70,025 results match your criteria gastric mucosa


Gastric metastasis before diagnosis of primary invasive lobular breast carcinoma: a rare case presentation from Pakistan.

Women Health 2021 Sep 26:1-5. Epub 2021 Sep 26.

BreathMAT Lab, Pakistan Institute of Nuclear Science and Technology, Islamabad, Pakistan.

Metastatic spread of invasive lobular breast carcinoma to stomach is rare especially before diagnosis of primary breast cancer. Incorrect diagnosis might result in delay of appropriate treatment for breast cancer. Recognition of this possibility enables better clinical management. Read More

View Article and Full-Text PDF
September 2021

Successful Endoscopic Resection of Primary Rectal Mucosa-Associated Lymphoid Tissue Lymphoma by Endoscopic Submucosal Dissection: A Case Report.

Front Med (Lausanne) 2021 10;8:715256. Epub 2021 Sep 10.

Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Mucosa-associated lymphoid tissue (MALT) lymphoma arises in extra-nodal sites from the malignant transformation of B lymphocytes that are mainly triggered by infection or autoimmune process. MALT lymphoma is frequently detected in the gastrointestinal tract. As the causal relationship between Helicobacter pylori (H. Read More

View Article and Full-Text PDF
September 2021

Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer.

Stem Cell Res Ther 2021 Sep 26;12(1):515. Epub 2021 Sep 26.

Department of Internal Medicine, Alborz University of Medical Science, Karaj, Iran.

Peptic ulcer is one of the most common gastrointestinal tract disorders worldwide, associated with challenges such as refractory morbidity, bleeding, interference with use of anticoagulants, and potential side effects associated with long-term use of proton pump inhibitors. A peptic ulcer is a defect in gastric or duodenal mucosa extending from muscularis mucosa to deeper layers of the stomach wall. In most cases, ulcers respond to standard treatments. Read More

View Article and Full-Text PDF
September 2021

CagA EPIYA Motif Variations Affect Metabolic Activity in B Cells.

Toxins (Basel) 2021 Aug 24;13(9). Epub 2021 Aug 24.

Division of Microbiology, Department of Biosciences, Paris-Lodron University of Salzburg, 5020 Salzburg, Austria.

Background: () colonizes the human stomach and can induce gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. Clinical observations suggest a role for the virulence factor cytotoxin-associated gene A (CagA) in pathogenesis. The pathogenic activity of CagA is partly regulated by tyrosine phosphorylation of C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs in host cells. Read More

View Article and Full-Text PDF

Comment on: The effect of sleeve ablation of gastric mucosa on body weight and glucose homeostasis in the rat.

Authors:
Vance L Albaugh

Surg Obes Relat Dis 2021 Aug 28. Epub 2021 Aug 28.

Assistant Professor of Metabolic Surgery, Pennington Biomedical Research Center, Baton Rouge, Louisiana.

View Article and Full-Text PDF

Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma.

Medicine (Baltimore) 2021 Sep;100(38):e27287

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Abstract: To investigate the mucosal microbiota in the stomach of patients with Helicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma by means of metagenomic analysis.Although some gastric MALT lymphomas are associated with the presence of H. pylori, other gastric MALT lymphomas occur independently of H. Read More

View Article and Full-Text PDF
September 2021

Gastric glomus tumour: A case report.

J Minim Access Surg 2021 Oct-Dec;17(4):551-553

Department of Pathology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India.

Glomus tumours (GTs) are rare, mesenchymal neoplasms arising from the glomus body. Atypical sites, like the stomach, have been reported with extreme rarity since the usual location lies under the nail beds. We report a rare case of gastric GT in a 28-year-old female presenting with upper abdominal pain, intermittent haematemesis and melena. Read More

View Article and Full-Text PDF
September 2021

Differential Expression of COL1A1, COL1A2, COL6A3, and SULF1 as Prognostic Biomarkers in Gastric Cancer.

Int J Gen Med 2021 17;14:5835-5843. Epub 2021 Sep 17.

Department of Oncology, The First People's Hospital of Jingzhou, Jingzhou, Hubei, 434000, People's Republic of China.

Background: Gastric cancer (GC) is among the most prevalent cancers globally. As such, there is a need to explore the mechanism underlying its pathogenesis and identify potential biomarkers for its prognosis.

Methods: ONCOMINE was used to screen differentially expressed genes between GC and normal gastric mucosa. Read More

View Article and Full-Text PDF
September 2021

Protective effect of standardised fruit extract of Roxb. ex Choisy against ethanol induced gastric mucosal lesions in Wistar rats.

Ann Med 2021 Dec;53(1):1696-1708

ICAR-Directorate of Medicinal and Aromatic Plants Research, Boriavi, Anand, India.

