6,965 results match your criteria gastric leukocytes

Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer.

Cancer Biol Med 2021 Jul 14. Epub 2021 Jul 14.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: To study the efficacy of the enhanced recovery after surgery (ERAS) program on postoperative recovery and complications in patients with gastric cancer.

Methods: Eighty patients in the perioperative period with radical gastrectomy were enrolled and randomly divided into 2 groups, the ERAS group and the non-ERAS group. The differences between the 2 groups in terms of postoperative recoveries and complications rate were determined. Read More

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Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice.

Sci Rep 2021 Jul 1;11(1):13640. Epub 2021 Jul 1.

Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.

Euglena gracilis is widely utilized as food or supplement to promote human and animal health, as it contains rich nutrients. In this study, we administered spray-dried powder of E. gracilis and paramylon, β-glucan stored in E. Read More

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Usefulness of inflammatory markers in detecting esophagojejunostomy leakage.

Rev Gastroenterol Mex (Engl Ed) 2021 Jul-Sep;86(3):229-235. Epub 2021 May 14.

Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Electronic address:

Introduction And Aim: Total gastrectomy is utilized in different pathologies. Esophagojejunostomy leakage is a frequent complication. Our aim was to determine the association of the neutrophil-lymphocyte ratio (NLR) with esophagojejunostomy leakage that subsequently required invasive treatment. Read More

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The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut.

Int J Mol Sci 2021 Jun 6;22(11). Epub 2021 Jun 6.

Institute of Pharmacology, Hannover Medical School, D-30625 Hannover, Germany.

Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (HR) antagonists, which are used to control allergic inflammation, antagonists at HR, which therapeutically decrease gastric acid release, and an antagonist at HR, which is indicated to treat narcolepsy. Read More

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Clinical Significance of Composition Changes in T-cell Subpopulations After Chemotherapy in Patients With Gastric Cancer.

In Vivo 2021 Jul-Aug;35(4):2417-2424

Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea

Background/aim: New therapeutic agents and prognostic biomarkers for gastric cancer are needed. We analyzed the composition of peripheral blood T-cell subpopulations in response to chemotherapy in patients with gastric cancer.

Patients And Methods: Peripheral blood samples were collected from patients diagnosed with gastric cancer before and after chemotherapy (FOLFOX; oxaliplatin, 5-fluorouracil, and leucovorin). Read More

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The circadian clock is associated with prognosis and immune infiltration in stomach adenocarcinoma.

Aging (Albany NY) 2021 06 23;13(12):16637-16655. Epub 2021 Jun 23.

Department of Emergency, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China.

Background: Stomach adenocarcinoma (STAD) is one of the most prevalent malignances and ranks fifth in incidence and third in cancer-related death among all malignances. The prognosis of STAD is poor. The circadian clock is regulated by interlocked transcriptional-translational feedback loops that orchestrate circadian rhythms in some biological processes, including the immune response and metabolism. Read More

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[rCsHscB derived from has therapeutic effect on dextran sodium sulfate-induced chronic ulcerative colitis in mice].

Nan Fang Yi Ke Da Xue Xue Bao 2021 May;41(5):664-670

Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Key Laboratory of Infection and Immunity, Department of Pathogen and Immunology, Xuzhou Medical University, Xuzhou 221004, China.

Objective: To investigate the therapeutic effect of rCsHscB derived from on dextran sodium sulfate (DSS)-induced chronic ulcerative colitis in mice.

Objective: C57BL/6 mice were randomized into negative control (NC) group (= 10), rCsHscB group (=10), DSS group (=15), and DSS+rCsHscB group (=15), and in the latter two groups, chronic ulcerative colitis was induced in the mice using 2% DSS. In rCsHscB and DSS+ rCsHscB groups, the mice received intraperitoneal injections of 125 μg/mL rCsHscB on the 4th and 7th day following DSS administration, and PBS was injected in the other two groups. Read More

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Significance of a preoperative systemic immune-inflammation index as a predictor of postoperative survival outcomes in gastric cancer.

World J Surg Oncol 2021 Jun 12;19(1):173. Epub 2021 Jun 12.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: Since inflammation and the immune system contribute to the development and progression of malignancies, parameters that reflect a host's immune-inflammatory status may be useful prognostic indicators of gastric cancer (GC). The present study examined the clinical significance of a preoperative systemic immune-inflammation index (SII) for predicting postoperative survival outcomes in GC.

