59,029 results match your criteria gastric ulcer


Protective effects of dried mature peel (Chenpi) and hesperidin on aspirin-induced oxidative damage.

J Clin Biochem Nutr 2021 Mar 13;68(2):149-155. Epub 2020 Oct 13.

School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Here we investigated the inhibitory effects in rats of mature peel (Chenpi) and its component hesperidin on aspirin-induced oxidative damage. The content of hesperidin in Chenpi extract was approximately 11.4%. Read More

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Acupoint catgut embedding for the treatment of peptic ulcers: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25562

Jiangxi University of Traditional Chinese Medicine.

Background: Peptic ulcer (PU) is a common clinical disease of the digestive system, which can occur in all ages, gastric and duodenal ulcers are the most commonly seen PUs in clinical practice. The main manifestations are chronic and periodic rhythmic upper abdominal pain, accompanied by indigestion symptoms such as pantothenic acid, belching, and nausea. Serious complications such as bleeding, perforation, obstruction and canceration are easy to occur, endangering the life safety of patients. Read More

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Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis.

BMC Gastroenterol 2021 Apr 20;21(1):181. Epub 2021 Apr 20.

Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.

Background: In general, all virulence factors of Helicobacter pylori (H. pylori) are involved in its infections. However, recent studies have shown that the homB gene is one of the virulence genes that affects the severity of the clinical results of this bacterium. Read More

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Diagnostic Accuracy of Ultrasound for Detecting Gastric or Duodenal Ulcers in Pediatric Patients.

J Ultrasound Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Radiology, Saitama Children's Medical Center, Saitama, Japan.

Objective: Direct ultrasound imaging findings alone have low sensitivity for diagnosing duodenal (65%) and gastric ulcers (40%). This retrospective study evaluated the efficiency of ultrasound in detecting gastric/duodenal ulcers in pediatric patients through direct and indirect findings.

Methods: We evaluated 244 children who underwent ultrasound and subsequent endoscopy within 4 weeks for direct and indirect imaging findings indicative of gastric/duodenal ulcers. Read More

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Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions.

Dose Response 2021 Jan-Mar;19(1):15593258211001259. Epub 2021 Mar 30.

Faculty of Pharmacy, Department of Pharmaceutics, King Abdulaziz University, Jeddah, Saudi Arabia.

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. Alpha-lipoic acid (ALA), a natural potent antioxidant, has been known as a gastroprotective drug yet its low bioavailability may restrict its therapeutic efficacy. This study aimed to formulate and optimize ALA using a self-nanoemulsifying drug delivery system (SNEDDS) with a size of nano-range, enhancing its absorption and augmenting its gastric ulcer protection efficacy. Read More

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Histopathological effects on stomach, liver and kidney associated with Cedrus deodara root oil in ulcer induced rats (Wistar strain).

Pak J Pharm Sci 2020 Nov;33(6):2483-2488

Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, 51 Deh Tor, Gadap Road, Near Toll Plaza, Super Highway, Karachi, Pakistan.

Cedrus deodara have been used traditionally in ayurvedic system against peptic ulcer. Present work is concerned with the determination of histopathological effects in ethanol induced ulcer on rats (Wistar Strain) treated with Cedrus deodara root oil at a dose of 200mg/kg and comparison of its antiulcer activity against control, positive control and standard anti-ulcer drug (Omeprazole). The aim was to find out the antiulcer effect of Cedrus deodara root oil and to observe histopathology of liver, kidney as well. Read More

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November 2020

Recurrent Aphthous Stomatitis Improved after Eradication Therapy for .

Case Rep Gastrointest Med 2021 30;2021:5543838. Epub 2021 Mar 30.

Gastroenterology Department, Loma Linda University Medical Center, Loma Linda, CA, USA.

