25,730 results match your criteria gastrointestinal microbiome

A microbial signature following bariatric surgery is robustly consistent across multiple cohorts.

Gut Microbes 2021 Jan-Dec;13(1):1930872

Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, USA.

Bariatric surgery induces significant shifts in the gut microbiota which could potentially contribute to weight loss and metabolic benefits. The aim of this study was to characterize a microbial signature following Roux-en-Y Gastric bypass (RYGB) surgery using novel and existing gut microbiota sequence data. We generated 16S rRNA gene and metagenomic sequences from fecal samples from patients undergoing RYGB surgery (n = 61 for 16S rRNA gene and n = 135 for metagenomics) at pre-surgical baseline and one, six, and twelve-month post-surgery. Read More

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Validity and safety of ID-JPL934 in lower gastrointestinal symptom improvement.

Sci Rep 2021 Jun 22;11(1):13046. Epub 2021 Jun 22.

Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173, Beon-gil, Seongnam, Gyeonggido, 13620, South Korea.

The study evaluated the efficacy of ID-JPL934, a probiotic preparation containing Lactobacillus johnsonii IDCC 9203, Lactobacillus plantarum IDCC 3501 and Bifidobacterium lactis IDCC 4301, in relieving lower gastrointestinal symptoms. A total of 112 subjects with lower gastrointestinal symptoms were consecutively enrolled. They were randomized into either ID-JPL934 administration group or placebo group. Read More

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Fecal microbiome alterations in pediatric patients with short bowel syndrome receiving a rotating cycle of gastrointestinal prophylactic antibiotics.

Pediatr Surg Int 2021 Jun 22. Epub 2021 Jun 22.

Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand.

Background: Pediatric patients with short bowel syndrome (SBS) are at risk of developing small intestinal bacterial overgrowth (SIBO). Prevention of SIBO using cyclic enteric antibiotics has been implemented to control the balance in microbial ecosystems, although its effectiveness has not been well studied.

Purpose: This study aimed to explore the change in the gut microbial composition in SBS patients during cyclic antibiotic phases and antibiotic-free period, and to compare the microbiota composition between healthy controls and SBS patients. Read More

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Wiad Lek 2021 ;74(4):1007-1010


Objective: The aim: To analyze the relationship between non-alcoholic fatty liver disease and changes in the gut microbiota.

Patients And Methods: Materials and methods: The publications of domestic and foreign editions in the databases of the United European Gastroenterology (UEG) Journal, PubMed, MEDLINE, Web of Science were processed and analyzed.

Conclusion: Conclusions: In recent years, non-alcoholic fatty liver disease was placed among the important diseases in gastroenterology. Read More

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Animal models of visceral pain and the role of the microbiome.

Neurobiol Pain 2021 Aug-Dec;10:100064. Epub 2021 May 28.

McMaster Brain-Body Institute at St Joseph's Healthcare, Hamilton, Ontario, Canada.

Visceral pain refers to pain arising from the internal organs and is distinctly different from the expression and mechanisms of somatic pain. Diseases and disorders with increased visceral pain are associated with significantly reduced quality of life and incur large financial costs due to medical visits and lost work productivity. In spite of the notable burden of illness associated with those disorders involving increased visceral pain, and some knowledge regarding etiology, few successful therapeutics have emerged, and thus increased attention to animal models of visceral hypersensitivity is warranted in order to elucidate new treatment opportunities. Read More

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Characterization of faecal and caecal microbiota of free-ranging black-tailed prairie dogs () using high-throughput sequencing of the V4 region of the 16S rRNA gene.

Conserv Physiol 2021 15;9(1):coab042. Epub 2021 Jun 15.

Ontario Veterinary College, University of Guelph, 50 Stone Road E., Guelph, Ontario N1G 2W1, Canada.

