Search Our Scientific Publications & Authors

J Perinat Med 2022 Aug 11. Epub 2022 Aug 11.

Women's Health Service Line, Division of Maternal-Fetal Medicine, Geisinger, Danville, PA, USA.

Objectives: To determine the optimal glucose challenge test (GCT) cutoff value for the screening of gestational diabetes mellitus (GDM) based on pre-pregnancy BMI.

Methods: An-IRB approved retrospective cohort analysis of singleton pregnancies at a large tertiary healthcare center from January 2004 to December 2020 was performed. The first GCT value completed between 20 and 32 weeks was used. Read More

J Reprod Infant Psychol 2022 Aug 10:1-17. Epub 2022 Aug 10.

Department of Psychology, Faculty of Education and Psychology, University of Tabriz, Tabriz, Iran.

Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications associated with pregnancy. Its treatment requires multidisciplinary cooperation, and identifying the psychosocial needs of patients is important in the management of their condition.

Objective: This study investigates the psychosocial needs of inpatient mothers with GDM from the joint perspectives of future mothers and healthcare providers. Read More

J Nepal Health Res Counc 2022 Jun 2;20(1):12-20. Epub 2022 Jun 2.

Department of Gynecology and Obstetrics, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Background: Gestational diabetes mellitus is a condition of glucose intolerance during pregnancy. The burden of Gestational diabetes mellitus is ever increasing including a lower middle-income country like Nepal.

Methods: This meta-analysis was conducted in accordance to the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Read More

Cardiovasc Ultrasound 2022 Aug 9;20(1):21. Epub 2022 Aug 9.

Cardiovascular Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.

Background: Gestational diabetes mellitus (GDM) may increase the risk of cardiovascular disease and accompany asymptomatic deterioration of the myocardial function. This study aims to identify the subclinical impact of GDM on maternal left ventricular function by two-dimensional speckle tracking echocardiography (2D-STE).

Methods: We prospectively recruited 47 women with GDM and 62 healthy pregnant women who underwent transthoracic echocardiography (TTE) at 24 to 28 weeks of pregnancy. Read More

BMC Pregnancy Childbirth 2022 Aug 8;22(1):627. Epub 2022 Aug 8.

Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, Macquarie University, 75 Talavera Rd, North Ryde, NSW, 2113, Sydney, Australia.

Background: Gestational diabetes mellitus (GDM) is a condition associated with pregnancy that engenders additional healthcare demand. A growing body of research includes empirical studies focused on pregnant women's GDM healthcare experiences. The aim of this scoping review is to map findings, highlight gaps and investigate the way research has been conducted into the healthcare experiences of women with GDM. Read More

Environ Sci Pollut Res Int 2022 Aug 8. Epub 2022 Aug 8.

Medical Information Office, The Maternal and Children Health Care Hospital (Huzhong Hospital) of Huadu, Guangzhou, Guangdong, 510800, People's Republic of China.

The global prevalence of gestational diabetes mellitus (GDM) is increasing annually, and previous research reports on the relationship between exposure to air pollutants and GDM are not completely consistent. We investigated the association between air pollutant exposure and GDM in pregnant women in a retrospective cohort study in Guangzhou. We found that in the first trimester, exposure to PM and CO showed a significant association with GDM. Read More

Matern Child Health J 2022 Aug 8. Epub 2022 Aug 8.

Center for Chemical Regulation and Food Safety, Exponent, Inc, 1150 Connecticut Avenue, NW, Suite 1100, Washington, DC, 20036, USA.

Objectives: Diet is an important factor in gestational health. Many pregnant women have suboptimal diets and dairy foods are an excellent source of key nutrients. The aim of this work was to investigate the relationships between dairy consumption (cup equivalents/day) or diet quality assessed using the Healthy Eating Index-2015 and gestational diabetes mellitus (GDM) or gestational weight gain (GWG) among pregnant women in the United States (US). Read More

Acta Diabetol 2022 Aug 8. Epub 2022 Aug 8.

Affiliated Hospital of Nantong University, Nantong, China.