Methods: A total of 447 patients who underwent curative gastrectomy for GC were included in the present study. Read More

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Baccharin and p-coumaric acid from green propolis mitigate inflammation by modulating the production of cytokines and eicosanoids.

J Ethnopharmacol 2021 Oct 29;278:114255. Epub 2021 May 29.

Centro Universitário Barão de Mauá (CBM), Ribeirão Preto, São Paulo, Brazil. Electronic address:

Ethnopharmacological Relevance: Green propolis is produced by Apis mellifera honeybees using Baccharis dracunculifolia D.C. (Asteraceae) as substrate. Read More

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October 2021

Gastric eosinophils are detrimental for Helicobacter pylori vaccine efficacy.

Vaccine 2021 06 25;39(27):3590-3601. Epub 2021 May 25.

Service of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland. Electronic address:

Helicobacter pylori (Hp) colonizes the human gastric mucosa with a high worldwide prevalence. Currently, Hp can be eradicated by the use of antibiotics. Due to the increase of antibiotic resistance, new therapeutic strategies need to be devised: one such approach being prophylactic vaccination. Read More

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Intratumoral CXCR5CD8T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.

Nat Commun 2021 05 25;12(1):3080. Epub 2021 May 25.

Department of Gastric Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China.

Studies that examined an association between CD8T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5CD8T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5CD8T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5CD8T cell infiltration are more likely to benefit from adjuvant chemotherapy. Read More

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Pediatric Buried Bumper Syndrome: Diagnostic Validity of Transabdominal Ultrasound and Artificial Intelligence.

Ultraschall Med 2021 May 25. Epub 2021 May 25.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University (FAU) Erlangen-Nuremberg, Germany.

Purpose:  Buried bumper syndrome (BBS) is a severe complication of percutaneous endoscopic gastrostomy (PEG) resulting from overgrowth of gastric mucosa and penetration of the inner holding plate into the gastric wall. The aim of this study was to evaluate the diagnostic value of transabdominal ultrasound (US) in comparison to an artificial intelligence (AI) model for the diagnosis of BBS in children.

Materials And Methods:  In this monocentric retrospective study, pediatric US data concerning BBS from a ten-year period (2009-2019) were analyzed. Read More

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Predictive Significance of Ki-67 and Platelet Lymphocyte Ratio in Patients with Gastric Cancer Receiving Neoadjuvant FLOT Chemotherapy.

J Coll Physicians Surg Pak 2021 May;30(5):546-552

Department of Medical Oncology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Objective: We aimed to determine the predictive significance of Ki-67 and platelet lymphocyte ratio (PLR) in patients with gastric cancer (GC), who received fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT) as neoadjuvant chemotherapy (NAC).

Study Design: Descriptive study.

Place And Duration Of Study: Department of Medical Oncology, Faculty of Medicine,  Ondokuz Mayıs University, Samsun, Turkey from March 2016 to January 2020. Read More

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Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component.

Biomed Res Int 2021 3;2021:9678363. Epub 2021 May 3.

Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Harbin 150081, China.

Background: The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of preoperative PLR on overall survival in gastric cancer patients with a mucinous component. Read More

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Association of ZNF331 and WIF1 methylation in peripheral blood leukocytes with the risk and prognosis of gastric cancer.

BMC Cancer 2021 May 15;21(1):551. Epub 2021 May 15.

Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, 157 Baojian Road, Harbin, 150081, Heilongjiang Province, People's Republic of China.

Background: Peripheral blood leukocyte (PBL) DNA methylation may serve as a surrogate marker to evaluate the susceptibility to and prognosis of gastric cancer (GC). In this study, blood-derived DNA methylation levels of two tumour-related genes, namely, ZNF331 and WIF1, and their impacts on the risk and prognosis of GC were evaluated.

Methods: In total, 398 GC cases and 397 controls were recruited for the study. Read More

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Cancer-Related Venous Thromboembolism: From Pathogenesis to Risk Assessment.

Semin Thromb Hemost 2021 May 14. Epub 2021 May 14.

Department of Medical Oncology, Centro Hospitalar Universitário do Porto, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.

Cancer-related venous thromboembolism (VTE) remains a major health problem, accounting for at least 18% of all cases of VTE. Cancer patients with VTE have worse prognosis than those without VTE. Prophylaxis reduces VTE risk, but it is not feasible for all outpatients with cancer due to an increased bleeding risk. Read More

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Glucocorticoids and Androgens Protect From Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation.