(. ) is a Gram-negative bacterium that colonizes gastric mucosa and is often transmitted through direct contact with saliva, contaminated food or water, and vomit. The majority of the infected individuals remain asymptomatic for a long period. Read More

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Iatrogenic injury of duodenum: malady of a therapeutic misadventure.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of General Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Endoscopic procedures are the front-runner of the management of bleeding duodenal ulcer. Rarely, surgical intervention is sought for acute bleeding, not amenable to endoscopic procedures. Oversewing of the gastroduodenal artery at ulcer crater by transduodenal approach is the most acceptable and recommended method of treatment. Read More

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Gastric Antral Diverticula: A Rare Diverticula with a Unique Presentation.

Case Rep Gastrointest Med 2021 26;2021:6623183. Epub 2021 Mar 26.

Department of Internal Medicine, Grand Strand Medical Center, Myrtle Beach, SC, USA.

Gastric diverticula are the least common gastrointestinal diverticula. Patients can be diagnosed incidentally on EGD or present with variable symptoms such as abdominal fullness, anorexia, and perforation. Gastric diverticula can be acquired from malignancy, peptic ulcer disease, or prior surgery or be congenital. Read More

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Anti-ulcerogenic effect of methanolic extract of Elaeagnus conferta Roxb. seeds in Wistar rats.

J Ethnopharmacol 2021 Apr 11:114115. Epub 2021 Apr 11.

Rayat Institute of Pharmacy, Railmajra, SBS Nagar, Punjab, India. Electronic address:

Ethnopharmacological Relevance: Elaeagnus conferta Roxb. (Elaeagnaceae) is a subtropical shrub mainly native to India, Vietnam, Malaysia and South China, whose various parts are used for treatment of diabetes, gastric ulcers, pain, oxidative stress and pulmonary disorders. Though the other parts of the plant have been reported for their ethnic use i. Read More

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STOMACH BEZOARIS, CAUSES OF DEVELOPMENT, DIAGNOSIS AND METHODS OF TREATMENT.

Wiad Lek 2021 ;74(1):128-131

NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.

Objective: The aim: Is to determine the tactics and methods of treatment of bezoars of the gastrointestinal tract.

Patients And Methods: Materials and methods: From 2001 to 2019, 17 patients were diagnosed with "bezoar".

Results: Results: Due to the "weariness" of the clinic, the diagnosis was made in the first 3 days only for 3 (17,6 %) patients. Read More

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Analysis of Digestive Endoscopic Results During COVID-19.

J Transl Int Med 2021 Mar 5;9(1):38-42. Epub 2021 Jan 5.

Department of Gastroenterology, The Second Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Objective: This study aims to explore the necessity and safety of digestive endoscopy during the epidemic of coronavirus disease 2019.

Methods: A retrospective cohort study method was used to collect patients' data from the endoscopy center of the Civil Aviation General Hospital of China from February 1 to May 31, 2020, as the observation group. The patients' data of endoscopic diagnosis and treatment during the same period in 2019 were used as a control group, to compare the differences in the number of diagnosis and treatment and the detection rate of gastrointestinal diseases in the two groups. Read More

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Perforated gastric ulcer as the initial manifestation of hyperparathyroidism.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

General Surgery, Hutt Valley District Health Board, Lower Hutt, New Zealand.

Primary hyperparathyroidism is characterised by autonomous production of parathyroid hormone resulting in hypercalcaemia. It is estimated that 12% of these patients present with peptic ulcer-related symptoms. The pathophysiological mechanism is not well established, but studies reveal serum calcium activating gastrin cell calcium receptors ultimately resulting in increased gastric acid production leading to peptic ulcer disease. Read More

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H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Clin Mol Allergy 2021 Apr 13;19(1). Epub 2021 Apr 13.

Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132, Genoa, Italy.

Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H-antagonists. Read More

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Potassium bromate (KBrO3) Modulates Oxidative stress and inflammatory biomarkers in NaOH induced crohn's colitis in Wistar rats.

Can J Physiol Pharmacol 2021 Apr 13. Epub 2021 Apr 13.

University of Ibadan, Faculty of Basic Medical Sciences, Physiology, Ibadan, Oyo, Nigeria.

Potassium bromate (KBrO3) present in consumed ozonised water was recently documented to exacerbate experimental gastric ulcer. Report is however vague as regards its effects in the colon; where water reabsorption occurs. In this study, we observed the possible effects of KBrO3 on oxidative stress and inflammatory biomarkers in NaOH induced crohn's colitis. Read More

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Inhibition of low-density lipoprotein uptake by Helicobacter pylori virulence factor CagA.