Aims: We aimed to investigate the association between maternal diabetes before or during pregnancy and visual acuity development in offspring at 1 and 4 years old.

Methods: This prospective cohort study comprised 301 individuals born in 2015-2017. Those who had maternal diabetes during or before pregnancy (type 1 diabetes, type 2 diabetes and gestational diabetes) were investigated. Read More

Comput Math Methods Med 2022 28;2022:4882061. Epub 2022 Jul 28.

Department of Obstetrics I, Yantaishan Hospital, Yantai 264000, China.

Objective: To explore the clinical effect and impact of exercise-diet therapy combined with Insulin Aspart Injection on gestational diabetes mellitus (GDM).

Methods: The objects of study were patients with pregestational diabetes mellitus (PGDM) and 62 patients with GDM who were diagnosed by oral glucose tolerance test (OGTT) and insulin release test from February 2017 to February 2019. According to the severity of the disease, enrolled patients were informed to have appropriate exercise and diet control or Insulin Aspart Injection on this basis until the completion of delivery. Read More

J Diabetes Complications 2022 Aug 2;36(9):108282. Epub 2022 Aug 2.

Department of Obstetrics and Gynecology at Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, United States of America. Electronic address:

Aims: While women with gestational diabetes mellitus (GDM) have a higher risk of developing type 2 diabetes mellitus (T2DM) and at a younger age, it is unknown whether T2DM following GDM is associated with worse clinical outcomes. This study aims to examine the impact of GDM on subsequent development of long-term complications of T2DM.

Methods: All women with T2DM from the National Health and Nutrition Examination Survey (NHANES), a nationally representative cross-sectional survey of US population, between 2007 and 2018 (n = 2494) were stratified into two groups: those with a history of GDM (n = 385) and those without (n = 2109). Read More

J Obstet Gynecol Neonatal Nurs 2022 Aug 3. Epub 2022 Aug 3.

Objective: To investigate the relationships among various factors that affect serum vitamin D levels and vitamin D in the first trimester and the risk of developing gestational diabetes mellitus (GDM).

Design: A prospective cohort design.

Setting: The family health center of Ankara, Turkey. Read More

Biol Reprod 2022 Aug 6. Epub 2022 Aug 6.

Department of Biomaterials Science (BK21 Four Program), College of Natural Resources & Life Science, Pusan National University, Miryang 50463, Republic of Korea.

The purpose of this study was to investigate lipid metabolism in the placenta of Gestational diabetes mellitus (GDM) individuals and to evaluate its effect on the fetus. We examined the expression of lipogenesis- and lipolysis-related proteins in the in vitro and in vivo GDM placenta models. The levels of sterol regulatory element binding protein-1c (SREBP-1c) were increased, and fat accumulated more during early hyperglycemia, indicating that lipogenesis was stimulated. Read More

Environ Res 2022 Aug 2:114008. Epub 2022 Aug 2.

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China. Electronic address:

Background: Previous studies have examined the associations between ambient fine particulate matter (PM) exposure and gestational diabetes mellitus (GDM). However, limited studies explored the relationships between PM exposure and blood glucose levels during pregnancy, especially in highly polluted areas.

Objectives: To examine the associations of prenatal ambient PM exposure with GDM and blood glucose levels, and to identify the sensitive exposure windows in a highly air-polluted area. Read More

J Clin Endocrinol Metab 2022 Aug 5. Epub 2022 Aug 5.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Context: The optimal 50g-glucose challenge test (GCT) cut-off for the diagnosis of gestational diabetes (GDM) in twin pregnancies is unknown.

Objective: To explore the screening accuracy of the 50g-GCT and its correlation with the risk of large for gestational age (LGA) newborn in twin compared to singleton pregnancies.

Design: Population-based retrospective cohort study (2007-2017). Read More

PLoS One 2022 5;17(8):e0272711. Epub 2022 Aug 5.

Department of Research Unit for General Medicine and Primary Health Care, University of Ioannina, Ioannina, Greece.

