71,319 results match your criteria gastrointestinal bleeding


A systematic review of symptomatic hamartomas of the jejunum and ileum.

Ann R Coll Surg Engl 2021 Sep 21. Epub 2021 Sep 21.

Western Sussex Hospitals NHS Foundation Trust, UK.

Introduction: Gastrointestinal hamartomas are rarely encountered benign growths made of an abnormal mixture of tissues normally found in the body where the growth occurs. Most hamartomas are asymptomatic and diagnosed incidentally. Evidence regarding symptomatic hamartomas of the jejunum and ileum is limited and restricted to anecdotal case reports. Read More

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September 2021

Effectiveness and Safety of Dabigatran in Atrial Fibrillation Patients with Severe Obesity: a Real-World Retrospective Cohort Study.

J Gen Intern Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.

Background: Direct oral anticoagulants such as dabigatran are the preferred anticoagulant in treating atrial fibrillation (AF) patients due to their effectiveness and safety. Whether this applies to severely obese patients needs to be determined.

Objective: To compare the effectiveness and safety of dabigatran with warfarin among AF patients with severe obesity. Read More

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September 2021

A Unique Case of Mantle Cell Lymphoma Masquerading as a Cecal Mass.

Case Rep Gastrointest Med 2021 10;2021:5581043. Epub 2021 Sep 10.

Department of Gastroenterology, St Michael's Medical Center, 111 Central Ave, Newark, NJ 07102, USA.

Mantle cell lymphoma (MCL), a type of B-cell non-Hodgkin's lymphoma, is a rare and aggressive disease with a poor prognosis due to its advanced presentation at diagnosis. It is characterized by a translocation in the Bcl-1 gene, which results in overexpression of cyclin D1. MCL is frequently seen in the form of multiple lymphomatous polyposis (MLP) in which innumerable polyps are observed in the gastrointestinal (GI) tract. Read More

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September 2021

Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: a nested case-control study of the UK primary care population.

Br J Gen Pract 2021 Jul 12. Epub 2021 Jul 12.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

Background: Pancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients in the UK were diagnosed at Stage IV.

Aim: This study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine neoplasms (PNEN), and comparatively characterise the symptomatology between the two tumour types to inform earlier diagnosis. Read More

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Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score.

Thromb Haemost 2021 Sep 20. Epub 2021 Sep 20.

Department of Acute Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Background:  Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.

Objectives:  To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, and (3) new prediction model. Read More

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September 2021

Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature.

Int J Surg Case Rep 2021 Sep 16;87:106420. Epub 2021 Sep 16.

Colorectal Research Center, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Leiomyosarcoma (LMS) of the colon is an extremely rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were highly limited. True LMS of the colon is such a rare disorder that there isn't much description of its nature. Read More

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September 2021

Quality of Care Before and After Mergers and Acquisitions of Rural Hospitals.

JAMA Netw Open 2021 Sep 1;4(9):e2124662. Epub 2021 Sep 1.

IBM Watson Health, Rochester, New York.

Importance: Rural hospitals are increasingly merging with other hospitals. The associations of hospital mergers with quality of care need further investigation.

Objectives: To examine changes in quality of care for patients at rural hospitals that merged compared with those that remained independent. Read More

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September 2021

The Diverticular Disease Registry (DDR Trial) by the Advanced International Mini-Invasive Surgery Academy Clinical Research Network: Protocol for a Multicenter, Prospective Observational Study.

Int J Surg Protoc 2021 30;25(1):194-200. Epub 2021 Aug 30.

General Surgery Department, Desio Hospital, ASST Brianza, Italy.

Diverticular disease is an increasingly common issue, with a variety of clinical presentations and treatment options. However, very few prospective cohort studies explore outcomes between the different presentations and treatments. The Diverticular Disease Registry (DDR Trial) is a multicenter, prospective, observational cohort study on behalf of the Advanced International Mini-Invasive Surgery (AIMS) academy clinical research network. Read More

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Duodenal Ganglioneuroma: A Rare Tumor Causing Upper Gastrointestinal Bleed.

Surg J (N Y) 2021 Jul 14;7(3):e255-e258. Epub 2021 Sep 14.

Department of GI Radiology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.

Neuroblastic tumors (NTs) include neuroblastoma, ganglioneuroblastoma, and ganglioneuroma (GN). They are very rare in adults. The Surveillance, Epidemiology, and End Results identified 144 patients ≥20 years old at diagnosis (6. Read More

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Thoracoabdominal duplication with hematochezia as an onset symptom in a baby: A case report.