Gastroenterology 2021 May 7. Epub 2021 May 7.

Molecular Endocrinology Group, Signal Transduction Laboratory, North Carolina. Electronic address:

Background & Aims: The immune compartment is critical for maintaining tissue homeostasis. A weak immune response increases susceptibility to infection, but immune hyperactivation causes tissue damage, and chronic inflammation may lead to cancer development. In the stomach, inflammation damages the gastric glands and drives the development of potentially preneoplastic metaplasia. Read More

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Tumor-Associated Macrophages and Inflammatory Microenvironment in Gastric Cancer: Novel Translational Implications.

Int J Mol Sci 2021 Apr 7;22(8). Epub 2021 Apr 7.

Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Gastric cancer (GC) represents the fifth most frequently diagnosed cancer worldwide, with a poor prognosis in patients with advanced disease despite many improvements in systemic treatments in the last decade. In fact, GC has shown resistance to several treatment options, and thus, notable efforts have been focused on the research and identification of novel therapeutic targets in this setting. The tumor microenvironment (TME) has emerged as a potential therapeutic target in several malignancies including GC, due to its pivotal role in cancer progression and drug resistance. Read More

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Rare Nivolumab-associated Super Hyper Progressive Disease in Patients With Advanced Gastric Cancer.

In Vivo 2021 May-Jun;35(3):1865-1875

Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Background/aim: Rapid tumor growth after administration of immune checkpoint inhibitors is designated hyper progressive disease (HPD). In this study, besides the conventional HPD category, we proposed the "super HPD" category where the disease is naturally rapidly growing.

Patients And Methods: Patients treated for advanced gastric cancer with irinotecan or nivolumab as a third-line treatment were retrospectively compared. Read More

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Apatinib combined with PD-L1 blockade synergistically enhances antitumor immune responses and promotes HEV formation in gastric cancer.

J Cancer Res Clin Oncol 2021 Aug 23;147(8):2209-2222. Epub 2021 Apr 23.

Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.

Purpose: Apatinib, an antiangiogenic drug, has shown beneficial effects only in a fraction of advanced gastric cancer (GC) patients. Given the recent success of immunotherapies, combination of apatinib with immune checkpoint inhibitor may provide sustained and potent antitumor responses.

Methods: Immunocompetent mice with subcutaneous MFC tumors grown were given a combination of apatinib and anti-PD-L1 antibody therapy. Read More

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Patterns of immune infiltration in gastric cancer and their clinical significance.

Jpn J Clin Oncol 2021 Jul;51(7):1067-1079

Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: The malignant phenotypes of cancer are defined not only by its intrinsic tumor cells but also by the tumor-infiltrating immune cells activated and recruited to the cancer microenvironment. However, a comprehensive introduction of gastric cancer immune cell infiltration has not been identified so far.

Methods: In this study, we comprehensively analyzed the tumor-infiltrating immune cells abundance in gastric cancer for the first time by CIBERSORT. Read More

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A gastro-colic fistula secondary to high-grade B-cell gastric lymphoma in a patient with AIDS: a case report.

J Int Med Res 2021 Apr;49(4):3000605211006602

Division of Gastroenterology & Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

To the best of our knowledge, there are no previous reports of a gastro-colic fistula (GCF) secondary to primary high-grade B-cell gastric lymphoma associated with acquired immunodeficiency syndrome (AIDS). Here, we report a 37-year-old man who presented with paroxysmal abdominal pain for 4 months, diarrhea for 15 days and weight loss of 4 kg. He had a history of human immunodeficiency virus (HIV) infection and was diagnosed with AIDS in 2013. Read More

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A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma.

Sci Transl Med 2021 04;13(588)

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR 999077, China.

Insufficient T cell infiltration into noninflamed tumors, such as hepatocellular carcinoma (HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of patients. Epigenetic therapy provides further opportunities to rewire cancer-associated transcriptional programs, but whether and how selective epigenetic inhibition counteracts the immune-excluded phenotype remain incompletely defined. Here, we showed that pharmacological inhibition of histone deacetylase 8 (HDAC8), a histone H3 lysine 27 (H3K27)-specific isozyme overexpressed in a variety of human cancers, thwarts HCC tumorigenicity in a T cell-dependent manner. Read More

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Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer.