Objective: We aimed at investigating the preventive role of exercise intervention during pregnancy, in high-risk women for gestational diabetes mellitus (GDM).

Materials And Methods: We searched PubMed, CENTRAL, and Scopus for randomized controlled trials (RCTs) that evaluated exercise interventions during pregnancy on women at high risk for GDM. Data were combined with random effects models. Read More

Front Endocrinol (Lausanne) 2022 19;13:942664. Epub 2022 Jul 19.

Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentation. Read More

Front Physiol 2022 19;13:954636. Epub 2022 Jul 19.

Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China.

The placenta is a vital organ for fetal development, providing the fetus with nutrients, oxygen, and other important factors. Placenta is rich in blood vessels. Abnormal placental vascular function and blood circulation may lead to insufficient blood supply to the fetus in the uterus, leading to serious consequences such as pregnancy complications, fetal distress and even stillbirth. Read More

J Hum Reprod Sci 2022 Apr-Jun;15(2):163-170. Epub 2022 Jun 1.

Department of Clinical Nutrition & Dietetics, University of Sharjah, Muwailih, Sharjah, United Arab Emirates.

Background: Thyroid dysfunction impairs female fertility and pregnancy outcome. Optimal preconception and gestational TSH level is still debatable in IVF-conceived pregnancies.

Aims: To explore the relationships of IVF success and pregnancy outcomes with maternal serum levels of TSH (at both preconception and 12-week IVF-conceived pregnancy). Read More

SSM Popul Health 2022 Sep 21;19:101176. Epub 2022 Jul 21.

University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.

Introduction: Racial/ethnic minority and foreign-born women in the United States are at high risk of experiencing racial discrimination, which is associated with adverse health outcomes. Although racial discrimination is associated with metabolic disturbances such as insulin resistance and type 2 diabetes, more studies should examine its effect on gestational diabetes mellitus (GDM), which is highest among racial/ethnic minority and foreign-born women.

Methods: We used New York City Pregnancy Risk and Assessment Monitoring System survey data (2012-2014) linked with birth certificate items (N = 4084) in bivariate and multivariate analyses to examine racial/ethnic/nativity differences in racial discrimination, and to test if racial discrimination explains racial/ethnic/nativity inequalities in GDM

Results: The 12-month prevalence of racial discrimination (9. Read More

J Obstet Gynaecol India 2022 Aug 13;72(Suppl 1):235-242. Epub 2022 Apr 13.

Department of Obstetrics and Gynaecology, All Is Well Multi Speciality Hospital, Burhanpur, Madhya Pradesh India.

Background/purpose: To study the clinical characteristics, outcomes, and the incidence of postpartum diabetes in women with overt diabetes and GDM.

Methods: This prospective cohort observational study was done on women with GDM diagnosed after the first trimester, attending the tertiary care hospitals for 2.3 years. Read More

Diabetes 2022 Aug 4. Epub 2022 Aug 4.

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, PR China.

To date, the microRNA (miRNA) expression profile of plasma exosomes in women whose pregnancy is complicated by gestational diabetes mellitus (GDM) has not been fully clarified. In this study, differentially expressed miRNAs in plasma exosomes were identified by high-throughput small RNA sequencing in 12 GDM and 12 normal glucose tolerance (NGT) pregnant women and validated in 102 GDM and 101 NGT pregnant women. A total of 22 exosomal miRNAs were found and five of them were verified by qRT-PCR. Read More

Front Microbiol 2022 18;13:911852. Epub 2022 Jul 18.

School of Public Health, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.

To verify whether the placenta harbors bacteria, and to explore the composition of placental microbiota (if yes) and its association with adverse pregnancy outcomes. The placental microbiota was detected by 16S rRNA gene sequencing technology. In the process of detecting placental samples, exogenous marine bacterial DNA that does not exist in the human body was artificially added to obtain a visible 16S band. Read More

Diabetes Metab Syndr 2022 Jul 16;16(8):102579. Epub 2022 Jul 16.

Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Background: Gestational diabetes is the most common complication during pregnancy and it is essential to identify the high-risk groups for gestational diabetes mellitus (GDM) in the first trimester. A large neck circumference (NC) in the first trimester is a measure of obesity.

