Fusion Gingival Gel ([NBFG] NanoCgureTech, Gangdong-gu, Seoul, Korea) as an aid along with oral hygiene advice and routine scaling in patients with malocclusion to control treatment-induced gingivitis and periodontitis in patients undergoing fixed orthodontic treatment.

Methods: A split-mouth design, prospective analysis after application of NBFG in 32 subjects with fixed orthodontic treatment-induced gingivitis was conducted. Patients applied NBFG to their gingiva twice daily, after brushing, for 90 consecutive days. Read More

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Vaginal treatment with lactic acid gel delays relapses in recurrent urinary tract infections: results from an open, multicentre observational study.

Arch Gynecol Obstet 2021 Mar 27. Epub 2021 Mar 27.

German Centre for Infections in Obstetrics and Gynecology, Wuppertal, Germany.

Purpose: The main objective of this open, prospective, multicentre, observational study is to investigate the relapse rate and tolerability of lactic acid gels in adult female patients with recurrent urinary tract infections during routine practice.

Methods: Data were collected from patients undergoing intermittent short courses of intravaginal treatment with lactic acid gel for prevention of recurrent urinary tract infections. The observation period for individual patients was 4 months, aimed at covering four short courses of intravaginal treatment. Read More

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Development of Thermosensitive Hydrogel Wound Dressing Containing Acinetobacter baumannii Phage against Wound Infections.

Int J Pharm 2021 Mar 22:120508. Epub 2021 Mar 22.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. Electronic address:

With the emergence of multidrug resistance (MDR) bacteria, wound infection continues to be a challenging problem and represents a considerable healthcare burden. This study aims to evaluate the applicability of a phage loaded thermosensitive hydrogel in managing wound infections caused by MDR Acinetobacter baumannii, using IME-AB2 phage and MDR-AB2 as the model phage and bacteria, respectively. Excellent storage stability of the IME-AB2 phage in a ∼18 wt% Poloxamer 407 (P407) hydrogel solution was first demonstrated with negligible titer loss (∼0. Read More

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Efficacy of platelet-poor plasma gel in combination with fractional CO laser in striae distensae: A clinical, histological, and immunohistochemical study.

J Cosmet Dermatol 2021 Mar 25. Epub 2021 Mar 25.

Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Platelet-poor plasma gel is a semi-solid plasma formulation that recently recommended as autologous bio-filler for treatment of atrophic dermal scars.

Aim: To compare the therapeutic efficacy and safety of intradermal injection of plasma gel in combination with fractional CO laser versus fractional CO laser alone in striae distensae (SD).

Patients And Methods: This study included 36 SD patients treated by three sessions (one session/1. Read More

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Microparticle Encapsulation of a Tuberculosis Subunit Vaccine Candidate containing a Nanoemulsion Adjuvant via Spray Drying.

Eur J Pharm Biopharm 2021 Mar 19. Epub 2021 Mar 19.

Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada. Electronic address:

Spray drying is a technique that can be used to stabilize biopharmaceuticals, such as vaccines, within dry particles. Compared to liquid pharmaceutical products, dry powder has the potential to reduce costs associated with refrigerated storage and transportation. In this study, spray drying was investigated for processing an adjuvanted tuberculosis subunit vaccine, formulated as an oil-in-water nanoemulsion, into a dry powder composed of microparticles. Read More

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Efficacy of a Coriolus versicolor-Based Vaginal Gel in Women With Human Papillomavirus-Dependent Cervical Lesions: The PALOMA Study.

J Low Genit Tract Dis 2021 Apr;25(2):130-136

Private Practice, Palma, Spain.

Objective: The aim of the study was to evaluate the efficacy of Papilocare, a Coriolus versicolor-based vaginal gel, in repairing human papillomavirus (HPV)-related low-grade cervical lesions.

Methods: The study is a multicenter, open-label, randomized, parallel-group, watchful waiting approach-controlled trial involving 91 HPV-positive women with low-grade Pap smear alterations and consistent colposcopy.

Results: The percentage of patients with normal Pap smear and concordant colposcopy 3 and 6 months after receiving treatment (78. Read More

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The effect of silica desiccation under different storage conditions on filter-immobilized environmental DNA.

BMC Res Notes 2021 Mar 21;14(1):106. Epub 2021 Mar 21.

Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

Objective: Silica gel beads have promise as a non-toxic, cost-effective, portable method for storing environmental DNA (eDNA) immobilized on filter membranes. Consequently, many ecological surveys are turning to silica bead filter desiccation rather than ethanol preservation. However, no systematic evaluation of silica bead storage conditions or duration past 1 week has been published. Read More

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Evaluation of the efficacy of platelet-rich plasma on healing of clean diabetic foot ulcers: A randomized clinical trial in Tehran, Iran.