World J Clin Cases 2021 Aug;9(24):7261-7268

Department of Surgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Background: Alimentary tract duplication is a rare congenital disease that may occur in any part of the alimentary tract, whereas thoracoabdominal duplications only account for approximately 2% of all alimentary tract duplication cases. Many symptoms, including abdominal pain, abdominal distension, vomiting, gastrointestinal bleeding, chest discomfort, chest pain, and shortness of breath, may be present in patients with abdominal or thoracic duplication.

Case Summary: A 10-mo-old infant, with a free previous medical history, was admitted to our hospital with melena three times in 6 d. Read More

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Secondary peripheral T-cell lymphoma and acute myeloid leukemia after Burkitt lymphoma treatment: A case report.

World J Clin Cases 2021 Aug;9(24):7237-7244

Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China.

Background: Multiple primary cancer refers to more than one synchronous or sequential cancer in the same individual. Multiple primary cancer always presents as solid cancer or acute myeloid leukemia (AML) secondary to lymphoma. Here, we report a rare case of secondary peripheral T-cell lymphoma and AML after Burkitt lymphoma treatment. Read More

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Safety of Inguinal Hernia Repair in the Elderly with Perioperative Continuation of Antithrombotic Therapy.

Visc Med 2021 Aug 6;37(4):315-322. Epub 2020 Nov 6.

Department of Gastrointestinal Surgery, Hernia Center, West China Hospital, Sichuan University, Chengdu, China.

Introduction: This study aimed to evaluate the safety of an inguinal hernia repair (IHR) under local anesthesia (LA) in the elderly with a perioperative continuation of antithrombotic therapy (AT).

Methods: A total of 120 patients undergoing elective primary IHR between August 2018 and August 2019 at the West China Hospital of China were prospectively studied, among which 60 patients also had coexisting cardiovascular diseases and had a continuation of AT perioperatively (antithrombotic group); the other 60 patients were not on any prior AT (control group). The primary endpoints were intra- and postoperative hemorrhagic complications, the required interventions for complications based on the Clavien-Dindo classification, and postoperative thromboembolic complications. Read More

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A prospective study on quality in endoscopic retrograde cholangiopancreatography (ERCP): trend in Italy from the REQUEST study.

Endosc Int Open 2021 Oct 16;9(10):E1563-E1571. Epub 2021 Sep 16.

Department of Gastroenterology, Nuovo Regina Margherita Hospital, Roma, Italy.

Endoscopic retrograde cholangiopancreatography (ERCP) is a complex procedure with a relatively high rate of adverse events. Data on training of operators and fulfillment of quality indicators in Italy are scarce. The goal of this study was to assess the overall quality of ERCP in Italy compared to international standards. Read More

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October 2021

Prognostic factors associated with upper gastrointestinal bleeding based on the French multicenter SANGHRIA trial.

Endosc Int Open 2021 Oct 16;9(10):E1504-E1511. Epub 2021 Sep 16.

Department of Gastroenterology, CH de Montfermeil, Montfermeil, France.

 Prognostic and risk factors for upper gastrointestinal bleeding (UGIB) might have changed overtime because of the increased use of direct oral anticoagulants and improved gastroenterological care. This study was undertaken to assess the outcomes of UGIB in light of these new determinants by establishing a new national, multicenter cohort 10 years after the first.  Consecutive outpatients and inpatients with UGIB symptoms consulting at 46 French general hospitals were prospectively included between November 2017 and October 2018. Read More

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October 2021

Complex Pathology and Management in the Obstetric Patient: A Narrative Review for the Anesthesiologist.

Cureus 2021 Aug 15;13(8):e17196. Epub 2021 Aug 15.

Anesthesiology, New York Medical College, Valhalla, USA.

Pregnant patients may present with multiple complex comorbidities that can affect peripartum management and anesthetic care. The preanesthesia clinic is the ideal setting for early evaluation of high-risk pregnant patients. Comorbidities may include cardiovascular pathology such as valvular abnormalities, septal defects, aortopathies, arrythmias and cardiomyopathies. Read More

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Octreotide acetate combined with somatostatin upregulates miR-1291 and downregulates miR-331-3p in patients with cirrhosis and upper gastrointestinal bleeding.

Am J Transl Res 2021 15;13(8):9883-9891. Epub 2021 Aug 15.

Department of Function, HanDan Central Hospital Handan 056001, Hebei, China.

