1,332 results match your criteria gds medical


Early efficacy of teprotumumab for the treatment of dysthyroid optic neuropathy: A multicenter study.

Am J Ophthalmol Case Rep 2021 Sep 14;23:101111. Epub 2021 May 14.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Purpose: To study post-interventional findings in patients with dysthyroid optic neuropathy (DON) treated with teprotumumab.

Observations: In this multicenter observational Case series patients with DON were treated with teprotumumab, an insulin-like growth factor I receptor inhibitor (10 mg/kg for the first infusion then 20 mg/kg for subsequent infusions, every three weeks for a total 8 infusions). This study included patients with acute and chronic thyroid eye disease (TED) with DON who had failed conventional therapies and were not candidates for surgical decompression. Read More

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September 2021

Impact of COVID-19 on the incidence of cardiac arrhythmias in implantable cardioverter defibrillator recipients followed by remote monitoring.

Arch Cardiovasc Dis 2021 May 24. Epub 2021 May 24.

Department of Cardiology and Vascular Diseases, CHU de Rennes, 35000 Rennes, France.

Background: The coronavirus disease 2019 (COVID-19) has been a fast-growing worldwide pandemic.

Aims: We aimed to investigate the incidence of cardiac arrhythmias among a large French cohort of implantable cardioverter defibrillator recipients over the first 5 months of 2020.

Methods: Five thousand nine hundred and fifty-four implantable cardioverter defibrillator recipients were followed by remote monitoring during the COVID-19 period (from 01 January to 31 May 2020). Read More

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An 18-year retrospective study on the epidemiology of early-onset neonatal sepsis - emergence of uncommon pathogens.

Pediatr Neonatol 2021 May 17. Epub 2021 May 17.

Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, Taiwan. Electronic address:

Background: Nationwide group B Streptococcus agalactiae (GBS) antepartum screening was instituted in Taiwan in 2012. The impact of the policy on early-onset sepsis (EOS) has not been evaluated. This study aimed to examine the impact of the policy on the incidence of neonatal EOS. Read More

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Psychiatric morbidity, Stress and Quality of Life Among Geriatric Dermatology Patients: Therapeutic Considerations from an Indian Perspective.

Dermatol Ther 2021 Jun 2:e15018. Epub 2021 Jun 2.

Central Michigan University, Saginaw, Michigan, USA.

We aimed to determine the prevalence of psychiatric morbidities, stress and quality of life, the pattern of skin diseases and associated psychosocial factors in geriatric population. Patients aged 60 years and older were recruited. Demographics and dermatological history and findings were collected using a preset Proforma. Read More

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Interferon Gamma Neutralization Reduces Blood Pressure, Uterine Artery Resistance Index, and Placental Oxidative Stress in Placental Ischemic Rats.

Am J Physiol Regul Integr Comp Physiol 2021 06 2. Epub 2021 Jun 2.

Departments of Pharmacology and Toxicology, University of Mississippi Medical Center, United States.

Preeclampsia (PE) is characterized by maternal hypertension, intrauterine growth restriction, increased cytolytic natural killer cells (cNKs), which secrete interferon gamma (IFNγ). However, the precise role of IFNγ in contributing to PE pathophysiology remains unclear. Using the Reduced Uterine Perfusion Pressure (RUPP) rat model of placental ischemia, we tested the hypothesis that neutralization of IFNγ in RUPPs will decrease placental reactive oxygen species (ROS) and improve vascular function resulting in decreased MAP and improved fetal growth. Read More

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The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.

Sleep Med 2021 Apr 3;83:280-289. Epub 2021 Apr 3.

Department of Neurology, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China; Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350001, Fujian, China; Department of Clinical Medicine, Fujian Medical University, Fuzhou 350001, Fujian, China. Electronic address:

Background: Depression and sleep disturbance are well-recognized non-motor features in patients with Parkinson's disease (PD). This meta-analysis aimed to explore the potential role of bright light therapy (BLT) in depression and sleep disturbances in Parkinson's Disease (PD).

Methods: Four databases were independently searched by two reviewers: PubMed, Cochrane, Web of Science and Embase until February 2021. Read More

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Tumor Necrosis Factor-alpha Blockade Improves Uterine Artery Resistance, Maternal Blood Pressure, and Fetal Growth in Placental Ischemic Rats.

Pregnancy Hypertens 2021 May 14;25:39-47. Epub 2021 May 14.