Objective: The present study investigated whether pregnant women's first-trimester NC and waist circumference (WC) measurements present a predictive index for GDM diagnosis. Read More

J Caring Sci 2022 May 29;11(2):94-104. Epub 2022 May 29.

Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Antioxidants and anti-inflammatory drugs have been suggested to treat preeclampsia. This systematic review and meta-analysis was conducted to investigate the efficacy of probiotic or synbiotic supplementation on hypertensive disorders in women with gestational diabetes mellitus (GDM) . The databases including Cochrane, Embase, Ovid, ProQuest, Scopus, Web of Science, and PubMed were systematically searched for collecting the randomized controlled trials (RCTs) investigating the efficacy of probiotic or synbiotic supplementation versus placebo on hypertensive disorders and pregnancy outcomes in GDM until July 2020. Read More

Menopause 2022 Aug 2. Epub 2022 Aug 2.

Department of Obstetrics and Gynecology, Midlife Women's Health Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Objective: The aim of this study was to evaluate the associations of a lifetime history of hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) with menopausal symptoms in midlife.

Methods: This was a secondary analysis of women participating in Project Viva, an ongoing cohort enrolled during pregnancy. The exposure was lifetime history of HDP or GDM assessed for the index pregnancy by review of outpatient and hospital medical records and for all other pregnancies by interview or questionnaire at study entry (1999-2002) and the midlife visit (2017-2021). Read More

J Clin Lab Anal 2022 Aug 2:e24627. Epub 2022 Aug 2.

Department of Clinical Laboratory, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Background: Gestational diabetes mellitus (GDM) and gestational diabetic nephropathy (GDN) have become an increasingly serious problem worldwide, which can cause a large number of adverse pregnancy consequences for mothers and infants. However, the diagnosis of GDM and GDN remains a challenge due to the lack of optimal biomarkers, and the examination has high requirements for patient compliance. We aimed to establish a simple early diagnostic model for GDM and GDN. Read More

J Diabetes Res 2022 21;2022:7083106. Epub 2022 Jul 21.

Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, China.

Studies on nutrient sequences during meals suggest that consuming carbohydrates last lowers postprandial glucose excursions more than consuming carbohydrates first. However, this phenomenon has not been studied in gestational diabetes mellitus (GDM). Ten women with GDM consumed the same caloric foods in different sequences over five successive days: (A) dish first, followed by carbohydrate and soup last; (B) carbohydrate first, followed by dish and soup last; (C) soup first, followed by dish and carbohydrate last; (D) three meals a day ad libitum; and (E) six meals a day as ad libitum. Read More

Br J Nutr 2022 Aug 2:1-19. Epub 2022 Aug 2.

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, China.

Background/objectives: With increasing focus on vitamin B12 and gestational diabetes mellitus (GDM) recently, their relationship remains controversial. To comprehensively evaluate the relationship between vitamin B12 and GDM, and to provide more information on GDM prevention, this study provides a systematic review and meta-analysis of vitamin B12 and GDM.

Methods: As of September 22, 2021, 304 articles were searched in PubMed, Web of Science, EMBASE, and Cochrane databases, of which 15 studies met the inclusion criteria. Read More

J Clin Endocrinol Metab 2022 Aug 2. Epub 2022 Aug 2.

Rovira i Virgili University, Tarragona, Spain.

Context: DNA methylation in the diagnosis of gestational diabetes.

Objective: To assess the value of DNA methylation in the diagnosis of gestational diabetes (GDM) and in the prediction of maternal postpartum glucose disturbances.

Design: Two-stage observational between July 2006 and December 2010. Read More

Am J Trop Med Hyg 2022 Aug 1. Epub 2022 Aug 1.

Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, New York.

Infection of HIV is associated with an increased diabetes risk, which also increases tuberculosis risk. It is unknown if similar associations exist with gestational diabetes (GDM). We screened pregnant women living with and without HIV for GDM using oral glucose tolerance testing. Read More