3,180 results match your criteria gdm increased


Diet and physical activity in pregnancy to prevent gestational diabetes: a protocol for an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation.

BMJ Open 2021 Jun 11;11(6):e048119. Epub 2021 Jun 11.

WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Introduction: Mothers with gestational diabetes mellitus (GDM) are at increased risk of pregnancy-related complications and developing type 2 diabetes after delivery. Diet and physical activity-based interventions may prevent GDM, but variations in populations, interventions and outcomes in primary trials have limited the translation of available evidence into practice. We plan to undertake an individual participant data (IPD) meta-analysis of randomised trials to assess the differential effects and cost-effectiveness of diet and physical activity-based interventions in preventing GDM and its complications. Read More

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Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.

Diabetes Care 2021 Jun 11. Epub 2021 Jun 11.

Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France.

Objective: Gestational diabetes mellitus (GDM) is associated with an increased risk of obesity and insulin resistance in offspring later in life, which might be explained by epigenetic changes in response to maternal hyperglycemic exposure.

Research Design And Methods: We explored the association between GDM exposure and maternal blood and newborn cord blood methylation in 536 mother-offspring pairs from the prospective FinnGeDi cohort using Illumina MethylationEPIC 850K BeadChip arrays. We assessed two hypotheses. Read More

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What happens after menopause? (WHAM): A prospective controlled study of sleep quality up to 12 months after premenopausal risk-reducing salpingo-oophorectomy.

Gynecol Oncol 2021 Jun 8. Epub 2021 Jun 8.

Center for Health Sciences, SRI International, California, USA.

Objective: Sleep difficulties impair function and increase the risk of depression at menopause and premenopausal oophorectomy may further worsen sleep. However, prospective data are limited, and it remains uncertain whether Hormone Therapy (HT) improves sleep. This prospective observational study measured sleep quality before and up to 12 months after risk-reducing salpingo-oophorectomy (RRSO) compared to a similar age comparison group who retained their ovaries. Read More

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Distribution of complete blood count constituents in gestational diabetes mellitus.

Medicine (Baltimore) 2021 Jun;100(23):e26301

Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong, China.

Background Trial Design: The incidence rate of gestational diabetes is high. In the long run, it harms the health of both the mother and child. In order to understand the distribution of hematological cells with gestational diabetes mellitus (GDM), a longitudinal cohort study was conducted from 2012 to 2018. Read More

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Association of Gestational Diabetes Mellitus with Adverse Pregnancy Outcomes and Its Interaction with Maternal Age in Chinese Urban Women.

J Diabetes Res 2021 18;2021:5516937. Epub 2021 May 18.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 10034, China.

Background: The prevalence of gestational diabetes mellitus (GDM) has been dramatically increasing worldwide. The aims of this study were to examine associations of GDM with pregnancy outcomes in Chinese urban women and to evaluate the interaction between GDM and other major risk factors for the risk of adverse pregnancy outcomes.

Methods: A retrospective analysis included 8844 women who delivered live singletons at ≥28 weeks of gestation between June 2012 and March 2013 among Chinese urban women. Read More

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Predictors of later insulin therapy for gestational diabetes diagnosed in early pregnancy.

Endocr J 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Interventions for gestational diabetes mellitus (GDM), diagnosed in early pregnancy, have been a topic of controversy. This study aimed to elucidate factors that predict patients with GDM diagnosed before 24 gestational weeks (early GDM: E-GDM) who require insulin therapy later during pregnancy. Furthermore, we identified patients whose impaired glucose tolerance should be strictly controlled from early gestation onward. Read More

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MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase.

Bioengineered 2021 Dec;12(1):2410-2419

First Department of Obstetrics, Chongqing Maternal and Child Health Hospital, Chongqing, China.

Gestational diabetes mellitus (GDM), a common complication of pregnancy, harms the health of pregnant women and fetuses. MicroRNAs (miRNAs) dysregulation in placenta is involved in GDM. Herein, we explored the roles of miR-362-5p in GDM. Read More

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December 2021

The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes.

Ann Palliat Med 2021 May;10(5):5652-5658

Obstetrics Department, Haikou Hospital of the Maternal and Child Health, Haikou, China.

Background: To investigate the effects of vitamin D and omega-3 fatty acids on glucose and blood lipid metabolism in gestational diabetes (GDM) women.