Black-tailed prairie dogs () are keystone species within their grassland ecosystems; their population stability affects a multitude of other species. The goals of this study were to explore, describe and compare the bacterial communities in caecal and hard faecal samples from free-ranging black-tailed prairie dogs ( = 36) from KS, USA, using high-throughput sequencing of the V4 region of the 16S rRNA gene and to compare sex and geographic locations. A total of 22 paired faecal and caecal samples were collected post-mortem from free-ranging black-tailed prairie dogs from 5 different geographical locations. Read More

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Review of Gastrointestinal Motility in Cystic Fibrosis.

J Cyst Fibros 2021 Jun 16. Epub 2021 Jun 16.

Associate Professor and Medical Director, Neurogastroenterology and Motility Program, Department of Pediatrics, Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children's Hospital, 1465 S Grand Blvd, St. Louis, MO 63104. Electronic address:

Gastrointestinal manifestations in patients with cystic fibrosis (CF) are extremely common and have recently become a research focus. Gastrointestinal (GI) dysfunction is poorly understood in the CF population, despite many speculations including the role of luminal pH, bacterial overgrowth, and abnormal microbiome. Nevertheless, dysmotility is emerging as a possible key player in CF intestinal symptoms. Read More

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Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis.

Gastroenterology 2021 Jun 16. Epub 2021 Jun 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria. Electronic address:

Background & Aims: Irritable bowel syndrome (IBS) and inflammatory bowel diseases result in a substantial reduction in quality of life and a considerable socio-economic impact. In IBS, diagnosis and treatment options are limited, but evidence for an involvement of the gut microbiome in disease pathophysiology is emerging. Here we analyzed the prevalence of endoscopically visible mucosal biofilms in gastrointestinal disease and associated changes in microbiome composition and metabolism. Read More

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Food-grade carrageenans and their implications in health and disease.

Compr Rev Food Sci Food Saf 2021 Jun 19. Epub 2021 Jun 19.

USDA-ARS Animal Genomics and Improvement Laboratory, Beltsville, Maryland, USA.

Food additives, often used to guarantee the texture, shelf-life, taste, and appearance of processed foods, have gained widespread attention due to their increased link to the growing incidence of chronic diseases. As one of the most common additives, carrageenans have been used in human diets for hundreds of years. While classified as generally recognized as safe (GRAS) for human consumption, numerous studies since the 1980s have suggested that carrageenans, particularly those with random coil conformations, may have adverse effects on gastrointestinal health, including aggravating intestinal inflammation. Read More

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Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome.

Neurogastroenterol Motil 2021 Jun 18:e14200. Epub 2021 Jun 18.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Background: We recently found fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients to be an effective and safe treatment after 3 months. The present follow-up study investigated the efficacy and safety of FMT at 1 year after treatment.

Methods: This study included 77 of the 91 IBS patients who had responded to FMT in our previous study. Read More

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Chronic Jet Lag Exacerbates Jejunal and Colonic Microenvironment in Mice.

Front Cell Infect Microbiol 2021 1;11:648175. Epub 2021 Jun 1.

Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institute of Digestive Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Evidence suggests that circadian rhythm disorder is associated with a variety of gastrointestinal diseases, and the circadian rhythm plays a key role in maintaining the homeostasis of intestinal flora. The underlying mechanisms are still not completely identified. This study was aimed to explore whether jet lag-caused circadian disruption influences gut microbiome and its metabolites. Read More

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Psychobiotics for Patients with Chronic Gastrointestinal Disorders Having Anxiety or Depression Symptoms.

J Multidiscip Healthc 2021 10;14:1395-1402. Epub 2021 Jun 10.

Internal Medicine Faculty, Hanoi Medical University, Hanoi, Vietnam.

Purpose: Using psychobiotics to modify the gut microbiome has been shown to improve the anxiety and depression situation of patients with chronic gastrointestinal (GI) symptoms. This study evaluated changes in depression, anxiety, GI symptomss and side effects when patients used a multispecies probiotics product.