Objective: This study aimed to explore the efficacy of octreotide acetate combined with somatostatin (OA + SS) for the treatment of patients with cirrhosis and upper gastrointestinal bleeding (UGIB).

Methods: A total of 118 patients with cirrhosis and UGIB in our hospital were enrolled from June 2018 to September 2019. Fifty-seven were treated with OA alone (Group A) whereas 61 were treated with OA + SS (Group B). Read More

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Magnet ingestion knows no borders: A threat for Latin American children.

Rev Gastroenterol Mex 2021 Sep 15. Epub 2021 Sep 15.

Departmento de Gastroenteología, Hepatología y Nutrición Pediátrica, University of Miami Miller School of Medicine, Miami, Florida, Estados Unidos. Electronic address:

Introduction And Aims: The ingestion of foreign bodies, such as magnets, is a potentially lethal accident that affects children and is associated with bleeding and gastrointestinal perforation, as well as death. There are no Latin American reports in the literature on cases of magnet ingestion in children. Our aim was to establish whether said ingestion has been seen by pediatric endoscopists and gastroenterologists in Latin America, to determine the scope of that potential threat in their patient populations. Read More

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September 2021

Utility of modified Rankin Scale for brain vascular malformations in hereditary hemorrhagic telangiectasia.

Orphanet J Rare Dis 2021 Sep 19;16(1):390. Epub 2021 Sep 19.

Toronto HHT Centre, St. Michael's Hospital and Li Ka Shing Knowledge Institute, Toronto, Canada.

Background: Approximately 10% of hereditary hemorrhagic telangiectasia (HHT) patients harbour brain vascular malformations (VMs). Intracranial hemorrhage (ICH) from brain VMs can lead to death or morbidity, while treatment options for brain VMs also have associated morbidity. The modified Rankin Scale (mRS) may provide an approach to identifying HHT-brain VM patients with poor outcomes, and their predictors. Read More

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September 2021

Early Versus Delayed Feeding After Therapeutic Endoscopic Procedures: A Meta-Analysis of Randomized Controlled Trials.

Dig Endosc 2021 Sep 18. Epub 2021 Sep 18.

Division of Emergency Medicine, Department of Emergency and Critical Care, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.

Introduction: Early feeding was previously considered to increase the risk of postprocedural bleeding. However, many trials have demonstrated the benefits of early feeding after therapeutic endoscopic procedures. We conducted a meta-analysis of randomized controlled trials to evaluate the safety and outcomes between early feeding and delayed feeding after therapeutic endoscopic procedures. Read More

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September 2021

Outcomes and Predictors of Readmission after Implantation of a Percutaneous Left Atrial Appendage Occlusion device in the United States: A Propensity Score-matched Analysis from the National Readmission Database.

J Cardiovasc Electrophysiol 2021 Sep 17. Epub 2021 Sep 17.

University of California San Diego Health, San Diego, California.

Background: LAAO devices have become a favorable alternative option among non-valvular atrial fibrillation (AF) patients with long-term contraindication to anticoagulation. Real-world experience with post-procedural readmission rates and predictors of readmission in LAAO patients is limited.

Objective: To assess all-cause 30-day readmission rate and predictors of readmission after Left atrial appendage occlusion (LAAO) procedure in the United States (US). Read More

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September 2021

Comparison of assessment tools in acute upper gastrointestinal bleeding: which one for which decision.

Scand J Gastroenterol 2021 Sep 17:1-7. Epub 2021 Sep 17.

Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy.

Background: Upper GI bleeding (UGIB) remains a common emergency with significant mortality. Scores help triage patients, but it is still unclear which score should be used in the different decision-making moments to identify patients at high or low death risk. We aimed to compare the overall performances of the most validated scores and their cut-off performance to identify patients at low and high death risk. Read More

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September 2021

Effects of nitro-butoxyl- and butyl-esters of non-steroidal anti-inflammatory drugs compared with parent compounds on the contractility of digital arterial smooth muscle from the fallow deer (Dama dama).

Inflammopharmacology 2021 Sep 16. Epub 2021 Sep 16.

Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are a major cause of upper gastro-intestinal (GI) ulceration and bleeding as well as cardiovascular (CV) diseases (e.g., myocardial infarction and stroke). Read More

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September 2021

Anatomical observation and clinical significance of the left gastric vein in laparoscopic radical gastrectomy.