Methods: A total of 150 patients with GDM aged 18-40 who were admitted to our hospital from May 2019 to December 2020 were enrolled in this study. The subjects were divided into test and control groups according to whether they took vitamin D and omega-3 fatty acids. Read More

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Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years.

Int J Clin Pract 2021 Jun 9:e14447. Epub 2021 Jun 9.

Department of Clinical Biochemistry, University Hospitals of the North Midlands NHS Trust, Stoke-on-Trent, UK.

Introduction: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance in two separate time periods. Read More

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Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring.

J Pain Res 2021 2;14:1573-1585. Epub 2021 Jun 2.

Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.

Purpose: Gestational diabetes mellitus (GDM) induces cardiovascular and metabolic disturbances in offspring. However, the effects of GDM in pain processing in offspring and whether male and female offspring are equally affected is not well known. Thus, we determined: i) whether GDM in mice affects offspring hindpaw mechanical sensitivity, capsaicin-induced spontaneous pain-like behaviors, and epidermal nerve fiber density (ENFD); and ii) whether there is sexual dimorphism in these parameters in offspring from GDM dams. Read More

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Changes in Serum Total Bile Acid Concentrations are Associated with the Risk of Developing Adverse Maternal and Perinatal Outcomes in Pregnant Chinese Women.

Clin Chim Acta 2021 Jun 5. Epub 2021 Jun 5.

Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University of Science and Technology, Shenzhen, China. Electronic address:

Background And Aims: We aimed to investigate the association between total bile acid (TBA) concentrations changes during the second and third trimesters and the risk of developing adverse maternal and perinatal outcomes (AMPO).

Methods: A total of 1569 pregnant Chinese women were enrolled. Serum TBA concentrations were measured during the 16-18 and 29-34 weeks of gestation. Read More

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Cell death mechanisms and their roles in pregnancy related disorders.

Adv Protein Chem Struct Biol 2021 27;126:195-225. Epub 2021 Feb 27.

Department of Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India. Electronic address:

Autophagy and apoptosis are catabolic pathways essential for homeostasis. They play a crucial role for normal placental and fetal development. These cell death mechanisms are exaggerated in placental disorders such as preeclampsia, intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM). Read More

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February 2021

High pre-pregnancy BMI with a history of gestational diabetes mellitus is associated with an increased risk of type 2 diabetes in Korean women.

PLoS One 2021 4;16(6):e0252442. Epub 2021 Jun 4.

Department of Home Economics Education, Korea National University of Education, Cheongju, Republic of Korea.

Despite the importance of pre-pregnancy body mass index (BMI) and a history of gestational diabetes mellitus (GDM) in the progression of GDM to type 2 diabetes, few studies have evaluated the combined effect of high pre-pregnancy BMI and GDM status on the future development of type 2 diabetes in Korean women. This study aimed to examine the relationship of pre-pregnancy BMI and GDM history with the risk of type 2 diabetes among Korean women. In addition, the effects of pre-pregnancy BMI and current BMI on the risk of type 2 diabetes were evaluated. Read More

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The cardio-ankle vascular index as a predictor of adverse pregnancy outcomes.

J Hypertens 2021 Jun 3. Epub 2021 Jun 3.

Department of Obstetrics and Gynecology Department of Internal medicine, Faculty of Medicine, Chiang Mai University, Thailand.

Objective: To assess the association between maternal hemodynamic parameters; cardio-ankle vascular index (CAVI), representing arterial stiffness; mean arterial pressure (MAP), uterine artery pulsatility index (Ut-PI), and adverse pregnancy outcomes including preeclampsia (PE), fetal growth restriction (FGR), and gestational diabetes mellitus (GDM).

Methods: A prospective cohort study was conducted on low-risk pregnancies. All were serially measured for the mean CAVI, MAP, and Ut-PI for four times at gestational age (GA) 11-14, 18-22, 28-32, and after 36 weeks. Read More

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Oxytocin signal contributes to the adaptative growth of islets during gestation.

Endocr Connect 2021 Jun 1. Epub 2021 Jun 1.

Q Shu, Department of Obstetrics, Shanghai First Maternity and Infant Health Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Increased insulin production and secretion by pancreatic β-cells are important for ensuring the high insulin demand during gestation. However, the underlying mechanism of β-cell adaptation during gestation or in gestational diabetes mellitus (GDM) remains unclear. Oxytocin is an important physiological hormone in gestation and delivery, and it also contributes to the maintenance of β-cell function. Read More

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Metabolomic Biomarkers in Gestational Diabetes Mellitus: A Review of the Evidence.