Patients And Methods: A single-center uncontrolled trial was conducted in patients with chronic GI symptoms, anxiety and depression who used a multispecies probiotics product. Read More

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Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense.

Sci Rep 2021 Jun 17;11(1):12808. Epub 2021 Jun 17.

Laboratory of Microbiology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.

Functionality of the gastrointestinal tract is essential for growth and development of newborns. Preterm infants have an immature gastrointestinal tract, which is a major challenge in neonatal care. This study aims to improve the understanding of gastrointestinal functionality and maturation during the early life of preterm infants by means of gastrointestinal enzyme activity assays and metaproteomics. Read More

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Host gut microbiome and potential therapeutics in Gulf War Illness: A short review.

Life Sci 2021 Jun 15;280:119717. Epub 2021 Jun 15.

Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA; Columbia VA Medical Center, Columbia, SC 29205, USA.

Aims: Since our troops had returned from the first Persian Gulf War in 1990-91, the veterans have reported chronic multisymptomatic illness widely referred to as Gulf War Illness (GWI). We aim to review the current directions of GWI pathology research in the context of chronic multisymptomatic illness and its possible gut microbiome targeted therapies. The veterans of Gulf War show symptoms of chronic fatigue, cognitive deficits, and a subsection report of gastrointestinal complications. Read More

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Impact of Early Empiric Antibiotic Regimens on the Gut Microbiota in Very Low Birth Weight Preterm Infants: An Observational Study.

Front Pediatr 2021 31;9:651713. Epub 2021 May 31.

Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan.

Frequent use of antibiotics in preterm infants disturbs their gut microbial balance. In this preliminary observational study, we investigated the effect of different antibiotic regimens, administered during the first week of life, on microbial composition and diversity in very low birth weight (VLBW) preterm infants. We performed fecal sampling of breastfed VLBW infants on days 7, 14, and 30. Read More

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Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection.

Front Immunol 2021 31;12:688886. Epub 2021 May 31.

St. Vincent's Clinical School, UNSW, Darlinghurst, NSW, Australia.

Background: Despite successful ART in people living with HIV infection (PLHIV) they experience increased morbidity and mortality compared with HIV-negative controls. A dominant paradigm is that gut-associated lymphatic tissue (GALT) destruction at the time of primary HIV infection leads to loss of gut integrity, pathological microbial translocation across the compromised gastrointestinal barrier and, consequently, systemic inflammation. We aimed to identify and measure specific changes in the gastrointestinal barrier that might allow bacterial translocation, and their persistence despite initiation of antiretroviral therapy (ART). Read More

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Orange Juice and Yogurt Carrying Probiotic GBI-30 6086: Impact of Intake on Wistar Male Rats Health Parameters and Gut Bacterial Diversity.

Front Microbiol 2021 1;12:623951. Epub 2021 Apr 1.

Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, Brazil.

This study aimed to investigate the impact of the food matrix (orange juice and yogurt) on the effects of the spore-forming probiotic microorganism GBI-30 6086 in health parameters and gastrointestinal tract (gut) bacterial diversity in male rats. Rats ( = 48) were randomly distributed into six groups. The groups were the Control (which received sterile distilled water), Juice (which received orange juice), Yogurt (which received yogurt), Probiotic (which received GBI-30 6086 in distilled water), Probiotic Juice (which received orange juice with GBI-30 6086), and Probiotic Yogurt (which received yogurt with GBI-30 6086). Read More

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Fecal microbiota transplantation ameliorates experimental colitis gut microbiota and T-cell modulation.

World J Gastroenterol 2021 Jun;27(21):2834-2849

Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.

Background: Emerging evidence has demonstrated that fecal microbiota transplantation (FMT) has a promising therapeutic effect on mice with experimental colitis and patients with ulcerative colitis (UC), although the mechanism of FMT is unclear.

Aim: To evaluate the protective effect of FMT on UC and clarify its potential dependence on the gut microbiota, through association analysis of gut microbiota with colon transcriptome in mice.

