Front Bioeng Biotechnol 2020 18;8:608951. Epub 2021 Jan 18.
EMBL Australia Node in Single Molecule Science and Cellular and Systems Physiology, Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but only if stimuli are applied directly at the interface between cells and their substrate, making this molecule a context-dependent force sensor. However, it remains unclear how TRPV4 is activated by mechanical inputs at the cell-substrate interface, which cell intrinsic and cell extrinsic parameters might modulate the mechanical activation of the channel and how mechanical activation differs from TRPV4 gating in response to other stimuli. Read More