Background And Aim: The fruit of is a rich and valuable source of bioactive compounds and is traditionally used for treating wounds and ulcers. The present study was carried out to investigate the protective effect of chromatographically standardized fruit extract of (GCE) on ethanol-induced gastric lesions in rats and its possible mechanisms.

Methods: The effect of GCE (200 and 400 mg/kg body weight) was evaluated by determining various gastric ulcer parameters like gastric wall mucus, non-protein sulfhydryls (NP-SH) content, microvascular permeability, endogenous antioxidant enzyme, and gastric histopathological study. Read More

View Article and Full-Text PDF
December 2021

Fecal filtrate transplantation protects against necrotizing enterocolitis.

ISME J 2021 Sep 22. Epub 2021 Sep 22.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disorder afflicting preterm infants, which is currently unpreventable. Fecal microbiota transplantation (FMT) is a promising preventive therapy, but the transfer of pathogenic microbes or toxic compounds raise concern. Removal of bacteria from donor feces by micropore filtering may reduce this risk of bacterial infection, while residual bacteriophages could maintain the NEC-preventive effects. Read More

View Article and Full-Text PDF
September 2021

Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer.

Inflamm Res 2021 Sep 21. Epub 2021 Sep 21.

Department of Gastroenterology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.

Objective: Helicobacter pylori (H. pylori) infects approximately half of the world's population, as one of the most common chronic infections. H. Read More

View Article and Full-Text PDF
September 2021

A Unique Case of Mantle Cell Lymphoma Masquerading as a Cecal Mass.

Case Rep Gastrointest Med 2021 10;2021:5581043. Epub 2021 Sep 10.

Department of Gastroenterology, St Michael's Medical Center, 111 Central Ave, Newark, NJ 07102, USA.

Mantle cell lymphoma (MCL), a type of B-cell non-Hodgkin's lymphoma, is a rare and aggressive disease with a poor prognosis due to its advanced presentation at diagnosis. It is characterized by a translocation in the Bcl-1 gene, which results in overexpression of cyclin D1. MCL is frequently seen in the form of multiple lymphomatous polyposis (MLP) in which innumerable polyps are observed in the gastrointestinal (GI) tract. Read More

View Article and Full-Text PDF
September 2021

Intestinal Metaplasia Influencing the Density of Ghrelin Expressing Cells in Morbid Obese Patients.

Obes Surg 2021 Sep 20. Epub 2021 Sep 20.

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Gastrointestinal Surgery, 16310, Yildirim, Bursa, Turkey.

Purpose: The aim was to compare the density of ghrelin-expressing cells (GECs) in morbid obese patients with or without intestinal metaplasia (IM).

Materials And Methods: The study included 48 patients out of 244 who underwent laparoscopic sleeve gastrectomy between 2015 and 2019. IM was detected in the sleeve gastrectomy specimens of 24 of these 244 patients. Read More

View Article and Full-Text PDF
September 2021

miR-511-5p Suppresses Cell Migration, Invasion and Epithelial-Mesenchymal Transition Through Targeting PAK2 in Gastric Cancer.

Biochem Genet 2021 Sep 20. Epub 2021 Sep 20.

Department of Essential Surgery, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, 410008, Hunan Province, People's Republic of China.

As a malignant tumor, gastric cancer (GC) is closely related with gastric mucosa and has a high mortality in the world. Since microRNA (miRNA) has become more and more important in tumor research, we intend to find out the functional role and mechanism of miR-511-5p in GC. Firstly, miR-511-5p level was examined in human GC cell lines and tissues, and its effect on cell migration and invasion of BGC-823 or HGC-27 cells was tested by migration assay and transwell assay. Read More

View Article and Full-Text PDF
September 2021

Thoracoabdominal duplication with hematochezia as an onset symptom in a baby: A case report.

World J Clin Cases 2021 Aug;9(24):7261-7268

Department of Surgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Background: Alimentary tract duplication is a rare congenital disease that may occur in any part of the alimentary tract, whereas thoracoabdominal duplications only account for approximately 2% of all alimentary tract duplication cases. Many symptoms, including abdominal pain, abdominal distension, vomiting, gastrointestinal bleeding, chest discomfort, chest pain, and shortness of breath, may be present in patients with abdominal or thoracic duplication.

Case Summary: A 10-mo-old infant, with a free previous medical history, was admitted to our hospital with melena three times in 6 d. Read More

View Article and Full-Text PDF

Multi-layer endoscopic suturing: a novel method of gastric fistula closure.

Endosc Int Open 2021 Oct 16;9(10):E1520-E1523. Epub 2021 Sep 16.

Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States.

 Current endoscopic methods of treating gastric fistulas are either too complex or have high rates of recurrence. We aimed to provide a novel endoscopic method for robust fistula closure.  This was a single-center, retrospective study of five patients who underwent multi-layer endoscopic suturing for closing of a chronic fistula (> 4 weeks). Read More

View Article and Full-Text PDF
October 2021

Therapeutic effects, immunogenicity and cytotoxicity of a cell penetrating peptide-peptide nucleic acid conjugate against of in cell culture and animal model.

Iran J Microbiol 2021 Jun;13(3):360-371

Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background And Objectives: causes several gastrointestinal diseases, including asymptomatic gastritis, chronic peptic ulcer, duodenal ulcer, lymphoma of the mucosa-associated lymphoid tissue (MALT), and gastric adenocarcinoma. In recent years, failure to eradicate infections has become an alarming problem for physicians. It is now clear that the current treatment strategies may become ineffective, necessitating the development of innovative antimicrobial compounds as alternative treatments. Read More

View Article and Full-Text PDF

Inflammation is involved in response of gastric mucosal epithelial cells under simulated microgravity by integrated transcriptomic analysis.

Am J Transl Res 2021 15;13(8):9195-9207. Epub 2021 Aug 15.

Medical School of Chinese PLA Beijing 100853, China.

Astronauts suffer from inflammatory changes induced by microgravity during space flight. Microgravity can significantly affect the inflammatory response of various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and digestive system. The aim of this research was to identify the key genes and pathways of gastric mucosa affected by microgravity. Read More

View Article and Full-Text PDF

Epstein-Barr virus associated gastric dysplasia: a new rare entity?

Virchows Arch 2021 Sep 19. Epub 2021 Sep 19.

Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, via Gabelli 61, 35121, Padua, Italy.

Epstein-Barr virus (EBV) infection characterizes a portion of gastric adenocarcinomas. However, since there is lack of evidence of EBV presence in pre-neoplastic lesions of gastric mucosa, the etiologic role of EBV in gastric carcinogenesis is still debated. We report an unusual case of an EBV-associated foveolar gastric dysplasia associated with a focus of EBV-positive low-grade tubular adenocarcinoma, arisen in the context of a lymphocytic-like (EBV-positive) gastritis. Read More

View Article and Full-Text PDF
September 2021

The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study.

Sci Rep 2021 Sep 16;11(1):18508. Epub 2021 Sep 16.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Recently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels are not ideal coating materials because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study to investigate the protective effect of a novel ulcer coating material, whose physical properties can be easily controlled and designed. Read More

View Article and Full-Text PDF
September 2021

Protective effect of the combination of essential oil from patchouli and tangerine peel against gastric ulcer in rats.

J Ethnopharmacol 2021 Sep 13:114645. Epub 2021 Sep 13.

State Key Laboratory of Southwestern Chinese Medicine Resources, 611137, Chengdu, PR China; Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, PR China. Electronic address:

Ethnopharmacological Relevance: Essential oil (EO) is the main extract of patchouli and tangerine peel with antiinflammatory, antiulcer, and other functions. However, the efficacy and mechanism of the combination of EO from patchouli and tangerine peel against gastric ulcer (GU) are unclear.

Aim Of The Study: This study aims to reveal the protective effect of the combination of EO from patchouli and tangerine peel against GU in rats, as well as explore the optimal ratio and possible mechanism of EO in GU treatment. Read More

View Article and Full-Text PDF
September 2021

CXCR4 PET/MRI for follow-up of gastric mucosa-associated lymphoid tissue lymphoma after first-line H. pylori eradication.

Blood 2021 Sep 15. Epub 2021 Sep 15.

Medical University of Vienna, Vienna, Austria.

Post-treatment evaluation of gastric mucosa-associated lymphoid tissue (MALT) lymphoma currently relies on esophagogastroduodenoscopy with histological assessment of biopsies. Overexpression of the G-protein-coupled C-X-C chemokine receptor type 4 (CXCR4) has been previously observed in MALT lymphoma. The aim of this prospective study was to evaluate PET with the novel CXCR4 tracer [68Ga]Pentixafor as a potential alternative to follow-up biopsies for assessment of residual disease (non-complete remission (CR)) after first-line H. Read More

View Article and Full-Text PDF
September 2021

Acute neutrophilic gastritis induced by nivolumab used as a treatment of non- metastatic malignant melanoma.

Rev Esp Enferm Dig 2021 Sep 15. Epub 2021 Sep 15.

Medicina Digestiva, Hospital General Universitario de Elche.