Diabetes Metab Syndr 2021 Mar-Apr;15(2):621-626. Epub 2021 Mar 10.

Clinical Research and Development Center at Shahid Modarres Hospital, Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: Diabetic foot ulcers (DFUs) are among challenging hurdles both for the patient and the physician. There is a recent trend toward finding novel and clinically efficient modalities to treat this potentially hazardous complication of diabetes mellitus in a timely manner. Herein, we aim to appraise the efficacy of platelet-rich plasma (PRP) in healing of clean DFUs. Read More

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Design and evaluation of microemulsion-based efinaconazole formulations for targeted treatment of onychomycosis through transungual route: Ex vivo and nail clipping studies.

Colloids Surf B Biointerfaces 2021 Feb 19;201:111652. Epub 2021 Feb 19.

Amneal Pharmaceutical Pvt Ltd., Ahmedabad, Gujarat, India.

The onychomycosis treatment remains a big challenge for onychologist due to the shorter nail residence time of topical formulations and the lack of availability of novel formulations in markets for new generation antifungal drugs. The objective of this work was to design, develop, optimize, and evaluate microemulsion formulations for effective delivery of efinaconazole through transungual route in onychomycosis treatment. Capmul® MCM (Glyceryl Caprylate/Caprate) as oil, Labrasol® (caprylocaproyl polyoxyl-8 glycerides) as a surfactant, and Transcutol® P (diethylene glycol monoethyl ether) as co-surfactant exhibited higher solubility of efinaconazole and surfactant-cosurfactant mixture (Smix) in a ratio of 1:1 rendered higher microemulsion region in the pseudo-ternary phase diagram. Read More

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February 2021

Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections.

PLoS One 2021 19;16(3):e0248857. Epub 2021 Mar 19.

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was to design, formulate and evaluate ion-activated in situ gel to enhance the ocular penetration and therapeutic performance of moxifloxacin in ophthalmic delivery. A simplex lattice design was utilized to examine the effect of various factors on experimental outcomes of the in situ gel system. Read More

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Evaluation of a New Tubular Finger Oxygen-Enriched Oil Inside-Coated Dressing Device in Pediatric Patients Undergoing Distal Hypospadias Repair: A Prospective Randomized Clinical Trial Part II.

Front Pediatr 2021 2;9:638406. Epub 2021 Mar 2.

Division of Pediatric Surgery, Federico II University of Naples, Naples, Italy.

This study was the second part of a prospective randomized clinical trial and aimed to evaluate the use of a tubular finger oxygen-enriched oil inside-coated dressing device and its effect on the post-operative outcome of children undergoing distal hypospadias repair. A prospective single-blinded randomized clinical trial was carried out between September 2019 and September 2020. We included all patients with distal hypospadias, who received Snodgrass urethroplasty and preputioplasty. Read More

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Ab-Externo Implantation of XEN Gel Stent for Refractory Steroid-Induced Glaucoma After Lamellar Keratoplasty.

Cureus 2021 Feb 12;13(2):e13320. Epub 2021 Feb 12.

Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

The hazy corneal donor-recipient interface after corneal transplant may cause difficulties when implanting the XEN gel stent via ab-interno approach. We aim to describe XEN gel stent implantation via ab-externo approach in refractory steroid-induced glaucoma after corneal lamellar keratoplasty. Under local anaesthesia, the XEN injector needle was inserted 7 mm behind the limbus with the bevel facing up, directly beneath the conjunctiva and advanced to the marked 2. Read More

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February 2021

Effects of Ab Interno XEN Gel Implantation on Postural Intraocular Pressure Elevations.

Semin Ophthalmol 2021 Mar 18:1-6. Epub 2021 Mar 18.

Department of Ophthalmology, University of Health Sciences Haydarpasa Education and Research Hospital, Istanbul, Turkey.

: The aim of this study was to analyze the postural intraocular pressure (IOP) changes in open-angle glaucoma after ab interno XEN gel implant surgery and to compare them with the changes observed with trabeculectomy and medical treatment.: The study sample included 18 patients with XEN gel implants, 30 patients who had trabeculectomy, and 30 medically managed glaucoma patients. All patients in XEN gel implant and trabeculectomy groups had at least 11 months of follow-up and had successful surgeries that resulted in medication-free control of IOP. Read More

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Two-Year Follow-Up: Therapeutic Success with Respect to Axial Length of Stand-Alone Xen45 Gel Stent Implantation and Combined Procedures.