Anticancer Res 2021 Mar;41(3):1571-1577

Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan.

Background/aim: Tumor-infiltrating Foxp3 regulatory T-cells (Ti-Tregs) promote tumor progression and contribute to poor prognosis in gastric cancer, but the relationship between Ti-Tregs and response to chemotherapy for liver metastases from gastric cancer (LMGC) is unclear. We estimated the correlation between pathological response to chemotherapy and Ti-Tregs in LMGC.

Patients And Methods: Ti-Tregs were analyzed with immunohistochemistry as CD3 Foxp3 cells in patients with synchronous LMGC. Read More

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Cancer-derived Exosomes Activate Immune Surveillance and Suppress Peritoneal Metastasis of Murine Colonic Cancer.

Anticancer Res 2021 Mar;41(3):1327-1339

Department of Surgery, Shiga University of Medical Science, Shiga, Japan.

Background: Colonic cancer is associated with a low incidence of peritoneal metastasis compared with gastric cancer; however, the reason for this remains unclear. In this study, a model of peritoneal dissemination using the CT26 murine colon cancer cell line was used to analyze the physiological roles of cancer-derived exosomes.

Materials And Methods: Exosomes were collected from the supernatant of CT26 cell culture by ultracentrifugation. Read More

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Monitoring FTD in the peripheral blood mononuclear cells of elderly patients with metastatic colorectal cancer administered FTD plus bevacizumab as first-line treatment.

Cancer Sci 2021 Jun 3;112(6):2436-2441. Epub 2021 May 3.

Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Trifluridine/tipiracil (FTD/TPI) is an orally administrated anticancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC) or gastric cancer. FTD, a key component of FTD/TPI, exerts antitumor effects via its incorporation into DNA. Using specific antibodies against bromodeoxyuridine, FTD incorporation into DNA is detected in tumors and peripheral blood mononuclear cells (PBMC) of patients with mCRC who are administered FTD/TPI. Read More

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Platelet to Lymphocyte Ratio Associated with Prolonged Hospital Length of Stay Postpeptic Ulcer Perforation Repair: An Observational Descriptive Analysis.

Biomed Res Int 2021 9;2021:6680414. Epub 2021 Mar 9.

Department of Surgery, Trauma Surgery, Hamad Medical Corporation, Doha, Qatar.

Background: The predictive role of platelet to lymphocyte ratio (P/LR) in patients with perforated peptic ulcer (PPU) is not well-studied. We aimed to investigate the association between the P/LR ratio and the hospital length of stay (HLOS) for surgically treated PPU.

Method: This is a retrospective observational study for surgically treated adult cases of PPU at Hamad Medical Corporation during the period from January 2012 to August 2017. Read More

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An Evaluation of the Effect of Preoperative Inflammation-based Factors on Survival in Gastric Cancer Patients.

J Coll Physicians Surg Pak 2021 Mar;31(3):282-287

Department of General Surgery, Ankara Training and Research Hospital, Turkey.

Objective: To investigate the predictive effect of preoperative inflammatory factors on overall survival (OS) in patients diagnosed with gastric adenocarcinoma (GAC).

Study Design: Observational study.

Place And Duration Of Study: Department of General Surgery, Ankara Training and Research Hospital, between January 2011 and October 2020. Read More

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Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer.

Cancer Med 2021 05 26;10(9):3129-3138. Epub 2021 Mar 26.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: A simple measure of immune cytolytic activity (CYT) base on mRNA expression levels of two genes, GZMA and PRF1, was recently reported. Here, we aimed to evaluate the CYT score's potential as a measure of antitumor immunity and predictor of clinical outcome in gastric cancer (GC) patients.

Materials And Methods: We evaluated the correlations between tumor-infiltrating immune cells and the CYT score in 238 GC samples from The Cancer Genome Atlas (TCGA). Read More

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Analysis of T Cell Responses to Helicobacter pylori Infection.

Methods Mol Biol 2021 ;2283:215-223

Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.

Analysis of human and mouse T-helper (Th) cell subset responses is key to understanding how the inflammatory response in the stomach is regulated, and links with pathology and disease outcomes. Here, we present methods for extracting cells from blood and tissue, and analyzing the balance of Th1, Th2, Th17, and regulatory T cell (Treg) subsets using flow cytometry and cytokine ELISA . Read More

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