We present a 47 year-old man with a personal history of malignant melanoma (pT3bN2M0) radically removed, who was receiving adjuvant Nivolumab for prevention of recurrence. He was admitted to our service complaining of epigastric pain and hyporexia after receiving the 9º dose of Nivolumab. He underwent a preferential esophagogastroduodenoscopy which showed an intense inflammation limited to the stomach. Read More

View Article and Full-Text PDF
September 2021

Ocular adnexal lymphoma: an updated review of pathogenesis, diagnosis, and treatment.

Yeungnam Univ J Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea.

Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of 'salmon patch', ocular adnexa lymphoma (OAL) should be suspected. Read More

View Article and Full-Text PDF
September 2021

Cancerous and non-neoplastic stem cells in the stomach similarly express CD44 and CD133.

Acta Histochem 2021 Sep 10;123(7):151787. Epub 2021 Sep 10.

Graduation Program of Pathology, Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceara, 60441750 Fortaleza, Brazil. Electronic address:

CD44 and CD133 have been considered as cancer stem cell (CSC) markers. Stem cell markers are rarely described in healthy stomach tissues. However, the clinicopathological and prognostic value of CD44 and CD133 in gastric cancer remains controversial. Read More

View Article and Full-Text PDF
September 2021

Effectiveness of the fruit of Rosa odorata sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils in the protection and the healing of ethanol-induced rat gastric mucosa ulcer based on Nrf2/NF-κB pathway regulation.

J Ethnopharmacol 2021 Sep 10;282:114626. Epub 2021 Sep 10.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin, 300380, China. Electronic address:

Ethnopharmacological Relevance: Rosa odorata Sweet var. gigantea (Coll. et Hemsl. Read More

View Article and Full-Text PDF
September 2021

A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy With Enzyme-Selective Fluorescent Probes: A Pilot Study.

Front Oncol 2021 27;11:634219. Epub 2021 Aug 27.

Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea.

Background: Endoscopy is the most important tool for gastric cancer diagnosis. However, it relies on naked-eye evaluation by endoscopists, and the histopathologic confirmation is time-consuming. We aimed to visualize and measure the activity of various enzymes through two-photon microscopy (TPM) using fluorescent probes and assess its diagnostic potential in gastric cancer. Read More

View Article and Full-Text PDF

Two Types of Polyp Shape Observed in the Stomach of Patients with Peutz-Jeghers Syndrome.

Acta Med Okayama 2021 Aug;75(4):471-477

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

The characteristics of gastric polyps in patients with Peutz-Jeghers (PJ) syndrome (PJS) have not been fully investigated. The objective of this study was to reveal the endoscopic and pathologic findings of gastric polyps in patients with PJS. We reviewed 11 patients with PJS treated at 6 institutions, and summarized the endo-scopic and pathologic features of their gastric polyps. Read More

View Article and Full-Text PDF

[Clinical characteristics of five patients with gastric emphysema].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(9):851-858

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Gastric emphysema is a rare condition in which gas from a nonbacterial source accumulates within the gastric wall. In this study, we retrospectively analyzed the cases of five patients who were diagnosed with gastric emphysema at the Okayama University Hospital between January 2010 and April 2021, to reveal the clinical features of the disease. Based on their reviews, we revealed that:i) gastric emphysema occurred in hospitalized bedridden patients (n=5), such as those during/after endotracheal intubation (n=3), those undergoing gastric tube placement (n=3), those undergoing percutaneous endoscopic gastrostomy (n=1), and those undergoing treatment for cerebral infarction (n=1);ii) gastric emphysema was accompanied by the accumulation of gas in the portal (n=4) or gastric veins (n=1);iii) gastric emphysema was accompanied by colon wall thickness increase (n=4);iv) esophagogastroduodenoscopy showed redness, erosions, coarse mucosa, and/or ulcers (n=5);v) a clear boundary between the damaged area and the intact mucosa was observed (n=5);vi) the anterior wall of the stomach was less affected (n=4);vii) mucosal damage was predominant in the gastric folds, whereas the furrow of the mucosa was less affected;and viii) treatment with enteral nutrition suspension and the administration of proton pump inhibitors and antibiotics resulted in the recovery of patients from gastric emphysema (n=5). Read More

View Article and Full-Text PDF
September 2021

[Integrin α5 promotes the proliferation, invasion and adhesion of gastric cancer by regulating the FAK/Src/Rac1 signaling pathway].

Zhonghua Yi Xue Za Zhi 2021 Sep;101(34):2692-2697

Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To elucidate the biological role and potential mechanism of integrin α5 (ITGA5) in gastric cancer (GC). From January 2019 to December 2020, 35 pairs of GC tissue [21 males and 14 females, aged (53.8±5. Read More

View Article and Full-Text PDF
September 2021