Klin Monbl Augenheilkd 2021 Mar 17. Epub 2021 Mar 17.

Augenklinik, Universitätsklinikum Erlangen, Erlangen, Germany.

Background: Up to now, no data have been available on the therapeutic success rate of Xen45 gel stent with respect to axial length (AL). The present study aimed to investigate a potential influence of AL on therapeutic success in stand-alone Xen45 gel stent implantation or combination with cataract surgery in open-angle glaucoma patients (OAG) with a follow-up of 2 years.

Materials And Methods: In this retrospective observational study, 98 eyes of 87 glaucoma patients of the Department of Ophthalmology, University of Erlangen Nürnberg, and from the Erlangen Glaucoma Registry (NCT00494923; ISSN 2191-5008, CS-2011) underwent stand-alone Xen45 gel stent implantation or a combination with cataract surgery. Read More

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Therapeutic Efficacy of Cryopreserved, Allogeneic Extracellular Vesicles for Treatment of Acute Myocardial Infarction.

Int Heart J 2021 Mar 17;62(2):381-389. Epub 2021 Mar 17.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania.

Extracellular vesicles (EV) that are derived from endothelial progenitor cells (EPC) have been determined to be a novel therapy for acute myocardial infarction, with a promise for immediate "off-the-shelf" delivery. Early experience suggests delivery of EVs from allogeneic sources is safe. Yet, clinical translation of this therapy requires assurances of both EV stability following cryopreservation and absence of an adverse immunologic response to EVs from allogeneic donors. Read More

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Testosterone therapy and bone quality in men with diabetes and hypogonadism: Study design and protocol.

Contemp Clin Trials Commun 2021 Mar 20;21:100723. Epub 2021 Jan 20.

Endocrinology, Diabetes, and Metabolism Section, Department of Medicine at Baylor College of Medicine, Houston, TX, USA.

Context: Type 2 diabetes mellitus (T2D) is often accompanied by male hypogonadism and both conditions are associated with increased risk for fractures. Testosterone (T) has been shown to improve the bone health of hypogonadal men but has not been tested in patients who also have T2D in addition to low T. To date, there is no treatment that is specifically recommended for bone disease among patients with T2D. Read More

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Injectable semi rigid penile prosthesis: study in rabbits and future perspectives.

Transl Androl Urol 2021 Feb;10(2):841-850

Head of Urology Department, Federal University of Pernambuco, Recife, Brazil.

Background: Penile prostheses are the third option in the treatment of erectile dysfunction, however, despite their proven effectiveness, the occurrence of infections, advanced age of patients and comorbidities are the main limiting factors for this treatment modality. In the continuous search for biointegrated, clinically durable and minimally invasive treatment options, a possible model of penile prosthesis was sought through the use of intracavernous bacterial cellulose (BC) gel, in an experimental model of orchiectomized rabbits.

Methods: Thirty adult New Zealand rabbits were equally distributed into three groups: BC; vehicle and control. Read More

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February 2021

Impact of changes of horse movement regulations on the risks of equine infectious anemia: A risk assessment approach.

Prev Vet Med 2021 Mar 3;190:105319. Epub 2021 Mar 3.

Laboratory of Veterinary Epidemiology (Epilab), Department of Preventive Veterinary Medicine, Universidade Federal do Rio Grande do Sul, RS, Brazil.

Equine infectious anemia virus (EIAV) is a transboundary disease affecting a large number of equines worldwide. In this study, we assessed the transmission risk of EIAV in Rio Grande do Sul, Brazil. Serum samples from 1010 animals from 341 farms were initially analyzed using agar gel immunodiffusion to detect viral antibodies, and no antibody-positive animals were found. Read More

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Measurement of Three-Dimensional Internal Dynamic Strains in the Intervertebral Disc of the Lumbar Spine With Mechanical Loading and Golden-Angle Radial Sparse Parallel-Magnetic Resonance Imaging.

J Magn Reson Imaging 2021 Mar 13. Epub 2021 Mar 13.

Bernard and Irene Schwartz Center for Biomedical Imaging (CBI), New York University School of Medicine, New York, New York, USA.

Background: Noninvasive measurement of internal dynamic strain can be potentially useful to characterize spine intervertebral disc (IVD) in the setting of injury or degenerative disease.

Purpose: To develop and demonstrate a noninvasive technique to quantify three-dimensional (3D) internal dynamic strains in the IVD using a combination of static mechanical loading of the IVD using a magnetic resonance imaging (MRI)-compatible ergometer.

Study Type: Prospective. Read More

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