Methods: Dextran sodium sulfate (DSS)-induced experimental colitis was established and fecal microbiota was transplanted by gavage. Read More

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Antibiotic-induced disruption of the microbiome exacerbates chemotherapy-induced diarrhoea and can be mitigated with autologous faecal microbiota transplantation.

Eur J Cancer 2021 Jun 12;153:27-39. Epub 2021 Jun 12.

Department of Medical Microbiology, University Medical Centre Groningen, The University of Groningen, Groningen, the Netherlands.

Background: Chemotherapy is well documented to disrupt the gut microbiome, leading to poor treatment outcomes and a heightened risk of adverse toxicity. Although strong associations exist between its composition and gastrointestinal toxicity, its causal contribution remains unclear. Our inability to move beyond association has limited the development and implementation of microbial-based therapeutics in chemotherapy adjuncts with no clear rationale of how and when to deliver them. Read More

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Renin-angiotensin system in intestinal inflammation - Angiotensin inhibitors to treat inflammatory bowel diseases?

Basic Clin Pharmacol Toxicol 2021 Jun 15. Epub 2021 Jun 15.

Pharmacology, Faculty of Medicine, University of Helsinki, Finland.

Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract, which manifest in recurring gastrointestinal inflammation. The current treatment options of IBD are not curative and are lacking in aspects like prevention of fibrosis. New treatment options are needed to fulfil the unmet needs and provide alternatives to drugs with resistances and side effects. Read More

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The impact of device-assisted therapies on the gut microbiome in Parkinson's disease.

J Neurol 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurogenetics, Faculty of Medicine and Health, Kolling Institute, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.

Background: Microbiome feedbacks are proposed to influence Parkinson's disease (PD) pathophysiology. A number of studies have evaluated the impact of oral medication on the gut microbiome (GM) in PD. However, the influence of PD device-assisted therapies (DATs) on the GM remains to be investigated. Read More

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Interaction Between the Intestinal Microbial Community and Transcriptome Profile in Common Carp ( L.).

Front Microbiol 2021 28;12:659602. Epub 2021 May 28.

Key Laboratory of Genetic Breeding and Aquaculture Biology of Freshwater Fishes, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, China.

In a previous study, we found that the growth performance of the new strain of Huanghe carp is related to gene expression and bacterial community in the gut. In order to better understand the relationship between the gene expression level and bacterial abundance in the gut, we studied the growth performance, gut bacterial structure, and transcriptome profile in the 4th generation of the new carp strain (selection group) at harvesting time, and compared them with the control line (traditional Huanghe carp). Body weight, depth, width, and length increased 14. Read More

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Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.

Microbiome 2021 Jun 14;9(1):139. Epub 2021 Jun 14.

Division of Digestive Disease, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, SW7 2AZ, UK.

Background: Bariatric surgery, used to achieve effective weight loss in individuals with severe obesity, modifies the gut microbiota and systemic metabolism in both humans and animal models. The aim of the current study was to understand better the metabolic functions of the altered gut microbiome by conducting deep phenotyping of bariatric surgery patients and bacterial culturing to investigate causality of the metabolic observations.

Methods: Three bariatric cohorts (n = 84, n = 14 and n = 9) with patients who had undergone Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG) or laparoscopic gastric banding (LGB), respectively, were enrolled. Read More

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Gut microbiome composition and serum metabolome profile among individuals with spinal cord injury and normal glucose tolerance or prediabetes/type 2 diabetes.

Arch Phys Med Rehabil 2021 Jun 11. Epub 2021 Jun 11.

Departments of Physical Medicine and Rehabilitation, the University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Objective: To compare the gut microbiome composition and serum metabolome profile among individuals with spinal cord injury (SCI) and normal glucose tolerance (NGT) or prediabetes/type 2 diabetes (P/DM).

Design: Cross-sectional design.