J Gastrointest Oncol 2021 Aug;12(4):1407-1415

Department of Gastrointestinal Surgery, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Background: The left gastric vein (LGV) plays an important role in laparoscopic radical gastrectomy (LRG). However, the anatomy of the LGV is complicated with significant variation, and it is often damaged and bleeding during LRG. The purpose of this study was to observe and analyze the anatomic types of the LGV in patients undergoing LRG and to explore its clinical significance. Read More

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Should we routinely prescribe proton pump inhibitors peri-operatively in elderly patients with hip fractures? A review of the literature.

EFORT Open Rev 2021 Aug 10;6(8):686-691. Epub 2021 Aug 10.

Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa.

Elderly hip fracture patients are at risk of stress-related gastric mucosal damage, and upper gastrointestinal bleeding is one of the underrecognized but devastating complications.Proton pump inhibitors (PPIs) offer effective prophylaxis against stress-related gastric mucosal damage.Systematic analysis of the literature revealed numerous articles on PPIs and hip fractures, but only three articles dedicated to the analysis of prophylactic use of PPIs in patients with a hip fracture. Read More

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Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit.

Sci Rep 2021 Sep 16;11(1):18467. Epub 2021 Sep 16.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.

Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear. In this retrospective, observational, comparative cohort study, PPIs and H2RAs for stress ulcer prophylaxis in critically ill patients were compared using a common data model. Read More

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September 2021

Apixaban and Dalteparin for the Treatment of Venous Thromboembolism in Patients with Different Sites of Cancer.

Thromb Haemost 2021 Sep 16. Epub 2021 Sep 16.

Internal Vascular and Emergency Medicine, University of Perugia, Perugia, Italy.

Efficacy and safety of anticoagulant treatment for venous thromboembolism (VTE) may vary in patients with different cancer sites. We evaluated the rates of VTE recurrence and major bleeding and the relative efficacy and safety of 6-month treatment with oral apixaban or subcutaneous dalteparin in patients with different cancer sites randomized in the Caravaggio study. Primary cancer was located at gastrointestinal sites in 375 patients (32. Read More

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September 2021

Long-term risk of upper gastrointestinal bleeding after Helicobacter pylori eradication: a population-based cohort study.

Aliment Pharmacol Ther 2021 Sep 16. Epub 2021 Sep 16.

Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.

Background: The long-term effects of H. pylori eradication in preventing upper GI bleeding (UGIB) remains unknown.

Aim: To determine the long-term risks of UGIB after H. Read More

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September 2021

Cost-Effectiveness and Cost-Utility Analysis of the Use of Clopidogrel and Pantoprazole in Comparison with Clopidogrel and Omeprazole for the Secondary Prevention of Myocardial Infarction in Iran.

J Res Pharm Pract 2021 Apr-Jun;10(2):90-95. Epub 2021 Aug 3.

Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: Gastrointestinal bleeding, a side effect of clopidogrel, is usually prevented by proton-pump inhibitors (PPIs). Due to omeprazole's inhibitory effects on the liver enzyme CYP2C19, its concomitant use with clopidogrel is argued to increase the risk of myocardial infarction (MI) recurrence, as CYP2C19 activates clopidogrel. Pantoprazole as an alternative PPI has shown no inhibitory effect on CYP2C19. Read More

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A Difficult and Rare Case of Warfarin Refractory Antiphospholipid Syndrome Presenting With Catastrophic Antiphospholipid Syndrome Complicated by Gastrointestinal Bleeding.

Cureus 2021 Aug 11;13(8):e17106. Epub 2021 Aug 11.

Hematology and Medical Oncology, Brooklyn Cancer Care, Brooklyn, USA.

Antiphospholipid syndrome (APS) is managed with warfarin for secondary prophylaxis in patients who have had a thrombotic event in the past. Warfarin has been deemed superior to novel oral anticoagulants in preventing venous and arterial thrombosis in conjunction with aspirin. The catastrophic variant of APS (CAPS) is very rarely reported, especially in those who have been on a therapeutic dose of warfarin therapy. Read More

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Gastric duplication cyst with a red flag presentation: a case report.

Pan Afr Med J 2021 18;39:141. Epub 2021 Jun 18.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.

Gastric duplication cyst (GDC) is a rare congenital malformation of the gastrointestinal (GI) tract. Despite being benign in the entity, its complications vary from an asymptomatic abdominal mass to fulminant or massive GI bleeding. A 28-year-old lady presented with unexplained GI haemorrhage, in which the upper endoscopy showed a classic feature of GI stromal tumour. Read More

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