Int J Mol Sci 2021 May 24;22(11). Epub 2021 May 24.

Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Melbourne 3168, Australia.

Gestational diabetes mellitus (GDM) is the fastest growing type of diabetes, affecting between 2 to 38% of pregnancies worldwide, varying considerably depending on diagnostic criteria used and sample population studied. Adverse obstetric outcomes include an increased risk of macrosomia, and higher rates of stillbirth, instrumental delivery, and birth trauma. Metabolomics, which is a platform used to analyse and characterise a large number of metabolites, is increasingly used to explore the pathophysiology of cardiometabolic conditions such as GDM. Read More

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Diet Quality Is Associated with a High Newborn Size and Reduction in the Risk of Low Birth Weight and Small for Gestational Age in a Group of Mexican Pregnant Women: An Observational Study.

Nutrients 2021 May 28;13(6). Epub 2021 May 28.

Nutrition and Bioprogramming Coordination, National Institute of Perinatology Nacional de Perinatología, Montes Urales 800, Lomas de Virreyes, Mexico City 11000, Mexico.

A high-quality diet during pregnancy may have positive effects on fetal growth and nutritional status at birth, and it may modify the risk of developing chronic diseases later in life. The aim of this study was to evaluate the association between diet quality and newborn nutritional status in a group of pregnant Mexican women. As part of the ongoing Mexican prospective cohort study, OBESO, we studied 226 healthy pregnant women. Read More

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Interaction between Metformin, Folate and Vitamin B and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.

Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence suggests metformin can cross the placenta during pregnancy, thereby exposing the fetus to high concentrations of metformin and potentially restricting placental and fetal growth. Offspring exposed to metformin during gestation are at increased risk of being born small for gestational age (SGA) and show signs of 'catch up' growth and obesity during childhood which increases their risk of future cardiometabolic diseases. Read More

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Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus.

Gynecol Endocrinol 2021 Jun 1:1-5. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.

Aims: To investigate the change of stress hormones, oxidative stress and insulin resistance (IR) in women with gestational diabetes mellitus (GDM) after supplement whey protein, in an attempt to gain insights into the prevention and treatment of GDM.

Materials And Methods: 60 GDM women were recruited in this study, and 30 women received a preload drink containing 20 g whey protein as group GDM-W, and the other 30 women received control flavoring drink as group GDM, and the trial lasted for 14 days. Plasma epinephrine (E), noradrenaline (NE), and cortisol were detected; we also determined levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH). Read More

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Cord serum metabolome and birth weight in patients with gestational diabetes treated with metformin, insulin, or diet alone.

BMJ Open Diabetes Res Care 2021 May;9(1)

Obstetrics and Gynecology, University of Turku, Turku, Finland.

Introduction: Recent research has demonstrated the benefits of metformin treatment in gestational diabetes (GDM) on short-term pregnancy outcomes (including excessive fetal growth and pre-eclampsia), but its effects on fetal metabolism remain mostly unknown. Our aim was to study the effects of metformin treatment compared with insulin or diet on the cord serum metabolome and also to assess how these metabolites are related to birth weight (BW) in pregnancies complicated by GDM.

Research Design And Methods: Cord serum samples were available from 113, 97, and 98 patients with GDM treated with diet, insulin, and metformin, respectively. Read More

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The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy.

Authors:
Wendy N Phoswa

Front Cardiovasc Med 2021 12;8:613930. Epub 2021 May 12.

Department of Life and Consumer Sciences, University of South Africa (UNISA), Science Campus, Florida, South Africa.

The main objective of this study is to investigate mechanisms associated with gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) in HIV infected pregnant women by looking how placental hormones such as (progesterone and prolactin) and basic haemostatic parameters are regulated in HIV infected pregnancies. HIV/AIDS are a major global obstetric health burden that lead to increased rate of morbidity and mortality. HIV/AIDS has been associated with the pathophysiology of GDM and HDP. Read More

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Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A.

J Diabetes Complications 2021 May 24:107959. Epub 2021 May 24.