Departments of Pharmacology and Toxicology, University of Mississippi Medical Center, United States; Emergency Medicine, University of Mississippi Medical Center, United States. Electronic address:

We recently reported that adoptive transfer of cytolytic Natural Killer cells (cNKs) from the Reduced Uterine Perfusion Pressure (RUPP) rat induces a preeclampsia (PE)-like phenotype in pregnant rats, accompanied by increased TNF-α. The purpose of this study was to investigate a role for increased TNF-α to induce oxidative stress (ROS), decrease nitric oxide (NO) bioavailability, and induce vascular dysfunction as mechanisms of hypertension (HTN) and intrauterine growth restriction (IUGR) in RUPPs. Pregnant Sprague Dawley rats underwent the RUPP or a Sham procedure on gestation day (GD) 14. Read More

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Validation of the Parkinson's Disease Caregiver Burden Questionnaire in Progressive Supranuclear Palsy.

Parkinsons Dis 2021 10;2021:9990679. Epub 2021 May 10.

Department of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover 30625, Germany.

Progressive supranuclear palsy (PSP) is an atypical Parkinson syndrome with axial akinetic-rigid symptoms, early postural instability, and ocular motor impairments. Patients experience a rapid loss of autonomy and care dependency; thus, caregivers must assist in the activities of daily living early in the course of the disease. Caregiver burden is an extremely important factor in disease management. Read More

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Specific cortical and subcortical grey matter regions are associated with insomnia severity.

PLoS One 2021 26;16(5):e0252076. Epub 2021 May 26.

Department of Neurology, Memory & Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, United States of America.

Background: There is an increasing awareness that sleep disturbances are a risk factor for dementia. Prior case-control studies suggested that brain grey matter (GM) changes involving cortical (i.e, prefrontal areas) and subcortical structures (i. Read More

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Development of a Neuropsychological Test to Evaluate Cognitive Flexibility.

Yonago Acta Med 2021 May 17;64(2):162-167. Epub 2021 Mar 17.

Department of Clinical Psychology, Tottori University Graduate School of Medical Sciences, Yonago 683-8503, Japan.

Background: Cognitive flexibility is also referred to as set-shifting and is considered to be an important activity of the frontal lobe. The objective of this study was to produce a Cognitive Flexibility Test (CFT) that can evaluate cognitive flexibility in a short time and in a simple manner and to verify the usefulness of the test.

Methods: The CFT, Mini Mental State Examination (MMSE), Verbal Fluency Test (VFT), and Geriatric Depression Scale 15 (GDS-15) were implemented among a total of 94 elderly people who live at home. Read More

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Functional outcomes following inpatient rehabilitation of guillain-barré syndrome patients: Intravenous immunoglobulins versus plasma exchange.

NeuroRehabilitation 2021 May 19. Epub 2021 May 19.

Department of Neurological Rehabilitation, The Chaim Sheba Medical Center, Tel Hashomer, Israel.

Background: Treatment with either Intravenous immunoglobulin (IVIg) or plasma exchange (PE) in patients with Guillain-Barré Syndrome (GBS) showed equivalent efficacy as attested by a commonly used disability scale. However, it has been suggested that this scale may not be sensitive enough to detect subtle functional changes between the two treatments since it mainly focuses on walking capability and respiratory function.

Objective: To evaluate functional outcomes following treatment with IVIg or PE using comprehensive scales that incorporate parameters of basic activities of daily living. Read More

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Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes.

Int J Geriatr Psychiatry 2021 May 19. Epub 2021 May 19.

Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Objectives: The APOE-ε4 genotype has been associated with old-age depression, but this relationship has been rarely investigated in type 2 diabetes (T2D) older adults, who are at significantly increased risk for depression, a major contributor to T2D complications. We examined whether trajectories of depression symptoms over time differ by APOE-ε4 genotype in older adults with T2D.

Methods: Participants (n = 754 [13. Read More

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Reasons for intending to accept or decline kidney cancer screening: thematic analysis of free text from an online survey.

BMJ Open 2021 05 18;11(5):e044961. Epub 2021 May 18.

The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, Cambridgeshire, UK

Objectives: Kidney cancer has been identified as a disease for which screening might provide significant benefit for patients. The aim of this study was to understand in detail the facilitators and barriers towards uptake of a future kidney cancer screening programme, and to compare these across four proposed screening modalities.

Design: An online survey including free-text responses. Read More

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Needs of older persons living in long-term care institutions: on the usefulness of cluster approach.

BMC Geriatr 2021 05 17;21(1):316. Epub 2021 May 17.

Department of Mental Health, Chair of Psychiatry, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572, Poznan, Poland.

Background: Long-term care units' residents do not constitute a homogeneous population. Providing effective care, tailored to individual needs, is crucial in this context. It can be facilitated by suitable tools and methods, which include needs assessment along with the physical, psychological and social aspects of care. Read More

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Anxiety in Parkinson's Disease: Correlation with Depression and Quality of Life.