Setting: Research university. Read More

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Gut microbiome skin axis in the development of atopic dermatitis.

J Pak Med Assoc 2021 Apr;71(4):1221-1227

Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Atopic dermatitis mostly starts with children in early life. Besides the aetiological factors, like environmental, dietary or medical exposures, gut-skin axis microbiome studies have an impact to investigate and to understand the relation between the gut microbiome and changes to the skin microbiom as well as resulting skin diseases like atopic dermatitis. Infants start forming their microbiome in early life and some studies suggest that this phase has a crucial role in AD development. Read More

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The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities.

Curr Oncol Rep 2021 Jun 14;23(8):92. Epub 2021 Jun 14.

Division of Gynecologic Oncology; Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Desk A81, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Purpose Of Review: We review the emerging evidence regarding the relationship between the microbiota of the gastrointestinal and female reproductive tracts and gynecologic cancer.

Recent Findings: The microbiome has essential roles in maintaining health. In recent years, the microbiota of the gastrointestinal and female reproductive tracts have been linked to many diseases, including gynecologic cancer. Read More

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Effects of Synbiotics on the Fecal Microbiome and Metabolomic Profiles of Healthy Research Dogs Administered Antibiotics: A Randomized, Controlled Trial.

Front Vet Sci 2021 26;8:665713. Epub 2021 May 26.

The Gastrointestinal Laboratory, Small Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.

Antibiotic-associated gastrointestinal signs occurred in 100% of dogs administered enrofloxacin with metronidazole in a previous study, and signs partially were mitigated by synbiotics. The objective of this randomized, double-blinded, placebo-controlled trial was to compare the fecal microbiome and metabolome of dogs administered enrofloxacin and metronidazole, followed by either a placebo or a bacterial/yeast synbiotic combination. Twenty-two healthy research dogs were randomized to two treatment groups. Read More

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Microbiome Analysis Reveals the Dynamic Alternations in Gut Microbiota of Diarrheal .

Front Vet Sci 2021 28;8:649372. Epub 2021 May 28.

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University Ithaca, NY, United States.

The ruminant gut microbial community's importance has been widely acknowledged due to its positive roles in physiology, metabolism, and health maintenance. Diarrhea has been demonstrated to cause adverse effects on gastrointestinal health and intestinal microecosystem, but studies regarding diarrheal influence on gut microbiota in have been insufficient to date. Here, this study was performed to investigate and compare gut microbial composition and variability between healthy and diarrheic . Read More

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Microbial Glycoside Hydrolases in the First Year of Life: An Analysis Review on Their Presence and Importance in Infant Gut.

Front Microbiol 2021 28;12:631282. Epub 2021 May 28.

Laboratory of Microbiology, Wageningen University & Research, Wageningen, Netherlands.

The first year of life is a crucial period during which the composition and functionality of the gut microbiota develop to stabilize and resemble that of adults. Throughout this process, the gut microbiota has been found to contribute to the maturation of the immune system, in gastrointestinal physiology, in cognitive advancement and in metabolic regulation. Breastfeeding, the "golden standard of infant nutrition," is a cornerstone during this period, not only for its direct effect but also due to its indirect effect through the modulation of gut microbiota. Read More

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Milk fat globule membrane phospholipids modify adhesion of Lactobacillus to mucus-producing Caco-2/Goblet cells by altering the cell envelope.

Food Res Int 2021 Aug 31;146:110471. Epub 2021 May 31.

Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, OH 43210, United States. Electronic address:

The importance of various Lactobacillus strains and milk components, such as the milk fat globule membrane, has been studied from various perspectives and proven to have a positive role in human health. On one end, lactic acid bacteria produce metabolites with direct effect in the immune system, changes of pH in the gut, and antagonistic substances for pathogenic bacteria as well as competition. On the other end, the milk fat globule membrane improves gastrointestinal status by promoting cell proliferation, epithelial tight junction patterns, and development of intestinal epithelial cells. Read More

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