Biochem Biophys Res Commun 2021 Apr 9;556:192-198. Epub 2021 Apr 9.

Department of Anatomy, Faculty of Medicine, Oita University, Yufu, Oita, 879-5593, Japan. Electronic address:

Helicobacter pylori (H. pylori) infection mainly causes gastroduodenal diseases, including chronic gastritis, peptic ulcer disease and gastric cancer. In recent years, several studies have demonstrated that infection with H. Read More

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Pharmaceuticals agents for preventing NSAID-induced gastric ulcers: a patent review.

Expert Rev Clin Pharmacol 2021 Apr 12:1-10. Epub 2021 Apr 12.

Federal University of Sergipe, Department of Pharmacy, São Cristovão, Sergipe, Brazil.

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used due to their pharmacological potential, demonstrating anti-inflammatory, analgesic, or antipyretic activity. However, prolonged use of these medications can lead to the development of gastric ulcers in patients. This review aimed to find patents for drugs with an anti-inflammatory and gastroprotective character to treat NSAID-induced gastric ulcers. Read More

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Exploring biologically active hybrid pharmacophore N-substituted hydrazine-carbothioamides for urease inhibition: In vitro and in silico approach.

Int J Biol Macromol 2021 Apr 9;182:534-544. Epub 2021 Apr 9.

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:

Urease is potential target for various human's health complications, such as peptic ulcer, gastric cancer and kidney stone formation. The present study was based on synthesis of new hybrid pharmacophore N-substituted hydrazine-carbothioamides as potential urease inhibitors. Presented method gave excellent yield in range of 85-95% for hydrazine-carbothioamides derivatives (3a-s) after reaction of mono- and disubstituted hydrazides (1a-k) and substituted isothiocyanates (2a-d). Read More

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Interplay of Biochemical, Genetic, and Immunohistochemical Factors in the Etio-Pathogenesis of Gastric Ulcer in Rats: A Comparative Study of the Effect of Pomegranate Loaded Nanoparticles Versus Pomegranate Peel Extract.

Front Physiol 2021 23;12:649462. Epub 2021 Mar 23.

Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Few data are available about the role of herbal extract loaded nanoparticles as an alternative safe medicine for the management of a gastric ulcer.

Aim: This work is targeted at exploring the physiological effects of pomegranate loaded nanoparticles (PLN) against an indomethacin IND-induced gastric ulcer and comparing the results with traditional pomegranate peel extract (PPE).

Methods: Twenty-four rats were equally distributed into four groups: control, IND-treated, PLN-treated, and PPE-treated groups. Read More

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Non-responsive celiac disease in children on a gluten free diet.

World J Gastroenterol 2021 Apr;27(13):1311-1320

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, United States.

Background: Non-responsive celiac disease (NRCD) is defined as the persistence of symptoms in individuals with celiac disease (CeD) despite being on a gluten-free diet (GFD). There is scant literature about NRCD in the pediatric population.

Aim: To determine the incidence, clinical characteristics and underlying causes of NRCD in children. Read More

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A 58-Year-Old Woman with Acute Gastric Perforation Due to Metastatic Ductal Carcinoma 18 Years Following Bilateral Mastectomy for Invasive Ductal Carcinoma of the Breast.

Am J Case Rep 2021 Apr 8;22:e927094. Epub 2021 Apr 8.

Department of Digestive Surgery, Hotel Dieu De France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

BACKGROUND Invasive lobular carcinoma and ductal carcinoma of the breast can metastasize to all sites in the body, including the gastrointestinal tract. Late presentation of metastases of lobular carcinoma of the breast to the gastrointestinal tract have previously been reported, but late metastasis of ductal carcinoma of the breast to the gastric mucosa is rare. This report is of a 58-year-old Lebanese woman who presented with acute gastric perforation due to metastatic ductal carcinoma,18 years following bilateral mastectomy for invasive ductal carcinoma of the breast. Read More

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Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats.