National Research Institute for Family Planning, Beijing, China; Graduate School, Peking Union Medical College, Beijing, China. Electronic address:

Gestational Diabetes Mellitus (GDM) is a complicated clinical process, and metabolic disorders during pregnancy are closely related to the structure and function of the placenta. The aberrant expression of miRNAs in the placenta may play a role in the occurrence and development of GDM. Analysis of microRNA (miRNA) expression signature in placenta showed that the level of miR-30d-5p was significantly down-regulated in GDM patients. Read More

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Prevalence of 'Hyperglycemia in pregnancy' remained stable between 2006 and 2015, despite rise in conventional risk factors: A hospital based study in Delhi, North India.

Diabetes Res Clin Pract 2021 May 26:108872. Epub 2021 May 26.

Department of Obstetrics and Gynaecology, St. Stephen's Hospital, Delhi.

Aims: Between 2006 and 2015, the trends in prevalence of Hyperglycemia in pregnancy (HIP);Gestational diabetes(GDM),Diabetes in Pregnancy(DIP), Pre existing diabetes (PDM) and GDM risk factors were studied in 30692 pregnancies among Asian Indian women.

Methods: GDM (n=4089) and DIP (n=259) diagnoses were by 75 g OGTT, while PDM (n=103) was identified by ICD code O24. Women with DIP and PDM were grouped together as pre-gestational diabetes (PGDM n=362). Read More

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Increased individual glucose tolerance test values in women with gestational diabetes.

Minerva Obstet Gynecol 2021 May 28. Epub 2021 May 28.

Department of Obstetrics and Gynecology, Nassau University Medical Center, East Meadow, New York, NY, USA -

Background: Individual oral glucose tolerance test (OGTT) values may be of interest to clinicians. We evaluate factors associated with these values.

Methods: This retrospective study included 225 pregnant women diagnosed with gestational diabetes by abnormal 100-gram oral GTT. Read More

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Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis.

J Diabetes Res 2021 10;2021:6692695. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Liaocheng People's Hospital and LiaochengClinical School of Shandong First Medical University, Liaocheng, Shandong 252000, China.

Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. Read More

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Universal HbA1c screening and gestational diabetes: a comparison with clinical risk factors.

J Matern Fetal Neonatal Med 2021 May 27:1-7. Epub 2021 May 27.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Screening strategies for gestational diabetes mellitus (GDM), particularly early GDM, have traditionally relied upon the use of clinical risk factors (CRFs). Although commonly used in nonpregnant patients, HbA1c screening is not widely used despite reports of abnormal HbA1c values being predictive of GDM development. The aims of this study are to assess the utility of universal HbA1c screening in predicting GDM and to compare universal screening to targeted CRF-based screening for the diagnosis of GDM. Read More

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Elevated Glucose Challenge Test in a Nondiabetic Index Pregnancy and Gestational Diabetes in a Subsequent Pregnancy.

Am J Perinatol 2021 May 27. Epub 2021 May 27.

Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, Illinois.

Objective:  The aim of this study was to evaluate whether a 1-hour glucose challenge test (GCT) ≥140 mg/dL in a nondiabetic index pregnancy is associated with the development of gestational diabetes mellitus (GDM) in a subsequent pregnancy.

Study Design:  We performed a retrospective cohort study from a single institution from June 2009 to December 2018. Women with a nondiabetic index singleton gestation who underwent a 1-hour GCT at 24 to 28 weeks and had a successive singleton delivery were included. Read More

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Strategies to improve postpartum glucose screening rates are needed.

J Obstet Gynaecol Res 2021 May 26. Epub 2021 May 26.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Aims: Women with gestational diabetes mellitus (GDM) require postpartum glucose screening, as they have a 70% lifetime risk of developing Type 2 diabetes mellitus. However, less than half complete postpartum screening.

Methods: We conducted a retrospective chart review of patients who delivered at our institution from 2001 to 2019. Read More

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The consumption of low-calorie sweetener containing foods during pregnancy: results from the ROLO study.

Eur J Clin Nutr 2021 May 26. Epub 2021 May 26.

UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.

Background/objectives: Women with gestational diabetes (GDM) are advised to adapt a low glycaemic index (GI) diet, which may impact consumption of low-calorie sweeteners (LCS). LCS are increasingly popular as they add sweetness without contributing calories. This study aims to investigate the reported intakes of LCS-containing foods in women during pregnancy. Read More

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