J Neurosci Rural Pract 2021 Apr 24;12(2):323-328. Epub 2021 Mar 24.

Department of Critical Care Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

 Anxiety is common in patients with Parkinson's disease (PD). Its prevalence ranges from 20 to 40% but despite that, the high prevalence anxiety in PD is often undiagnosed and untreated. This research was aimed to study the pattern of anxiety with regard to its prevalence and risk factors and to establish the association of anxiety with depression and quality of life (QOL) in patients with PD. Read More

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Health-related quality of life in elderly, multimorbid individuals with and without depression and/or mild cognitive impairment using a telemonitoring application.

Qual Life Res 2021 May 13. Epub 2021 May 13.

Department of Psychiatry, Psychotherapy and Psychosomatics, Alexianer Hospital Hedwigshöhe, St. Hedwig Hospital Berlin, Berlin, Germany.

Purpose: Multimorbidity leads to decreasing health-related quality of life (HRQoL). Telemedicine may help to improve HRQoL. The present study was conducted to show (I) differences in HRQoL and changes in HRQoL over time in elderly, multimorbid individuals with and without depression and/or mild cognitive impairment (MCI) using a telemonitoring application (TMA) and (II) associations between engagement with measurements by study participants using a TMA and changes in their HRQoL. Read More

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Favorable Effects of 24-Week Whole-Body Vibration on Glycemic Control and Comprehensive Diabetes Therapy in Elderly Patients with Type 2 Diabetes.

Diabetes Ther 2021 Jun 12;12(6):1751-1761. Epub 2021 May 12.

Tokuyama Clinic, Chiba, Japan.

Background: Elderly patients with type 2 diabetes (T2DM) are vulnerable to treatment-inducible hypoglycemia, falls, and depressive symptoms. Although it is challenging for elderly patients to adhere to regular exercise, its positive effect on functional ability, glycemic control, and mental wellness offers comprehensive diabetes treatment. In the present study, we aimed to investigate a novel exercise approach for the elderly, focusing on whole-body vibration (WBV). Read More

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IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis.

J Neuroinflammation 2021 May 11;18(1):108. Epub 2021 May 11.

Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.

Background: Interleukin 9 (IL-9), produced mainly by T helper 9 (Th9) cells, has been recognized as an important regulator in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Astrocytes respond to IL-9 and reactive astrocytes always associate with blood-brain barrier damage, immune cell infiltration, and spinal injury in MS and EAE. Several long non-coding RNAs (lncRNAs) with aberrant expression have been identified in the pathogenesis of MS. Read More

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Handgrip Strength and Depression Among Older Chinese Inpatients: A Cross-Sectional Study.

Neuropsychiatr Dis Treat 2021 30;17:1267-1277. Epub 2021 Apr 30.

Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, People's Republic of China.

Objective: There have been studies exploring the association between handgrip and depression among community-dwelling adults; however, evidence for this association among hospitalized older adults is scarce. We aimed to use a larger-scale population from multiple centers to explore the association between low handgrip strength and depression.

Methods: This was a cross-sectional study that included hospitalized patients aged 65 years or older from different hospitals in China. Read More

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Low-Intensity Exercise as a Modifier of Depressive Symptoms and Self-Perceived Stress Level in Women with Metabolic Syndrome.

J Sports Sci Med 2021 Jun 5;20(2):222-228. Epub 2021 Mar 5.

Faculty of Physiotherapy, University School of Physical Education in Wrocław, Poland.

The study aims to determine the impact of low-intensity exercise and psychoeducation on depressive symptoms and self-perceived stress in women with metabolic syndrome (MetS). Seventy-four women (mean age 69.35 ± 7. Read More

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Impact of mixed meal tolerance test composition on measures of beta-cell function in type 2 diabetes.

Nutr Metab (Lond) 2021 May 4;18(1):47. Epub 2021 May 4.

Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.

Background: Application of mixed meal tolerance tests (MMTT) to measure beta-cell function in long-term studies is limited by modification of the commercial products occurring over time. This study assessed the intra-individual reliability of MMTTs and compared the effects of liquid meals differing in macronutrient composition on the estimation of beta-cell function in type 2 diabetes (T2DM).

Methods: To test the reliability of MMTTs, 10 people with T2DM (age 58 ± 11 years, body mass index 30. Read More

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Generic drug prescribing in primary care: A nationwide analysis.

Int J Clin Pract 2021 Apr 29:e14284. Epub 2021 Apr 29.