J Tradit Chin Med 2021 04;41(2):270-275

Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.

Objective: To investigate the efficacy of the extract from Ononis spinosa L. (O. spinosa) on ethanol-induced gastric ulcer in rats. Read More

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Outcomes of Nonoperative Treatment for Gastroduodenal Ulcer Perforation: a Nationwide Study of 14,918 Inpatients in Japan.

J Gastrointest Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Gastroduodenal ulcer perforation is a common abdominal emergency that may be curable without surgical repair in non-elderly patients with localized and stable symptoms. However, the outcomes of nonoperative approaches have rarely been described.

Methods: Using a Japanese national inpatient database, we identified 14,918 patients with gastroduodenal ulcer perforation who were hospitalized and received nonoperative treatment from July 2010 to March 2017. Read More

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Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in .

Front Microbiol 2021 19;12:629163. Epub 2021 Mar 19.

Department of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Naples, Italy.

Our understanding of the function of bacterial carbonic anhydrases (CAs, EC 4.2.1. Read More

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Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol-Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities.

Int J Nanomedicine 2021 26;16:2461-2475. Epub 2021 Mar 26.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

Aim: To explore the effects of Radix Sophorae Flavescentis carbonisata-based carbon dots (RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model.

Methods: The structure, optical properties, functional groups and elemental composition of RSFC-CDs synthesized by one-step pyrolysis were characterized. The gastric protective effects of RSFC-CDs were evaluated and confirmed by applying a rat model of ethanol-induced acute gastric ulcers. Read More

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CagE, cagA and cagA 3' region polymorphism of Helicobacter pylori and their association with the intra-gastric diseases in Moroccan population.

Diagn Microbiol Infect Dis 2021 Mar 13;100(3):115372. Epub 2021 Mar 13.

Laboratoire de Pathologie Humaine Biomédecine et Environnement, Equipe micro-organismes génomique et facteurs oncogènes, Faculté de médecine et de Pharmacie de Fès (FMPF), Université Sidi Mohammed Ben Abdellah (USMBA), Fès, Maroc.; Laboratoire de microbiologie et de Biologie Moléculaire, FMPF, USMBA. Electronic address:

Helicobacter pylori infection is the most important etiological factor in gastroduodenal diseases development. Its evolution is influenced by several factors, including bacterial virulence genes such as cagA and cagE. This work aimed to evaluate the predictive value of cagE alone and in combination with cagA and CagA-EPIYA-C motifs number as a marker of the infection evolution. Read More

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Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation.

Molecules 2021 Mar 26;26(7). Epub 2021 Mar 26.

Department of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, Korea.

Phytoncide is known to have antimicrobial and anti-inflammatory properties. This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Read More

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Tablet of L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects.

Molecules 2021 Mar 12;26(6). Epub 2021 Mar 12.

Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, PB 58429-500, Brazil.

L. (Anacardiaceae) has a worldwide distribution and is present in all regions of Brazil. Its leaves, flowers and bark are used as teas in folk medicine to treat diseases of the digestive system. Read More

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Protective Effect of Maxim. Extract against Ethanol-Induced Gastritis in Rats.

Antioxidants (Basel) 2021 Mar 12;10(3). Epub 2021 Mar 12.

Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.

Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine for asthma, cough, and atopic dermatitis in Korea and China. Although it was originally shown to possess anti-inflammatory, antioxidant, and antiatopic properties, its gastroprotective effects have not been investigated. In the present study, we evaluated the protective effects of Maxim extract (PUE) against ethanol-induced gastritis in rats. Read More

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Novel Carbon Dots Derived from and Their Anti-Gastric Ulcer Effect.

Molecules 2021 Mar 10;26(6). Epub 2021 Mar 10.

Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100029, China.

(GRR) is one of the commonly used traditional Chinese medicines in clinical practice, which has been applied to treat digestive system diseases for hundreds of years. GRR is preferred for anti-gastric ulcer, however, the main active compounds are still unknown. In this study, GRR was used as precursor to synthesize carbon dots (CDs) by a environment-friendly one-step pyrolysis process. Read More

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