Department of Medical Pharmacology, Marmara University School of Medicine, Istanbul, Turkey.

Introduction: Dissemination of generic drug (GD) use could provide significant savings on drug expenditures and contribute to the long-term sustainability of healthcare. We aimed to exhibit the nationwide trend of GD use in primary care and investigate potentially relevant drug and patient factors.

Methods: Prescriptions written by primary care physicians in Turkey between 2013 and 2016 were analysed using the National Prescribing Information System. Read More

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Influence of comorbidities on functional outcomes in patients with surgically treated fragility hip fractures: a retrospective cohort study.

BMC Geriatr 2021 04 28;21(1):283. Epub 2021 Apr 28.

Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea.

Background: The incidence and number of fragility hip fractures are gradually increasing, resulting in a wide consumption of medical resources. Various factors affecting functional recovery in patients with fragility hip fractures are known, and comorbid diseases are one of them. The purpose of this study is to determine the effect of comorbidities on functional outcomes in patients surgically treated for fragility hip fractures, thereby contributing to the efficient distribution of medical resources. Read More

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A pilot study of aquatic prehabilitation in adults with knee osteoarthritis undergoing total knee arthroplasty - short term outcome.

BMC Musculoskelet Disord 2021 Apr 26;22(1):388. Epub 2021 Apr 26.

J.B. Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Background: Knee osteoarthritis (KOA) is increasingly more prevalent and significant number of patients require knee arthroplasty. Although knee arthroplasty is generally successful, it takes months to recover physical function. Preoperative physical function is known to predict postoperative outcomes and exercise can improve preoperative physical function. Read More

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Gender-specified mediation of depression between sleep quality and short-term memory in older adults: Study in a semi-closed Island of Xiamen, China.

Int J Geriatr Psychiatry 2021 Apr 26. Epub 2021 Apr 26.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.

Background: Both the quality of sleep and depression impact short-term memory (STM) while they influence each other. However, the underlying mechanisms are not yet clear. Herein, we aimed to explore the mediating effect of depression between sleep quality and STM in older adults and further test the gender differences in this relationship. Read More

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Hospitalization-associated muscle weakness and functional outcomes among oldest old patients: A hospital-based cohort study.

Exp Gerontol 2021 Jul 20;150:111353. Epub 2021 Apr 20.

Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Aging and Health Research Center, National Yang Ming Chiao Tung University, Hsin-Chu, Taiwan; Department of Geriatric Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.

Aim: To investigate the prognostic significance of hospitalization-associated muscle weakness for short-term and long-term functional declines among oldest old hospitalized patients.

Methods: We conducted a retrospective cohort study in the Geriatric Evaluation and Management Unit (GEMU) of a tertiary medical center in Taiwan. Data from patients admitted to the GEMU were collected, including demographic characteristics, underlying diseases, functional assessments, and nutritional status. Read More

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Plasma Cytokine Levels As Predictors of Global and Domain-Specific Human Immunodeficiency Virus-Associated Neurocognitive Impairment in Treatment-Naive Individuals.

J Interferon Cytokine Res 2021 Apr;41(4):153-160

National Health Laboratory Service (NHLS), Tygerberg Business Unity, Cape Town, South Africa.

Central nervous system dysfunction, associated with human immunodeficiency virus (HIV) infection, remains a significant clinical concern, affecting at least 50% of infected people. Imbalances in cytokine expression levels have been linked to HIV-associated neurocognitive disorders. The aim of this study was to evaluate plasma cytokine levels as predictor neurocognitive impairment in HIV infection using a multiplex profiling kit. Read More

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Whole-Exome Sequencing for Identifying Genetic Causes of Intellectual Developmental Disorders.

Int J Gen Med 2021 13;14:1275-1282. Epub 2021 Apr 13.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510280, People's Republic of China.

Background: Intellectual developmental disorders (IDD) generally refers to the persistent impairment of cognitive activities and mental retardation caused by physical damage to the brain or incomplete brain development. We aimed to explore its genetic causes.

Methods: In this study, 21 IDD patients were recruited. Read More

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[Cortical morphological study in cerebral small vessel disease patients with subcortical ischemic depression].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(15):1057-1063

Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

To explore the characteristics of cortical morphology in cerebral small vessel disease (CSVD) patients with subcortical ischemic depression (SID) and its relationship with clinical symptoms. A total of 88 patients with CSVD in the First Affiliated Hospital of Anhui Medical University were enrolled from July 2017 to July 2020. The subjects were divided into CSVD-non depression group (CSVD-ND, =58) and SID group (=30) according to the geriatric depression scale (GDS). Read More

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